ATE277630T1 - Stabile konzentrierte insulin präparationen zur pulmonaren verabreichung - Google Patents

Stabile konzentrierte insulin präparationen zur pulmonaren verabreichung

Info

Publication number: ATE277630T1
Authority: AT; Austria
Prior art keywords: pulmonary administration; insulin preparations; stable concentrated; concentrated insulin; formulations
Prior art date: 1998-10-16

Application number

AT01126054T

Other languages

English (en)

Inventor

Svend Havelund

Original Assignee

Novo Nordisk As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-10-16

Filing date

1999-10-15

Publication date

2004-10-15

1999-10-15 Application filed by Novo Nordisk As filed Critical Novo Nordisk As

2004-10-15 Application granted granted Critical

2004-10-15 Publication of ATE277630T1 publication Critical patent/ATE277630T1/de

Links

NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 4
102000004877 Insulin Human genes 0.000 title abstract 2
108090001061 Insulin Proteins 0.000 title abstract 2
229940125396 insulin Drugs 0.000 title abstract 2
230000002685 pulmonary effect Effects 0.000 title abstract 2
238000002360 preparation method Methods 0.000 title 1
238000009472 formulation Methods 0.000 abstract 2
239000000203 mixture Substances 0.000 abstract 2
239000000126 substance Substances 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/28—Steroids, e.g. cholesterol, bile acids or glycyrrhetinic acid

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
General Chemical & Material Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Chemical Kinetics & Catalysis (AREA)
Endocrinology (AREA)
Oil, Petroleum & Natural Gas (AREA)
Zoology (AREA)
Inorganic Chemistry (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Dispersion Chemistry (AREA)
Hematology (AREA)
Obesity (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pulmonology (AREA)
Emergency Medicine (AREA)
Otolaryngology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Peptides Or Proteins (AREA)

AT01126054T 1998-10-16 1999-10-15 Stabile konzentrierte insulin präparationen zur pulmonaren verabreichung ATE277630T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DKPA199801327		1998-10-16

Publications (1)

Publication Number	Publication Date
ATE277630T1 true ATE277630T1 (de)	2004-10-15

Family

ID=8103620

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
AT01126054T ATE277630T1 (de)	1998-10-16	1999-10-15	Stabile konzentrierte insulin präparationen zur pulmonaren verabreichung
AT99948725T ATE218364T1 (de)	1998-10-16	1999-10-15	Stabile konzentrierte insulin präparationen zur pulmonaren verabreichung

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
AT99948725T ATE218364T1 (de)	1998-10-16	1999-10-15	Stabile konzentrierte insulin präparationen zur pulmonaren verabreichung

Country Status (22)

Country	Link
EP (2)	EP1121144B1 (de)
JP (1)	JP4212240B2 (de)
KR (1)	KR100617286B1 (de)
CN (1)	CN1210058C (de)
AT (2)	ATE277630T1 (de)
AU (1)	AU758146B2 (de)
BR (1)	BR9914585A (de)
CA (1)	CA2346969A1 (de)
CZ (1)	CZ20011134A3 (de)
DE (2)	DE69920767T2 (de)
DK (2)	DK1121144T3 (de)
ES (2)	ES2177323T3 (de)
HU (1)	HUP0104111A3 (de)
IL (2)	IL142011A0 (de)
NO (1)	NO323365B1 (de)
PL (1)	PL197504B1 (de)
PT (2)	PT1121144E (de)
RU (1)	RU2218935C2 (de)
TW (1)	TWI223597B (de)
UA (1)	UA65636C2 (de)
WO (1)	WO2000023098A1 (de)
ZA (1)	ZA200102105B (de)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5783556A (en) *	1996-08-13	1998-07-21	Genentech, Inc.	Formulated insulin-containing composition
DE10114178A1 (de)	2001-03-23	2002-10-10	Aventis Pharma Gmbh	Zinkfreie und zinkarme Insulinzubereitungen mit verbesserter Stabilität
NZ519403A (en) *	2001-06-21	2005-03-24	Pfizer Prod Inc	Use of insulin in a medicament to reduce weight gain in a diabetic patient who is using exogenous insulin to control blood sugar levels
JP5599543B2 (ja)	2002-05-07	2014-10-01	ノヴォノルディスクアー／エス	単量体インスリン及びアシル化インスリンを含む可溶性製剤
DE10227232A1 (de)	2002-06-18	2004-01-15	Aventis Pharma Deutschland Gmbh	Saure Insulinzubereitungen mit verbesserter Stabilität
JP4607010B2 (ja) *	2003-02-28	2011-01-05	中外製薬株式会社	タンパク質含有安定化製剤
WO2004080480A1 (en) *	2003-03-11	2004-09-23	Novo Nordisk A/S	Pharmaceutical preparations comprising acid-stabilised insulin
JP4463814B2 (ja)	2003-08-05	2010-05-19	ノボノルディスクアクティーゼルスカブ	新規のインスリン誘導体
EP1969004B1 (de)	2005-12-28	2011-08-10	Novo Nordisk A/S	Ein acyliertes insulin und zink enthaltende zusammensetzungen und verfahren zur herstellung dieser zusammensetzungen
CN101573133B (zh)	2006-07-31	2014-08-27	诺沃-诺迪斯克有限公司	Peg化延长的胰岛素
WO2008034881A1 (en)	2006-09-22	2008-03-27	Novo Nordisk A/S	Protease resistant insulin analogues
CN101674812B (zh)	2007-04-30	2013-12-11	诺沃-诺迪斯克有限公司	干燥蛋白组合物的方法、干燥的蛋白组合物和包含干燥的蛋白的药物组合物
US20100120660A1 (en) *	2007-04-30	2010-05-13	Per Balschmidt	Highly concentrated insulin solutions and compositions
US9034818B2 (en)	2007-06-13	2015-05-19	Novo Nordisk A/S	Pharmaceutical formulations comprising an insulin derivative
WO2009112583A2 (en)	2008-03-14	2009-09-17	Novo Nordisk A/S	Protease-stabilized insulin analogues
PT2910570T (pt)	2008-03-18	2017-01-24	Novo Nordisk As	Análogos de insulina acilados, estabilizados contra proteases
TWI451876B (zh) *	2008-06-13	2014-09-11	Lilly Co Eli	聚乙二醇化之離脯胰島素化合物
AU2011235959C1 (en) *	2008-06-13	2013-10-10	Eli Lilly And Company	PEGylated insulin lispro compounds
RS59913B1 (sr)	2008-10-17	2020-03-31	Sanofi Aventis Deutschland	Kombinacija insulina i glp-1-agonista
ES2607003T3 (es)	2008-10-30	2017-03-28	Novo Nordisk A/S	Tratamiento de diabetes mellitus utilizando inyecciones de insulina con una frecuencia de inyección inferior a la diaria
SG10201403840VA (en)	2009-07-06	2014-10-30	Sanofi Aventis Deutschland	Aqueous insulin preparations containing methionine
PL2498801T3 (pl)	2009-11-13	2018-08-31	Sanofi Aventis Deutschland	Kompozycja farmaceutyczna zawierająca desPro<sup>36</sup>eksendyno-4(1-39)-Lys6-NH2 i metioninę
SI2498802T1 (sl)	2009-11-13	2015-05-29	Sanofi-Aventis Deutschland Gmbh	Farmacevtski sestavek, ki vsebuje agonist GLP-1, inzulin in metionin
BR112013004756B1 (pt)	2010-08-30	2020-04-28	Sanofi Aventis Deutschland	uso de ave0010 para a fabricação de um medicamento para o tratamento da diabetes melito tipo 2
DK2632478T3 (da)	2010-10-27	2019-10-07	Novo Nordisk As	Behandling af diabetes melitus under anvendelse af insulinindsprøjtninger indgivet med varierende indsprøjtningsintervaller
US9821032B2 (en)	2011-05-13	2017-11-21	Sanofi-Aventis Deutschland Gmbh	Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
CA2846413C (en)	2011-08-29	2021-11-02	Sanofi-Aventis Deutschland Gmbh	Pharmaceutical combination for use in glycemic control in diabetes type 2 patients
TWI559929B (en)	2011-09-01	2016-12-01	Sanofi Aventis Deutschland	Pharmaceutical composition for use in the treatment of a neurodegenerative disease
CA2870313A1 (en)	2012-04-11	2013-10-17	Novo Nordisk A/S	Insulin formulations
AU2013368990B2 (en) *	2012-12-26	2017-05-18	Wockhardt Limited	Pharmaceutical composition
CN110354255B (zh)	2013-04-03	2024-05-14	赛诺菲	通过长效胰岛素制剂治疗糖尿病
JP2016519127A (ja)	2013-04-30	2016-06-30	ノヴォノルディスクアー／エス	新規投与レジメン
CN105636979B (zh)	2013-10-07	2020-01-10	诺和诺德股份有限公司	胰岛素类似物的新衍生物
TWI758239B (zh)	2014-12-12	2022-03-21	德商賽諾菲阿凡提斯德意志有限公司	甘精胰島素/利司那肽固定比率配製劑
TWI748945B (zh)	2015-03-13	2021-12-11	德商賽諾菲阿凡提斯德意志有限公司	第２型糖尿病病患治療
TW201705975A (zh)	2015-03-18	2017-02-16	賽諾菲阿凡提斯德意志有限公司	第２型糖尿病病患之治療
GB201607918D0 (en)	2016-05-06	2016-06-22	Arecor Ltd	Novel formulations
DK3554534T3 (da)	2016-12-16	2021-08-23	Novo Nordisk As	Farmaceutisk sammensætning omfattende insulin
US10335464B1 (en)	2018-06-26	2019-07-02	Novo Nordisk A/S	Device for titrating basal insulin
JP7518149B2 (ja) *	2019-07-12	2024-07-17	ノヴォノルディスクアー／エス	高濃度インスリン製剤

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Publication number	Priority date	Publication date	Assignee	Title
FI78616C (fi) *	1982-02-05	1989-09-11	Novo Industri As	Foerfarande foer framstaellning av en foer infusionsaendamaol avsedd stabiliserad insulinloesning, som har en foerhoejd zinkhalt.
US5506203C1 (en) *	1993-06-24	2001-02-06	Astra Ab	Systemic administration of a therapeutic preparation
US5474978A (en) *	1994-06-16	1995-12-12	Eli Lilly And Company	Insulin analog formulations
US5504188A (en) *	1994-06-16	1996-04-02	Eli Lilly And Company	Preparation of stable zinc insulin analog crystals
PL188736B1 (pl) *	1996-06-20	2005-04-29	Novo Nordisk As	Wodny preparat insuliny oraz sposób jego przygotowania
WO1998042367A1 (en) *	1997-03-20	1998-10-01	Novo Nordisk A/S	Method for preparation of a therapeutic powder through coprecipitation of insulin and absorption enhancer
ATE219942T1 (de) *	1997-03-20	2002-07-15	Novo Nordisk As	Therapeutische pulverformulierung zur pulmonaren anwendung, welche kristallines insulin enthält

1999
- 1999-10-15 AU AU61889/99A patent/AU758146B2/en not_active Ceased
- 1999-10-15 WO PCT/DK1999/000556 patent/WO2000023098A1/en not_active Ceased
- 1999-10-15 JP JP2000576871A patent/JP4212240B2/ja not_active Expired - Fee Related
- 1999-10-15 ES ES99948725T patent/ES2177323T3/es not_active Expired - Lifetime
- 1999-10-15 ES ES01126054T patent/ES2228728T3/es not_active Expired - Lifetime
- 1999-10-15 DE DE69920767T patent/DE69920767T2/de not_active Expired - Lifetime
- 1999-10-15 IL IL14201199A patent/IL142011A0/xx active IP Right Grant
- 1999-10-15 PL PL347210A patent/PL197504B1/pl not_active IP Right Cessation
- 1999-10-15 EP EP99948725A patent/EP1121144B1/de not_active Expired - Lifetime
- 1999-10-15 RU RU2001113271/14A patent/RU2218935C2/ru not_active IP Right Cessation
- 1999-10-15 PT PT99948725T patent/PT1121144E/pt unknown
- 1999-10-15 CA CA002346969A patent/CA2346969A1/en not_active Abandoned
- 1999-10-15 EP EP01126054A patent/EP1172114B1/de not_active Expired - Lifetime
- 1999-10-15 CN CNB998122084A patent/CN1210058C/zh not_active Expired - Fee Related
- 1999-10-15 BR BR9914585-5A patent/BR9914585A/pt not_active Application Discontinuation
- 1999-10-15 PT PT01126054T patent/PT1172114E/pt unknown
- 1999-10-15 UA UA2001042148A patent/UA65636C2/uk unknown
- 1999-10-15 AT AT01126054T patent/ATE277630T1/de not_active IP Right Cessation
- 1999-10-15 DK DK99948725T patent/DK1121144T3/da active
- 1999-10-15 KR KR1020017004702A patent/KR100617286B1/ko not_active Expired - Fee Related
- 1999-10-15 AT AT99948725T patent/ATE218364T1/de not_active IP Right Cessation
- 1999-10-15 CZ CZ20011134A patent/CZ20011134A3/cs unknown
- 1999-10-15 DK DK01126054T patent/DK1172114T3/da active
- 1999-10-15 HU HU0104111A patent/HUP0104111A3/hu unknown
- 1999-10-15 DE DE69901726T patent/DE69901726T2/de not_active Expired - Lifetime
- 1999-10-20 TW TW088118264A patent/TWI223597B/zh not_active IP Right Cessation
2001
- 2001-03-14 ZA ZA200102105A patent/ZA200102105B/xx unknown
- 2001-03-14 IL IL142011A patent/IL142011A/en not_active IP Right Cessation
- 2001-04-10 NO NO20011842A patent/NO323365B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
DK1121144T3 (da)	2002-09-23
IL142011A0 (en)	2002-03-10
PT1172114E (pt)	2005-02-28
ES2228728T3 (es)	2005-04-16
RU2218935C2 (ru)	2003-12-20
DE69920767D1 (de)	2004-11-04
DE69920767T2 (de)	2006-02-02
DE69901726D1 (de)	2002-07-11
PT1121144E (pt)	2002-11-29
PL197504B1 (pl)	2008-04-30
KR20010075631A (ko)	2001-08-09
NO20011842D0 (no)	2001-04-10
DE69901726T2 (de)	2002-12-19
CN1323219A (zh)	2001-11-21
ES2177323T3 (es)	2002-12-01
JP2002527487A (ja)	2002-08-27
ZA200102105B (en)	2001-10-12
EP1121144B1 (de)	2002-06-05
EP1172114A2 (de)	2002-01-16
AU758146B2 (en)	2003-03-13
NO323365B1 (no)	2007-04-10
NO20011842L (no)	2001-06-15
CA2346969A1 (en)	2000-04-27
EP1121144A1 (de)	2001-08-08
WO2000023098A1 (en)	2000-04-27
CN1210058C (zh)	2005-07-13
JP4212240B2 (ja)	2009-01-21
AU6188999A (en)	2000-05-08
TWI223597B (en)	2004-11-11
KR100617286B1 (ko)	2006-08-30
CZ20011134A3 (cs)	2001-08-15
IL142011A (en)	2007-07-04
EP1172114B1 (de)	2004-09-29
UA65636C2 (uk)	2004-04-15
DK1172114T3 (da)	2005-01-24
BR9914585A (pt)	2001-07-03
HUP0104111A2 (hu)	2002-04-29
ATE218364T1 (de)	2002-06-15
HUP0104111A3 (en)	2002-05-28
EP1172114A3 (de)	2003-07-23
PL347210A1 (en)	2002-03-25

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2005-06-15

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Publication	Publication Date	Title
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