DK1121144T3 - Stabile koncentrerede insulinpræparater til pulmonar indgivelse - Google Patents

Stabile koncentrerede insulinpræparater til pulmonar indgivelse

Info

Publication number: DK1121144T3
Authority: DK; Denmark
Prior art keywords: pulmonary administration; insulin preparations; stable concentrated; concentrated insulin; formulations
Prior art date: 1998-10-16

Application number

DK99948725T

Other languages

Danish (da)

English (en)

Inventor

Svend Havelund

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-10-16

Filing date

1999-10-15

Publication date

2002-09-23

1999-10-15 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

2002-09-23 Application granted granted Critical

2002-09-23 Publication of DK1121144T3 publication Critical patent/DK1121144T3/da

Links

NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 4
102000004877 Insulin Human genes 0.000 title abstract 2
108090001061 Insulin Proteins 0.000 title abstract 2
229940125396 insulin Drugs 0.000 title abstract 2
230000002685 pulmonary effect Effects 0.000 title abstract 2
238000002360 preparation method Methods 0.000 title 1
238000009472 formulation Methods 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
239000000126 substance Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Proteomics, Peptides & Aminoacids (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Endocrinology (AREA)
Oil, Petroleum & Natural Gas (AREA)
Inorganic Chemistry (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Immunology (AREA)
Pulmonology (AREA)
Hematology (AREA)
Emergency Medicine (AREA)
Obesity (AREA)
Organic Chemistry (AREA)
Dispersion Chemistry (AREA)
Otolaryngology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Peptides Or Proteins (AREA)

DK99948725T 1998-10-16 1999-10-15 Stabile koncentrerede insulinpræparater til pulmonar indgivelse DK1121144T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DKPA199801327		1998-10-16
PCT/DK1999/000556 WO2000023098A1 (en)	1998-10-16	1999-10-15	Stable concentrated insulin preparations for pulmonary delivery

Publications (1)

Publication Number	Publication Date
DK1121144T3 true DK1121144T3 (da)	2002-09-23

Family

ID=8103620

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK99948725T DK1121144T3 (da)	1998-10-16	1999-10-15	Stabile koncentrerede insulinpræparater til pulmonar indgivelse
DK01126054T DK1172114T3 (da)	1998-10-16	1999-10-15	Stabile koncentrerede insulinpræparater til pulmonær indgivelse

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DK01126054T DK1172114T3 (da)	1998-10-16	1999-10-15	Stabile koncentrerede insulinpræparater til pulmonær indgivelse

Country Status (22)

Country	Link
EP (2)	EP1172114B1 (de)
JP (1)	JP4212240B2 (de)
KR (1)	KR100617286B1 (de)
CN (1)	CN1210058C (de)
AT (2)	ATE277630T1 (de)
AU (1)	AU758146B2 (de)
BR (1)	BR9914585A (de)
CA (1)	CA2346969A1 (de)
CZ (1)	CZ20011134A3 (de)
DE (2)	DE69901726T2 (de)
DK (2)	DK1121144T3 (de)
ES (2)	ES2177323T3 (de)
HU (1)	HUP0104111A3 (de)
IL (2)	IL142011A0 (de)
NO (1)	NO323365B1 (de)
PL (1)	PL197504B1 (de)
PT (2)	PT1121144E (de)
RU (1)	RU2218935C2 (de)
TW (1)	TWI223597B (de)
UA (1)	UA65636C2 (de)
WO (1)	WO2000023098A1 (de)
ZA (1)	ZA200102105B (de)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
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US5783556A (en) *	1996-08-13	1998-07-21	Genentech, Inc.	Formulated insulin-containing composition
DE10114178A1 (de)	2001-03-23	2002-10-10	Aventis Pharma Gmbh	Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität
NZ519403A (en) *	2001-06-21	2005-03-24	Pfizer Prod Inc	Use of insulin in a medicament to reduce weight gain in a diabetic patient who is using exogenous insulin to control blood sugar levels
JP5599543B2 (ja)	2002-05-07	2014-10-01	ノヴォノルディスクアー／エス	単量体インスリン及びアシル化インスリンを含む可溶性製剤
DE10227232A1 (de)	2002-06-18	2004-01-15	Aventis Pharma Deutschland Gmbh	Saure Insulinzubereitungen mit verbesserter Stabilität
KR101235507B1 (ko) *	2003-02-28	2013-02-20	추가이 세이야쿠 가부시키가이샤	단백질을 함유하는 안정화 제제
EP1610812A1 (de) *	2003-03-11	2006-01-04	Novo Nordisk A/S	Pharmazeutische zusammnesetzungen enthaltend insulin stabilisiert mit einer säure
MXPA06001283A (es)	2003-08-05	2006-04-11	Novo Nordisk As	Derivados de insulina novedosos.
JP4808785B2 (ja)	2005-12-28	2011-11-02	ノボ・ノルデイスク・エー／エス	インスリン組成物および組成物の製造方法
ES2542146T3 (es)	2006-07-31	2015-07-31	Novo Nordisk A/S	Insulinas extendidas PEGiladas.
DK2074141T3 (en)	2006-09-22	2016-11-28	Novo Nordisk As	The protease resistant insulin analogues.
US9387176B2 (en)	2007-04-30	2016-07-12	Novo Nordisk A/S	Method for drying a protein composition, a dried protein composition and a pharmaceutical composition comprising the dried protein
WO2008132229A2 (en) *	2007-04-30	2008-11-06	Novo Nordisk A/S	Highly concentrated insulin solutions and compositions
US9034818B2 (en)	2007-06-13	2015-05-19	Novo Nordisk A/S	Pharmaceutical formulations comprising an insulin derivative
WO2009112583A2 (en)	2008-03-14	2009-09-17	Novo Nordisk A/S	Protease-stabilized insulin analogues
CN102037008B (zh)	2008-03-18	2016-08-31	诺沃-诺迪斯克有限公司	蛋白酶稳定化的、酰化胰岛素类似物
TWI451876B (zh) *	2008-06-13	2014-09-11	Lilly Co Eli	聚乙二醇化之離脯胰島素化合物
AU2011235959C1 (en) *	2008-06-13	2013-10-10	Eli Lilly And Company	PEGylated insulin lispro compounds
CN102256618A (zh)	2008-10-17	2011-11-23	赛诺菲-安万特德国有限公司	胰岛素和glp-1激动剂的组合
AU2009309623B9 (en)	2008-10-30	2014-10-02	Novo Nordisk A/S	Treating diabetes melitus using insulin injections with less than daily injection frequency
PL2451437T3 (pl)	2009-07-06	2017-05-31	Sanofi-Aventis Deutschland Gmbh	Wodne preparaty insuliny zawierające metioninę
NZ599847A (en)	2009-11-13	2013-09-27	Sanofi Aventis Deutschland	Pharmaceutical composition comprising a glp-1 agonist and methionine
TR201809460T4 (tr)	2009-11-13	2018-07-23	Sanofi Aventis Deutschland	Bir GLP- 1-agonisti, bir insülin ve metiyonin içeren farmasötik bileşim.
WO2012028172A1 (en)	2010-08-30	2012-03-08	Sanofi-Aventis Deutschland Gmbh	Use of ave0010 for the manufacture of a medicament for the treatment of diabetes mellitus type 2
DK2632478T3 (da)	2010-10-27	2019-10-07	Novo Nordisk As	Behandling af diabetes melitus under anvendelse af insulinindsprøjtninger indgivet med varierende indsprøjtningsintervaller
US9821032B2 (en)	2011-05-13	2017-11-21	Sanofi-Aventis Deutschland Gmbh	Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
AR087693A1 (es)	2011-08-29	2014-04-09	Sanofi Aventis Deutschland	Combinacion farmaceutica para uso en el control glucemico en pacientes con diabetes de tipo 2
TWI559929B (en)	2011-09-01	2016-12-01	Sanofi Aventis Deutschland	Pharmaceutical composition for use in the treatment of a neurodegenerative disease
US9481721B2 (en)	2012-04-11	2016-11-01	Novo Nordisk A/S	Insulin formulations
JP2016505601A (ja) *	2012-12-26	2016-02-25	ウォックハートリミテッド	医薬組成物
EP2983697B1 (de)	2013-04-03	2018-10-31	Sanofi	Behandlung von diabetes mellitus durch neue dosierungen von glargine insulin
JP2016519127A (ja)	2013-04-30	2016-06-30	ノヴォノルディスクアー／エス	新規投与レジメン
AU2014333979B2 (en)	2013-10-07	2018-02-15	Novo Nordisk A/S	Novel derivative of an insulin analogue
PE20171622A1 (es)	2014-12-12	2017-11-02	Sanofi Aventis Deutschland	Formulacion de relacion fija de insulina glargina/lixisenatida
TWI748945B (zh)	2015-03-13	2021-12-11	德商賽諾菲阿凡提斯德意志有限公司	第２型糖尿病病患治療
TW201705975A (zh)	2015-03-18	2017-02-16	賽諾菲阿凡提斯德意志有限公司	第２型糖尿病病患之治療
GB201607918D0 (en)	2016-05-06	2016-06-22	Arecor Ltd	Novel formulations
TWI700091B (zh)	2016-12-16	2020-08-01	丹麥商諾佛儂迪克股份有限公司	含胰島素醫藥組成物
US10335464B1 (en)	2018-06-26	2019-07-02	Novo Nordisk A/S	Device for titrating basal insulin
US12343383B2 (en)	2019-07-12	2025-07-01	Novo Nordisk A/S	High concentration insulin formulation

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FI78616C (fi) *	1982-02-05	1989-09-11	Novo Industri As	Foerfarande foer framstaellning av en foer infusionsaendamaol avsedd stabiliserad insulinloesning, som har en foerhoejd zinkhalt.
US5506203C1 (en) *	1993-06-24	2001-02-06	Astra Ab	Systemic administration of a therapeutic preparation
US5504188A (en) *	1994-06-16	1996-04-02	Eli Lilly And Company	Preparation of stable zinc insulin analog crystals
US5474978A (en) *	1994-06-16	1995-12-12	Eli Lilly And Company	Insulin analog formulations
PL188736B1 (pl) *	1996-06-20	2005-04-29	Novo Nordisk As	Wodny preparat insuliny oraz sposób jego przygotowania
ATE219942T1 (de) *	1997-03-20	2002-07-15	Novo Nordisk As	Therapeutische pulverformulierung zur pulmonaren anwendung, welche kristallines insulin enthält
EP0969860B1 (de) *	1997-03-20	2002-07-17	Novo Nordisk A/S	Verfahren zur herstellung eines therapeutischen puders durch copräzipitation von insulin und einem absorptionsverstärker

1999
- 1999-10-15 ES ES99948725T patent/ES2177323T3/es not_active Expired - Lifetime
- 1999-10-15 CZ CZ20011134A patent/CZ20011134A3/cs unknown
- 1999-10-15 ES ES01126054T patent/ES2228728T3/es not_active Expired - Lifetime
- 1999-10-15 DK DK99948725T patent/DK1121144T3/da active
- 1999-10-15 AT AT01126054T patent/ATE277630T1/de not_active IP Right Cessation
- 1999-10-15 CA CA002346969A patent/CA2346969A1/en not_active Abandoned
- 1999-10-15 HU HU0104111A patent/HUP0104111A3/hu unknown
- 1999-10-15 RU RU2001113271/14A patent/RU2218935C2/ru not_active IP Right Cessation
- 1999-10-15 PT PT99948725T patent/PT1121144E/pt unknown
- 1999-10-15 EP EP01126054A patent/EP1172114B1/de not_active Expired - Lifetime
- 1999-10-15 AU AU61889/99A patent/AU758146B2/en not_active Ceased
- 1999-10-15 AT AT99948725T patent/ATE218364T1/de not_active IP Right Cessation
- 1999-10-15 CN CNB998122084A patent/CN1210058C/zh not_active Expired - Fee Related
- 1999-10-15 PT PT01126054T patent/PT1172114E/pt unknown
- 1999-10-15 JP JP2000576871A patent/JP4212240B2/ja not_active Expired - Fee Related
- 1999-10-15 BR BR9914585-5A patent/BR9914585A/pt not_active Application Discontinuation
- 1999-10-15 DE DE69901726T patent/DE69901726T2/de not_active Expired - Lifetime
- 1999-10-15 DE DE69920767T patent/DE69920767T2/de not_active Expired - Lifetime
- 1999-10-15 IL IL14201199A patent/IL142011A0/xx active IP Right Grant
- 1999-10-15 KR KR1020017004702A patent/KR100617286B1/ko not_active Expired - Fee Related
- 1999-10-15 PL PL347210A patent/PL197504B1/pl not_active IP Right Cessation
- 1999-10-15 UA UA2001042148A patent/UA65636C2/uk unknown
- 1999-10-15 WO PCT/DK1999/000556 patent/WO2000023098A1/en not_active Ceased
- 1999-10-15 DK DK01126054T patent/DK1172114T3/da active
- 1999-10-15 EP EP99948725A patent/EP1121144B1/de not_active Expired - Lifetime
- 1999-10-20 TW TW088118264A patent/TWI223597B/zh not_active IP Right Cessation
2001
- 2001-03-14 IL IL142011A patent/IL142011A/en not_active IP Right Cessation
- 2001-03-14 ZA ZA200102105A patent/ZA200102105B/xx unknown
- 2001-04-10 NO NO20011842A patent/NO323365B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
AU6188999A (en)	2000-05-08
DE69920767T2 (de)	2006-02-02
IL142011A (en)	2007-07-04
JP2002527487A (ja)	2002-08-27
HUP0104111A2 (hu)	2002-04-29
NO20011842L (no)	2001-06-15
DE69920767D1 (de)	2004-11-04
AU758146B2 (en)	2003-03-13
PT1121144E (pt)	2002-11-29
DE69901726D1 (de)	2002-07-11
BR9914585A (pt)	2001-07-03
DK1172114T3 (da)	2005-01-24
EP1172114B1 (de)	2004-09-29
HUP0104111A3 (en)	2002-05-28
ES2228728T3 (es)	2005-04-16
EP1121144A1 (de)	2001-08-08
ATE218364T1 (de)	2002-06-15
EP1172114A3 (de)	2003-07-23
CN1323219A (zh)	2001-11-21
JP4212240B2 (ja)	2009-01-21
WO2000023098A1 (en)	2000-04-27
UA65636C2 (uk)	2004-04-15
ATE277630T1 (de)	2004-10-15
KR20010075631A (ko)	2001-08-09
CZ20011134A3 (cs)	2001-08-15
PL347210A1 (en)	2002-03-25
EP1172114A2 (de)	2002-01-16
PL197504B1 (pl)	2008-04-30
ZA200102105B (en)	2001-10-12
ES2177323T3 (es)	2002-12-01
KR100617286B1 (ko)	2006-08-30
NO20011842D0 (no)	2001-04-10
RU2218935C2 (ru)	2003-12-20
PT1172114E (pt)	2005-02-28
CN1210058C (zh)	2005-07-13
CA2346969A1 (en)	2000-04-27
EP1121144B1 (de)	2002-06-05
NO323365B1 (no)	2007-04-10
DE69901726T2 (de)	2002-12-19
TWI223597B (en)	2004-11-11
IL142011A0 (en)	2002-03-10

Publication	Publication Date	Title
DK1121144T3 (da)	2002-09-23	Stabile koncentrerede insulinpræparater til pulmonar indgivelse
DE69708121D1 (de)	2001-12-13	Halogenid-enthaltende insulinzubereitungen
YU59092A (sh)	1994-12-28	Formulacije aerosola koji ne sadrže hlorofluorougljenična jedinjenja
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