DK1133497T3 - Krystalmodifikation B af 8-cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicyclo[4.3.0]nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-quinolincarboxylsyre - Google Patents

Krystalmodifikation B af 8-cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicyclo[4.3.0]nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-quinolincarboxylsyre

Info

Publication number: DK1133497T3
Authority: DK; Denmark
Prior art keywords: quinolinecarboxylic; nonan; diazabicyclo; cyan; cyclopropyl
Prior art date: 1998-11-25

Application number

DK99959278T

Other languages

English (en)

Inventor

Thomas Himmler

Werner Hallenbach

Hubert Rast

Original Assignee

Bayer Healthcare Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-11-25

Filing date

1999-11-15

Publication date

2005-05-17

1999-11-15 Application filed by Bayer Healthcare Ag filed Critical Bayer Healthcare Ag

2005-05-17 Application granted granted Critical

2005-05-17 Publication of DK1133497T3 publication Critical patent/DK1133497T3/da

Links

239000013078 crystal Substances 0.000 title 1
230000004048 modification Effects 0.000 title 1
238000012986 modification Methods 0.000 title 1
-1 nonan-8-yl Chemical group 0.000 title 1
LOAUVZALPPNFOQ-UHFFFAOYSA-N quinaldic acid Chemical compound C1=CC=CC2=NC(C(=O)O)=CC=C21 LOAUVZALPPNFOQ-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

DK99959278T 1998-11-25 1999-11-15 Krystalmodifikation B af 8-cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicyclo[4.3.0]nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-quinolincarboxylsyre DK1133497T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19854355A DE19854355A1 (de)	1998-11-25	1998-11-25	Kristallmodifikation B von 8-Cyan-1-cyclopropyl-7-(1S, 6S-2,8-diazabicyclo-/4.3.O/nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäure
PCT/EP1999/008776 WO2000031076A1 (de)	1998-11-25	1999-11-15	Kristallmodifikation b von 8-cyan- 1-cyclopropyl -7-(1s,6s-2, 8-diazabicyclo -[4.3.0]nonan -8-yl)-6- fluor-1, 4-dihydro- 4-oxo-3- chinolincarbonsaure

Publications (1)

Publication Number	Publication Date
DK1133497T3 true DK1133497T3 (da)	2005-05-17

Family

ID=7888959

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK99959278T DK1133497T3 (da)	1998-11-25	1999-11-15	Krystalmodifikation B af 8-cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicyclo[4.3.0]nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-quinolincarboxylsyre

Country Status (29)

Country	Link
US (1)	US6664268B1 (da)
EP (1)	EP1133497B1 (da)
JP (2)	JP5127094B2 (da)
KR (1)	KR100740950B1 (da)
CN (1)	CN1150193C (da)
AR (1)	AR028467A1 (da)
AT (1)	ATE289606T1 (da)
AU (1)	AU767890B2 (da)
BR (1)	BRPI9915682B8 (da)
CA (1)	CA2351707C (da)
CZ (1)	CZ300012B6 (da)
DE (2)	DE19854355A1 (da)
DK (1)	DK1133497T3 (da)
ES (1)	ES2237186T3 (da)
HK (1)	HK1042705B (da)
HU (1)	HU229071B1 (da)
IL (2)	IL142695A0 (da)
NO (1)	NO318065B1 (da)
NZ (1)	NZ511862A (da)
PL (1)	PL196078B1 (da)
PT (1)	PT1133497E (da)
RU (1)	RU2248355C2 (da)
SK (1)	SK285554B6 (da)
TR (1)	TR200101444T2 (da)
TW (1)	TWI245767B (da)
UA (1)	UA67873C2 (da)
UY (1)	UY25818A (da)
WO (1)	WO2000031076A1 (da)
ZA (1)	ZA200103187B (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19854356A1 (de)	1998-11-25	2000-05-31	Bayer Ag	Kristallmodifikation A von 8-Cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicyclo-/4.3.0/nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäure
DE19854355A1 (de) *	1998-11-25	2000-05-31	Bayer Ag	Kristallmodifikation B von 8-Cyan-1-cyclopropyl-7-(1S, 6S-2,8-diazabicyclo-/4.3.O/nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäure
DE19908448A1 (de)	1999-02-26	2000-08-31	Bayer Ag	Kristallmodifikation D von 8-Cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicylo[4.3.0)nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chino incarbonsäure
DE19908449A1 (de)	1999-02-26	2000-08-31	Bayer Ag	Kristallmodifikation C von 8-Cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicylo-[4.3.0]nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chino/incarbonsäure
DE102004015981A1 (de)	2004-04-01	2005-10-20	Bayer Healthcare Ag	Neue kirstalline Form von 8-Cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicyclo[4.3.0]nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäure
DE102005055385A1 (de) *	2004-12-09	2006-06-14	Bayer Healthcare Ag	Arzneimittel zur hygienischen Applikation im Ohr
DE102006049520A1 (de) *	2006-10-20	2008-04-24	Bayer Healthcare Ag	Verfahren zur Herstellung von Pradofloxacin
DE102007026550A1 (de) *	2007-06-08	2008-12-11	Bayer Healthcare Ag	Extrudate mit verbesserter Geschmacksmaskierung
MX387370B (es)	2017-02-13	2025-03-18	Elanco Animal Health Gmbh	Composición líquida que contiene pradofloxacina.

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
UA25898A1 (uk) *	1987-02-02	1999-02-26	Пфайзер Інк.	Спосіб одержаhhя кристалічhої hатрієвої солі 5-хлор-3-(2-теhоїл)-2-оксііhдол-1-карбоксаміду
JP2676521B2 (ja) *	1988-03-22	1997-11-17	北陸製薬株式会社	キノロンカルボン酸化合物ｉ型結晶の製造法
DE3906365A1 (de) *	1988-07-15	1990-01-18	Bayer Ag	7-(1-pyrrolidinyl)-3-chinolon- und -naphthyridoncarbonsaeure-derivate, verfahren sowie substituierte (oxa)diazabicyclooctane und -nonane als zwischenprodukte zu ihrer herstellung, und sie enthaltende antibakterielle mittel und futterzusatzstoffe
DE3910663A1 (de) *	1989-04-03	1990-10-04	Bayer Ag	5-alkylchinoloncarbonsaeuren
JP2832848B2 (ja) *	1989-10-21	1998-12-09	株式会社林原生物化学研究所	結晶２―Ｏ―α―Ｄ―グルコピラノシル―Ｌ―アスコルビン酸とその製造方法並びに用途
EP0790992A1 (en)	1994-11-18	1997-08-27	PHARMACIA & UPJOHN COMPANY	A new physically stable solid form of a fluoroquinolone
DE19546249A1 (de) *	1995-12-12	1997-06-19	Bayer Ag	Neue Kristallmodifikation des 1-Cyclopropyl-7-([S,S]-2,8-diazabicyclo[4,3,0]non-8-yl)-6-fluor-1,4-dihydro-8-methoxy-4-oxo-3-chinolincarbonsäure Hydrochlorid (CDCH), Verfahren zu dessen Herstellung und diese enthaltende pharmazeutische Zubereitungen
DE19633805A1 (de) *	1996-02-23	1997-08-28	Bayer Ag	Gegenenenfalls substituierte 8-Cyan-l-cyclopropyl-7-(2,8-diazabicyclo-[4.3.0]-nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäuren und ihre Derivate
PL186737B1 (pl) *	1996-02-23	2004-02-27	Bayer Ag	Kwasy 8-cyjano-1-cyklopropylo-7-/2, 8-diazabicyklo [ 4.3.0 ] nonan-8-ylo/-6-fluoro-1,4-dihydro-4-okso-3-chinolinokarboksylowe i ich pochodne, sposób ich wytwarzania, środki medyczne je zawierające i ich zastosowanie do wytwarzania środków medycznychi antybakteryjnych
DE19649681A1 (de) *	1996-11-29	1998-06-04	Basf Ag	Verfahren zur Herstellung eines kristallinen Feststoffes aus Glycin-N,N-diessigsäure-Derivaten mit hinreichend geringer Hygroskopizität
DE19854356A1 (de)	1998-11-25	2000-05-31	Bayer Ag	Kristallmodifikation A von 8-Cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicyclo-/4.3.0/nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäure
DE19854355A1 (de) *	1998-11-25	2000-05-31	Bayer Ag	Kristallmodifikation B von 8-Cyan-1-cyclopropyl-7-(1S, 6S-2,8-diazabicyclo-/4.3.O/nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chinolincarbonsäure
DE19908448A1 (de)	1999-02-26	2000-08-31	Bayer Ag	Kristallmodifikation D von 8-Cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicylo[4.3.0)nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chino incarbonsäure
DE19908449A1 (de)	1999-02-26	2000-08-31	Bayer Ag	Kristallmodifikation C von 8-Cyan-1-cyclopropyl-7-(1S,6S-2,8-diazabicylo-[4.3.0]nonan-8-yl)-6-fluor-1,4-dihydro-4-oxo-3-chino/incarbonsäure

1998
- 1998-11-25 DE DE19854355A patent/DE19854355A1/de not_active Withdrawn
1999
- 1999-11-15 US US09/856,670 patent/US6664268B1/en not_active Expired - Lifetime
- 1999-11-15 AT AT99959278T patent/ATE289606T1/de active
- 1999-11-15 NZ NZ511862A patent/NZ511862A/en not_active IP Right Cessation
- 1999-11-15 CZ CZ20011857A patent/CZ300012B6/cs not_active IP Right Cessation
- 1999-11-15 TW TW088119808A patent/TWI245767B/zh not_active IP Right Cessation
- 1999-11-15 CA CA2351707A patent/CA2351707C/en not_active Expired - Lifetime
- 1999-11-15 CN CNB998136727A patent/CN1150193C/zh not_active Expired - Lifetime
- 1999-11-15 KR KR1020017005420A patent/KR100740950B1/ko not_active Expired - Lifetime
- 1999-11-15 WO PCT/EP1999/008776 patent/WO2000031076A1/de not_active Ceased
- 1999-11-15 BR BRPI9915682A patent/BRPI9915682B8/pt not_active IP Right Cessation
- 1999-11-15 ES ES99959278T patent/ES2237186T3/es not_active Expired - Lifetime
- 1999-11-15 PT PT99959278T patent/PT1133497E/pt unknown
- 1999-11-15 JP JP2000583904A patent/JP5127094B2/ja not_active Expired - Lifetime
- 1999-11-15 EP EP99959278A patent/EP1133497B1/de not_active Expired - Lifetime
- 1999-11-15 AU AU16517/00A patent/AU767890B2/en not_active Expired
- 1999-11-15 HK HK02104458.5A patent/HK1042705B/zh not_active IP Right Cessation
- 1999-11-15 RU RU2001117521/04A patent/RU2248355C2/ru active
- 1999-11-15 HU HU0104713A patent/HU229071B1/hu unknown
- 1999-11-15 TR TR2001/01444T patent/TR200101444T2/xx unknown
- 1999-11-15 IL IL14269599A patent/IL142695A0/xx active IP Right Grant
- 1999-11-15 PL PL347785A patent/PL196078B1/pl unknown
- 1999-11-15 UA UA2001064425A patent/UA67873C2/uk unknown
- 1999-11-15 DK DK99959278T patent/DK1133497T3/da active
- 1999-11-15 SK SK683-2001A patent/SK285554B6/sk not_active IP Right Cessation
- 1999-11-15 DE DE59911666T patent/DE59911666D1/de not_active Expired - Lifetime
- 1999-11-22 AR ARP990105938A patent/AR028467A1/es active IP Right Grant
- 1999-11-25 UY UY0001025818A patent/UY25818A/es not_active Application Discontinuation
2001
- 2001-04-19 ZA ZA2001/03187A patent/ZA200103187B/en unknown
- 2001-04-19 IL IL142695A patent/IL142695A/en not_active IP Right Cessation
- 2001-05-18 NO NO20012461A patent/NO318065B1/no not_active IP Right Cessation
2012
- 2012-07-27 JP JP2012167352A patent/JP2012236841A/ja active Pending

Also Published As

Publication number	Publication date
TR200101444T2 (tr)	2002-01-21
CZ20011857A3 (cs)	2001-09-12
AU1651700A (en)	2000-06-13
UA67873C2 (uk)	2004-07-15
AR028467A1 (es)	2003-05-14
SK285554B6 (sk)	2007-03-01
CA2351707C (en)	2011-02-01
JP2002530407A (ja)	2002-09-17
KR100740950B1 (ko)	2007-07-19
NO20012461D0 (no)	2001-05-18
PL196078B1 (pl)	2007-12-31
DE19854355A1 (de)	2000-05-31
HUP0104713A2 (hu)	2002-04-29
CA2351707A1 (en)	2000-06-02
HU229071B1 (en)	2013-07-29
CN1328556A (zh)	2001-12-26
IL142695A (en)	2006-04-10
DE59911666D1 (de)	2005-03-31
WO2000031076A1 (de)	2000-06-02
ZA200103187B (en)	2002-06-26
RU2248355C2 (ru)	2005-03-20
JP2012236841A (ja)	2012-12-06
ATE289606T1 (de)	2005-03-15
HK1042705B (zh)	2005-03-11
NO20012461L (no)	2001-05-18
PT1133497E (pt)	2005-07-29
CZ300012B6 (cs)	2009-01-14
CN1150193C (zh)	2004-05-19
TWI245767B (en)	2005-12-21
PL347785A1 (en)	2002-04-22
SK6832001A3 (en)	2001-12-03
UY25818A (es)	2016-06-30
AU767890B2 (en)	2003-11-27
NO318065B1 (no)	2005-01-31
KR20010080927A (ko)	2001-08-25
HK1042705A1 (en)	2002-08-23
IL142695A0 (en)	2002-03-10
NZ511862A (en)	2003-08-29
BRPI9915682B8 (pt)	2021-05-25
EP1133497B1 (de)	2005-02-23
EP1133497A1 (de)	2001-09-19
ES2237186T3 (es)	2005-07-16
BRPI9915682B1 (pt)	2017-02-21
US6664268B1 (en)	2003-12-16
HUP0104713A3 (en)	2002-12-28
JP5127094B2 (ja)	2013-01-23
BR9915682A (pt)	2001-08-14

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