DK1123103T3 - Fremgangsmåde til fremstilling af en jerndextranforbindelse - Google Patents

Fremgangsmåde til fremstilling af en jerndextranforbindelse

Info

Publication number
DK1123103T3
DK1123103T3 DK99934521T DK99934521T DK1123103T3 DK 1123103 T3 DK1123103 T3 DK 1123103T3 DK 99934521 T DK99934521 T DK 99934521T DK 99934521 T DK99934521 T DK 99934521T DK 1123103 T3 DK1123103 T3 DK 1123103T3
Authority
DK
Denmark
Prior art keywords
preparing
iron dextran
dextran compound
compound
iron
Prior art date
Application number
DK99934521T
Other languages
English (en)
Inventor
Hans Berg Andreasen
Lars Christensen
Original Assignee
Pharmacosmos Holding As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacosmos Holding As filed Critical Pharmacosmos Holding As
Application granted granted Critical
Publication of DK1123103T3 publication Critical patent/DK1123103T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0021—Dextran, i.e. (alpha-1,4)-D-glucan; Derivatives thereof, e.g. Sephadex, i.e. crosslinked dextran
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/721—Dextrans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Nutrition Science (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicinal Preparation (AREA)
DK99934521T 1998-11-20 1999-07-29 Fremgangsmåde til fremstilling af en jerndextranforbindelse DK1123103T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK199801526A DK173138B1 (da) 1998-11-20 1998-11-20 Fremgangsmåde til fremstilling af en jerndextranforbindelse, jerndextranforbindelse fremstillet efter fremgangsmåden, farma
PCT/DK1999/000425 WO2000030657A1 (en) 1998-11-20 1999-07-29 A process for producing an iron-dextran compound

Publications (1)

Publication Number Publication Date
DK1123103T3 true DK1123103T3 (da) 2002-11-25

Family

ID=8105751

Family Applications (2)

Application Number Title Priority Date Filing Date
DK199801526A DK173138B1 (da) 1998-11-20 1998-11-20 Fremgangsmåde til fremstilling af en jerndextranforbindelse, jerndextranforbindelse fremstillet efter fremgangsmåden, farma
DK99934521T DK1123103T3 (da) 1998-11-20 1999-07-29 Fremgangsmåde til fremstilling af en jerndextranforbindelse

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK199801526A DK173138B1 (da) 1998-11-20 1998-11-20 Fremgangsmåde til fremstilling af en jerndextranforbindelse, jerndextranforbindelse fremstillet efter fremgangsmåden, farma

Country Status (26)

Country Link
US (2) US6977249B1 (da)
EP (1) EP1123103B1 (da)
JP (1) JP2002530345A (da)
KR (1) KR20010071767A (da)
CN (1) CN1308539A (da)
AR (1) AR019403A1 (da)
AT (1) ATE225180T1 (da)
AU (1) AU756555B2 (da)
BR (1) BR9910834A (da)
CA (1) CA2332882A1 (da)
DE (1) DE69903329T2 (da)
DK (2) DK173138B1 (da)
EA (1) EA003278B1 (da)
ES (1) ES2183582T3 (da)
HU (1) HUP0101802A3 (da)
ID (1) ID26997A (da)
NO (1) NO20006021L (da)
NZ (1) NZ508225A (da)
PL (1) PL345125A1 (da)
PT (1) PT1123103E (da)
SI (1) SI1123103T1 (da)
SK (1) SK19432000A3 (da)
TR (1) TR200003648T2 (da)
UA (1) UA57140C2 (da)
WO (1) WO2000030657A1 (da)
ZA (1) ZA200006878B (da)

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US6104802A (en) 1997-02-10 2000-08-15 Genesys Telecommunications Laboratories, Inc. In-band signaling for routing
EP1522318A3 (en) * 1999-04-09 2005-07-06 Advanced Magnetics Incorporated Heat stable coated colloidal iron oxides
US7871597B2 (en) 1999-04-09 2011-01-18 Amag Pharmaceuticals, Inc. Polyol and polyether iron oxide complexes as pharmacological and/or MRI contrast agents
DK1169062T3 (da) 1999-04-09 2010-01-25 Amag Pharmaceuticals Inc Varmestabile overtrukne kolloide jernoxider
DE10249552A1 (de) 2002-10-23 2004-05-13 Vifor (International) Ag Wasserlösliche Eisen-Kohlenhydrat-Komplexe, deren Herstellung und diese enthaltende Arzneimittel
US7964568B2 (en) 2003-05-30 2011-06-21 Chromaceutical Advanced Technologies, Inc. Synthesis of high molecular weight iron-saccharidic complexes
US20050191246A1 (en) * 2003-12-13 2005-09-01 Boehringer Ingelheim Pharma Gmbh & Co. Kg Powders comprising low molecular dextran and methods of producing those powders
ITMO20050056A1 (it) 2005-03-15 2006-09-16 Biofer Spa Processo per la preparazione di complessi del ferro trivalente con zuccheri mono-, di- e polisaccaridi.
EP1973549B1 (en) 2006-01-06 2016-07-20 Luitpold Pharmaceuticals, Inc. Methods and compositions for administration of iron
DE102007054794A1 (de) * 2007-11-13 2009-05-14 Agilan Gmbh Wässrige Eisen-Dextran-Zubereitung mit ein oder mehreren Verbindungen der para-Hydroxy-Benzoesäureester und/oder deren Salzen
LT3156075T (lt) 2009-03-25 2021-01-11 Pharmacosmos Holding A/S Oligosacharidas ir jo paruošimo būdas
EP2537866A1 (en) * 2011-06-21 2012-12-26 Serumwerk Bernburg AG Hydroxyethyl starch derivatives, method for manufacturing the same and therapeutical uses thereof
EA028147B1 (ru) 2012-11-30 2017-10-31 Фармакосмос А/С Криозащитный агент, содержащая его композиция и способ криоконсервирования
WO2015150394A1 (en) 2014-04-01 2015-10-08 Pharmacosmos A/S Cryoprotective agent, cryoprotective and cryopreserved compositions, uses thereof, and methods of cryopreservation
EP3157516A4 (en) 2014-06-22 2017-12-13 Dexcel Pharma Technologies Ltd. Pharmaceutical compositions comprising ferric citrate and methods for the production thereof
US10059779B2 (en) 2014-11-05 2018-08-28 E I Du Pont De Nemours And Company Enzymatically polymerized gelling dextrans
JP2018513249A (ja) 2015-04-03 2018-05-24 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニーＥ．Ｉ．Ｄｕ Ｐｏｎｔ Ｄｅ Ｎｅｍｏｕｒｓ Ａｎｄ Ｃｏｍｐａｎｙ 酸化デキストラン
CN107580606B (zh) 2015-04-03 2021-06-08 营养与生物科学美国4公司 凝胶化右旋糖酐醚
WO2018198135A1 (en) 2017-04-26 2018-11-01 Mylan Laboratories Ltd. Improved process for the preparation of iron complex
HUE070809T2 (hu) 2017-09-11 2025-07-28 Pharmacosmos Holding As Vaskomplex vegyületek gyógyászati alkalmazásra
CN109646454A (zh) * 2018-12-29 2019-04-19 博瑞生物医药（苏州）股份有限公司 异麦芽糖酐铁1000的制备方法
CN110183548B (zh) * 2019-06-28 2021-05-18 瑞普（天津）生物药业有限公司 一种低分子葡聚糖铁的制备方法及其应用
CN110551019A (zh) * 2019-09-12 2019-12-10 天津医科大学 一种亚铁糖(ⅱ)复合物、制备方法及其应用
CN110804107B (zh) * 2019-09-29 2021-08-31 山东金洋药业有限公司 一种使用右旋糖酐制备右旋糖酐铁水溶液的方法
CA3280511A1 (en) 2024-07-18 2026-03-01 Malian Biologicals Gmbh Iron supplementation in affective disorders and/or post-traumatic stress disorder (ptsd) and/or serotonin-dependent diseases and iron supplementation in neurodevelopmental or psychiatric disorder

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK117730A (da)
USRE24642E (en) 1959-04-28 Therapeutic preparations of iron
US2885393A (en) 1956-02-24 1959-05-05 R K Laros Company Dextran-iron complex and process for making same
US3093545A (en) 1960-08-29 1963-06-11 Armour Pharma Therapeutic iron-dextran preparations
US3234209A (en) 1963-09-13 1966-02-08 Chemicals Inc Process for making iron hydrogenated dextran
GB1200902A (en) 1967-05-13 1970-08-05 Fisons Pharmaceuticals Ltd Iron-dextran complexes
US3549614A (en) * 1967-07-13 1970-12-22 Jan Zbigniew Mioduszewski Method of manufacture of mixed complex compounds of ferric iron with hydrogenated dextran and citric acid or sodium citrate
SU364625A1 (ru) * 1968-07-12 1972-12-28 Способ получения комплексных соединений
US3697502A (en) 1969-11-03 1972-10-10 Christensen Henry M Method of making iron dextran-preparations
HU176073B (hu) 1978-03-08 1980-12-28 Chinoin Gyogyszer Es Vegyeszet Eljárás nagy vastartalmú vasdextrán előállítására
US4370476A (en) * 1979-07-17 1983-01-25 Usher Thomas C Dextran polycarboxylic acids, ferric hydroxide complexes
US4788281A (en) * 1984-01-04 1988-11-29 Tosoni Anthony L Dextran hexonic acid derivative, ferric hydroxide complex and method manufacture thereof
US4827945A (en) 1986-07-03 1989-05-09 Advanced Magnetics, Incorporated Biologically degradable superparamagnetic materials for use in clinical applications
US5102652A (en) 1986-07-03 1992-04-07 Advanced Magnetics Inc. Low molecular weight carbohydrates as additives to stabilize metal oxide compositions
US5075885A (en) * 1988-12-21 1991-12-24 National Semiconductor Corporation Ecl eprom with cmos programming
SU1797196A1 (ru) * 1991-03-29 1996-02-10 Научно-исследовательский ветеринарный институт Нечерноземной зоны РСФСР Препарат для профилактики алиментарной анемии поросят
EP0634174A1 (en) * 1993-07-13 1995-01-18 Takeda Chemical Industries, Ltd. Antianemic composition for veterinary use
US5624668A (en) 1995-09-29 1997-04-29 Luitpold Pharmaceuticals, Inc. Iron dextran formulations
DE69627171T2 (de) * 1995-11-09 2004-02-12 Abbott Laboratories, Abbott Park Verfahren zur herstellung eines kristallinen eisendextrans
DK172860B1 (da) 1998-03-25 1999-08-16 Pharmacosmos Holding As Jerndextranforbindelse til anvendelse som komponent i et terapeutisk middel til forebyggelse af eller behandling af jernman

Also Published As

Publication number Publication date
ATE225180T1 (de) 2002-10-15
BR9910834A (pt) 2001-02-13
KR20010071767A (ko) 2001-07-31
NO20006021D0 (no) 2000-11-28
AU756555B2 (en) 2003-01-16
TR200003648T2 (tr) 2001-08-21
ES2183582T3 (es) 2003-03-16
PT1123103E (pt) 2003-02-28
EA200001086A1 (ru) 2001-06-25
DE69903329D1 (de) 2002-11-07
EA003278B1 (ru) 2003-04-24
DK173138B1 (da) 2000-02-07
CA2332882A1 (en) 2000-06-02
JP2002530345A (ja) 2002-09-17
SK19432000A3 (sk) 2001-06-11
AU5027399A (en) 2000-06-13
CN1308539A (zh) 2001-08-15
HUP0101802A3 (en) 2003-07-28
EP1123103A1 (en) 2001-08-16
ID26997A (id) 2001-02-22
PL345125A1 (en) 2001-12-03
US20030083310A1 (en) 2003-05-01
SI1123103T1 (en) 2003-04-30
ZA200006878B (en) 2001-05-10
UA57140C2 (uk) 2003-06-16
HUP0101802A2 (hu) 2001-10-28
WO2000030657A1 (en) 2000-06-02
US6977249B1 (en) 2005-12-20
DE69903329T2 (de) 2003-07-10
NO20006021L (no) 2000-11-28
EP1123103B1 (en) 2002-10-02
DK199801526A (da) 2000-02-07
NZ508225A (en) 2003-10-31
AR019403A1 (es) 2002-02-20

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