DK1117403T3 - MGLUR5-antagonister til behandling af smerte og angst - Google Patents

MGLUR5-antagonister til behandling af smerte og angst

Info

Publication number: DK1117403T3
Authority: DK; Denmark
Prior art keywords: pain; treatment; anxiety; antagonists; mglur5 antagonists
Prior art date: 1998-10-02

Application number

DK99948905T

Other languages

English (en)

Inventor

Hans Allgeier

Nicholas David Cosford

Fabrizio Gasparini

Conrad Gentsch

Stephen D Hess

Edwin Carl Johnson

Rainer Kuhn

Laszlo Urban

Mark Andrew Varney

Elebi Goenuel Veli

Katharine Walker

Peter Josef Flor

Mark Tricklebank

Original Assignee

Sibia Neurosciences Inc

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-10-02

Filing date

1999-09-30

Publication date

2004-04-13

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26314451&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK1117403(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1998-10-02 Priority claimed from GBGB9821503.1A external-priority patent/GB9821503D0/en

1999-09-30 Application filed by Sibia Neurosciences Inc, Novartis Ag filed Critical Sibia Neurosciences Inc

2004-04-13 Application granted granted Critical

2004-04-13 Publication of DK1117403T3 publication Critical patent/DK1117403T3/da

Links

239000005557 antagonist Substances 0.000 title abstract 3
208000019901 Anxiety disease Diseases 0.000 title abstract 2
230000036506 anxiety Effects 0.000 title abstract 2
101150087728 Grm5 gene Proteins 0.000 title 1
102100038357 Metabotropic glutamate receptor 5 Human genes 0.000 title 1
102000012777 Metabotropic Glutamate 5 Receptor Human genes 0.000 abstract 1
108010065028 Metabotropic Glutamate 5 Receptor Proteins 0.000 abstract 1
102000016193 Metabotropic glutamate receptors Human genes 0.000 abstract 1
108010010914 Metabotropic glutamate receptors Proteins 0.000 abstract 1
230000000202 analgesic effect Effects 0.000 abstract 1
230000003993 interaction Effects 0.000 abstract 1
229940124807 mGLUR antagonist Drugs 0.000 abstract 1
230000002093 peripheral effect Effects 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Epidemiology (AREA)
Psychiatry (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pyridine Compounds (AREA)

DK99948905T 1998-10-02 1999-09-30 MGLUR5-antagonister til behandling af smerte og angst DK1117403T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB9821503.1A GB9821503D0 (en)	1998-10-02	1998-10-02	Organic compounds
US22081398A	1998-12-23	1998-12-23
PCT/EP1999/007239 WO2000020001A1 (en)	1998-10-02	1999-09-30	Mglur5 antagonists for the treatment of pain and anxiety

Publications (1)

Publication Number	Publication Date
DK1117403T3 true DK1117403T3 (da)	2004-04-13

Family

ID=26314451

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK99948905T DK1117403T3 (da)	1998-10-02	1999-09-30	MGLUR5-antagonister til behandling af smerte og angst

Country Status (21)

Country	Link
EP (1)	EP1117403B1 (da)
JP (1)	JP2002526408A (da)
KR (1)	KR20010088832A (da)
CN (1)	CN1187048C (da)
AT (1)	ATE255894T1 (da)
AU (1)	AU765644B2 (da)
BR (1)	BR9914215A (da)
CA (1)	CA2345137A1 (da)
DE (1)	DE69913548T2 (da)
DK (1)	DK1117403T3 (da)
ES (1)	ES2213389T3 (da)
HU (1)	HUP0200553A3 (da)
ID (1)	ID29095A (da)
IL (2)	IL142047A0 (da)
NO (1)	NO20011440L (da)
NZ (1)	NZ510743A (da)
PL (1)	PL202906B1 (da)
PT (1)	PT1117403E (da)
RU (1)	RU2232017C2 (da)
SK (1)	SK4382001A3 (da)
WO (1)	WO2000020001A1 (da)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0005700D0 (en) *	2000-03-09	2000-05-03	Glaxo Group Ltd	Therapy
ATE297734T1 (de)	2000-12-22	2005-07-15	Hoffmann La Roche	Tetrahydro-(benzo- oder thieno-)azepin-pyrazin und triazinderivative als mglur 1 antagonisten
GB0128996D0 (en)	2001-12-04	2002-01-23	Novartis Ag	Organic compounds
SE0303418D0 (sv) *	2003-12-17	2003-12-17	Astrazeneca Ab	New use 1
SE0303419D0 (sv) *	2003-12-17	2003-12-17	Astrazeneca Ab	New use 11
FR2883180B1 (fr) *	2005-03-18	2007-05-25	Pierre Fabre Medicament Sa	Utilisation de l'acetyl-leucine pour la preparation d'un medicament destine au traitement de troubles de l'equilibre
GB0525068D0 (en)	2005-12-08	2006-01-18	Novartis Ag	Organic compounds
DE102005062985A1 (de) *	2005-12-28	2007-07-05	Grünenthal GmbH	Substituierte bis(hetero)aromatische N-Ethylpropiolamide und ihre Verwendung zur Herstellung von Arzneimitteln
DK2083811T3 (da)	2006-11-22	2017-01-30	Clinical Res Ass Llc	Fremgangsmåder til behandling af downs syndrom, fragilt x-syndrom og autisme
US8349852B2 (en)	2009-01-13	2013-01-08	Novartis Ag	Quinazolinone derivatives useful as vanilloid antagonists
US8586581B2 (en) *	2009-12-17	2013-11-19	Hoffmann-La Roche Inc	Ethynyl compounds useful for treatment of CNS disorders
CN102762572A (zh)	2010-02-01	2012-10-31	诺瓦提斯公司	作为CRF-1受体拮抗剂的吡唑并[5,1b]*唑衍生物
AR080056A1 (es)	2010-02-01	2012-03-07	Novartis Ag	Derivados de ciclohexil-amida como antagonistas de los receptores de crf
EP2531490B1 (en)	2010-02-02	2014-10-15	Novartis AG	Cyclohexyl amide derivatives as crf receptor antagonists
US20130058915A1 (en)	2010-03-02	2013-03-07	Children's Medica Center Corporation	Methods and compositions for treatment of angelman syndrome and autism spectrum disorders
WO2011150380A1 (en)	2010-05-28	2011-12-01	Xenoport, Inc.	Methods of treatment of fragile x syndrome, down's syndrome, autism and related disorders
US20120016021A1 (en)	2010-07-15	2012-01-19	Xenoport, Inc.	Methods of treating fragile x syndrome, down's syndrome, autism and related disorders
WO2012054724A1 (en)	2010-10-21	2012-04-26	Massachusetts Institute Of Technology	Methods of treating seizure disorders
UY34094A (es)	2011-05-27	2013-01-03	Novartis Ag	Derivados de la piperidina 3-espirocíclica como agonistas de receptores de la ghrelina
EP2557183A1 (de)	2011-08-12	2013-02-13	Siemens Aktiengesellschaft	Verfahren zum Betrieb einer Konti-Glühe für die Verarbeitung eines Walzguts
WO2013164790A1 (en)	2012-05-03	2013-11-07	Novartis Ag	L-malate salt of 2, 7 - diaza - spiro [4.5 ] dec- 7 - yle derivatives and crystalline forms thereof as ghrelin receptor agonists
AU2016273751B2 (en)	2015-06-03	2020-04-02	F. Hoffmann-La Roche Ag	Ethynyl derivatives
KR20200035035A (ko)	2017-07-31	2020-04-01	노파르티스 아게	코카인 사용 감소 또는 코카인 사용 재발 예방에 있어서 마보글루란트의 용도
EP3459939A1 (en)	2017-09-26	2019-03-27	Pragma Therapeutics	Novel heterocyclic compounds as modulators of mglur7
KR102027368B1 (ko) *	2018-05-29	2019-10-01	서울대학교산학협력단	통증의 강도를 측정하는 방법

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2056983T3 (es) *	1988-03-21	1994-10-16	Boehringer Ingelheim Pharma	Compuestos para inhibir la biosintesis de metabolitos de acido araquidonico derivados de lipoxigenasa.
TW544448B (en) *	1997-07-11	2003-08-01	Novartis Ag	Pyridine derivatives

1999
- 1999-09-30 ID IDW20010730A patent/ID29095A/id unknown
- 1999-09-30 WO PCT/EP1999/007239 patent/WO2000020001A1/en not_active Ceased
- 1999-09-30 AT AT99948905T patent/ATE255894T1/de active
- 1999-09-30 PL PL346876A patent/PL202906B1/pl not_active IP Right Cessation
- 1999-09-30 IL IL14204799A patent/IL142047A0/xx active IP Right Grant
- 1999-09-30 CN CNB998117110A patent/CN1187048C/zh not_active Expired - Fee Related
- 1999-09-30 SK SK438-2001A patent/SK4382001A3/sk unknown
- 1999-09-30 PT PT99948905T patent/PT1117403E/pt unknown
- 1999-09-30 EP EP99948905A patent/EP1117403B1/en not_active Revoked
- 1999-09-30 BR BR9914215-5A patent/BR9914215A/pt not_active Application Discontinuation
- 1999-09-30 HU HU0200553A patent/HUP0200553A3/hu unknown
- 1999-09-30 JP JP2000573360A patent/JP2002526408A/ja active Pending
- 1999-09-30 CA CA002345137A patent/CA2345137A1/en not_active Abandoned
- 1999-09-30 ES ES99948905T patent/ES2213389T3/es not_active Expired - Lifetime
- 1999-09-30 NZ NZ510743A patent/NZ510743A/en unknown
- 1999-09-30 DK DK99948905T patent/DK1117403T3/da active
- 1999-09-30 KR KR1020017004152A patent/KR20010088832A/ko not_active Ceased
- 1999-09-30 RU RU2001111868/14A patent/RU2232017C2/ru not_active IP Right Cessation
- 1999-09-30 DE DE69913548T patent/DE69913548T2/de not_active Revoked
- 1999-09-30 AU AU61984/99A patent/AU765644B2/en not_active Ceased
2001
- 2001-03-15 IL IL142047A patent/IL142047A/en not_active IP Right Cessation
- 2001-03-21 NO NO20011440A patent/NO20011440L/no unknown

Also Published As

Publication number	Publication date
CN1321087A (zh)	2001-11-07
DE69913548D1 (de)	2004-01-22
BR9914215A (pt)	2001-07-03
NO20011440L (no)	2001-05-15
SK4382001A3 (en)	2001-08-06
EP1117403B1 (en)	2003-12-10
HUP0200553A3 (en)	2002-11-28
AU6198499A (en)	2000-04-26
NZ510743A (en)	2003-10-31
KR20010088832A (ko)	2001-09-28
ES2213389T3 (es)	2004-08-16
EP1117403A1 (en)	2001-07-25
CA2345137A1 (en)	2000-04-13
JP2002526408A (ja)	2002-08-20
PL346876A1 (en)	2002-03-11
DE69913548T2 (de)	2004-09-23
IL142047A (en)	2007-09-20
IL142047A0 (en)	2002-03-10
HUP0200553A2 (hu)	2002-07-29
AU765644B2 (en)	2003-09-25
NO20011440D0 (no)	2001-03-21
ID29095A (id)	2001-07-26
PL202906B1 (pl)	2009-08-31
PT1117403E (pt)	2004-04-30
RU2232017C2 (ru)	2004-07-10
WO2000020001A1 (en)	2000-04-13
CN1187048C (zh)	2005-02-02
ATE255894T1 (de)	2003-12-15

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IS2494B (is)	2009-02-15	Notkun á morfólínóli til meðhöndlunar á kynferðislegri vanvirkni
EP1129089A4 (en)	2003-01-22	SPIRO-INDOLE AS Y5 RECEPTOR ANTAGONISTS
ATE322258T1 (de)	2006-04-15	Methoden und zusammensetzungen zur modulation der aktivität der alpha-adrenergen rezeptoren
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