DK1102745T3 - Fremgangsmåde til fremstilling af zofenoprilcalciumsalt - Google Patents

Fremgangsmåde til fremstilling af zofenoprilcalciumsalt

Info

Publication number: DK1102745T3
Authority: DK; Denmark
Prior art keywords: zofenopril; salt; calcium salt; preparation; potassium salt
Prior art date: 1998-08-04

Application number

DK99939416T

Other languages

English (en)

Inventor

Raffaello Giorgi

Antonio Giachetti

Carlo Mannucci

Anita Falezza

Original Assignee

Menarini Int Operations Lu Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-08-04

Filing date

1999-07-30

Publication date

2004-08-02

1999-07-30 Application filed by Menarini Int Operations Lu Sa filed Critical Menarini Int Operations Lu Sa

2004-08-02 Application granted granted Critical

2004-08-02 Publication of DK1102745T3 publication Critical patent/DK1102745T3/da

Links

238000000034 method Methods 0.000 title abstract 2
238000002360 preparation method Methods 0.000 title abstract 2
NSYUKKYYVFVMST-LETVYOFWSA-L zofenopril calcium Chemical class [Ca+2].C([C@@H](C)C(=O)N1[C@@H](C[C@@H](C1)SC=1C=CC=CC=1)C([O-])=O)SC(=O)C1=CC=CC=C1.C([C@@H](C)C(=O)N1[C@@H](C[C@@H](C1)SC=1C=CC=CC=1)C([O-])=O)SC(=O)C1=CC=CC=C1 NSYUKKYYVFVMST-LETVYOFWSA-L 0.000 title abstract 2
IAIDUHCBNLFXEF-MNEFBYGVSA-N zofenopril Chemical compound C([C@@H](C)C(=O)N1[C@@H](C[C@@H](C1)SC=1C=CC=CC=1)C(O)=O)SC(=O)C1=CC=CC=C1 IAIDUHCBNLFXEF-MNEFBYGVSA-N 0.000 abstract 3
239000007864 aqueous solution Substances 0.000 abstract 2
238000006243 chemical reaction Methods 0.000 abstract 2
XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 abstract 2
238000011084 recovery Methods 0.000 abstract 2
229960002769 zofenopril Drugs 0.000 abstract 2
XXNAGGDFBCTLQA-DHTOPLTISA-N (2r,4r)-4-phenylsulfanylpyrrolidine-2-carboxylic acid;hydrochloride Chemical compound Cl.C1N[C@@H](C(=O)O)C[C@H]1SC1=CC=CC=C1 XXNAGGDFBCTLQA-DHTOPLTISA-N 0.000 abstract 1
BCAYPPFBOJCRPN-MRVPVSSYSA-N (2s)-3-benzoylsulfanyl-2-methylpropanoic acid Chemical compound OC(=O)[C@H](C)CSC(=O)C1=CC=CC=C1 BCAYPPFBOJCRPN-MRVPVSSYSA-N 0.000 abstract 1
UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
230000002378 acidificating effect Effects 0.000 abstract 1
230000001476 alcoholic effect Effects 0.000 abstract 1
239000001110 calcium chloride Substances 0.000 abstract 1
229910001628 calcium chloride Inorganic materials 0.000 abstract 1
235000011148 calcium chloride Nutrition 0.000 abstract 1
159000000007 calcium salts Chemical class 0.000 abstract 1
238000010899 nucleation Methods 0.000 abstract 1
238000001556 precipitation Methods 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
239000000243 solution Substances 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01F—COMPOUNDS OF THE METALS BERYLLIUM, MAGNESIUM, ALUMINIUM, CALCIUM, STRONTIUM, BARIUM, RADIUM, THORIUM, OR OF THE RARE-EARTH METALS
- C01F11/00—Compounds of calcium, strontium, or barium
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Heart & Thoracic Surgery (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)
Geology (AREA)
Inorganic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyrrole Compounds (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK99939416T 1998-08-04 1999-07-30 Fremgangsmåde til fremstilling af zofenoprilcalciumsalt DK1102745T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT1998MI001833A IT1301993B1 (it)	1998-08-04	1998-08-04	Processo per la preparazione di zofenopril sale di calcio.

Publications (1)

Publication Number	Publication Date
DK1102745T3 true DK1102745T3 (da)	2004-08-02

Family

ID=11380611

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK99939416T DK1102745T3 (da)	1998-08-04	1999-07-30	Fremgangsmåde til fremstilling af zofenoprilcalciumsalt

Country Status (32)

Country	Link
US (2)	US6521760B1 (da)
EP (1)	EP1102745B1 (da)
JP (1)	JP2002522417A (da)
KR (1)	KR100593428B1 (da)
CN (1)	CN1146538C (da)
AT (1)	ATE266635T1 (da)
AU (1)	AU5372299A (da)
BG (1)	BG65022B1 (da)
BR (1)	BR9912842A (da)
CA (1)	CA2339283C (da)
CU (1)	CU23171A3 (da)
CZ (1)	CZ301908B6 (da)
DE (1)	DE69917282T2 (da)
DK (1)	DK1102745T3 (da)
EA (1)	EA003454B1 (da)
EE (1)	EE04798B1 (da)
ES (1)	ES2221417T3 (da)
HK (1)	HK1039616B (da)
HR (1)	HRP20010083B1 (da)
HU (1)	HU227557B1 (da)
IL (1)	IL141222A0 (da)
IT (1)	IT1301993B1 (da)
NO (1)	NO319773B1 (da)
PL (1)	PL193828B1 (da)
PT (1)	PT1102745E (da)
RS (1)	RS49768B (da)
SI (1)	SI1102745T1 (da)
SK (1)	SK285527B6 (da)
TR (1)	TR200100272T2 (da)
UA (1)	UA65628C2 (da)
WO (1)	WO2000007984A1 (da)
ZA (1)	ZA200100907B (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PT1899297E (pt) *	2005-07-01	2016-03-21	Generics Uk Ltd	Zofenopril de cálcio em forma polimórfica c
EA012845B1 (ru) *	2005-12-09	2009-12-30	Менарини Интернэшнл Оперейшнс Люксембург С. А.	Фармацевтическая композиция, содержащая зофеноприл и hctz, для лечения гипертензии
RS53733B1 (sr) *	2006-05-26	2015-06-30	Generics	Postupci za pripremu zofenopril kalcijuma
GB0715626D0 (en) *	2007-08-10	2007-09-19	Generics Uk Ltd	Crystalline form of zofenopril calcium
CA2715726C (en) *	2008-02-27	2014-12-02	Vinayak Gore	Novel crystalline forms
US8853421B2 (en)	2008-02-27	2014-10-07	Generics [Uk] Limited	Crystalline forms of zofenopril calcium
WO2010084515A2 (en) *	2009-01-23	2010-07-29	Glenmark Generics Limited	A process for the preparation of zofenopril and its pharmaceutically acceptable salts thereof
SI23949A (sl)	2011-12-19	2013-06-28	Silverstone Pharma	Nove kristalne soli zofenoprila, postopek za njihovo dobivanje in njihova uporaba v terapiji
CN104138359B (zh) *	2013-05-06	2016-03-02	扬子江药业集团上海海尼药业有限公司	佐芬普利钙片的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4105776A (en) *	1976-06-21	1978-08-08	E. R. Squibb & Sons, Inc.	Proline derivatives and related compounds
US4154935A (en) *	1978-02-21	1979-05-15	E. R. Squibb & Sons, Inc.	Halogen substituted mercaptoacylamino acids
US4316906A (en) *	1978-08-11	1982-02-23	E. R. Squibb & Sons, Inc.	Mercaptoacyl derivatives of substituted prolines

1998
- 1998-08-04 IT IT1998MI001833A patent/IT1301993B1/it active IP Right Grant
1999
- 1999-07-30 HK HK02101248.6A patent/HK1039616B/zh not_active IP Right Cessation
- 1999-07-30 AT AT99939416T patent/ATE266635T1/de active
- 1999-07-30 DK DK99939416T patent/DK1102745T3/da active
- 1999-07-30 CA CA002339283A patent/CA2339283C/en not_active Expired - Lifetime
- 1999-07-30 RS YUP-75/01A patent/RS49768B/sr unknown
- 1999-07-30 ES ES99939416T patent/ES2221417T3/es not_active Expired - Lifetime
- 1999-07-30 WO PCT/EP1999/005461 patent/WO2000007984A1/en not_active Ceased
- 1999-07-30 BR BR9912842-0A patent/BR9912842A/pt not_active Application Discontinuation
- 1999-07-30 EE EEP200100065A patent/EE04798B1/xx unknown
- 1999-07-30 HR HR20010083A patent/HRP20010083B1/xx not_active IP Right Cessation
- 1999-07-30 UA UA2001010590A patent/UA65628C2/uk unknown
- 1999-07-30 CZ CZ20010408A patent/CZ301908B6/cs not_active IP Right Cessation
- 1999-07-30 PL PL99345814A patent/PL193828B1/pl unknown
- 1999-07-30 TR TR2001/00272T patent/TR200100272T2/xx unknown
- 1999-07-30 KR KR1020017001379A patent/KR100593428B1/ko not_active Expired - Lifetime
- 1999-07-30 CN CNB998105171A patent/CN1146538C/zh not_active Expired - Lifetime
- 1999-07-30 EA EA200100095A patent/EA003454B1/ru not_active IP Right Cessation
- 1999-07-30 EP EP99939416A patent/EP1102745B1/en not_active Expired - Lifetime
- 1999-07-30 SK SK163-2001A patent/SK285527B6/sk not_active IP Right Cessation
- 1999-07-30 AU AU53722/99A patent/AU5372299A/en not_active Abandoned
- 1999-07-30 PT PT99939416T patent/PT1102745E/pt unknown
- 1999-07-30 SI SI9930575T patent/SI1102745T1/xx unknown
- 1999-07-30 DE DE69917282T patent/DE69917282T2/de not_active Expired - Lifetime
- 1999-07-30 JP JP2000563619A patent/JP2002522417A/ja active Pending
- 1999-07-30 HU HU0103826A patent/HU227557B1/hu unknown
- 1999-07-30 IL IL14122299A patent/IL141222A0/xx not_active IP Right Cessation
- 1999-07-30 US US09/762,054 patent/US6521760B1/en not_active Expired - Fee Related
2001
- 2001-01-24 BG BG105176A patent/BG65022B1/bg unknown
- 2001-02-01 CU CU20010032A patent/CU23171A3/es unknown
- 2001-02-01 ZA ZA200100907A patent/ZA200100907B/en unknown
- 2001-02-01 NO NO20010552A patent/NO319773B1/no not_active IP Right Cessation
2002
- 2002-05-28 US US10/155,129 patent/US6515012B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
HRP20010083B1 (en)	2005-02-28
YU7501A (sh)	2005-06-10
CU23171A3 (es)	2006-09-22
HUP0103826A3 (en)	2002-03-28
JP2002522417A (ja)	2002-07-23
ES2221417T3 (es)	2004-12-16
IT1301993B1 (it)	2000-07-20
ZA200100907B (en)	2001-10-04
HU227557B1 (en)	2011-08-29
NO20010552D0 (no)	2001-02-01
CA2339283C (en)	2009-03-17
CN1146538C (zh)	2004-04-21
PL193828B1 (pl)	2007-03-30
HK1039616A1 (en)	2002-05-03
NO20010552L (no)	2001-02-01
IL141222A0 (en)	2002-03-10
HRP20010083A2 (en)	2002-02-28
KR100593428B1 (ko)	2006-06-28
EP1102745B1 (en)	2004-05-12
HUP0103826A2 (hu)	2002-02-28
US6515012B2 (en)	2003-02-04
RS49768B (sr)	2008-06-05
HK1039616B (zh)	2004-10-08
SI1102745T1 (en)	2004-10-31
US6521760B1 (en)	2003-02-18
BR9912842A (pt)	2001-10-16
US20020156293A1 (en)	2002-10-24
SK1632001A3 (en)	2001-09-11
ITMI981833A1 (it)	2000-02-04
DE69917282T2 (de)	2005-05-25
PT1102745E (pt)	2004-08-31
UA65628C2 (uk)	2004-04-15
ITMI981833A0 (it)	1998-08-04
EA003454B1 (ru)	2003-06-26
CZ301908B6 (cs)	2010-07-28
NO319773B1 (no)	2005-09-12
BG105176A (en)	2001-11-30
EE200100065A (et)	2002-06-17
SK285527B6 (sk)	2007-03-01
CZ2001408A3 (cs)	2001-07-11
WO2000007984A1 (en)	2000-02-17
KR20010072171A (ko)	2001-07-31
EA200100095A1 (ru)	2001-08-27
DE69917282D1 (de)	2004-06-17
PL345814A1 (en)	2002-01-14
BG65022B1 (bg)	2006-12-29
CN1316992A (zh)	2001-10-10
AU5372299A (en)	2000-02-28
TR200100272T2 (tr)	2001-05-21
CA2339283A1 (en)	2000-02-17
EP1102745A1 (en)	2001-05-30
EE04798B1 (et)	2007-04-16
ATE266635T1 (de)	2004-05-15

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ATE233728T1 (de)	2003-03-15	Verfahren zur reinigung von kreatin
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