DK1144421T3 - Phosphiniske pseudopeptider, som er inhibitorer af matrix-metalloproteaser - Google Patents

Phosphiniske pseudopeptider, som er inhibitorer af matrix-metalloproteaser

Info

Publication number: DK1144421T3
Authority: DK; Denmark
Prior art keywords: amino acid; natural; lateral chain; inhibitors; pseudopeptides
Prior art date: 1999-01-19

Application number

DK00900598T

Other languages

English (en)

Inventor

Vincent Dive

Philippe Cuniasse

Marie-Christine Rio

Athanasios Yotakis

Fabrice Beau

Stamania Vassiliou

Paul Di Basset

Original Assignee

Commissariat Energie Atomique

Inst Nat Sante Rech Med

Centre Nat Rech Scient

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-01-19

Filing date

2000-01-18

Publication date

2004-02-16

2000-01-18 Application filed by Commissariat Energie Atomique, Inst Nat Sante Rech Med, Centre Nat Rech Scient filed Critical Commissariat Energie Atomique

2004-02-16 Application granted granted Critical

2004-02-16 Publication of DK1144421T3 publication Critical patent/DK1144421T3/da

Links

239000011159 matrix material Substances 0.000 title abstract 2
102000005741 Metalloproteases Human genes 0.000 title 1
108010006035 Metalloproteases Proteins 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
150000001413 amino acids Chemical class 0.000 abstract 3
241000024188 Andala Species 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
101710204001 Zinc metalloprotease Proteins 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000000539 amino acid group Chemical group 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
125000003710 aryl alkyl group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
230000002401 inhibitory effect Effects 0.000 abstract 1
239000003475 metalloproteinase inhibitor Substances 0.000 abstract 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
108090000765 processed proteins & peptides Proteins 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
- C07F9/301—Acyclic saturated acids which can have further substituents on alkyl
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
- C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Rheumatology (AREA)
Physical Education & Sports Medicine (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Immunology (AREA)
Orthopedic Medicine & Surgery (AREA)
Biomedical Technology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Cosmetics (AREA)

DK00900598T 1999-01-19 2000-01-18 Phosphiniske pseudopeptider, som er inhibitorer af matrix-metalloproteaser DK1144421T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9900509A FR2788525B1 (fr)	1999-01-19	1999-01-19	Pseudo-peptides phosphiniques, utilisables comme inhibiteurs des metalloproteases a zinc matricielles

Publications (1)

Publication Number	Publication Date
DK1144421T3 true DK1144421T3 (da)	2004-02-16

Family

ID=9540989

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK00900598T DK1144421T3 (da)	1999-01-19	2000-01-18	Phosphiniske pseudopeptider, som er inhibitorer af matrix-metalloproteaser

Country Status (10)

Country	Link
US (1)	US6630501B1 (da)
EP (1)	EP1144421B1 (da)
JP (1)	JP2003517450A (da)
AT (1)	ATE251630T1 (da)
CA (1)	CA2360787A1 (da)
DE (1)	DE60005788T2 (da)
DK (1)	DK1144421T3 (da)
ES (1)	ES2208260T3 (da)
FR (1)	FR2788525B1 (da)
WO (1)	WO2000043404A1 (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9922577D0 (en) *	1999-09-23	1999-11-24	Center For Clinical & Basic Re	Substituted phosphinate based peptide derivatives
PE20030701A1 (es)	2001-12-20	2003-08-21	Schering Corp	Compuestos para el tratamiento de trastornos inflamatorios
EP1685142B1 (en) *	2003-11-11	2008-01-09	F. Hoffmann-La Roche Ag	Phosphinic acid derivatives, beta-secretase inhibitors for the treatment of alzheimer's disease
US20080125354A1 (en) *	2005-11-21	2008-05-29	Florida Atlantic University	Selective inhibition of matrix metalloproteinases
FR2996003B1 (fr)	2012-09-25	2014-10-17	Commissariat Energie Atomique	Methode pour detecter specifiquement dans un echantillon une metalloprotease matricielle (mmp) d'interet uniquement dans sa forme active
TWI743023B (zh) *	2014-05-21	2021-10-21	日商Ｋｍ生物醫藥股份有限公司	基質金屬蛋白酶 7(mmp-7)聚集體之單體化方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2676059B1 (fr) *	1991-05-02	1993-07-23	Commissariat Energie Atomique	Nouveaux derives de peptides utilisables comme inhibiteurs de collagenases bacteriennes.
JPH07503016A (ja) *	1992-01-15	1995-03-30	メルク　エンド　カンパニー　インコーポレーテッド	変形防止剤としての置換されたホスフィン酸含有ペプチジル誘導体
FR2689764B1 (fr)	1992-04-10	1995-05-12	Commissariat Energie Atomique	Utilisation de dérivés de peptides pour la fabrication de médicaments inhibiteurs des endopeptidases 24.15 et 24.16.
FR2730235A1 (fr)	1995-02-06	1996-08-09	Commissariat Energie Atomique	Nouveaux derives de peptides utilisables comme inhibiteur de l'endopeptidase a zinc 24-15
KR20000067904A (ko) *	1996-07-18	2000-11-25	디. 제이. 우드, 스피겔 알렌 제이	매트릭스 메탈로프로테아제의 포스피네이트계 억제제

1999
- 1999-01-19 FR FR9900509A patent/FR2788525B1/fr not_active Expired - Fee Related
2000
- 2000-01-18 EP EP00900598A patent/EP1144421B1/fr not_active Expired - Lifetime
- 2000-01-18 WO PCT/FR2000/000093 patent/WO2000043404A1/fr not_active Ceased
- 2000-01-18 DE DE60005788T patent/DE60005788T2/de not_active Expired - Fee Related
- 2000-01-18 ES ES00900598T patent/ES2208260T3/es not_active Expired - Lifetime
- 2000-01-18 JP JP2000594820A patent/JP2003517450A/ja active Pending
- 2000-01-18 AT AT00900598T patent/ATE251630T1/de not_active IP Right Cessation
- 2000-01-18 US US09/869,303 patent/US6630501B1/en not_active Expired - Fee Related
- 2000-01-18 DK DK00900598T patent/DK1144421T3/da active
- 2000-01-18 CA CA002360787A patent/CA2360787A1/fr not_active Abandoned

Also Published As

Publication number	Publication date
DE60005788D1 (en)	2003-11-13
FR2788525B1 (fr)	2002-11-29
CA2360787A1 (fr)	2000-07-27
ES2208260T3 (es)	2004-06-16
EP1144421B1 (fr)	2003-10-08
US6630501B1 (en)	2003-10-07
ATE251630T1 (de)	2003-10-15
DE60005788T2 (de)	2004-08-19
JP2003517450A (ja)	2003-05-27
FR2788525A1 (fr)	2000-07-21
WO2000043404A1 (fr)	2000-07-27
EP1144421A1 (fr)	2001-10-17

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BR0210504A (pt)	2004-05-18	Derivados de naftil-indol substituidos, atuantes como inibidores do inibidor tipo 1 (pai-1) do ativador de plasminogênio
ATE302001T1 (de)	2005-09-15	Stabilisierte askorbinsäurederivate
TW200604175A (en)	2006-02-01	Ortho substituted aryl or heteroaryl amide compounds
DOP2005000071A (es)	2005-11-30	"compuestos de metil-aril o heteroaril-amida sustituida"
EA200100600A3 (ru)	2002-04-25	Новые соединения дифенилмочевины, способ их получения и содержащие их фармацевтические композиции
PT1250340E (pt)	2005-04-29	Metodos e compostos para inibicao de mrp1
CO4990932A1 (es)	2000-12-26	Derivados de 2,1,3-benzotiadiazol y proceso para su preparacion
ATE19251T1 (de)	1986-05-15	Hemmer der kollagenase der saeugetiere.
DK1144421T3 (da)	2004-02-16	Phosphiniske pseudopeptider, som er inhibitorer af matrix-metalloproteaser
CY1107990T1 (el)	2013-09-04	Τριπεπτιδια και παραγωγα τριπεπτιδιων για τη θepαπεια νευροεκφυλιστικων ασθενειων
AU2009292741A8 (en)	2012-07-19	Dendrimeric compounds comprising amino acids, hyperbranched core compound, process for preparation of dendrimeric compounds comprising amino acids and hyperbranched core compound, and use thereof
AU4663301A (en)	2001-10-08	Method for preparing (2S,3R,4S)-4-hydroxyisoleucine and analogues thereof
DE69712758D1 (de)	2002-06-27	Fungizide zusammensetzungen
EA200200807A1 (ru)	2002-12-26	Аминокислотные соединения и их применение в качестве ингибиторов nep, ace и ece
PE45295A1 (es)	1995-12-29	Peptidos inhibidores de proteasa
AU2003220441A8 (en)	2003-10-27	Dipeptidic growth hormone secretagogues
ATE342250T1 (de)	2006-11-15	Verfahren zur herstellung von (aminomethyl)trifluoromethylcarbinol-derivaten
DE602004026110D1 (de)	2010-04-29	Verfahren zur inhibierung der verfärbung von methylenbisanilinverbindungen
BR0316368A (pt)	2005-10-04	Análogos de ácido fosfìnico de glutamato
Green et al.	2000	Substrate related O, O-dialkyldipeptidyly ψ carboxybenzylphosphonates, a new type of thrombin inhibitor
BRPI0413743A (pt)	2006-10-24	inibidores de catepsina s
Chen et al.	2002	Phosphonamidate based inhibitors of angiotensin-converting enzyme (ACE)
AU2003222329A1 (en)	2003-09-02	Phosphinic pseudo-peptide derivatives for selective inhibition of the active c-terminal site of angiotensin converting enzyme (i) (ace)
WO2004065411A3 (en)	2005-01-27	Peptides
TW200510330A (en)	2005-03-16	Enhancement of bone growth and inhibition of bone resorption