DK1127877T3 - 5-cyano-10-hydroxy-10,11-dihydro-5H-bibenz[b,f]azepin, fremgangsmåder til dets fremstilling og til dets omdannelse til 5-carbomoyl-10-oxo-10,11-dihydro-5H-dibenz[b,f]azepin eller til 5-carbomoyl-5H-dibenz[b,f]azepin - Google Patents

5-cyano-10-hydroxy-10,11-dihydro-5H-bibenz[b,f]azepin, fremgangsmåder til dets fremstilling og til dets omdannelse til 5-carbomoyl-10-oxo-10,11-dihydro-5H-dibenz[b,f]azepin eller til 5-carbomoyl-5H-dibenz[b,f]azepin

Info

Publication number: DK1127877T3
Authority: DK; Denmark
Prior art keywords: azepine; carbomoyl; dibenz; dihydro; preparation
Prior art date: 2000-02-25

Application number

DK01103475T

Other languages

English (en)

Inventor

Attilio Citterio

Gabriele Breviglieri

Giacomo Bruno

Original Assignee

Farchemia Srl

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-02-25

Filing date

2001-02-14

Publication date

2004-10-11

2001-02-14 Application filed by Farchemia Srl filed Critical Farchemia Srl

2004-10-11 Application granted granted Critical

2004-10-11 Publication of DK1127877T3 publication Critical patent/DK1127877T3/da

Links

238000000034 method Methods 0.000 title abstract 2
XYOVOXDWRFGKEX-UHFFFAOYSA-N azepine Chemical compound N1C=CC=CC=C1 XYOVOXDWRFGKEX-UHFFFAOYSA-N 0.000 title 1
238000006243 chemical reaction Methods 0.000 title 1
FFGPTBGBLSHEPO-UHFFFAOYSA-N carbamazepine Chemical compound C1=CC2=CC=CC=C2N(C(=O)N)C2=CC=CC=C21 FFGPTBGBLSHEPO-UHFFFAOYSA-N 0.000 abstract 1
229960000623 carbamazepine Drugs 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
CTRLABGOLIVAIY-UHFFFAOYSA-N oxcarbazepine Chemical compound C1C(=O)C2=CC=CC=C2N(C(=O)N)C2=CC=CC=C21 CTRLABGOLIVAIY-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
- C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
- C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
- C07D223/26—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom having a double bond between positions 10 and 11
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
- C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
- C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
- C07D223/28—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom having a single bond between positions 10 and 11

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)

DK01103475T 2000-02-25 2001-02-14 5-cyano-10-hydroxy-10,11-dihydro-5H-bibenz[b,f]azepin, fremgangsmåder til dets fremstilling og til dets omdannelse til 5-carbomoyl-10-oxo-10,11-dihydro-5H-dibenz[b,f]azepin eller til 5-carbomoyl-5H-dibenz[b,f]azepin DK1127877T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT2000MI000345A IT1317854B1 (it)	2000-02-25	2000-02-25	5-ciano-10-idrossi-10,11-diidro-5h-dibenz(b,f)azepina e procedimentiper la sua preparazione e per la sua conversione in

Publications (1)

Publication Number	Publication Date
DK1127877T3 true DK1127877T3 (da)	2004-10-11

Family

ID=11444177

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK01103475T DK1127877T3 (da)	2000-02-25	2001-02-14	5-cyano-10-hydroxy-10,11-dihydro-5H-bibenz[b,f]azepin, fremgangsmåder til dets fremstilling og til dets omdannelse til 5-carbomoyl-10-oxo-10,11-dihydro-5H-dibenz[b,f]azepin eller til 5-carbomoyl-5H-dibenz[b,f]azepin

Country Status (9)

Country	Link
US (1)	US6384217B1 (da)
EP (1)	EP1127877B1 (da)
AT (1)	ATE268325T1 (da)
DE (1)	DE60103568T2 (da)
DK (1)	DK1127877T3 (da)
ES (1)	ES2219447T3 (da)
IT (1)	IT1317854B1 (da)
PT (1)	PT1127877E (da)
SI (1)	SI1127877T1 (da)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ITMI20042230A1 (it) *	2004-11-19	2005-02-19	Farchemia Srl	Procedimento per la preparazione della 10,11-diidro-10 idrossi-5h-dibenz-b,f-azepin-5carbossiammide
ITMI20042291A1 (it)	2004-11-26	2005-02-26	Farchema S R L	Procedimento per la preparazione della -s-piu-10,11-diidro-10-idrossi-5h-dibenz-b,f-azepin-5-carbossiammide
CA2658675A1 (en) *	2006-07-24	2008-01-31	Jubilant Organosys Limited	Process for producing 10-oxo-10, 11-dihydr0-5h-dibenz [b, f] azepine-5-carboxamide starting from 5-cyanoiminostilbene
CN110563652B (zh) *	2018-06-06	2021-01-22	新发药业有限公司	一种中间体化合物、卡马西平及其衍生物及奥卡西平及其衍生物的制备方法
CN118994010B (zh) *	2024-08-05	2025-09-30	衢州市浙工大生态工业创新研究院	一种合成奥卡西平关键中间体的方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BE597793A (fr) *	1960-12-05	1961-06-05	Geigy Ag J R	Nouveaux dérivés de l'azépine et leur préparation.
CH500196A (de) *	1969-03-10	1970-12-15	Ciba Geigy Ag	Verfahren zur Herstellung von neuen Azepinderivaten
JPS5681565A (en) *	1979-10-30	1981-07-03	Ciba Geigy Ag	Manufacture of nnheterocyclic compound
FI75561C (fi) *	1979-10-30	1988-07-11	Ciba Geigy Ag	Foerfarande foer framstaellning av 5- karbamoyl-10-oxo-10,11-dihydro-5h-dibens/b,f/azepin och daertill noedvaendiga mellanprodukter.
DD265759A3 (de) *	1987-05-25	1989-03-15	Dresden Arzneimittel	Verfahren zur herstellung von 5-carbamoyl-5h-dibenz[b,f]azepin
JP4038834B2 (ja) *	1997-06-13	2008-01-30	東レ株式会社	発光素子

2000
- 2000-02-25 IT IT2000MI000345A patent/IT1317854B1/it active
2001
- 2001-02-14 PT PT01103475T patent/PT1127877E/pt unknown
- 2001-02-14 DK DK01103475T patent/DK1127877T3/da active
- 2001-02-14 EP EP01103475A patent/EP1127877B1/en not_active Expired - Lifetime
- 2001-02-14 AT AT01103475T patent/ATE268325T1/de active
- 2001-02-14 ES ES01103475T patent/ES2219447T3/es not_active Expired - Lifetime
- 2001-02-14 SI SI200130114T patent/SI1127877T1/xx unknown
- 2001-02-14 DE DE60103568T patent/DE60103568T2/de not_active Expired - Lifetime
- 2001-02-17 US US09/788,048 patent/US6384217B1/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP1127877A2 (en)	2001-08-29
IT1317854B1 (it)	2003-07-15
ATE268325T1 (de)	2004-06-15
SI1127877T1 (en)	2004-08-31
EP1127877A3 (en)	2002-11-27
ITMI20000345A1 (it)	2001-08-25
DE60103568D1 (de)	2004-07-08
PT1127877E (pt)	2004-08-31
ES2219447T3 (es)	2004-12-01
ITMI20000345A0 (it)	2000-02-25
DE60103568T2 (de)	2004-09-30
US6384217B1 (en)	2002-05-07
EP1127877B1 (en)	2004-06-02

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