DK1147115T5 - Tricycliske benzodiazepiner som vasopressinreceptorantagonister - Google Patents

Tricycliske benzodiazepiner som vasopressinreceptorantagonister

Info

Publication number
DK1147115T5
DK1147115T5 DK99966495T DK99966495T DK1147115T5 DK 1147115 T5 DK1147115 T5 DK 1147115T5 DK 99966495 T DK99966495 T DK 99966495T DK 99966495 T DK99966495 T DK 99966495T DK 1147115 T5 DK1147115 T5 DK 1147115T5
Authority
DK
Denmark
Prior art keywords
receptor antagonists
vasopressin receptor
tricyclic benzodiazepines
benzodiazepines
tricyclic
Prior art date
Application number
DK99966495T
Other languages
Danish (da)
English (en)
Other versions
DK1147115T3 (da
Inventor
Jay M Matthews
William J Hoekstra
Alexey B Dyatkin
Bruce E Maryanoff
Original Assignee
Ortho Mcneil Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc
Publication of DK1147115T3 publication Critical patent/DK1147115T3/da
Application granted granted Critical
Publication of DK1147115T5 publication Critical patent/DK1147115T5/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
DK99966495T 1999-01-19 1999-12-21 Tricycliske benzodiazepiner som vasopressinreceptorantagonister DK1147115T5 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11635899P 1999-01-19 1999-01-19
US46865099A 1999-12-21 1999-12-21
PCT/US1999/030423 WO2000043398A2 (en) 1999-01-19 1999-12-21 Tricyclic benzodiazepines as vasopressin receptor antagonists

Publications (2)

Publication Number Publication Date
DK1147115T3 DK1147115T3 (da) 2004-01-12
DK1147115T5 true DK1147115T5 (da) 2008-12-08

Family

ID=26814157

Family Applications (1)

Application Number Title Priority Date Filing Date
DK99966495T DK1147115T5 (da) 1999-01-19 1999-12-21 Tricycliske benzodiazepiner som vasopressinreceptorantagonister

Country Status (27)

Country Link
US (2) US6713475B2 (de)
EP (1) EP1147115B3 (de)
KR (1) KR100771184B1 (de)
CN (1) CN1174986C (de)
AR (1) AR035837A1 (de)
AT (1) ATE249465T1 (de)
AU (1) AU772397B2 (de)
BR (1) BRPI9917086B8 (de)
CA (1) CA2360767C (de)
CZ (1) CZ302647B6 (de)
DE (2) DE69911259D1 (de)
DK (1) DK1147115T5 (de)
ES (1) ES2207333T7 (de)
HK (1) HK1038361B (de)
HU (1) HU229074B1 (de)
IL (2) IL144270A0 (de)
ME (1) ME00129B (de)
MY (1) MY128065A (de)
NO (1) NO327896B1 (de)
NZ (1) NZ512960A (de)
PL (1) PL205704B1 (de)
PT (1) PT1147115E (de)
RS (1) RS50820B (de)
TR (1) TR200102069T2 (de)
TW (1) TWI289564B (de)
UA (1) UA70984C2 (de)
WO (1) WO2000043398A2 (de)

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AU772397B2 (en) * 1999-01-19 2004-04-29 Ortho-Mcneil Pharmaceutical, Inc. Tricyclic benzodiazepines as vasopressin receptor antagonists
ES2288899T3 (es) * 2000-10-04 2008-02-01 Astellas Pharma Inc. Uso de un antagonista de vasopresina tal como conivaptan en la fabricacion de un medicamento para el tratamiento de la hipertension pulmonar.
US7053083B2 (en) 2001-04-12 2006-05-30 Wyeth Cyclohexylphenyl vasopressin agonists
JP2004530668A (ja) 2001-04-12 2004-10-07 ワイス バソプレッシンアゴニストとしてのｎ−ビフェニルカルボニル−およびｎ−フェニルピリジルカルボニル置換二および三環アゼピンおよびジアゼピン
HUP0401722A3 (en) 2001-10-29 2008-07-28 Ortho Mcneil Pharm Inc Benzo[e][1,4]diazepine derivatives condensed with bridged bicycle, their preparation and their use as vasopressin receptor antagonists
EP1364968A1 (de) * 2002-05-23 2003-11-26 Bayer Aktiengesellschaft Diagnostika und Therapeutika für Krankheiten, die mit Arginin-Vasopressin-Rezeptor 1 (AVPR1) assoziiert sind
GB0303852D0 (en) * 2003-02-19 2003-03-26 Pfizer Ltd Triazole compounds useful in therapy
AP2005003376A0 (en) * 2003-02-19 2005-09-30 Pfizer Triazole compounds useful in therapy.
US7119088B2 (en) 2003-02-19 2006-10-10 Pfizer Inc. Triazole compounds useful in therapy
JP2008518915A (ja) 2004-10-28 2008-06-05 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ バソプレシンｖ２受容体アンタゴニストとしての新規な［１，４］ベンゾジアゼピン
DE102005003632A1 (de) 2005-01-20 2006-08-17 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Katheter für die transvaskuläre Implantation von Herzklappenprothesen
US20070213813A1 (en) 2005-12-22 2007-09-13 Symetis Sa Stent-valves for valve replacement and associated methods and systems for surgery
US20090318412A1 (en) * 2006-07-11 2009-12-24 Takahiro Matsumoto Tricyclic heterocyclic compound and use thereof
US7896915B2 (en) 2007-04-13 2011-03-01 Jenavalve Technology, Inc. Medical device for treating a heart valve insufficiency
WO2011104269A1 (en) 2008-02-26 2011-09-01 Jenavalve Technology Inc. Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient
US9044318B2 (en) 2008-02-26 2015-06-02 Jenavalve Technology Gmbh Stent for the positioning and anchoring of a valvular prosthesis
SI2356123T1 (sl) * 2008-11-13 2013-01-31 F. Hoffmann-La Roche Ag Piro-5,6-dihidro-4h-2,3,5,10b-tetraaza-benzo(e)azuleni
KR101385433B1 (ko) * 2008-11-18 2014-04-14 에프. 호프만-라 로슈 아게 다이하이드로테트라아자벤조아줄렌의 알킬사이클로헥실에터
HRP20131067T1 (hr) * 2008-11-28 2013-12-06 F. Hoffmann - La Roche Ag Arilcikloheksileteri od dihidrotetraazabenzoazulena za primjenu kao antagonista receptora vazopresina v1a
DE102009033392A1 (de) * 2009-07-16 2011-01-20 Merck Patent Gmbh Heterocyclische Verbindungen als Autotaxin-Inhibitoren II
JP2013505914A (ja) * 2009-09-24 2013-02-21 シャイア−モベティス エヌ．ブイ． バソプレシンｖ２受容体アンタゴニストとしての［１，４］−ベンゾジアゼピン
US8420633B2 (en) 2010-03-31 2013-04-16 Hoffmann-La Roche Inc. Aryl-cyclohexyl-tetraazabenzo[e]azulenes
US8461151B2 (en) 2010-04-13 2013-06-11 Hoffmann-La Roche Inc. Aryl-/heteroaryl-cyclohexenyl-tetraazabenzo[e]azulenes
US8492376B2 (en) 2010-04-21 2013-07-23 Hoffmann-La Roche Inc. Heteroaryl-cyclohexyl-tetraazabenzo[e]azulenes
US8481528B2 (en) 2010-04-26 2013-07-09 Hoffmann-La Roche Inc. Heterobiaryl-cyclohexyl-tetraazabenzo[e]azulenes
US8513238B2 (en) 2010-05-10 2013-08-20 Hoffmann-La Roche Inc. Heteroaryl-cyclohexyl-tetraazabenzo[E]azulenes
US10856978B2 (en) 2010-05-20 2020-12-08 Jenavalve Technology, Inc. Catheter system
CN103002833B (zh) 2010-05-25 2016-05-11 耶拿阀门科技公司 人工心脏瓣及包括人工心脏瓣和支架的经导管输送的内假体
US8828989B2 (en) 2011-09-26 2014-09-09 Hoffmann-La Roche Inc. Oxy-cyclohexyl-4H,6H-5-oxa-2,3,10b-triaza-benzo[E]azulenes as V1A antagonists
WO2015028209A1 (en) 2013-08-30 2015-03-05 Jenavalve Technology Gmbh Radially collapsible frame for a prosthetic valve and method for manufacturing such a frame
EP3226690B1 (de) 2014-12-05 2020-05-20 Merck Sharp & Dohme Corp. Neuartige tricyclische verbindungen als inhibitoren von mutanten idh-enzymen
WO2016089830A1 (en) * 2014-12-05 2016-06-09 Merck Sharp & Dohme Corp. Novel tricyclic compounds as inhibitors of mutant idh enzymes
US10442819B2 (en) 2014-12-05 2019-10-15 Merck Sharp & Dohme Corp. Tricyclic compounds as inhibitors of mutant IDH enzymes
WO2016150806A1 (en) 2015-03-20 2016-09-29 Jenavalve Technology, Inc. Heart valve prosthesis delivery system and method for delivery of heart valve prosthesis with introducer sheath
CN107530168B (zh) 2015-05-01 2020-06-09 耶拿阀门科技股份有限公司 在心脏瓣膜替换中具有降低的起搏器比例的装置和方法
CN109475419B (zh) 2016-05-13 2021-11-09 耶拿阀门科技股份有限公司 用于通过引导鞘和装载系统来递送心脏瓣膜假体的心脏瓣膜假体递送系统和方法
CN110392557A (zh) 2017-01-27 2019-10-29 耶拿阀门科技股份有限公司 心脏瓣膜模拟
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US3860600A (en) 1972-07-10 1975-01-14 Sterling Drug Inc Octahydropyrrido{8 2,1-c{9 {8 1,4{9 benzodiazepines
US3763183A (en) * 1972-07-10 1973-10-02 Sterling Drug Inc 1,2,3,10,11,11a-hexahydro-5h-pyrrolo (2,1-c)(1,4)benzodiazepines
US5516774A (en) * 1993-07-29 1996-05-14 American Cyanamid Company Tricyclic diazepine vasopressin antagonists and oxytocin antagonists
US5521173A (en) * 1995-01-17 1996-05-28 American Home Products Corporation Tricyclic benzazepine vasopressin antagonists
CA2285343A1 (en) * 1997-03-31 1998-10-08 Wakamoto Pharmaceutical Co., Ltd. Biphenyl derivatives and medicinal compositions
DE69826487T2 (de) * 1997-07-30 2005-12-01 Wyeth Trizyclische vasopressin-agonisten
AU772397B2 (en) * 1999-01-19 2004-04-29 Ortho-Mcneil Pharmaceutical, Inc. Tricyclic benzodiazepines as vasopressin receptor antagonists

Also Published As

Publication number Publication date
AU772397C (en) 2000-08-07
DE69911259D1 (de) 2003-10-16
BR9917086B1 (pt) 2013-12-03
CZ302647B6 (cs) 2011-08-17
UA70984C2 (uk) 2004-11-15
US20040242866A1 (en) 2004-12-02
HUP0105034A3 (en) 2004-11-29
ES2207333T3 (es) 2004-05-16
AU772397B2 (en) 2004-04-29
KR20010101577A (ko) 2001-11-14
PL205704B1 (pl) 2010-05-31
TWI289564B (en) 2007-11-11
BRPI9917086B8 (pt) 2016-05-24
US20020103373A1 (en) 2002-08-01
EP1147115A2 (de) 2001-10-24
DE69911259T4 (de) 2009-07-09
HK1038361B (en) 2004-05-07
NO20013515L (no) 2001-09-17
TR200102069T2 (tr) 2001-11-21
US7317005B2 (en) 2008-01-08
ES2207333T7 (es) 2009-06-18
AR035837A1 (es) 2004-07-21
PT1147115E (pt) 2004-02-27
US6713475B2 (en) 2004-03-30
AU2201400A (en) 2000-08-07
CZ20012598A3 (cs) 2002-08-14
HU229074B1 (en) 2013-07-29
KR100771184B1 (ko) 2007-10-29
RS50820B (sr) 2010-08-31
PL349778A1 (en) 2002-09-09
DK1147115T3 (da) 2004-01-12
IL144270A0 (en) 2002-05-23
NZ512960A (en) 2004-01-30
WO2000043398A3 (en) 2001-01-11
NO20013515D0 (no) 2001-07-16
HUP0105034A2 (hu) 2002-04-29
ATE249465T1 (de) 2003-09-15
WO2000043398A2 (en) 2000-07-27
HK1038361A1 (en) 2002-03-15
IL144270A (en) 2010-04-29
ME00129B (me) 2010-10-10
CA2360767A1 (en) 2000-07-27
CA2360767C (en) 2009-11-03
CN1174986C (zh) 2004-11-10
YU51901A (sh) 2004-03-12
MEP17808A (en) 2010-06-10
NO327896B1 (no) 2009-10-12
MY128065A (en) 2007-01-31
CN1339038A (zh) 2002-03-06
BR9917086A (pt) 2001-10-30
EP1147115B3 (de) 2008-12-24
EP1147115B1 (de) 2003-09-10
DE69911259T2 (de) 2004-12-02

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