ATE251630T1 - Phosphinic pseudopeptide als matrix metalloprotease-inhibitoren - Google Patents

Phosphinic pseudopeptide als matrix metalloprotease-inhibitoren

Info

Publication number
ATE251630T1
ATE251630T1 AT00900598T AT00900598T ATE251630T1 AT E251630 T1 ATE251630 T1 AT E251630T1 AT 00900598 T AT00900598 T AT 00900598T AT 00900598 T AT00900598 T AT 00900598T AT E251630 T1 ATE251630 T1 AT E251630T1
Authority
AT
Austria
Prior art keywords
amino acid
natural
metalloprotease inhibitors
lateral chain
pseudopeptides
Prior art date
Application number
AT00900598T
Other languages
English (en)
Inventor
Paul Di Basset
Vincent Dive
Philippe Cuniasse
Marie-Christine Rio
Athanasios Yotakis
Fabrice Beau
Stamania Vassiliou
Original Assignee
Commissariat Energie Atomique
Inst Nat Sante Rech Med
Centre Nat Rech Scient
Basset Genevieve Lf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Commissariat Energie Atomique, Inst Nat Sante Rech Med, Centre Nat Rech Scient, Basset Genevieve Lf filed Critical Commissariat Energie Atomique
Application granted granted Critical
Publication of ATE251630T1 publication Critical patent/ATE251630T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/30—Phosphinic acids [R2P(=O)(OH)]; Thiophosphinic acids ; [R2P(=X1)(X2H) (X1, X2 are each independently O, S or Se)]
    • C07F9/301—Acyclic saturated acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Cosmetics (AREA)
AT00900598T 1999-01-19 2000-01-18 Phosphinic pseudopeptide als matrix metalloprotease-inhibitoren ATE251630T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9900509A FR2788525B1 (fr) 1999-01-19 1999-01-19 Pseudo-peptides phosphiniques, utilisables comme inhibiteurs des metalloproteases a zinc matricielles
PCT/FR2000/000093 WO2000043404A1 (fr) 1999-01-19 2000-01-18 Pseudo-peptides phosphiniques inhibiteurs des metalloproteases matricielles

Publications (1)

Publication Number Publication Date
ATE251630T1 true ATE251630T1 (de) 2003-10-15

Family

ID=9540989

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00900598T ATE251630T1 (de) 1999-01-19 2000-01-18 Phosphinic pseudopeptide als matrix metalloprotease-inhibitoren

Country Status (10)

Country Link
US (1) US6630501B1 (de)
EP (1) EP1144421B1 (de)
JP (1) JP2003517450A (de)
AT (1) ATE251630T1 (de)
CA (1) CA2360787A1 (de)
DE (1) DE60005788T2 (de)
DK (1) DK1144421T3 (de)
ES (1) ES2208260T3 (de)
FR (1) FR2788525B1 (de)
WO (1) WO2000043404A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9922577D0 (en) * 1999-09-23 1999-11-24 Center For Clinical & Basic Re Substituted phosphinate based peptide derivatives
PE20030701A1 (es) 2001-12-20 2003-08-21 Schering Corp Compuestos para el tratamiento de trastornos inflamatorios
WO2005044830A1 (en) * 2003-11-11 2005-05-19 F. Hoffmann-La Roche Ag Phosphinic acids derivatives, beta-secretase inhibitors for the treatment of alzheimer’s disease
WO2007062376A2 (en) * 2005-11-21 2007-05-31 Florida Atlantic University Selective inhibition of matrix metalloproteinases
FR2996003B1 (fr) 2012-09-25 2014-10-17 Commissariat Energie Atomique Methode pour detecter specifiquement dans un echantillon une metalloprotease matricielle (mmp) d'interet uniquement dans sa forme active
TWI743023B (zh) * 2014-05-21 2021-10-21 日商Ｋｍ生物醫藥股份有限公司 基質金屬蛋白酶 7(mmp-7)聚集體之單體化方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2676059B1 (fr) 1991-05-02 1993-07-23 Commissariat Energie Atomique Nouveaux derives de peptides utilisables comme inhibiteurs de collagenases bacteriennes.
AU3475393A (en) * 1992-01-15 1993-08-03 Merck & Co., Inc. Substituted phosphinic acid-containing peptidyl derivatives as antidegenerative agents
FR2689764B1 (fr) 1992-04-10 1995-05-12 Commissariat Energie Atomique Utilisation de dérivés de peptides pour la fabrication de médicaments inhibiteurs des endopeptidases 24.15 et 24.16.
FR2730235A1 (fr) 1995-02-06 1996-08-09 Commissariat Energie Atomique Nouveaux derives de peptides utilisables comme inhibiteur de l'endopeptidase a zinc 24-15
EP0923585B1 (de) * 1996-07-18 2002-05-08 Pfizer Inc. Matrix metalloprotease-inhibitoren auf basis von phosphinsäuren

Also Published As

Publication number Publication date
ES2208260T3 (es) 2004-06-16
DE60005788T2 (de) 2004-08-19
US6630501B1 (en) 2003-10-07
DK1144421T3 (da) 2004-02-16
FR2788525B1 (fr) 2002-11-29
FR2788525A1 (fr) 2000-07-21
JP2003517450A (ja) 2003-05-27
WO2000043404A1 (fr) 2000-07-27
CA2360787A1 (fr) 2000-07-27
EP1144421B1 (de) 2003-10-08
DE60005788D1 (en) 2003-11-13
EP1144421A1 (de) 2001-10-17

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Legal Events

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