ATE268767T1 - N-aryl-piperidinderivate und ihre verwendung als 5-ht1b-rezeptorliganden - Google Patents
N-aryl-piperidinderivate und ihre verwendung als 5-ht1b-rezeptorligandenInfo
- Publication number
- ATE268767T1 ATE268767T1 AT98400711T AT98400711T ATE268767T1 AT E268767 T1 ATE268767 T1 AT E268767T1 AT 98400711 T AT98400711 T AT 98400711T AT 98400711 T AT98400711 T AT 98400711T AT E268767 T1 ATE268767 T1 AT E268767T1
- Authority
- AT
- Austria
- Prior art keywords
- aryl
- piperidine derivatives
- receptor ligands
- ht1b receptor
- alkyl
- Prior art date
Links
- 102100027499 5-hydroxytryptamine receptor 1B Human genes 0.000 title 1
- 101710138639 5-hydroxytryptamine receptor 1B Proteins 0.000 title 1
- 239000003446 ligand Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 125000005073 adamantyl group Chemical group C12(CC3CC(CC(C1)C3)C2)* 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D411/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms
- C07D411/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D411/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Psychiatry (AREA)
- Child & Adolescent Psychology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR9703760A FR2761358B1 (fr) | 1997-03-27 | 1997-03-27 | Nouveaux composes de n-aryl piperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE268767T1 true ATE268767T1 (de) | 2004-06-15 |
Family
ID=9505236
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT98400711T ATE268767T1 (de) | 1997-03-27 | 1998-03-26 | N-aryl-piperidinderivate und ihre verwendung als 5-ht1b-rezeptorliganden |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US5965575A (de) |
| EP (1) | EP0867436B1 (de) |
| JP (1) | JPH10279578A (de) |
| CN (1) | CN1090628C (de) |
| AT (1) | ATE268767T1 (de) |
| AU (1) | AU731018B2 (de) |
| BR (1) | BR9803295A (de) |
| CA (1) | CA2232116C (de) |
| DE (1) | DE69824332T2 (de) |
| DK (1) | DK0867436T3 (de) |
| ES (1) | ES2223110T3 (de) |
| FR (1) | FR2761358B1 (de) |
| NO (1) | NO314628B1 (de) |
| NZ (1) | NZ330041A (de) |
| PL (1) | PL194118B1 (de) |
| PT (1) | PT867436E (de) |
| ZA (1) | ZA982607B (de) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2782515B1 (fr) * | 1998-08-21 | 2000-09-22 | Adir | NOUVEAUX DERIVES DE L'INDANE-1-Ol, LEUR PROCEDE DE PREPARATION ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT |
| JP2002535365A (ja) * | 1999-01-28 | 2002-10-22 | ブリストル−マイヤーズ スクイブ カンパニー | 抗うつ性複素環化合物 |
| EP1189900B1 (de) * | 1999-06-30 | 2004-01-14 | Bristol-Myers Squibb Company | Heterocyclische aminopyrrolidon-derivate als melatonergene wirkstoffe |
| GB0013737D0 (en) | 2000-06-07 | 2000-07-26 | Astrazeneca Ab | Novel compounds |
| SE0103650D0 (sv) * | 2001-11-01 | 2001-11-01 | Astrazeneca Ab | Therapeutic heterocyclic compounds |
| SE0103646D0 (sv) * | 2001-11-01 | 2001-11-01 | Astrazeneca Ab | Therapeutic chroman compounds |
| NZ526699A (en) * | 2001-01-16 | 2005-03-24 | Astrazeneca Ab | 8-amino derivatives and their use in treating migraine |
| NZ535574A (en) * | 2001-01-16 | 2006-07-28 | Astrazeneca Ab | Therapeutic heterocyclic compounds |
| WO2002069973A1 (en) * | 2001-03-02 | 2002-09-12 | Sepracor, Inc. | Piperidine-piperazine ligand for neurotransmitter receptors |
| SE0103836D0 (sv) * | 2001-11-16 | 2001-11-16 | Astrazeneca Ab | Novel compounds |
| JP2005343790A (ja) * | 2002-05-31 | 2005-12-15 | Ajinomoto Co Inc | カルシウムチャネル拮抗薬を含有する医薬組成物 |
| SE0300480D0 (sv) | 2003-02-21 | 2003-02-21 | Astrazeneca Ab | Novel compounds |
| GB0312609D0 (en) | 2003-06-02 | 2003-07-09 | Astrazeneca Ab | Novel compounds |
| ES2331519T3 (es) * | 2003-06-30 | 2010-01-07 | Nycomed Gmbh | Derivados de pirrolo-dihidroisoquinolina como inhibidores de pde10. |
| RS20050945A (sr) * | 2003-06-30 | 2008-06-05 | Altana Pharma Ag., | Novi pirolodihidroizohinolini koji se mogu upotrebiti u tretmanu kancera |
| EP1661894A4 (de) * | 2003-07-14 | 2007-02-28 | Ube Industries | Verfahren zur herstellung von 4-aminotetrahydropyranen und deren salzen mit säuren, zwischenprodukte für das verfahren und verfahren zur herstellung davon |
| AR045258A1 (es) * | 2003-08-21 | 2005-10-19 | Altana Pharma Ag | Un producto farmaceutico para inyeccion |
| US20060085924A1 (en) * | 2004-10-13 | 2006-04-27 | Gaelle Brun | Coloring composition comprising at least one pigment and at least one electrophilic cyanoacrylate monomer |
| AU2006218054A1 (en) * | 2005-01-12 | 2006-08-31 | Nycomed Gmbh | Novel pyrrolodihydroisoquinolines as PDE10 inhibitors |
| WO2006075012A2 (en) * | 2005-01-12 | 2006-07-20 | Nycomed Gmbh | Pyrrolodihydroisoquinolines as antiproliferative agents |
| US8599822B2 (en) * | 2005-03-23 | 2013-12-03 | Cisco Technology, Inc. | Slot-based transmission synchronization mechanism in wireless mesh networks |
| FR2884251B1 (fr) * | 2005-04-08 | 2007-07-13 | Servier Lab | Derives de piperazine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| UY29892A1 (es) * | 2005-11-04 | 2007-06-29 | Astrazeneca Ab | Nuevos derivados de cromano, composiciones farmaceuticas conteniendolos, procesos de preparacion y aplicaciones |
| MX2008014450A (es) | 2006-05-18 | 2009-03-09 | Mannkind Corp | Inhibidores de cinasa intracelular. |
| BRPI0809106A2 (pt) | 2007-03-22 | 2014-08-26 | Astrazeneca Ab | Derivados de quinolina para o tratamento de doenças inflamatórias |
| US8106073B2 (en) | 2007-11-30 | 2012-01-31 | Astrazeneca Ab | Quinoline derivatives 057 |
| TW200944523A (en) * | 2008-02-08 | 2009-11-01 | Organon Nv | (Dihydro)pyrrolo[2,1-a]isoquinolines |
| WO2020183011A1 (en) | 2019-03-14 | 2020-09-17 | Institut Curie | Htr1d inhibitors and uses thereof in the treatment of cancer |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2692264B1 (fr) * | 1992-06-12 | 1994-08-05 | Adir | Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les contenant. |
| GB9318431D0 (en) * | 1993-09-06 | 1993-10-20 | Boots Co Plc | Therapeutic agents |
| FR2734819B1 (fr) * | 1995-05-31 | 1997-07-04 | Adir | Nouveaux composes de la piperazine, de la piperidine et de la 1,2,5,6-tetrahydropyridine, leur procede de preparation et les compositions pharmaceutiques les contenant |
-
1997
- 1997-03-27 FR FR9703760A patent/FR2761358B1/fr not_active Expired - Fee Related
-
1998
- 1998-03-12 CA CA002232116A patent/CA2232116C/fr not_active Expired - Fee Related
- 1998-03-26 NZ NZ330041A patent/NZ330041A/xx unknown
- 1998-03-26 EP EP98400711A patent/EP0867436B1/de not_active Expired - Lifetime
- 1998-03-26 PT PT98400711T patent/PT867436E/pt unknown
- 1998-03-26 CN CN98109437A patent/CN1090628C/zh not_active Expired - Fee Related
- 1998-03-26 AT AT98400711T patent/ATE268767T1/de not_active IP Right Cessation
- 1998-03-26 DE DE69824332T patent/DE69824332T2/de not_active Expired - Fee Related
- 1998-03-26 PL PL325575A patent/PL194118B1/pl not_active IP Right Cessation
- 1998-03-26 ES ES98400711T patent/ES2223110T3/es not_active Expired - Lifetime
- 1998-03-26 DK DK98400711T patent/DK0867436T3/da active
- 1998-03-27 BR BR9803295A patent/BR9803295A/pt not_active Application Discontinuation
- 1998-03-27 US US09/049,233 patent/US5965575A/en not_active Expired - Fee Related
- 1998-03-27 ZA ZA982607A patent/ZA982607B/xx unknown
- 1998-03-27 NO NO19981415A patent/NO314628B1/no unknown
- 1998-03-27 AU AU59677/98A patent/AU731018B2/en not_active Ceased
- 1998-03-27 JP JP10081710A patent/JPH10279578A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| BR9803295A (pt) | 2000-03-21 |
| EP0867436A1 (de) | 1998-09-30 |
| EP0867436B1 (de) | 2004-06-09 |
| FR2761358A1 (fr) | 1998-10-02 |
| DE69824332D1 (de) | 2004-07-15 |
| FR2761358B1 (fr) | 1999-05-07 |
| ES2223110T3 (es) | 2005-02-16 |
| PL325575A1 (en) | 1998-09-28 |
| CA2232116C (fr) | 2003-09-16 |
| CN1197072A (zh) | 1998-10-28 |
| DE69824332T2 (de) | 2005-06-16 |
| PL194118B1 (pl) | 2007-04-30 |
| JPH10279578A (ja) | 1998-10-20 |
| AU731018B2 (en) | 2001-03-22 |
| DK0867436T3 (da) | 2004-10-04 |
| HK1014954A1 (en) | 1999-10-08 |
| US5965575A (en) | 1999-10-12 |
| CA2232116A1 (fr) | 1998-09-27 |
| NO981415L (no) | 1998-09-28 |
| PT867436E (pt) | 2004-09-30 |
| NO314628B1 (no) | 2003-04-22 |
| AU5967798A (en) | 1998-10-01 |
| CN1090628C (zh) | 2002-09-11 |
| NO981415D0 (no) | 1998-03-27 |
| ZA982607B (en) | 1998-09-30 |
| NZ330041A (en) | 1999-01-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69824332D1 (de) | N-Aryl-piperidinderivate und ihre Verwendung als 5-HT1B-Rezeptorliganden | |
| NO20002169D0 (no) | Nye pyridazinderivater og medikamenter inneholdende disse som effektive ingredienser | |
| ATE82966T1 (de) | Pyridincarboxamid-derivate und ihre verwendung als fungizides mittel. | |
| DE69028136D1 (de) | Alkoxyiminoacetamid-Derivate und ihre Verwendung als pilztötendes Mittel | |
| ATE243697T1 (de) | Substitutierte heterozyclische derivate als crf antagonisten | |
| ATE208779T1 (de) | Substituierte spiroheterocyclische 1h-3-aryl- pyrrolidin-2,4-dion-derivate, verfahren zu deren herstellung und deren verwendung als schädlingsbekämpfungsmittel | |
| DE69628276D1 (de) | Zubereitung von xanthinderivaten als feste dispersion | |
| DK0733621T3 (da) | Hidtil ukendte imidazolderivater og fremgangsmåde til fremstilling af disse | |
| DE69717970D1 (de) | Chinolin carbonsaure-derivate und ihre salze | |
| NO953052D0 (no) | Nye pyrrolokarbazoler | |
| ATE71619T1 (de) | Pyridazinon-derivate. | |
| DE69430839D1 (de) | Trizyklische Indol-2-carbonsäure Derivate als selektive NMDA Rezeptor Antagonisten | |
| DE69906243D1 (de) | 2-Indanmethanolderivate und ihre Verwendung als Riechstoffe | |
| HUP9800687A1 (hu) | N-aril-piperidin-származékok, eljárás előállításukra, és e vegyületeket tartalmazó gyógyszerkészítmények |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 0867436 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |