ITMI20042291A1 - Procedimento per la preparazione della -s-piu-10,11-diidro-10-idrossi-5h-dibenz-b,f-azepin-5-carbossiammide - Google Patents

Procedimento per la preparazione della -s-piu-10,11-diidro-10-idrossi-5h-dibenz-b,f-azepin-5-carbossiammide

Info

Publication number: ITMI20042291A1
Authority: IT; Italy
Prior art keywords: dibenz; hydroxy; carbossiammide; diidro; piu
Prior art date: 2004-11-26

Application number

IT002291A

Other languages

English (en)

Inventor

Gabriele Breviglieri

Eileen Campana

Mauro Panunzio

Sabatino Pulcini

Original Assignee

Farchema S R L

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2004-11-26

Filing date

2004-11-26

Publication date

2005-02-26

2004-11-26 Application filed by Farchema S R L filed Critical Farchema S R L

2004-11-26 Priority to IT002291A priority Critical patent/ITMI20042291A1/it

2005-02-26 Publication of ITMI20042291A1 publication Critical patent/ITMI20042291A1/it

2005-11-15 Priority to DE602005017073T priority patent/DE602005017073D1/de

2005-11-15 Priority to ES05819292T priority patent/ES2331320T3/es

2005-11-15 Priority to AT05819292T priority patent/ATE444954T1/de

2005-11-15 Priority to CA2589147A priority patent/CA2589147C/en

2005-11-15 Priority to PCT/EP2005/012205 priority patent/WO2006056339A1/en

2005-11-15 Priority to EP05819292A priority patent/EP1833798B1/en

2005-11-15 Priority to US11/791,582 priority patent/US7858780B2/en

2005-11-15 Priority to PT05819292T priority patent/PT1833798E/pt

2009-10-30 Priority to CY20091101130T priority patent/CY1110526T1/el

Links

230000007062 hydrolysis Effects 0.000 abstract 2
238000006460 hydrolysis reaction Methods 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
QQSMCHOABQHASF-HNNXBMFYSA-N (5s)-5-hydroxy-5,6-dihydrobenzo[b][1]benzazepine-11-carbonitrile Chemical compound O[C@H]1CC2=CC=CC=C2N(C#N)C2=CC=CC=C12 QQSMCHOABQHASF-HNNXBMFYSA-N 0.000 abstract 1
ARWDKBAZURSFOU-HNNXBMFYSA-N 2-[(5S)-5-hydroxy-5,6-dihydrobenzo[b][1]benzazepin-11-yl]acetamide Chemical compound O[C@H]1CC2=C(N(C3=C1C=CC=C3)CC(=O)N)C=CC=C2 ARWDKBAZURSFOU-HNNXBMFYSA-N 0.000 abstract 1
QQSMCHOABQHASF-UHFFFAOYSA-N 5-hydroxy-5,6-dihydrobenzo[b][1]benzazepine-11-carbonitrile Chemical compound OC1CC2=CC=CC=C2N(C#N)C2=CC=CC=C12 QQSMCHOABQHASF-UHFFFAOYSA-N 0.000 abstract 1
239000003513 alkali Substances 0.000 abstract 1
125000003368 amide group Chemical group 0.000 abstract 1
125000002560 nitrile group Chemical group 0.000 abstract 1
125000000864 peroxy group Chemical group O(O*)* 0.000 abstract 1
125000000612 phthaloyl group Chemical group C(C=1C(C(=O)*)=CC=CC1)(=O)* 0.000 abstract 1
238000000926 separation method Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
- C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
- C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
- C07D223/28—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom having a single bond between positions 10 and 11
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
- C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
- C07D223/30—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hetero atoms directly attached to the ring nitrogen atom

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Other In-Based Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

IT002291A 2004-11-26 2004-11-26 Procedimento per la preparazione della -s-piu-10,11-diidro-10-idrossi-5h-dibenz-b,f-azepin-5-carbossiammide ITMI20042291A1 (it)

Priority Applications (10)

Application Number	Priority Date	Filing Date	Title
IT002291A ITMI20042291A1 (it)	2004-11-26	2004-11-26	Procedimento per la preparazione della -s-piu-10,11-diidro-10-idrossi-5h-dibenz-b,f-azepin-5-carbossiammide
DE602005017073T DE602005017073D1 (de)	2004-11-26	2005-11-15	Verfahren zur herstellung von s)-(+)-10,11-dihydro-10-hydroxy-5h-dibenzäb,füazepin-5-carboxamid
ES05819292T ES2331320T3 (es)	2004-11-26	2005-11-15	Procedimiento para la preparacion de (s)-(+)-10,11-dihidro-10-hidroxi-5h-dibenzo(b,f)azepin-5-carboxamida.
AT05819292T ATE444954T1 (de)	2004-11-26	2005-11-15	Verfahren zur herstellung von s)-(+)-10,11- dihydro-10-hydroxy-5h-dibenzäb,füazepin-5- carboxamid
CA2589147A CA2589147C (en)	2004-11-26	2005-11-15	A process for the preparation of (s)-(+)-10,11-dihydro-10-hydroxy-5h-dibenz (b,f) azepine-5-carboxyamide
PCT/EP2005/012205 WO2006056339A1 (en)	2004-11-26	2005-11-15	A process for the preparation of (s)-(+)-10,11-dihydro-10-hydroxy-5h-dibenz (b,f) azepine-5-carboxyamide
EP05819292A EP1833798B1 (en)	2004-11-26	2005-11-15	A process for the preparation of (s)-(+)-10,11-dihydro-10-hydroxy-5h-dibenz[b,f]azepine-5-carboxamide
US11/791,582 US7858780B2 (en)	2004-11-26	2005-11-15	Process for the preparation of (S)-(+)-10,11-dihydro-10-hydroxy-5H-dibenz (b,f)azepine-5-carboxamide
PT05819292T PT1833798E (pt)	2004-11-26	2005-11-15	Processo para a preparação de (s)-(+)-10,11-dihidro-10- hidroxi-5h-dibenzo[b,f]azepin-5-carboxamida
CY20091101130T CY1110526T1 (el)	2004-11-26	2009-10-30	Μια μεθοδος για την παρασκευη (s)-(+)-10,11-διυδρο-10-υδροξυ-5 η-διβενζ (b,f) αζεπινο-5-καρβοξαμιδιου

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT002291A ITMI20042291A1 (it)	2004-11-26	2004-11-26	Procedimento per la preparazione della -s-piu-10,11-diidro-10-idrossi-5h-dibenz-b,f-azepin-5-carbossiammide

Publications (1)

Publication Number	Publication Date
ITMI20042291A1 true ITMI20042291A1 (it)	2005-02-26

Family

ID=36084359

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IT002291A ITMI20042291A1 (it)	2004-11-26	2004-11-26	Procedimento per la preparazione della -s-piu-10,11-diidro-10-idrossi-5h-dibenz-b,f-azepin-5-carbossiammide

Country Status (10)

Country	Link
US (1)	US7858780B2 (it)
EP (1)	EP1833798B1 (it)
AT (1)	ATE444954T1 (it)
CA (1)	CA2589147C (it)
CY (1)	CY1110526T1 (it)
DE (1)	DE602005017073D1 (it)
ES (1)	ES2331320T3 (it)
IT (1)	ITMI20042291A1 (it)
PT (1)	PT1833798E (it)
WO (1)	WO2006056339A1 (it)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2011045648A2 (en) *	2009-10-12	2011-04-21	Matrix Laboratories Limited	Process for preparing (s)-(-)-10-acetoxy-10,11-dihydro-5h-dibenz[b,f]azepine-5-carboxamide and its esters thereof
WO2012120356A2 (en)	2011-03-08	2012-09-13	Jubilant Life Sciences Limited	Process for the preparation of (s)-(+)-or (r)-(-)-10 hydroxy dihydrodibenz[b,f]azepines by enantioselective reduction of 10, 11-dihydro-10-oxo-5h-dibenz[b,f]azepines and polymorphs thereof
WO2012156987A2 (en) *	2011-05-19	2012-11-22	Glenmark Generics Limited	A novel process for the preparation of eslicarbazepine
IN2015DN02296A (it)	2012-09-26	2015-08-21	Ranbaxy Lab Ltd
EP3064490A1 (en)	2015-03-06	2016-09-07	F.I.S.- Fabbrica Italiana Sintetici S.p.A.	Improved process for the preparation of eslicarbazepine and eslicarbazepine acetate

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1317854B1 (it) *	2000-02-25	2003-07-15	Farchemia Srl	5-ciano-10-idrossi-10,11-diidro-5h-dibenz(b,f)azepina e procedimentiper la sua preparazione e per la sua conversione in
GB0112812D0 (en)	2001-05-25	2001-07-18	Portela & Ca Sa	Mthd for preparation of 10, 11-dihydro-10-hydroxy-5H-dibenz/B,F/azepine-5-c arboxamide and 10,11-dihydro-10-oxo-5H-dibenz/B,F/azepine-5-carb oxamide therefrom

2004
- 2004-11-26 IT IT002291A patent/ITMI20042291A1/it unknown
2005
- 2005-11-15 ES ES05819292T patent/ES2331320T3/es not_active Expired - Lifetime
- 2005-11-15 PT PT05819292T patent/PT1833798E/pt unknown
- 2005-11-15 WO PCT/EP2005/012205 patent/WO2006056339A1/en not_active Ceased
- 2005-11-15 EP EP05819292A patent/EP1833798B1/en not_active Expired - Lifetime
- 2005-11-15 US US11/791,582 patent/US7858780B2/en not_active Expired - Fee Related
- 2005-11-15 CA CA2589147A patent/CA2589147C/en not_active Expired - Fee Related
- 2005-11-15 AT AT05819292T patent/ATE444954T1/de not_active IP Right Cessation
- 2005-11-15 DE DE602005017073T patent/DE602005017073D1/de not_active Expired - Fee Related
2009
- 2009-10-30 CY CY20091101130T patent/CY1110526T1/el unknown

Also Published As

Publication number	Publication date
CY1110526T1 (el)	2015-04-29
ES2331320T3 (es)	2009-12-29
PT1833798E (pt)	2009-10-28
DE602005017073D1 (de)	2009-11-19
EP1833798B1 (en)	2009-10-07
WO2006056339A1 (en)	2006-06-01
EP1833798A1 (en)	2007-09-19
ATE444954T1 (de)	2009-10-15
CA2589147A1 (en)	2006-06-01
CA2589147C (en)	2013-11-05
US7858780B2 (en)	2010-12-28
US20090105472A1 (en)	2009-04-23

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