DK1107996T3 - Humane anti-faktor IX/IXa-antistoffer - Google Patents

Humane anti-faktor IX/IXa-antistoffer

Info

Publication number: DK1107996T3
Authority: DK; Denmark
Prior art keywords: factor; ixa; fix; human anti; inhibiting
Prior art date: 1998-08-28

Application number

DK99943928T

Other languages

English (en)

Inventor

Camellia W Adams

Brigitte Devaux

Dan L Eaton

Philip E Hass

J Kevin Judice

Daniel Kirchhofer

Shelley Suggett

Original Assignee

Genentech Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-08-28

Filing date

1999-08-26

Publication date

2002-09-16

1999-08-26 Application filed by Genentech Inc filed Critical Genentech Inc

2002-09-16 Application granted granted Critical

2002-09-16 Publication of DK1107996T3 publication Critical patent/DK1107996T3/da

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/36—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/54—F(ab')2
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Immunology (AREA)
Hematology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Toxicology (AREA)
Diabetes (AREA)
Vascular Medicine (AREA)
Pulmonology (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Investigating Or Analysing Biological Materials (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)

DK99943928T 1998-08-28 1999-08-26 Humane anti-faktor IX/IXa-antistoffer DK1107996T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US9823398P	1998-08-28	1998-08-28
US12276799P	1999-03-03	1999-03-03
PCT/US1999/019453 WO2000012562A1 (en)	1998-08-28	1999-08-26	HUMAN ANTI-FACTOR IX/IXa ANTIBODIES

Publications (1)

Publication Number	Publication Date
DK1107996T3 true DK1107996T3 (da)	2002-09-16

Family

ID=26794469

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK99943928T DK1107996T3 (da)	1998-08-28	1999-08-26	Humane anti-faktor IX/IXa-antistoffer

Country Status (15)

Country	Link
US (3)	US6624295B1 (da)
EP (1)	EP1107996B1 (da)
JP (1)	JP4638035B2 (da)
CN (1)	CN1183160C (da)
AT (1)	ATE217889T1 (da)
AU (1)	AU766551C (da)
BR (1)	BR9913435A (da)
CA (1)	CA2341276C (da)
DE (1)	DE69901569T2 (da)
DK (1)	DK1107996T3 (da)
ES (1)	ES2177316T3 (da)
IL (1)	IL140917A0 (da)
NZ (1)	NZ509430A (da)
PT (1)	PT1107996E (da)
WO (1)	WO2000012562A1 (da)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AT411997B (de) *	1999-09-14	2004-08-26	Baxter Ag	Faktor ix/faktor ixa aktivierende antikörper und antikörper-derivate
SE0000675D0 (sv) *	2000-03-02	2000-03-02	Protease Ab	Monoclonal antibodies
DE10012732A1 (de) *	2000-03-18	2001-09-20	Aventis Behring Gmbh	Thrombin-Zubereitungen und Verfahren zu ihrer Herstellung
BR0015872A (pt) *	2000-05-15	2004-08-03	Smithkline Beecham Corp	Agentes antitrombóticos
GB2378949B (en) *	2001-08-16	2005-09-07	Morten Steen Hanefeld Dziegiel	Recombinant anti-plasmodium falciparum antibodies
DE10311248A1 (de)	2003-03-14	2004-09-30	Müller-Hermelink, Hans Konrad, Prof. Dr.	Humaner monoklonaler Antikörper
GB0309126D0 (en) *	2003-04-17	2003-05-28	Neutec Pharma Plc	Clostridium difficile focussed antibodies
DE10353175A1 (de)	2003-11-14	2005-06-16	Müller-Hermelink, Hans Konrad, Prof. Dr.	Humaner monoklonaler Antikörper mit fettsenkender Wirkung
EP1531162A1 (en) *	2003-11-14	2005-05-18	Heinz Vollmers	Adenocarcinoma specific antibody SAM-6, and uses thereof
GB0414886D0 (en)	2004-07-02	2004-08-04	Neutec Pharma Plc	Treatment of bacterial infections
ATE493503T1 (de) *	2006-09-22	2011-01-15	Wacker Chemie Ag	Verfahren zur fermentativen herstellung von proteinen
WO2010045388A2 (en) *	2008-10-14	2010-04-22	Dyax Corp.	Use of mmp-9 and mmp-12 binding proteins for the treatment and prevention of systemic sclerosis
DK2552948T3 (da)	2010-03-30	2016-10-17	Octapharma Ag	Fremgangsmåde til rensning af vækstfaktorprotein G-CSF
EP2553095B1 (en) *	2010-03-30	2016-10-12	Octapharma AG	A process for purifying vitamin K dependent proteins such as coagulation factor IX
CA2795325A1 (en) *	2010-04-13	2011-10-20	Medimmune, Llc	Fibronectin type iii domain-based multimeric scaffolds
WO2012161226A1 (ja) *	2011-05-23	2012-11-29	積水メディカル株式会社	Pivka-ii測定試薬における非特異反応の抑制方法
TWI603980B (zh) *	2015-09-01	2017-11-01	免疫功坊股份有限公司	用以治療病理性血栓的聯合接合物構型藥物
CN110325211A (zh) *	2016-12-23	2019-10-11	诺华股份有限公司	采用抗因子XI/XIa抗体治疗的方法
EP3577140A1 (en)	2017-02-01	2019-12-11	Novo Nordisk A/S	Procoagulant antibodies
US11220554B2 (en)	2018-09-07	2022-01-11	Novo Nordisk A/S	Procoagulant antibodies
CN115448985A (zh) *	2021-06-08	2022-12-09	上海循曜生物科技有限公司	新型抗栓抗体
CN116333145B (zh) *	2023-04-14	2023-11-07	北京基科晟斯医药科技有限公司	结合活化凝血因子ix的抗体

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3720983A1 (de) *	1987-06-25	1989-01-05	Hoechst Ag	Immunometrisches bestimmungsverfahren
WO1991016353A1 (en)	1990-04-23	1991-10-31	Corvas International N.V.	Thrombus-specific antibody derivatives
ES2159529T5 (es)	1993-03-05	2011-03-09	Bayer Corporation	Anticuerpos monoclonales humanos anti-tnf alfa.
CZ292061B6 (cs)	1994-03-17	2003-07-16	Merck Patent Gmbh	Jednořetězcové fragmenty protilátek a protilátky proti receptoru epidermálního růstového faktoru, způsob jejich přípravy a farmaceutický prostředek, který je obsahuje
MA24512A1 (fr)	1996-01-17	1998-12-31	Univ Vermont And State Agrienl	Procede pour la preparation d'agents anticoagulants utiles dans le traitement de la thrombose

1999
- 1999-08-26 BR BR9913435-7A patent/BR9913435A/pt not_active IP Right Cessation
- 1999-08-26 NZ NZ509430A patent/NZ509430A/en not_active IP Right Cessation
- 1999-08-26 PT PT99943928T patent/PT1107996E/pt unknown
- 1999-08-26 DE DE69901569T patent/DE69901569T2/de not_active Expired - Lifetime
- 1999-08-26 ES ES99943928T patent/ES2177316T3/es not_active Expired - Lifetime
- 1999-08-26 CN CNB998100838A patent/CN1183160C/zh not_active Expired - Lifetime
- 1999-08-26 US US09/383,667 patent/US6624295B1/en not_active Expired - Lifetime
- 1999-08-26 EP EP99943928A patent/EP1107996B1/en not_active Expired - Lifetime
- 1999-08-26 CA CA002341276A patent/CA2341276C/en not_active Expired - Lifetime
- 1999-08-26 AU AU56923/99A patent/AU766551C/en not_active Expired
- 1999-08-26 IL IL14091799A patent/IL140917A0/xx not_active IP Right Cessation
- 1999-08-26 DK DK99943928T patent/DK1107996T3/da active
- 1999-08-26 WO PCT/US1999/019453 patent/WO2000012562A1/en not_active Ceased
- 1999-08-26 JP JP2000567575A patent/JP4638035B2/ja not_active Expired - Lifetime
- 1999-08-26 AT AT99943928T patent/ATE217889T1/de active
2003
- 2003-07-08 US US10/614,959 patent/US7049411B2/en not_active Expired - Lifetime
2006
- 2006-03-31 US US11/396,115 patent/US7354585B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
AU5692399A (en)	2000-03-21
NZ509430A (en)	2002-04-26
AU766551C (en)	2005-02-17
EP1107996B1 (en)	2002-05-22
AU766551B2 (en)	2003-10-16
EP1107996A1 (en)	2001-06-20
US20060088534A1 (en)	2006-04-27
DE69901569D1 (de)	2002-06-27
US7049411B2 (en)	2006-05-23
US20060193851A1 (en)	2006-08-31
WO2000012562A1 (en)	2000-03-09
JP4638035B2 (ja)	2011-02-23
PT1107996E (pt)	2002-10-31
DE69901569T2 (de)	2002-12-19
CN1183160C (zh)	2005-01-05
US6624295B1 (en)	2003-09-23
ATE217889T1 (de)	2002-06-15
US7354585B2 (en)	2008-04-08
IL140917A0 (en)	2002-02-10
BR9913435A (pt)	2001-09-25
ES2177316T3 (es)	2002-12-01
CA2341276A1 (en)	2000-03-09
JP2002523081A (ja)	2002-07-30
CN1317015A (zh)	2001-10-10
CA2341276C (en)	2005-10-11

Publication	Publication Date	Title
DK1107996T3 (da)	2002-09-16	Humane anti-faktor IX/IXa-antistoffer
ID29393A (id)	2001-08-30	Komposisi pengobatan kanker dan metoda penggunaan minyak-minyak esensil tanaman alamiah
MEP8209A (en)	2011-12-20	Modified factor viii
ATE286053T1 (de)	2005-01-15	Naphthyridinone zur hemmung der durch protein- tyrosin-kinase und zellzyklus kinase hervorgerufenen zellvermehrung
DE60022692D1 (de)	2005-10-20	(S,S)-Reboxetin zur Behandlung von Migränekopfschmerzen
MXPA03005273A (es)	2003-09-25	Anticuerpos producidos procarioticamente y sus usos.
EP1474121A4 (en)	2006-05-03	SMALL MOLECULAR ANTAGONISTS OF PROTEINS OF THE BCL2 FAMILY
DK0922102T3 (da)	2010-08-16	Receptor-agonister af hepatocyt-vækstfaktor og anvendelser deraf
BR0116452A (pt)	2003-09-30	Composto, composição farmacêutica, uso de um composto
DK1117440T3 (da)	2003-12-01	Farmaceutiske sammensætninger indeholdende paclitaxel
ATE376026T1 (de)	2007-11-15	Klebstoffzusammensetzungen mit selbstorganisierenden molekülen, klebstoffe, gegenstände und verfahren
DK1368060T3 (da)	2010-08-30	HMGB1-proteininhibitorer og/eller antagonister til behandlingen af vaskulære sygdomme
DK1053256T3 (da)	2011-10-03	Antistoffer mod Dødsreceptor 4 (DR4) og anvendelser deraf
TR200001954T2 (tr)	2000-12-21	Faktör XA'nın önleyicileri olarak indol türevleri.
DE50010115D1 (de)	2005-05-25	Zusammensetzung und verfahren zur entkeimung von luft
DK0842934T3 (da)	2004-03-08	5-HT1F agonister
ATE458057T1 (de)	2010-03-15	Varianten der faktor-vii- oder -viia-gla-domäne
EP1064308A4 (en)	2004-08-11	METHODS FOR IDENTIFYING INDUCERS AND INHIBITORS OF PROTEOLYTIC ANTIBODIES, AND COMPOSITIONS AND USES THEREOF
DE60013098D1 (de)	2004-09-23	Zusammensetzung zur hautdesinfizierung
ATE302002T1 (de)	2005-09-15	Verwendung von pyrazolderivaten zur behandlung von unfruchtbarkeit
IL144199A0 (en)	2002-05-23	Novel bretylium compositions and kits, and their use in preventing and treating cardiovascular conditions
TR200402070T4 (tr)	2004-09-21	Siklobüten-dion türevleri ve bunların damar sertliği tedavisinde kullanımı
PT1107793E (pt)	2005-02-28	Conjugados de dextrano-leptina, composicoes farmaceuticas e processos relacionados
DE50205466D1 (de)	2006-02-02	Substituierte 2,5-diamidoindole als ece-inhibitoren zur behandlung von kardiovaskulären erkrankungen
BRPI0415285A (pt)	2006-12-19	derivados de aminoalcanol