DK110189A - Peptider og antistoffer til inhibering af blodpladeadhaesion - Google Patents

Peptider og antistoffer til inhibering af blodpladeadhaesion

Info

Publication number
DK110189A
DK110189A DK110189A DK110189A DK110189A DK 110189 A DK110189 A DK 110189A DK 110189 A DK110189 A DK 110189A DK 110189 A DK110189 A DK 110189A DK 110189 A DK110189 A DK 110189A
Authority
DK
Denmark
Prior art keywords
antibodies
peptides
libs
platelet adhesion
inhibit platelet
Prior art date
Application number
DK110189A
Other languages
English (en)
Other versions
DK110189D0 (da
DK175655B1 (da
Inventor
Edward F Plow
Mark H Ginsberg
Original Assignee
Scripps Clinic Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Clinic Res filed Critical Scripps Clinic Res
Publication of DK110189D0 publication Critical patent/DK110189D0/da
Publication of DK110189A publication Critical patent/DK110189A/da
Application granted granted Critical
Publication of DK175655B1 publication Critical patent/DK175655B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2839—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G01N33/56972—White blood cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/811—Test for named disease, body condition or organ function

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Virology (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK198901101A 1987-07-08 1989-03-07 Polypeptidanalog til en kryptisk hGPllb-determinant, monoklonal antistofsammensætning, antistofsammensætning, hybridom, diagnostisk system i form af et sæt, fremgangsmåde til dannelse af et monoklonalt antistof, fremgangsmåde til detektering..... DK175655B1 (da)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US7095387A 1987-07-08 1987-07-08
US7095387 1987-07-08
US17534288 1988-03-31
US07/175,342 US5114842A (en) 1987-07-08 1988-03-31 Peptides and antibodies that inhibit platelet adhesion
US8802312 1988-07-08
PCT/US1988/002312 WO1989000200A1 (en) 1987-07-08 1988-07-08 Peptides and antibodies that inhibit platelet adhesion

Publications (3)

Publication Number Publication Date
DK110189D0 DK110189D0 (da) 1989-03-07
DK110189A true DK110189A (da) 1989-05-08
DK175655B1 DK175655B1 (da) 2005-01-10

Family

ID=26751678

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198901101A DK175655B1 (da) 1987-07-08 1989-03-07 Polypeptidanalog til en kryptisk hGPllb-determinant, monoklonal antistofsammensætning, antistofsammensætning, hybridom, diagnostisk system i form af et sæt, fremgangsmåde til dannelse af et monoklonalt antistof, fremgangsmåde til detektering.....

Country Status (9)

Country Link
US (4) US5114842A (da)
EP (1) EP0326595B1 (da)
JP (3) JP3184878B2 (da)
AT (1) ATE128183T1 (da)
DE (1) DE3854496T2 (da)
DK (1) DK175655B1 (da)
FI (1) FI105276B (da)
NO (1) NO300505B1 (da)
WO (1) WO1989000200A1 (da)

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US5306620A (en) * 1987-07-08 1994-04-26 The Scripps Research Institute Antibodies that bind to a ligand-induced binding site on integrin and induce integrin activation
US5827821A (en) * 1987-12-10 1998-10-27 The Burnham Institute Conformationally stabilized cell adhesion peptides
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CA2000048A1 (en) * 1988-10-03 1990-04-03 Edward F. Plow Peptides and antibodies that inhibit integrin-ligand bindin g
EP1201757A3 (en) * 1988-12-22 2002-09-11 Genentech, Inc. Method for preparing water soluble polypeptides
US5378464A (en) * 1989-03-08 1995-01-03 Board Of Regents Of The University Of Oklahoma Modulation of inflammatory responses by administration of GMP-140 or antibody to GMP-140
US5464778A (en) * 1989-03-08 1995-11-07 Board Of Regents Of The University Of Oklahoma Glycoprotein ligand for P-selectin and methods of use thereof
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US5384309A (en) * 1989-07-17 1995-01-24 Genentech, Inc. Cyclized peptides and their use as platelet aggregation inhibitors
WO1991001380A1 (fr) * 1989-07-25 1991-02-07 Institut National De La Sante Et De La Recherche Medicale Anticorps monoclonaux diriges contre des proteines impliquees dans les fonctions plaquettaires, leur application en tant qu'agent diagnostique et therapeutique
FR2650186B1 (fr) * 1989-07-25 1992-02-28 Inst Nat Sante Rech Med Anticorps monoclonaux diriges contre des proteines impliquees dans les fonctions plaquettaires. leur application en tant qu'agent diagnostique et therapeutique
US5196511A (en) * 1989-12-01 1993-03-23 The Scripps Research Institute Peptides and antibodies that inhibit integrin-ligand binding
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US6884590B1 (en) 1994-02-11 2005-04-26 Cedars-Sinai Medical Center Methods of screening for ulcerative colitis and crohn's disease
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US5763199A (en) * 1994-09-29 1998-06-09 Mount Sinai School Of Medicine Of The City University Of New York Platelet blockade assay
US5877155A (en) * 1995-03-17 1999-03-02 The Research Foundation Of State University Of New York Mimotopes and anti-mimotopes of human platelet glycoprotein Ib/IX
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KR102343212B1 (ko) 2013-03-27 2021-12-23 세다르스-신나이 메디칼 센터 Tl1a 기능 및 관련된 신호전달 경로의 저해에 의한 섬유증 및 염증의 완화 및 반전
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Also Published As

Publication number Publication date
DK110189D0 (da) 1989-03-07
EP0326595A4 (en) 1990-09-05
JP3420747B2 (ja) 2003-06-30
FI891078L (fi) 1989-03-07
EP0326595B1 (en) 1995-09-20
US5470738A (en) 1995-11-28
DE3854496D1 (de) 1995-10-26
US5284751A (en) 1994-02-08
JP2001190287A (ja) 2001-07-17
NO890981L (no) 1989-05-05
DK175655B1 (da) 2005-01-10
JPH02500085A (ja) 1990-01-18
JPH10276778A (ja) 1998-10-20
JP3184878B2 (ja) 2001-07-09
FI105276B (fi) 2000-07-14
FI891078A0 (fi) 1989-03-07
EP0326595A1 (en) 1989-08-09
DE3854496T2 (de) 1996-06-13
NO300505B1 (no) 1997-06-09
WO1989000200A1 (en) 1989-01-12
US5498499A (en) 1996-03-12
NO890981D0 (no) 1989-03-07
US5114842A (en) 1992-05-19
JP3541122B2 (ja) 2004-07-07
ATE128183T1 (de) 1995-10-15

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