ATE229029T1 - 2'-geschützter 3'-dimethylamin, 9-etheroxim erythromycin a derivate - Google Patents

2'-geschützter 3'-dimethylamin, 9-etheroxim erythromycin a derivate

Info

Publication number: ATE229029T1
Authority: AT; Austria
Prior art keywords: erythromycin; etheroxime; protected; derivatives; dimethylamine
Prior art date: 1996-04-02

Application number

AT97905824T

Other languages

English (en)

Inventor

Chengxi Yang

Hemantkumar H Patel

Yi-Kin Ku

Jih-Hua Liu

Original Assignee

Abbott Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-04-02

Filing date

1997-02-06

Publication date

2002-12-15

1997-02-06 Application filed by Abbott Lab filed Critical Abbott Lab

2002-12-15 Application granted granted Critical

2002-12-15 Publication of ATE229029T1 publication Critical patent/ATE229029T1/de

Links

ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical class O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 title abstract 3
229930006677 Erythromycin A Natural products 0.000 abstract 1
125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 abstract 1
150000001412 amines Chemical class 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
AGOYDEPGAOXOCK-KCBOHYOISA-N clarithromycin Chemical class O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@](C)([C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)OC)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 AGOYDEPGAOXOCK-KCBOHYOISA-N 0.000 abstract 1
229960003276 erythromycin Drugs 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
125000006239 protecting group Chemical group 0.000 abstract 1
150000003839 salts Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Saccharide Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

AT97905824T 1996-04-02 1997-02-06 2'-geschützter 3'-dimethylamin, 9-etheroxim erythromycin a derivate ATE229029T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/627,795 US5719272A (en)	1996-04-02	1996-04-02	2'-protected 3'-dimethylamine, 9-etheroxime erythromycin A derivatives
PCT/US1997/001952 WO1997036912A1 (en)	1996-04-02	1997-02-06	2'-protected 3'-dimethylamine, 9-etheroxime erythromycin a derivatives

Publications (1)

Publication Number	Publication Date
ATE229029T1 true ATE229029T1 (de)	2002-12-15

Family

ID=24516163

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT97905824T ATE229029T1 (de)	1996-04-02	1997-02-06	2'-geschützter 3'-dimethylamin, 9-etheroxim erythromycin a derivate

Country Status (9)

Country	Link
US (1)	US5719272A (de)
EP (1)	EP0891370B1 (de)
JP (1)	JP4116674B2 (de)
AT (1)	ATE229029T1 (de)
DE (1)	DE69717613T2 (de)
DK (1)	DK0891370T3 (de)
ES (1)	ES2188896T3 (de)
PT (1)	PT891370E (de)
WO (1)	WO1997036912A1 (de)

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DE69730138T2 (de)	1996-07-29	2005-03-03	Abbott Laboratories, Abbott Park	Herstellung von kristallinen form ii von clarithromycin
US5858986A (en)	1996-07-29	1999-01-12	Abbott Laboratories	Crystal form I of clarithromycin
US5945405A (en)	1997-01-17	1999-08-31	Abbott Laboratories	Crystal form O of clarithromycin
AP1060A (en) *	1998-01-02	2002-04-23	Pfizer Prod Inc	Novel erythromycin derivatives.
KR100317907B1 (ko) *	1998-11-24	2001-12-24	김 완 주	신규한 중간체, 이를 이용한 마크로라이드계 항생제의제조방법
AR023264A1 (es) *	1999-04-08	2002-09-04	Hokuriku Pharmaceutical	Derivados de eritromicina
HUP0201516A3 (en)	1999-05-24	2003-03-28	Pfizer Prod Inc	13-methyl-erythromycin derivatives, process for their preparation and pharmaceutical compositions containing them
US6437106B1 (en)	1999-06-24	2002-08-20	Abbott Laboratories	Process for preparing 6-o-substituted erythromycin derivatives
GB9915745D0 (en) *	1999-07-06	1999-09-08	Biochemie Sa	Organic compounds
WO2001044262A1 (en)	1999-12-16	2001-06-21	Teva Pharmaceutical Industries Ltd.	Processes for preparing clarithromycin polymorphs and novel polymorph iv
AU2261901A (en)	2000-01-11	2001-07-24	Teva Pharma	Processes for preparing clarithromycin polymorphs
US6565882B2 (en) *	2000-02-24	2003-05-20	Advancis Pharmaceutical Corp	Antibiotic composition with inhibitor
US6544555B2 (en) *	2000-02-24	2003-04-08	Advancis Pharmaceutical Corp.	Antibiotic product, use and formulation thereof
KR20030047873A (ko) *	2000-02-29	2003-06-18	테바 파마슈티컬 인더스트리즈 리미티드	클라리트로마이신 및 클라리트로마이신 중간체의 제조방법, 실질적으로는 옥심이 제거된 클라리트로마이신 및이를 포함하는 약학적 조성물
US20020068078A1 (en) *	2000-10-13	2002-06-06	Rudnic Edward M.	Antifungal product, use and formulation thereof
US6541014B2 (en) *	2000-10-13	2003-04-01	Advancis Pharmaceutical Corp.	Antiviral product, use and formulation thereof
US20020197314A1 (en) *	2001-02-23	2002-12-26	Rudnic Edward M.	Anti-fungal composition
AU2002357482B2 (en) *	2001-11-07	2009-03-26	Sanofi-Aventis Deutschland Gmbh	Method for the production of desclarithromycin, and intermediate products
EP1638549A4 (de)	2003-03-10	2011-06-15	Optimer Pharmaceuticals Inc	Neue antibakterielle mittel
US7435805B2 (en)	2003-05-30	2008-10-14	Glaxpsmithkline Istrazivacki	O-alkyl macrolide and azalide derivatives and regioselective process for their preparation
AU2004258949B2 (en) *	2003-07-21	2011-02-10	Shionogi, Inc.	Antibiotic product, use and formulation thereof
AU2004258953B2 (en) *	2003-07-21	2011-02-10	Shionogi, Inc.	Antibiotic product, use and formulation thereof
JP2006528185A (ja) *	2003-07-21	2006-12-14	アドバンシスファーマスーティカルコーポレイション	抗生物質製剤、その使用法及び作成方法
CA2535177A1 (en) *	2003-08-11	2005-02-24	Advancis Pharmaceutical Corporation	Robust pellet
US8062672B2 (en) *	2003-08-12	2011-11-22	Shionogi Inc.	Antibiotic product, use and formulation thereof
AU2004270170B2 (en) *	2003-08-29	2011-01-27	Shionogi, Inc.	Antibiotic product, use and formulation thereof
CA2538064C (en) *	2003-09-15	2013-12-17	Advancis Pharmaceutical Corporation	Antibiotic product, use and formulation thereof
AU2004308419B2 (en) *	2003-12-24	2011-06-02	Victory Pharma, Inc.	Enhanced absorption of modified release dosage forms
CA2572292A1 (en) *	2004-07-02	2006-02-09	Advancis Pharmaceutical Corporation	Tablet for pulsed delivery
US20060111560A1 (en) *	2004-11-01	2006-05-25	Glenmark Pharmaceuticals Limited	Process for the preparation of crystalline form II of clarithromycin
US8778924B2 (en) *	2006-12-04	2014-07-15	Shionogi Inc.	Modified release amoxicillin products
US8357394B2 (en)	2005-12-08	2013-01-22	Shionogi Inc.	Compositions and methods for improved efficacy of penicillin-type antibiotics
US7595300B2 (en)	2005-12-13	2009-09-29	Kosan Biosciences Incorporated	7-quinolyl ketolide antibacterial agents
US8299052B2 (en)	2006-05-05	2012-10-30	Shionogi Inc.	Pharmaceutical compositions and methods for improved bacterial eradication
GB0616865D0 (en) *	2006-08-25	2007-03-28	Phoenix Chemicals Ltd	Process
US20090054634A1 (en) *	2007-08-09	2009-02-26	Vinod Kumar Kansal	Process for the preparation of clarithromycin
EP2214484A4 (de)	2007-10-25	2013-01-02	Cempra Pharmaceuticals Inc	Verfahren zur herstellung von antibakteriellen makrolid-wirkstoffen
JP5711135B2 (ja)	2008-10-24	2015-04-30	センプラファーマシューティカルズ，インコーポレイテッド	胃腸疾患を治療するための方法
US9937194B1 (en)	2009-06-12	2018-04-10	Cempra Pharmaceuticals, Inc.	Compounds and methods for treating inflammatory diseases
ES2608285T3 (es)	2009-09-10	2017-04-07	Cempra Pharmaceuticals, Inc.	Procedimientos para el tratamiento de paludismo, tuberculosis y enfermedades por MAC
CN102917708B (zh)	2010-05-20	2015-11-25	森普拉制药公司	制备大环内酯和酮内酯及其中间体的方法
EP2613630A4 (de)	2010-09-10	2014-01-15	Cempra Pharmaceuticals Inc	Wasserstoffbindung zur formung von fluorketoliden zur behandlung von krankheiten
NZ700182A (en)	2012-03-27	2017-02-24	Cempra Pharmaceuticals Inc	Parenteral formulations for administering macrolide antibiotics
AU2014239959A1 (en)	2013-03-14	2015-10-01	Cempra Pharmaceuticals, Inc.	Methods for treating respiratory diseases and formulations therefor
CN105188712A (zh)	2013-03-15	2015-12-23	森普拉制药公司	用于制备大环内酯抗菌剂的收敛方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS60214796A (ja) *	1984-04-06	1985-10-28	Taisho Pharmaceut Co Ltd	６−０−メチルエリスロマイシン類の製法
US4670549A (en) *	1985-03-18	1987-06-02	Taisho Pharmaceutical Co., Ltd.	Method for selective methylation of erythromycin a derivatives
EP0260938B1 (de) *	1986-09-18	1992-12-09	Taisho Pharmaceutical Co. Ltd	Erythromycin-A-Derivate und Verfahren zu ihrer Herstellung
KR960000434B1 (ko) *	1986-12-17	1996-01-06	다이쇼 세이야꾸 가부시끼가이샤	에리스로마이신 a유도체 및 그의 제조 방법
US5350839A (en) *	1990-10-15	1994-09-27	Taisho Pharmaceutical Co., Ltd.	2'-position modified compound of erythromycin or its derivative

1996
- 1996-04-02 US US08/627,795 patent/US5719272A/en not_active Expired - Lifetime
1997
- 1997-02-06 DK DK97905824T patent/DK0891370T3/da active
- 1997-02-06 WO PCT/US1997/001952 patent/WO1997036912A1/en not_active Ceased
- 1997-02-06 AT AT97905824T patent/ATE229029T1/de not_active IP Right Cessation
- 1997-02-06 DE DE69717613T patent/DE69717613T2/de not_active Expired - Fee Related
- 1997-02-06 EP EP97905824A patent/EP0891370B1/de not_active Expired - Lifetime
- 1997-02-06 ES ES97905824T patent/ES2188896T3/es not_active Expired - Lifetime
- 1997-02-06 PT PT97905824T patent/PT891370E/pt unknown
- 1997-02-06 JP JP53525197A patent/JP4116674B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
DK0891370T3 (da)	2003-03-24
US5719272A (en)	1998-02-17
WO1997036912A1 (en)	1997-10-09
DE69717613T2 (de)	2003-09-18
DE69717613D1 (en)	2003-01-16
PT891370E (pt)	2003-04-30
JP4116674B2 (ja)	2008-07-09
JP2000507573A (ja)	2000-06-20
EP0891370B1 (de)	2002-12-04
ES2188896T3 (es)	2003-07-01
EP0891370A1 (de)	1999-01-20

Legal Events

Date

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Title

Description

2003-05-15

UEP

Publication of translation of european patent specification

Ref document number: 0891370

Country of ref document: EP

2010-11-15

REN

Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
ATE229029T1 (de)	2002-12-15	2'-geschützter 3'-dimethylamin, 9-etheroxim erythromycin a derivate
CA2279932A1 (en)	1998-08-20	3'-n-oxide, 3'-n-dimethylamine, 9-oxime erythromycin a derivatives
AP9801253A0 (en)	1999-12-04	9-Oxime erythromycin derivatives.
CA2354774A1 (en)	2000-06-29	Farnesyl protein transferase inhibitors
DK1044209T3 (da)	2004-11-22	Fremgangsmåde till fremstilling af 6-O-methylerythromycin A ved at anvende derivater af 9-hydroxyerythromycin
BG42675A3 (bg)	1988-01-15	Метод за получаване на 20-амино-макролидни производни
AU2555592A (en)	1993-04-05	Method for synthesizing glucuronides of 4,5-epoxy morphinanes
ZA966601B (en)	1997-02-19	Process for producing erythromycin derivatives.
CA2264513A1 (en)	1998-03-19	Substituted benzocycloheptapyridine derivatives useful for inhibition of farnesyl protein transferase
FI953841L (fi)	1996-02-17	Substituoituja kinoliinijohdannaisia, menetelmä niiden valmistamseksi
DK0784605T3 (da)	2000-07-31	Selektiv fremgangsmåde til deacyleringen af acylforbindelser
CA2250736A1 (en)	1997-10-09	2'-protected 3'-dimethylamine, 9-etheroxime erythromycin a derivatives
HUP9900377A3 (en)	2000-03-28	Novel process for preparing 2,3-dihydro-benzofuranol derivatives
FR2749585B1 (fr)	1998-08-14	Nouveaux derives aromatiques substitues par un ribose, leur procede de preparation et leur application comme medicaments
PL315422A1 (en)	1997-02-03	Novel compounds and their salts, method of obtaining them as well as pharmaceutic agent and method of obtaining same
PL327581A1 (en)	1998-12-21	Method of selectively protecting bacatin derivatives and application thereof in a process of synthesising taxanes
NZ335325A (en)	2000-08-25	Erythromycin derivatives, method for preparing them and their use as medicine
CA2195975A1 (en)	1996-02-29	An improved process for preparing side chain derivatives of cyclohexapeptidyl lipopeptides
ATE354580T1 (de)	2007-03-15	Oleandomycin-derivate
MY133929A (en)	2007-11-30	A cost effective method for selective methylation of erythromycin a derivatives
PL315707A1 (en)	1997-02-17	Novel compounds and their salts, method of obtaining them as well as pharmaceutic preparation and method of obtaining same
WO2001012642A3 (de)	2001-06-07	Nucleosidderivate und verfahren zu deren herstellung
IL123386A0 (en)	1998-09-24	3-Deoxy-3-descladinose derivatives of erythromycins
DE69218005D1 (de)	1997-04-10	2'-deoxy-2'-fluorcoformycin und stereoisomere davon
DE69601451D1 (de)	1999-03-11	UCK14-Verbindungen