DK1133511T3 - Hidtil ukendte mellemprodukter, fremgangsmåde til fremstilling af makrolidantibiotikum derudfra - Google Patents

Hidtil ukendte mellemprodukter, fremgangsmåde til fremstilling af makrolidantibiotikum derudfra

Info

Publication number: DK1133511T3
Authority: DK; Denmark
Prior art keywords: macrolide antibiotics; new intermediates; therefrom; producing macrolide; producing
Prior art date: 1998-11-24

Application number

DK99958490T

Other languages

English (en)

Inventor

Tae Suk Lee

Chang Hyun Yoo

Kyoung Soo Kim

Hyun Suk An

Jung Young Kim

Wan Joo Kim

Original Assignee

Chemtech Res Inc

Hansol Chemience Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-11-24

Filing date

1999-11-24

Publication date

2003-07-14

1999-11-24 Application filed by Chemtech Res Inc, Hansol Chemience Co Ltd filed Critical Chemtech Res Inc

2003-07-14 Application granted granted Critical

2003-07-14 Publication of DK1133511T3 publication Critical patent/DK1133511T3/da

Links

238000000034 method Methods 0.000 title abstract 2
239000000543 intermediate Substances 0.000 title 1
239000003120 macrolide antibiotic agent Substances 0.000 title 1
ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 abstract 2
229930006677 Erythromycin A Natural products 0.000 abstract 2
229960003276 erythromycin Drugs 0.000 abstract 2
230000015572 biosynthetic process Effects 0.000 abstract 1
229960002626 clarithromycin Drugs 0.000 abstract 1
AGOYDEPGAOXOCK-KCBOHYOISA-N clarithromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@](C)([C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)OC)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 AGOYDEPGAOXOCK-KCBOHYOISA-N 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
238000002360 preparation method Methods 0.000 abstract 1
239000012453 solvate Substances 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1
125000000026 trimethylsilyl group Chemical group [H]C([H])([H])[Si]([*])(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Health & Medical Sciences (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Life Sciences & Earth Sciences (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

DK99958490T 1998-11-24 1999-11-24 Hidtil ukendte mellemprodukter, fremgangsmåde til fremstilling af makrolidantibiotikum derudfra DK1133511T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
KR19980050425		1998-11-24
KR1019990050802A KR100317907B1 (ko)	1998-11-24	1999-11-16	신규한 중간체, 이를 이용한 마크로라이드계 항생제의제조방법
PCT/KR1999/000708 WO2000031099A1 (en)	1998-11-24	1999-11-24	Novel intermediates, process for preparing macrolide antibiotic agent therefrom

Publications (1)

Publication Number	Publication Date
DK1133511T3 true DK1133511T3 (da)	2003-07-14

Family

ID=26634358

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK99958490T DK1133511T3 (da)	1998-11-24	1999-11-24	Hidtil ukendte mellemprodukter, fremgangsmåde til fremstilling af makrolidantibiotikum derudfra

Country Status (21)

Country	Link
US (1)	US6600025B1 (da)
EP (1)	EP1133511B1 (da)
JP (1)	JP3848837B2 (da)
KR (1)	KR100317907B1 (da)
CN (1)	CN1354753A (da)
AT (1)	ATE234321T1 (da)
AU (1)	AU751874B2 (da)
BR (1)	BR9915646A (da)
CA (1)	CA2352162A1 (da)
CZ (1)	CZ20011803A3 (da)
DE (1)	DE69905935T2 (da)
DK (1)	DK1133511T3 (da)
ES (1)	ES2190275T3 (da)
HU (1)	HUP0104600A3 (da)
IL (1)	IL143331A0 (da)
MX (1)	MXPA01005248A (da)
PL (1)	PL348607A1 (da)
PT (1)	PT1133511E (da)
RU (1)	RU2208615C2 (da)
TR (1)	TR200101474T2 (da)
WO (1)	WO2000031099A1 (da)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7601695B2 (en)	2003-03-10	2009-10-13	Optimer Pharmaceuticals, Inc.	Antibacterial agents
ES2221807B1 (es) *	2003-06-24	2005-12-16	Ercros Industrial, S.A.	Un procedimiento para la obtencion de claritromicina.
US7767797B1 (en) *	2004-09-30	2010-08-03	Synovo Gmbh	Macrocyclic compounds and methods of use thereof
US7582611B2 (en) *	2005-05-24	2009-09-01	Pfizer Inc.	Motilide compounds
WO2007008537A2 (en) *	2005-07-07	2007-01-18	Elan Pharma International, Limited	Nanoparticulate clarithromycin formulations
US20090054634A1 (en) *	2007-08-09	2009-02-26	Vinod Kumar Kansal	Process for the preparation of clarithromycin
AU2008316830B2 (en)	2007-10-25	2016-03-17	Cempra Pharmaceuticals, Inc.	Process for the preparation of macrolide antibacterial agents
CN107854477A (zh)	2008-10-24	2018-03-30	森普拉制药公司	使用含三唑的大环内酯治疗抗性疾病的方法
US9937194B1 (en)	2009-06-12	2018-04-10	Cempra Pharmaceuticals, Inc.	Compounds and methods for treating inflammatory diseases
US9480679B2 (en)	2009-09-10	2016-11-01	Cempra Pharmaceuticals, Inc.	Methods for treating malaria, tuberculosis and MAC diseases
HRP20160168T1 (hr) *	2010-03-22	2016-03-25	Cempra Pharmaceuticals Inc	Kristalne forme makrolida i njihova uporaba
BR112012029586A2 (pt)	2010-05-20	2016-08-02	Cempra Pharmaceuticals Inc	processos para preparar macrolídeos e cetolídeos e intermediários dos mesmos
KR20130120458A (ko)	2010-09-10	2013-11-04	셈프라 파마슈티컬스, 인크.	질환을 치료하기 위한 수소결합 형성 플루오로 케토라이드
WO2013148891A1 (en)	2012-03-27	2013-10-03	Cempra Pharmaceuticals, Inc.	Parenteral formulations for administering macrolide antibiotics
WO2014152326A1 (en)	2013-03-14	2014-09-25	Cempra Pharmaceuticals, Inc.	Methods for treating respiratory diseases and formulations therefor
AU2014233240B2 (en)	2013-03-15	2018-08-09	Cempra Pharmaceuticals, Inc.	Convergent processes for preparing macrolide antibacterial agents

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL99995A (en) *	1990-11-21	1997-11-20	Roussel Uclaf	Erythromycin derivatives, their preparation and pharmaceutical compositions containing them
US5872229A (en) *	1995-11-21	1999-02-16	Abbott Laboratories	Process for 6-O-alkylation of erythromycin derivatives
US5719272A (en) *	1996-04-02	1998-02-17	Abbott Laboratories	2'-protected 3'-dimethylamine, 9-etheroxime erythromycin A derivatives
US5864023A (en) *	1997-02-13	1999-01-26	Abbott Laboratories	3'-N'oxide, 3'-n-dimethylamine, 9-oxime erythromycin a derivatives
US5929219A (en) *	1997-09-10	1999-07-27	Abbott Laboratories	9-hydrazone and 9-azine erythromycin derivatives and a process of making the same
KR20010032613A (ko) *	1997-12-01	2001-04-25	스티븐 에프. 웨인스톡	6-ｏ-알킬 에리트로마이신 ｃ의 화학적 합성 방법
ES2177448B1 (es) *	1997-12-22	2004-08-01	Biochemie S.A.	"oxima de eritromicina a.".
AU2658899A (en) *	1998-02-04	1999-08-23	Teva Pharmaceutical Industries Ltd.	Process for making clarithromycin

1999
- 1999-11-16 KR KR1019990050802A patent/KR100317907B1/ko not_active Expired - Lifetime
- 1999-11-24 AU AU15847/00A patent/AU751874B2/en not_active Ceased
- 1999-11-24 IL IL14333199A patent/IL143331A0/xx unknown
- 1999-11-24 DE DE69905935T patent/DE69905935T2/de not_active Expired - Fee Related
- 1999-11-24 CZ CZ20011803A patent/CZ20011803A3/cs unknown
- 1999-11-24 BR BR9915646-6A patent/BR9915646A/pt not_active IP Right Cessation
- 1999-11-24 CN CN99813690A patent/CN1354753A/zh active Pending
- 1999-11-24 RU RU2001117216/04A patent/RU2208615C2/ru not_active IP Right Cessation
- 1999-11-24 HU HU0104600A patent/HUP0104600A3/hu unknown
- 1999-11-24 WO PCT/KR1999/000708 patent/WO2000031099A1/en not_active Ceased
- 1999-11-24 CA CA002352162A patent/CA2352162A1/en not_active Abandoned
- 1999-11-24 AT AT99958490T patent/ATE234321T1/de not_active IP Right Cessation
- 1999-11-24 MX MXPA01005248A patent/MXPA01005248A/es not_active Application Discontinuation
- 1999-11-24 JP JP2000583926A patent/JP3848837B2/ja not_active Expired - Fee Related
- 1999-11-24 US US09/856,383 patent/US6600025B1/en not_active Expired - Fee Related
- 1999-11-24 TR TR2001/01474T patent/TR200101474T2/xx unknown
- 1999-11-24 ES ES99958490T patent/ES2190275T3/es not_active Expired - Lifetime
- 1999-11-24 PT PT99958490T patent/PT1133511E/pt unknown
- 1999-11-24 PL PL99348607A patent/PL348607A1/xx unknown
- 1999-11-24 EP EP99958490A patent/EP1133511B1/en not_active Expired - Lifetime
- 1999-11-24 DK DK99958490T patent/DK1133511T3/da active

Also Published As

Publication number	Publication date
DE69905935T2 (de)	2003-09-04
WO2000031099A1 (en)	2000-06-02
CA2352162A1 (en)	2000-06-02
US6600025B1 (en)	2003-07-29
KR20000057013A (ko)	2000-09-15
RU2208615C2 (ru)	2003-07-20
EP1133511B1 (en)	2003-03-12
TR200101474T2 (tr)	2001-12-21
AU751874B2 (en)	2002-08-29
DE69905935D1 (de)	2003-04-17
BR9915646A (pt)	2001-08-07
EP1133511A1 (en)	2001-09-19
JP3848837B2 (ja)	2006-11-22
MXPA01005248A (es)	2003-08-19
JP2002530423A (ja)	2002-09-17
PT1133511E (pt)	2003-06-30
AU1584700A (en)	2000-06-13
HUP0104600A2 (hu)	2002-03-28
KR100317907B1 (ko)	2001-12-24
HUP0104600A3 (en)	2003-12-29
CZ20011803A3 (cs)	2001-10-17
ATE234321T1 (de)	2003-03-15
ES2190275T3 (es)	2003-07-16
CN1354753A (zh)	2002-06-19
PL348607A1 (en)	2002-06-03
IL143331A0 (en)	2002-04-21

Publication	Publication Date	Title
CZ20011803A3 (cs)	2001-10-17	Způsob přípravy makrolidových antibiotických látek z nových intermediátů
ES2191982T3 (es)	2003-09-16	Derivados de 6-o-alquilo de eritronolida b.
CA2412541A1 (en)	2002-01-03	9.alpha.-chloro-6.alpha.-fluoro-17.alpha.-hydroxy-16-methyl-17-.beta.-methoxycarbonyl-androst-1,4-dienes esterified in position 17.alpha. by a cyclic acyl group
EP2258711A3 (en)	2011-03-30	New forms of 5-azacytidine
BR0209918A (pt)	2004-03-30	Formas cristalinas da azitromicina
AU3172793A (en)	1993-07-28	5-0-desosaminylerythronolide derivative
AP2001002236A0 (en)	2001-09-30	Macrolide antibiotics.
ZA200201820B (en)	2003-03-05	Pesticidal macrolides.
DE60128296D1 (de)	2007-06-21	Saccharid-Alkylenoxyderivate und Tinte
ATE229029T1 (de)	2002-12-15	2'-geschützter 3'-dimethylamin, 9-etheroxim erythromycin a derivate
CA2279932A1 (en)	1998-08-20	3'-n-oxide, 3'-n-dimethylamine, 9-oxime erythromycin a derivatives
MY149146A (en)	2013-07-15	Processes and intermediates useful in the preparation of pharmaceutical compounds such as fulvestrant
DK1255747T3 (da)	2007-02-12	Syntese af 3,6-dialkyl-5,6-dihydro-4-hydroxy-pyran-2-on
NO20024321L (no)	2002-09-10	Fremgangsmate for fremstilling av krystallinsk form I av kabergolin
WO2003014136A1 (en)	2003-02-20	11a-AZALIDE COMPOUNDS AND PROCESS FOR PRODUCING THE SAME
MY133397A (en)	2007-11-30	Novel crystalline forms of a macrolide antibiotic
AU2001289303A1 (en)	2002-02-18	Process for producing crystalline tagatose
BG106123A (en)	2002-05-31	Diphosphate salt of a 4"-substituted-9-deoxo-9a-aza-9a-homoerythromycin derivative and its pharmaceutical composition
AU3067900A (en)	2000-07-24	Novel derivatives from the class of oleandomycin
ES2197790A1 (es)	2004-01-01	Compuesto intermedio de utilidad en la sintesis de macrolidos.
YU57900A (sh)	2003-02-28	Sinteza karbamatno ketolidnih antibiotika
ES8801703A1 (es)	1988-02-16	Un nuevo procedimiento para producir el (los) antibiotico (s) macrolido (s) 4s-02930 k-d-e o-h.
DE69842005D1 (de)	2010-12-30	Kristallines anthracyclin antibiotikum und seine herstellung
DK1000952T3 (da)	2011-06-27	Nye 2-halogen-derivater af 5-O-deosaminylerythronolid A, fremgangsmåde til fremstilling deraf samt anvendelse deraf som lægemidler
TW200504159A (en)	2005-02-01	Monoazo compound and process for making same