DK1150976T3 - 3-(Thiosubstituerede amido)lactamer, der er nyttige som inhibitorer af matrixmetalloproteinase - Google Patents

3-(Thiosubstituerede amido)lactamer, der er nyttige som inhibitorer af matrixmetalloproteinase

Info

Publication number: DK1150976T3
Authority: DK; Denmark
Prior art keywords: thiosubstituted; amido; inhibitors; matrix metalloproteinase; lactams useful
Prior art date: 1998-12-31

Application number

DK99962921T

Other languages

Danish (da)

English (en)

Inventor

Alan Warshawsky

Michael J Janusz

Gary A Flynn

Joseph P Burkhart

Original Assignee

Aventis Pharma Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-12-31

Filing date

1999-11-30

Publication date

2003-06-02

1999-11-30 Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc

2003-06-02 Application granted granted Critical

2003-06-02 Publication of DK1150976T3 publication Critical patent/DK1150976T3/da

Links

102000002274 Matrix Metalloproteinases Human genes 0.000 title 1
108010000684 Matrix Metalloproteinases Proteins 0.000 title 1
125000003368 amide group Chemical group 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
150000003951 lactams Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/021—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)n-C(=0)-, n being 5 or 6; for n > 6, classification in C07K5/06 - C07K5/10, according to the moiety having normal peptide bonds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Cardiology (AREA)
Genetics & Genomics (AREA)
Heart & Thoracic Surgery (AREA)
Rheumatology (AREA)
Biochemistry (AREA)
Physical Education & Sports Medicine (AREA)
Vascular Medicine (AREA)
Pulmonology (AREA)
Crystallography & Structural Chemistry (AREA)
Biomedical Technology (AREA)
Pain & Pain Management (AREA)
Ophthalmology & Optometry (AREA)
Immunology (AREA)
Urology & Nephrology (AREA)
Neurology (AREA)
Orthopedic Medicine & Surgery (AREA)
Neurosurgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)

DK99962921T 1998-12-31 1999-11-30 3-(Thiosubstituerede amido)lactamer, der er nyttige som inhibitorer af matrixmetalloproteinase DK1150976T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US22394198A	1998-12-31	1998-12-31
PCT/US1999/028236 WO2000040578A1 (en)	1998-12-31	1999-11-30	3-(thio-substituted amido)-lactams useful as inhibitors of matrix metalloproteinase

Publications (1)

Publication Number	Publication Date
DK1150976T3 true DK1150976T3 (da)	2003-06-02

Family

ID=22838632

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK99962921T DK1150976T3 (da)	1998-12-31	1999-11-30	3-(Thiosubstituerede amido)lactamer, der er nyttige som inhibitorer af matrixmetalloproteinase

Country Status (11)

Country	Link
EP (1)	EP1150976B1 (de)
JP (1)	JP2002534425A (de)
AR (1)	AR033642A1 (de)
AT (1)	ATE233259T1 (de)
AU (1)	AU1926700A (de)
CA (1)	CA2358939A1 (de)
DE (1)	DE69905621T2 (de)
DK (1)	DK1150976T3 (de)
ES (1)	ES2190672T3 (de)
PT (1)	PT1150976E (de)
WO (1)	WO2000040578A1 (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0114004D0 (en)	2001-06-08	2001-08-01	Glaxo Group Ltd	Chemical compounds
GB0114005D0 (en)	2001-06-08	2001-08-01	Glaxo Group Ltd	Chemical compounds
PE20030701A1 (es)	2001-12-20	2003-08-21	Schering Corp	Compuestos para el tratamiento de trastornos inflamatorios

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5527795A (en) *	1990-10-18	1996-06-18	Merrell Pharmaceuticals Inc.	Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
AU668707B2 (en) *	1992-02-14	1996-05-16	Merrell Pharmaceuticals Inc.	Aminoacetylmercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ACE
US5821231A (en) *	1993-12-06	1998-10-13	Cytel Corporation	CS-1 peptidomimetics, compositions and methods of using same
DE69516128T2 (de) *	1994-02-14	2000-12-21	Merrell Pharmaceuticals Inc., Cincinnati	Mercaptoacetylamid-1,3,4,5-tetrahydrobenzo(c)azepin-3-ein disulfidderivate als enkephalinase und ace inhibitoren
ATE177098T1 (de) *	1994-02-14	1999-03-15	Merrell Pharma Inc	Mercaptoacetylamid disulfidderivate als enkephalinase und ace inhibitoren
CZ288436B6 (en) *	1994-10-05	2001-06-13	Darwin Discovery Ltd	Peptidyl derivatives, their therapeutic use as inhibitors of metalloproteinases and pharmaceutical preparation in which they are comprised
US5672598A (en) *	1995-03-21	1997-09-30	The Procter & Gamble Company	Lactam-containing hydroxamic acids
GB9702377D0 (en) *	1996-02-23	1997-03-26	Zeneca Ltd	Peptide derivatives
GB9624562D0 (en) *	1996-11-27	1997-01-15	Zeneca Ltd	Peptide derivatives
GB9625865D0 (en) *	1996-12-12	1997-01-29	Zeneca Ltd	Peptides

1999
- 1999-11-30 EP EP99962921A patent/EP1150976B1/de not_active Expired - Lifetime
- 1999-11-30 JP JP2000592286A patent/JP2002534425A/ja active Pending
- 1999-11-30 AT AT99962921T patent/ATE233259T1/de not_active IP Right Cessation
- 1999-11-30 DE DE69905621T patent/DE69905621T2/de not_active Expired - Fee Related
- 1999-11-30 DK DK99962921T patent/DK1150976T3/da active
- 1999-11-30 CA CA002358939A patent/CA2358939A1/en not_active Abandoned
- 1999-11-30 PT PT99962921T patent/PT1150976E/pt unknown
- 1999-11-30 AU AU19267/00A patent/AU1926700A/en not_active Abandoned
- 1999-11-30 ES ES99962921T patent/ES2190672T3/es not_active Expired - Lifetime
- 1999-11-30 WO PCT/US1999/028236 patent/WO2000040578A1/en not_active Ceased
- 1999-12-30 AR ARP990106859A patent/AR033642A1/es not_active Application Discontinuation

Also Published As

Publication number	Publication date
DE69905621T2 (de)	2003-11-27
DE69905621D1 (de)	2003-04-03
JP2002534425A (ja)	2002-10-15
WO2000040578A1 (en)	2000-07-13
AR033642A1 (es)	2004-01-07
PT1150976E (pt)	2003-07-31
EP1150976B1 (de)	2003-02-26
ES2190672T3 (es)	2003-08-01
CA2358939A1 (en)	2000-07-13
EP1150976A1 (de)	2001-11-07
ATE233259T1 (de)	2003-03-15
AU1926700A (en)	2000-07-24

Publication	Publication Date	Title
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DK0946512T3 (da)	2004-01-12	6-Phenylpyridyl-2-aminderivater, der er nyttige som NOS-inhibitorer
ATE245142T1 (de)	2003-08-15	No-synthase inhibitoren
DK0996622T3 (da)	2002-12-30	Hidtil ukendte spiroazabicycliske, heterocykliske forbindelser
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DK1218372T3 (da)	2003-10-20	Nye heterocykliske forbindelser, der er anvendelige som reversible inhibitorer af cysteinproteaser
DK1100797T3 (da)	2003-04-22	Heterocycliske forbindelser som inhibitorer af rotamaseenzymer
DK1001934T3 (da)	2002-12-30	Indolforbindelser som COX-2-inhibitorer
NO20004121D0 (no)	2000-08-17	Nye forbindelser og deres anvendelse som positive AMPA- reseptormodulatorer
DE69906311D1 (de)	2003-04-30	Diarylbenzopyranderivate als cyclooxygenase-2-inhibitoren
DE69900356D1 (de)	2001-11-22	Nitro-Isoharnstoffderivate
DK1060178T3 (da)	2003-11-24	Heterocyklisk forbindelser som inhibitorer af rotamase enzymer
DK1404667T3 (da)	2006-07-10	Piperidinderivater, der er anvendelige som modulatorer af chemokinreceptoraktivitet
NO20021115D0 (no)	2002-03-06	Ny sammensetning
EE200000717A (et)	2001-08-15	Uus 3-arüül-2-hüdroksüpropaanhappe derivaat III
DK0928291T3 (da)	2003-03-17	3-Mercaptoacetylamino-1,5-substituerede 2-oxo-azepanderivater, der er nyttige som inhibitorer af matrixmetalloproteinase
DK0912537T3 (da)	2004-08-30	Fremgangsmåde til fremstilling af phenylheterocykliske forbindelser, der er anvendelige som cox-2-inhibitorer
DK1210326T3 (da)	2004-06-21	Hydroxamsyreforbindelser, der er nyttige som matrixmetalloproteinaseinhibitorer
NO991994D0 (no)	1999-04-27	Substituerte 4-bifenyl-4-hydroksysm°rsyrederivater som matriks-metalloproteaseinhibitorer
ID28945A (id)	2001-07-19	Turunan-turunan 3-(benzalol-7-il)-ih-pirimidin-2,4-dion
ID24264A (id)	2000-07-13	Komposisi yang terdiri dari 5-[4-[2-(n-metil-n-2-piridil)amino) etoksi[benzil] tiazolidin-2,4-dion
DK1222467T3 (da)	2006-08-07	Leptin-assay, der er baseret på påvisning af Ang-2-ekspression