DK1144421T3 - Phosphiniske pseudopeptider, som er inhibitorer af matrix-metalloproteaser - Google Patents

Phosphiniske pseudopeptider, som er inhibitorer af matrix-metalloproteaser

Info

Publication number: DK1144421T3
Authority: DK; Denmark
Prior art keywords: amino acid; natural; lateral chain; inhibitors; pseudopeptides
Prior art date: 1999-01-19

Application number

DK00900598T

Other languages

English (en)

Inventor

Vincent Dive

Philippe Cuniasse

Marie-Christine Rio

Athanasios Yotakis

Fabrice Beau

Stamania Vassiliou

Paul Di Basset

Original Assignee

Commissariat Energie Atomique

Inst Nat Sante Rech Med

Centre Nat Rech Scient

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-01-19

Filing date

2000-01-18

Publication date

2004-02-16

2000-01-18 Application filed by Commissariat Energie Atomique, Inst Nat Sante Rech Med, Centre Nat Rech Scient filed Critical Commissariat Energie Atomique

2004-02-16 Application granted granted Critical

2004-02-16 Publication of DK1144421T3 publication Critical patent/DK1144421T3/da

Links

239000011159 matrix material Substances 0.000 title abstract 2
102000005741 Metalloproteases Human genes 0.000 title 1
108010006035 Metalloproteases Proteins 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
150000001413 amino acids Chemical class 0.000 abstract 3
241000024188 Andala Species 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
101710204001 Zinc metalloprotease Proteins 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000000539 amino acid group Chemical group 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
239000003475 metalloproteinase inhibitor Substances 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C07F9/301—Acyclic saturated acids which can have further substituents on alkyl
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
- C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Biomedical Technology (AREA)
Pain & Pain Management (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Cosmetics (AREA)

DK00900598T 1999-01-19 2000-01-18 Phosphiniske pseudopeptider, som er inhibitorer af matrix-metalloproteaser DK1144421T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9900509A FR2788525B1 (fr)	1999-01-19	1999-01-19	Pseudo-peptides phosphiniques, utilisables comme inhibiteurs des metalloproteases a zinc matricielles

Publications (1)

Publication Number	Publication Date
DK1144421T3 true DK1144421T3 (da)	2004-02-16

Family

ID=9540989

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK00900598T DK1144421T3 (da)	1999-01-19	2000-01-18	Phosphiniske pseudopeptider, som er inhibitorer af matrix-metalloproteaser

Country Status (10)

Country	Link
US (1)	US6630501B1 (da)
EP (1)	EP1144421B1 (da)
JP (1)	JP2003517450A (da)
AT (1)	ATE251630T1 (da)
CA (1)	CA2360787A1 (da)
DE (1)	DE60005788T2 (da)
DK (1)	DK1144421T3 (da)
ES (1)	ES2208260T3 (da)
FR (1)	FR2788525B1 (da)
WO (1)	WO2000043404A1 (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9922577D0 (en) *	1999-09-23	1999-11-24	Center For Clinical & Basic Re	Substituted phosphinate based peptide derivatives
PE20030701A1 (es)	2001-12-20	2003-08-21	Schering Corp	Compuestos para el tratamiento de trastornos inflamatorios
PL1685142T3 (pl) *	2003-11-11	2008-06-30	Hoffmann La Roche	Pochodne kwasu fosfinowego, inhibitory beta-sekterazy do leczenia choroby Alzheimera
WO2007062376A2 (en) *	2005-11-21	2007-05-31	Florida Atlantic University	Selective inhibition of matrix metalloproteinases
FR2996003B1 (fr)	2012-09-25	2014-10-17	Commissariat Energie Atomique	Methode pour detecter specifiquement dans un echantillon une metalloprotease matricielle (mmp) d'interet uniquement dans sa forme active
TWI743023B (zh) *	2014-05-21	2021-10-21	日商Ｋｍ生物醫藥股份有限公司	基質金屬蛋白酶 7(mmp-7)聚集體之單體化方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2676059B1 (fr) *	1991-05-02	1993-07-23	Commissariat Energie Atomique	Nouveaux derives de peptides utilisables comme inhibiteurs de collagenases bacteriennes.
JPH07503016A (ja) *	1992-01-15	1995-03-30	メルク　エンド　カンパニー　インコーポレーテッド	変形防止剤としての置換されたホスフィン酸含有ペプチジル誘導体
FR2689764B1 (fr)	1992-04-10	1995-05-12	Commissariat Energie Atomique	Utilisation de dérivés de peptides pour la fabrication de médicaments inhibiteurs des endopeptidases 24.15 et 24.16.
FR2730235A1 (fr)	1995-02-06	1996-08-09	Commissariat Energie Atomique	Nouveaux derives de peptides utilisables comme inhibiteur de l'endopeptidase a zinc 24-15
EP0923585B1 (en) *	1996-07-18	2002-05-08	Pfizer Inc.	Phosphinate based inhibitors of matrix metalloproteases

1999
- 1999-01-19 FR FR9900509A patent/FR2788525B1/fr not_active Expired - Fee Related
2000
- 2000-01-18 DK DK00900598T patent/DK1144421T3/da active
- 2000-01-18 AT AT00900598T patent/ATE251630T1/de not_active IP Right Cessation
- 2000-01-18 ES ES00900598T patent/ES2208260T3/es not_active Expired - Lifetime
- 2000-01-18 US US09/869,303 patent/US6630501B1/en not_active Expired - Fee Related
- 2000-01-18 CA CA002360787A patent/CA2360787A1/fr not_active Abandoned
- 2000-01-18 DE DE60005788T patent/DE60005788T2/de not_active Expired - Fee Related
- 2000-01-18 JP JP2000594820A patent/JP2003517450A/ja active Pending
- 2000-01-18 WO PCT/FR2000/000093 patent/WO2000043404A1/fr not_active Ceased
- 2000-01-18 EP EP00900598A patent/EP1144421B1/fr not_active Expired - Lifetime

Also Published As

Publication number	Publication date
DE60005788D1 (en)	2003-11-13
CA2360787A1 (fr)	2000-07-27
ES2208260T3 (es)	2004-06-16
FR2788525B1 (fr)	2002-11-29
FR2788525A1 (fr)	2000-07-21
EP1144421A1 (fr)	2001-10-17
JP2003517450A (ja)	2003-05-27
US6630501B1 (en)	2003-10-07
DE60005788T2 (de)	2004-08-19
EP1144421B1 (fr)	2003-10-08
ATE251630T1 (de)	2003-10-15
WO2000043404A1 (fr)	2000-07-27

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DE60301345D1 (de)	2005-09-22	Stabilisierte askorbinsäurederivate
TW200604175A (en)	2006-02-01	Ortho substituted aryl or heteroaryl amide compounds
DOP2005000071A (es)	2005-11-30	"compuestos de metil-aril o heteroaril-amida sustituida"
EA200100600A3 (ru)	2002-04-25	Новые соединения дифенилмочевины, способ их получения и содержащие их фармацевтические композиции
ATE383160T1 (de)	2008-01-15	Phosphinsäurederivate, inhibitoren von beta- sekretase zur behandlung von alzheimer-krankheit
PT1250340E (pt)	2005-04-29	Metodos e compostos para inibicao de mrp1
CO4990932A1 (es)	2000-12-26	Derivados de 2,1,3-benzotiadiazol y proceso para su preparacion
ATE19251T1 (de)	1986-05-15	Hemmer der kollagenase der saeugetiere.
DK1144421T3 (da)	2004-02-16	Phosphiniske pseudopeptider, som er inhibitorer af matrix-metalloproteaser
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AU2009292741A8 (en)	2012-07-19	Dendrimeric compounds comprising amino acids, hyperbranched core compound, process for preparation of dendrimeric compounds comprising amino acids and hyperbranched core compound, and use thereof
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DE69712758D1 (de)	2002-06-27	Fungizide zusammensetzungen
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Green et al.	2000	Substrate related O, O-dialkyldipeptidyly ψ carboxybenzylphosphonates, a new type of thrombin inhibitor
BRPI0413743A (pt)	2006-10-24	inibidores de catepsina s
AU2003222329A1 (en)	2003-09-02	Phosphinic pseudo-peptide derivatives for selective inhibition of the active c-terminal site of angiotensin converting enzyme (i) (ace)
WO2004065411A3 (en)	2005-01-27	Peptides
TW200510330A (en)	2005-03-16	Enhancement of bone growth and inhibition of bone resorption