DK1117689T3 - Knoglemorfogenese-proteinantagonist baseret på det modne protein - Google Patents

Knoglemorfogenese-proteinantagonist baseret på det modne protein

Info

Publication number: DK1117689T3
Authority: DK; Denmark
Prior art keywords: residue; amino acid; residues; protein; mature
Prior art date: 1998-10-09

Application number

DK99944750.1T

Other languages

English (en)

Inventor

Mieko Katsuura

Michio Kimura

Original Assignee

Bioph Biotech Entw Pharm Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-10-09

Filing date

1999-10-04

Publication date

2012-07-09

1999-10-04 Application filed by Bioph Biotech Entw Pharm Gmbh filed Critical Bioph Biotech Entw Pharm Gmbh

2012-07-09 Application granted granted Critical

2012-07-09 Publication of DK1117689T3 publication Critical patent/DK1117689T3/da

Links

102000004169 proteins and genes Human genes 0.000 title abstract 4
108090000623 proteins and genes Proteins 0.000 title abstract 4
230000034127 bone morphogenesis Effects 0.000 title 1
229940076372 protein antagonist Drugs 0.000 title 1
125000000539 amino acid group Chemical group 0.000 abstract 4
238000007385 chemical modification Methods 0.000 abstract 4
108010007726 Bone Morphogenetic Proteins Proteins 0.000 abstract 3
102000007350 Bone Morphogenetic Proteins Human genes 0.000 abstract 3
230000003042 antagnostic effect Effects 0.000 abstract 3
229940112869 bone morphogenetic protein Drugs 0.000 abstract 3
125000000430 tryptophan group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12 0.000 abstract 3
125000003275 alpha amino acid group Chemical group 0.000 abstract 2
125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 abstract 2
101000762366 Homo sapiens Bone morphogenetic protein 2 Proteins 0.000 abstract 1
101000762379 Homo sapiens Bone morphogenetic protein 4 Proteins 0.000 abstract 1
101000899361 Homo sapiens Bone morphogenetic protein 7 Proteins 0.000 abstract 1
101100472152 Trypanosoma brucei brucei (strain 927/4 GUTat10.1) REL1 gene Proteins 0.000 abstract 1
238000005804 alkylation reaction Methods 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
102000045896 human BMP2 Human genes 0.000 abstract 1
102000046148 human BMP4 Human genes 0.000 abstract 1
238000007254 oxidation reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Physical Education & Sports Medicine (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Toxicology (AREA)
Biochemistry (AREA)
Gastroenterology & Hepatology (AREA)
Urology & Nephrology (AREA)
Neurology (AREA)
Heart & Thoracic Surgery (AREA)
Vascular Medicine (AREA)
Cardiology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

DK99944750.1T 1998-10-09 1999-10-04 Knoglemorfogenese-proteinantagonist baseret på det modne protein DK1117689T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP10288103A JP2000119192A (ja)	1998-10-09	1998-10-09	骨誘導因子アンタゴニスト活性を有する成熟型蛋白質
PCT/IB1999/001621 WO2000021998A1 (en)	1998-10-09	1999-10-04	Bone morphogenetic protein antagonist based on the mature protein

Publications (1)

Publication Number	Publication Date
DK1117689T3 true DK1117689T3 (da)	2012-07-09

Family

ID=17725844

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK99944750.1T DK1117689T3 (da)	1998-10-09	1999-10-04	Knoglemorfogenese-proteinantagonist baseret på det modne protein

Country Status (11)

Country	Link
US (1)	US7132397B1 (da)
EP (1)	EP1117689B1 (da)
JP (1)	JP2000119192A (da)
AT (1)	ATE551359T1 (da)
AU (1)	AU5756099A (da)
CA (1)	CA2345201C (da)
CY (1)	CY1112822T1 (da)
DK (1)	DK1117689T3 (da)
ES (1)	ES2382992T3 (da)
PT (1)	PT1117689E (da)
WO (1)	WO2000021998A1 (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6586388B2 (en)	1988-04-08	2003-07-01	Stryker Corporation	Method of using recombinant osteogenic protein to repair bone or cartilage defects
CA2363965C (en)	1991-03-11	2010-05-18	Curis, Inc.	Protein-induced morphogenesis
US7811793B2 (en)	1996-12-25	2010-10-12	Biopharma Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh	Process for preparing purified active monomer of bone-derived factor
DE10026713A1 (de) *	2000-05-30	2001-12-06	Walter Sebald	Mutein einer Kette eines Proteins aus der Superfamilie des Wachstumsfaktors TGF-beta
US8257438B2 (en) *	2005-04-12	2012-09-04	Warsaw Orthopedic, Inc.	Methods and devices for preserving motion in an articulating prosthetic disc
ES2382464T3 (es) *	2005-11-18	2012-06-08	Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka Mbh	Mutantes de factor del crecimiento de actividad elevada
US8075562B2 (en) *	2007-06-25	2011-12-13	Wisconsin Alumni Research Foundation	Controlled release of biopharmaceutical growth factors from hydroxyapatite coating on bioresorbable interference screws used in cruciate ligament reconstruction surgery
EP2602264A1 (en)	2011-12-05	2013-06-12	Biopharm Gesellschaft Zur Biotechnologischen Entwicklung Von Pharmaka mbH	GDF-5 mutant for inducing cartilage formation

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0691349A3 (en)	1994-07-04	1997-09-10	Hoechst Japan	Dimeric bone morphogenetic proteins and their fragments and analogues and pharmaceutical preparations containing them

1998
- 1998-10-09 JP JP10288103A patent/JP2000119192A/ja active Pending
1999
- 1999-10-04 ES ES99944750T patent/ES2382992T3/es not_active Expired - Lifetime
- 1999-10-04 AU AU57560/99A patent/AU5756099A/en not_active Abandoned
- 1999-10-04 PT PT99944750T patent/PT1117689E/pt unknown
- 1999-10-04 AT AT99944750T patent/ATE551359T1/de active
- 1999-10-04 DK DK99944750.1T patent/DK1117689T3/da active
- 1999-10-04 WO PCT/IB1999/001621 patent/WO2000021998A1/en not_active Ceased
- 1999-10-04 US US09/806,368 patent/US7132397B1/en not_active Expired - Fee Related
- 1999-10-04 EP EP99944750A patent/EP1117689B1/en not_active Expired - Lifetime
- 1999-10-04 CA CA2345201A patent/CA2345201C/en not_active Expired - Fee Related
2012
- 2012-06-06 CY CY20121100513T patent/CY1112822T1/el unknown

Also Published As

Publication number	Publication date
AU5756099A (en)	2000-05-01
EP1117689A1 (en)	2001-07-25
US7132397B1 (en)	2006-11-07
CY1112822T1 (el)	2016-02-10
JP2000119192A (ja)	2000-04-25
PT1117689E (pt)	2012-06-01
CA2345201A1 (en)	2000-04-20
ES2382992T3 (es)	2012-06-15
EP1117689B1 (en)	2012-03-28
WO2000021998A1 (en)	2000-04-20
CA2345201C (en)	2011-05-24
ATE551359T1 (de)	2012-04-15

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