ATE249465T1 - Tricyclische benzodiazepine als vasopressin antagonisten - Google Patents

Tricyclische benzodiazepine als vasopressin antagonisten

Info

Publication number: ATE249465T1
Authority: AT; Austria
Prior art keywords: vasopressin antagonists; tricyclic benzodiazepines; benzodiazepines; tricyclic; vasopressin
Prior art date: 1999-01-19

Application number

AT99966495T

Other languages

English (en)

Inventor

William J Hoekstra

Alexey B Dyatkin

Bruce E Maryanoff

Jay M Matthews

Original Assignee

Ortho Mcneil Pharm Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-01-19

Filing date

1999-12-21

Publication date

2003-09-15

1999-12-21 Application filed by Ortho Mcneil Pharm Inc filed Critical Ortho Mcneil Pharm Inc

2003-09-15 Application granted granted Critical

2003-09-15 Publication of ATE249465T1 publication Critical patent/ATE249465T1/de

Links

229940116211 Vasopressin antagonist Drugs 0.000 title 1
229940049706 benzodiazepine Drugs 0.000 title 1
150000001557 benzodiazepines Chemical class 0.000 title 1
239000003038 vasopressin antagonist Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Urology & Nephrology (AREA)
Hematology (AREA)
Endocrinology (AREA)
Hospice & Palliative Care (AREA)
Vascular Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

AT99966495T 1999-01-19 1999-12-21 Tricyclische benzodiazepine als vasopressin antagonisten ATE249465T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US11635899P	1999-01-19	1999-01-19
US46865099A	1999-12-21	1999-12-21
PCT/US1999/030423 WO2000043398A2 (en)	1999-01-19	1999-12-21	Tricyclic benzodiazepines as vasopressin receptor antagonists

Publications (1)

Publication Number	Publication Date
ATE249465T1 true ATE249465T1 (de)	2003-09-15

Family

ID=26814157

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT99966495T ATE249465T1 (de)	1999-01-19	1999-12-21	Tricyclische benzodiazepine als vasopressin antagonisten

Country Status (27)

Country	Link
US (2)	US6713475B2 (de)
EP (1)	EP1147115B3 (de)
KR (1)	KR100771184B1 (de)
CN (1)	CN1174986C (de)
AR (1)	AR035837A1 (de)
AT (1)	ATE249465T1 (de)
AU (1)	AU772397B2 (de)
BR (1)	BRPI9917086B8 (de)
CA (1)	CA2360767C (de)
CZ (1)	CZ302647B6 (de)
DE (2)	DE69911259T4 (de)
DK (1)	DK1147115T5 (de)
ES (1)	ES2207333T7 (de)
HK (1)	HK1038361B (de)
HU (1)	HU229074B1 (de)
IL (2)	IL144270A0 (de)
ME (1)	ME00129B (de)
MY (1)	MY128065A (de)
NO (1)	NO327896B1 (de)
NZ (1)	NZ512960A (de)
PL (1)	PL205704B1 (de)
PT (1)	PT1147115E (de)
RS (1)	RS50820B (de)
TR (1)	TR200102069T2 (de)
TW (1)	TWI289564B (de)
UA (1)	UA70984C2 (de)
WO (1)	WO2000043398A2 (de)

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ES2207333T7 (es) *	1999-01-19	2009-06-18	Orto-Mcneil Pharmaceutical, Inc.	Benzodiazepinas triciclicas utilizadas como antagonistas del receptor de la vasopresina.
EP1195166B1 (de) *	2000-10-04	2007-07-25	Astellas Pharma Inc.	Verwendung von einem Vasopressin-Antagonisten wie Conivaptan zur Herstellung eines Medikaments für die Behandlung der pulmonalen Hypertension
DE60222879T2 (de)	2001-04-12	2008-07-24	Wyeth	Cyclohexylphenyl vasopressin agonisten
BR0208823A (pt)	2001-04-12	2004-03-09	Wyeth Corp	Composto, método de tratamento de distúrbios que são remediados ou aliviados pela atividade de agonista de vasopressina em um mamìfero necessitando do mesmo, e, composição farmacêutica
PL370114A1 (en)	2001-10-29	2005-05-16	Ortho-Mcneil Pharmaceutical, Inc.	Bridged bicycle (1,4) benzodiazepine vasopressin receptor antagonists
EP1364968A1 (de) *	2002-05-23	2003-11-26	Bayer Aktiengesellschaft	Diagnostika und Therapeutika für Krankheiten, die mit Arginin-Vasopressin-Rezeptor 1 (AVPR1) assoziiert sind
RS20050638A (sr) *	2003-02-19	2007-12-31	Pfizer Inc.,	Triazolska jedinjenja korisna u terapiji
GB0303852D0 (en) *	2003-02-19	2003-03-26	Pfizer Ltd	Triazole compounds useful in therapy
US7119088B2 (en)	2003-02-19	2006-10-10	Pfizer Inc.	Triazole compounds useful in therapy
EP1809296A4 (de) *	2004-10-28	2009-03-11	Janssen Pharmaceutica Nv	Neue [1,4]-benzodiazepine als vasopressin v2-rezeptorantagonisten
DE102005003632A1 (de)	2005-01-20	2006-08-17	Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.	Katheter für die transvaskuläre Implantation von Herzklappenprothesen
US20070213813A1 (en)	2005-12-22	2007-09-13	Symetis Sa	Stent-valves for valve replacement and associated methods and systems for surgery
WO2008007661A1 (en) *	2006-07-11	2008-01-17	Takeda Pharmaceutical Company Limited	Tricyclic heterocyclic compound and use thereof
US7896915B2 (en)	2007-04-13	2011-03-01	Jenavalve Technology, Inc.	Medical device for treating a heart valve insufficiency
WO2011104269A1 (en)	2008-02-26	2011-09-01	Jenavalve Technology Inc.	Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient
US9044318B2 (en)	2008-02-26	2015-06-02	Jenavalve Technology Gmbh	Stent for the positioning and anchoring of a valvular prosthesis
PE20110537A1 (es) *	2008-11-13	2011-08-04	Hoffmann La Roche	ESPIRO-5,6-DIHIDRO-4H-2,3,5,10B-TETRAAZA-BENZO[E]AZULENOS COMO ANTAGONISTAS DE LA V1a
PL2358714T3 (pl) *	2008-11-18	2012-12-31	Hoffmann La Roche	Etery alkilocykloheksylowe dihydrotetraazabenzoazulenu
SG171846A1 (en) *	2008-11-28	2011-07-28	Hoffmann La Roche	Arylcyclohexylethers of dihydrotetraazabenzoazulenes for use as vasopressin via receptor antagonists
DE102009033392A1 (de) *	2009-07-16	2011-01-20	Merck Patent Gmbh	Heterocyclische Verbindungen als Autotaxin-Inhibitoren II
CN102510859A (zh) *	2009-09-24	2012-06-20	希里-莫韦蒂斯有限公司	用作为加压素v2受体拮抗剂的[1,4]-苯二氮
US8420633B2 (en)	2010-03-31	2013-04-16	Hoffmann-La Roche Inc.	Aryl-cyclohexyl-tetraazabenzo[e]azulenes
US8461151B2 (en)	2010-04-13	2013-06-11	Hoffmann-La Roche Inc.	Aryl-/heteroaryl-cyclohexenyl-tetraazabenzo[e]azulenes
US8492376B2 (en)	2010-04-21	2013-07-23	Hoffmann-La Roche Inc.	Heteroaryl-cyclohexyl-tetraazabenzo[e]azulenes
US8481528B2 (en)	2010-04-26	2013-07-09	Hoffmann-La Roche Inc.	Heterobiaryl-cyclohexyl-tetraazabenzo[e]azulenes
US8513238B2 (en)	2010-05-10	2013-08-20	Hoffmann-La Roche Inc.	Heteroaryl-cyclohexyl-tetraazabenzo[E]azulenes
US10856978B2 (en)	2010-05-20	2020-12-08	Jenavalve Technology, Inc.	Catheter system
CA2799459A1 (en)	2010-05-25	2011-12-01	Jenavalve Technology Inc.	Prosthetic heart valve and transcatheter delivered endoprosthesis comprising a prosthetic heart valve and a stent
US8828989B2 (en)	2011-09-26	2014-09-09	Hoffmann-La Roche Inc.	Oxy-cyclohexyl-4H,6H-5-oxa-2,3,10b-triaza-benzo[E]azulenes as V1A antagonists
CN105491978A (zh)	2013-08-30	2016-04-13	耶拿阀门科技股份有限公司	用于假体瓣膜的径向可折叠框架及其制造方法
WO2016089833A1 (en) *	2014-12-05	2016-06-09	Merck Sharp & Dohme Corp.	Novel tricyclic compounds as inhibitors of mutant idh enzymes
EP3226689B1 (de)	2014-12-05	2020-01-15	Merck Sharp & Dohme Corp.	Neuartige tricyclische verbindungen als inhibitoren von mutanten idh-enzymen
EP3226688B1 (de) *	2014-12-05	2020-07-01	Merck Sharp & Dohme Corp.	Tricyclische verbindungen als inhibitoren von mutanten idh-enzymen
EP3270825B1 (de)	2015-03-20	2020-04-22	JenaValve Technology, Inc.	Herzklappenprothesenzuführsystem
EP3632378B1 (de)	2015-05-01	2024-05-29	JenaValve Technology, Inc.	Vorrichtung mit reduzierter herzschrittmacherrate bei herzklappenersatz
US11065138B2 (en)	2016-05-13	2021-07-20	Jenavalve Technology, Inc.	Heart valve prosthesis delivery system and method for delivery of heart valve prosthesis with introducer sheath and loading system
CN110392557A (zh)	2017-01-27	2019-10-29	耶拿阀门科技股份有限公司	心脏瓣膜模拟
EP3875078A1 (de) *	2020-03-06	2021-09-08	Dompe' Farmaceutici S.P.A.	Verbindungen zur behandlung von covid 19
US12171658B2 (en)	2022-11-09	2024-12-24	Jenavalve Technology, Inc.	Catheter system for sequential deployment of an expandable implant

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US3732212A (en)	1970-04-20	1973-05-08	Sterling Drug Inc	1,2,3,10,11,11a-hexahydro-5h-pyrrolo(2,1-c)(1,4)benzodiazepine-5,11-diones
US3763183A (en) *	1972-07-10	1973-10-02	Sterling Drug Inc	1,2,3,10,11,11a-hexahydro-5h-pyrrolo (2,1-c)(1,4)benzodiazepines
US3860600A (en)	1972-07-10	1975-01-14	Sterling Drug Inc	Octahydropyrrido{8 2,1-c{9 {8 1,4{9 benzodiazepines
US5516774A (en) *	1993-07-29	1996-05-14	American Cyanamid Company	Tricyclic diazepine vasopressin antagonists and oxytocin antagonists
US5521173A (en) *	1995-01-17	1996-05-28	American Home Products Corporation	Tricyclic benzazepine vasopressin antagonists
EP0987266A4 (de)	1997-03-31	2000-07-26	Wakamoto Pharma Co Ltd	Biphenylderivate und medizinische zubereitungen
CN1183134C (zh) *	1997-07-30	2005-01-05	惠氏公司	三环后叶加压素激动剂
ES2207333T7 (es) *	1999-01-19	2009-06-18	Orto-Mcneil Pharmaceutical, Inc.	Benzodiazepinas triciclicas utilizadas como antagonistas del receptor de la vasopresina.

1999
- 1999-12-21 ES ES99966495T patent/ES2207333T7/es active Active
- 1999-12-21 WO PCT/US1999/030423 patent/WO2000043398A2/en not_active Ceased
- 1999-12-21 KR KR1020017009039A patent/KR100771184B1/ko not_active Expired - Fee Related
- 1999-12-21 DE DE69911259T patent/DE69911259T4/de not_active Expired - Lifetime
- 1999-12-21 HK HK02100064.9A patent/HK1038361B/en not_active IP Right Cessation
- 1999-12-21 BR BRPI9917086A patent/BRPI9917086B8/pt not_active IP Right Cessation
- 1999-12-21 TR TR2001/02069T patent/TR200102069T2/xx unknown
- 1999-12-21 ME MEP-2008-178A patent/ME00129B/me unknown
- 1999-12-21 PT PT99966495T patent/PT1147115E/pt unknown
- 1999-12-21 HU HU0105034A patent/HU229074B1/hu not_active IP Right Cessation
- 1999-12-21 CA CA002360767A patent/CA2360767C/en not_active Expired - Fee Related
- 1999-12-21 AU AU22014/00A patent/AU772397B2/en not_active Ceased
- 1999-12-21 IL IL14427099A patent/IL144270A0/xx unknown
- 1999-12-21 CN CNB998164887A patent/CN1174986C/zh not_active Expired - Fee Related
- 1999-12-21 UA UA2001075136A patent/UA70984C2/uk unknown
- 1999-12-21 CZ CZ20012598A patent/CZ302647B6/cs not_active IP Right Cessation
- 1999-12-21 AT AT99966495T patent/ATE249465T1/de active
- 1999-12-21 EP EP99966495A patent/EP1147115B3/de not_active Expired - Lifetime
- 1999-12-21 DK DK99966495T patent/DK1147115T5/da active
- 1999-12-21 DE DE69911259A patent/DE69911259D1/de not_active Expired - Lifetime
- 1999-12-21 PL PL349778A patent/PL205704B1/pl unknown
- 1999-12-21 NZ NZ512960A patent/NZ512960A/en not_active IP Right Cessation
2000
- 2000-01-18 AR ARP000100214A patent/AR035837A1/es active IP Right Grant
- 2000-01-19 MY MYPI20000169A patent/MY128065A/en unknown
- 2000-02-24 TW TW089100772A patent/TWI289564B/zh not_active IP Right Cessation
- 2000-12-21 RS YUP-519/01A patent/RS50820B/sr unknown
2001
- 2001-07-11 IL IL144270A patent/IL144270A/en not_active IP Right Cessation
- 2001-07-16 NO NO20013515A patent/NO327896B1/no not_active IP Right Cessation
- 2001-07-24 US US09/911,605 patent/US6713475B2/en not_active Expired - Lifetime
2004
- 2004-02-10 US US10/775,675 patent/US7317005B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
BR9917086B1 (pt)	2013-12-03
WO2000043398A3 (en)	2001-01-11
EP1147115B3 (de)	2008-12-24
DE69911259T4 (de)	2009-07-09
NO20013515D0 (no)	2001-07-16
PL349778A1 (en)	2002-09-09
CZ20012598A3 (cs)	2002-08-14
HU229074B1 (en)	2013-07-29
AU2201400A (en)	2000-08-07
DE69911259D1 (de)	2003-10-16
DK1147115T5 (da)	2008-12-08
DK1147115T3 (da)	2004-01-12
EP1147115B1 (de)	2003-09-10
AR035837A1 (es)	2004-07-21
KR20010101577A (ko)	2001-11-14
ES2207333T7 (es)	2009-06-18
AU772397B2 (en)	2004-04-29
WO2000043398A2 (en)	2000-07-27
MEP17808A (en)	2010-06-10
IL144270A0 (en)	2002-05-23
PT1147115E (pt)	2004-02-27
IL144270A (en)	2010-04-29
DE69911259T2 (de)	2004-12-02
US6713475B2 (en)	2004-03-30
ES2207333T3 (es)	2004-05-16
US7317005B2 (en)	2008-01-08
MY128065A (en)	2007-01-31
TWI289564B (en)	2007-11-11
KR100771184B1 (ko)	2007-10-29
ME00129B (me)	2010-10-10
RS50820B (sr)	2010-08-31
CN1339038A (zh)	2002-03-06
US20020103373A1 (en)	2002-08-01
CA2360767A1 (en)	2000-07-27
AU772397C (en)	2000-08-07
HK1038361B (en)	2004-05-07
BRPI9917086B8 (pt)	2016-05-24
PL205704B1 (pl)	2010-05-31
CZ302647B6 (cs)	2011-08-17
EP1147115A2 (de)	2001-10-24
UA70984C2 (uk)	2004-11-15
US20040242866A1 (en)	2004-12-02
HUP0105034A3 (en)	2004-11-29
CA2360767C (en)	2009-11-03
CN1174986C (zh)	2004-11-10
TR200102069T2 (tr)	2001-11-21
BR9917086A (pt)	2001-10-30
HUP0105034A2 (hu)	2002-04-29
HK1038361A1 (en)	2002-03-15
YU51901A (sh)	2004-03-12
NZ512960A (en)	2004-01-30
NO327896B1 (no)	2009-10-12
NO20013515L (no)	2001-09-17

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