DK1153023T3 - Fremgangsmåde til fremstilling af paroxetin - Google Patents

Fremgangsmåde til fremstilling af paroxetin

Info

Publication number: DK1153023T3
Authority: DK; Denmark
Prior art keywords: paroxetine; sesamol; derivatisation; dealkylation; tetrahydropyridine
Prior art date: 1999-02-23

Application number

DK00909228T

Other languages

English (en)

Inventor

Renzo Rossi

Stefano Turchetta

Maria Donnarumma

Original Assignee

Recordati Chem Pharm

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-02-23

Filing date

2000-02-22

Publication date

2003-08-11

2000-02-22 Application filed by Recordati Chem Pharm filed Critical Recordati Chem Pharm

2003-08-11 Application granted granted Critical

2003-08-11 Publication of DK1153023T3 publication Critical patent/DK1153023T3/da

Links

AHOUBRCZNHFOSL-YOEHRIQHSA-N (+)-Casbol Chemical compound C1=CC(F)=CC=C1[C@H]1[C@H](COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-YOEHRIQHSA-N 0.000 title abstract 3
AHOUBRCZNHFOSL-UHFFFAOYSA-N Paroxetine hydrochloride Natural products C1=CC(F)=CC=C1C1C(COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-UHFFFAOYSA-N 0.000 title abstract 3
238000000034 method Methods 0.000 title abstract 3
229960002296 paroxetine Drugs 0.000 title abstract 3
UIOFUWFRIANQPC-JKIFEVAISA-N Floxacillin Chemical compound N([C@@H]1C(N2[C@H](C(C)(C)S[C@@H]21)C(O)=O)=O)C(=O)C1=C(C)ON=C1C1=C(F)C=CC=C1Cl UIOFUWFRIANQPC-JKIFEVAISA-N 0.000 abstract 1
LUSZGTFNYDARNI-UHFFFAOYSA-N Sesamol Natural products OC1=CC=C2OCOC2=C1 LUSZGTFNYDARNI-UHFFFAOYSA-N 0.000 abstract 1
ZSYVGBLSRONTAI-UHFFFAOYSA-N [4-(4-fluorophenyl)-1,2,3,6-tetrahydropyridin-3-yl]methanol Chemical class OCC1CNCC=C1C1=CC=C(F)C=C1 ZSYVGBLSRONTAI-UHFFFAOYSA-N 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
238000006900 dealkylation reaction Methods 0.000 abstract 1
238000001212 derivatisation Methods 0.000 abstract 1
238000005984 hydrogenation reaction Methods 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
239000003446 ligand Substances 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
238000010534 nucleophilic substitution reaction Methods 0.000 abstract 1
230000000707 stereoselective effect Effects 0.000 abstract 1
229910052723 transition metal Inorganic materials 0.000 abstract 1
150000003624 transition metals Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Pain & Pain Management (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Psychiatry (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Plural Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK00909228T 1999-02-23 2000-02-22 Fremgangsmåde til fremstilling af paroxetin DK1153023T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT1999MI000364A IT1308629B1 (it)	1999-02-23	1999-02-23	Processo per la produzione di paroxetina.
PCT/EP2000/001430 WO2000050422A1 (en)	1999-02-23	2000-02-22	Process for the production of paroxetine

Publications (1)

Publication Number	Publication Date
DK1153023T3 true DK1153023T3 (da)	2003-08-11

Family

ID=11382007

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK00909228T DK1153023T3 (da)	1999-02-23	2000-02-22	Fremgangsmåde til fremstilling af paroxetin

Country Status (28)

Country	Link
US (1)	US6583287B1 (da)
EP (1)	EP1153023B1 (da)
JP (1)	JP2002537394A (da)
KR (1)	KR20010102366A (da)
CN (1)	CN1161353C (da)
AT (1)	ATE238295T1 (da)
AU (1)	AU759441B2 (da)
BR (1)	BR0008220A (da)
CA (1)	CA2361758A1 (da)
CZ (1)	CZ20012997A3 (da)
DE (1)	DE60002303T2 (da)
DK (1)	DK1153023T3 (da)
ES (1)	ES2195876T3 (da)
HK (1)	HK1040516B (da)
HR (1)	HRP20010608A2 (da)
HU (1)	HUP0105482A3 (da)
IL (1)	IL144883A (da)
IT (1)	IT1308629B1 (da)
MX (1)	MXPA01008502A (da)
NO (1)	NO319724B1 (da)
PL (1)	PL349358A1 (da)
PT (1)	PT1153023E (da)
RU (1)	RU2242473C2 (da)
SK (1)	SK12042001A3 (da)
TR (1)	TR200102441T2 (da)
TW (1)	TWI221473B (da)
WO (1)	WO2000050422A1 (da)
YU (1)	YU60801A (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2289650T3 (es) *	2004-03-03	2008-02-01	Chemi S.P.A.	Sal monosodica del acido 3-piridil-1-hidroxietiliden-1,1-bifosfonico amorfa y procedimiento para la preparacion de la misma.
US9138430B2 (en) *	2007-12-27	2015-09-22	Mylan Specialty L.P.	Formulation and method for the release of paroxetine in the large intestine
BR112014016197A8 (pt) *	2012-01-31	2017-07-04	Eisai R&D Man Co Ltd	derivado de paroxetina
CN106831736A (zh) *	2017-02-15	2017-06-13	浙江华海药业股份有限公司	一种制备帕罗西汀杂质的方法
CN112521377A (zh) *	2020-11-26	2021-03-19	北京福元医药股份有限公司	一种盐酸帕罗西汀的连续化制备方法
CN115260153B (zh) *	2022-07-21	2023-10-27	威尚（上海）生物医药有限公司	一种6取代手性纯二氟哌啶喹唑啉衍生物及其制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH0757758B2 (ja)	1988-10-24	1995-06-21	高砂香料工業株式会社	ルテニウム―ホスフィン錯体
DK715988D0 (da) *	1988-12-22	1988-12-22	Ferrosan As	Etherifikation og dealkylering af piperidin-derivater samt intermediater
US5233084A (en)	1989-06-22	1993-08-03	Monsanto Company	Method for preparing α-arylpropionic acids
FR2651152B1 (fr) *	1989-08-23	1991-11-29	Elf Aquitaine	Perfectionnement a la preparation de catalyseurs chiraux a base de complexes du ruthenium et du phosphore.
GB9209687D0 (en)	1992-05-06	1992-06-17	Smithkline Beecham Plc	Novel process
DE4422672A1 (de) *	1994-06-30	1996-01-04	Hoechst Ag	Halogenierte Biphenyl-2,2'-diyl-bis-diphenylphosphine, ihre Herstellung und ihre Verwendung
AR001982A1 (es) *	1995-02-06	1998-01-07	Smithkline Beecham Plc	Clorhidrato de paroxetina anhidratado, y procedimiento para su preparacion
BR9608471A (pt)	1995-05-17	1998-12-29	Novo Nordisk As	Processo para a preparação de um composto
HU221921B1 (hu) *	1996-07-08	2003-02-28	Richter Gedeon Vegyészeti Gyár Rt.	N-benzil-piperidin- és tetrahidropiridinszármazékok és eljárás azok előállítására
WO1998050359A1 (en) *	1997-05-06	1998-11-12	Novo Nordisk A/S	Novel heterocyclic compounds
WO1998052687A1 (en) *	1997-05-20	1998-11-26	Firmenich S.A.	Ruthenium catalysts and their use in the asymmetric hydrogenation of weakly coordinating substrates

1999
- 1999-02-23 IT IT1999MI000364A patent/IT1308629B1/it active
2000
- 2000-02-18 TW TW089102997A patent/TWI221473B/zh not_active IP Right Cessation
- 2000-02-22 WO PCT/EP2000/001430 patent/WO2000050422A1/en not_active Ceased
- 2000-02-22 KR KR1020017010760A patent/KR20010102366A/ko not_active Ceased
- 2000-02-22 MX MXPA01008502A patent/MXPA01008502A/es active IP Right Grant
- 2000-02-22 CN CNB008041873A patent/CN1161353C/zh not_active Expired - Fee Related
- 2000-02-22 AT AT00909228T patent/ATE238295T1/de not_active IP Right Cessation
- 2000-02-22 RU RU2001125933/04A patent/RU2242473C2/ru not_active IP Right Cessation
- 2000-02-22 DE DE60002303T patent/DE60002303T2/de not_active Expired - Fee Related
- 2000-02-22 JP JP2000601002A patent/JP2002537394A/ja active Pending
- 2000-02-22 YU YU60801A patent/YU60801A/sh unknown
- 2000-02-22 ES ES00909228T patent/ES2195876T3/es not_active Expired - Lifetime
- 2000-02-22 PT PT00909228T patent/PT1153023E/pt unknown
- 2000-02-22 DK DK00909228T patent/DK1153023T3/da active
- 2000-02-22 HR HR20010608A patent/HRP20010608A2/hr not_active Application Discontinuation
- 2000-02-22 IL IL14488300A patent/IL144883A/en not_active IP Right Cessation
- 2000-02-22 AU AU31583/00A patent/AU759441B2/en not_active Ceased
- 2000-02-22 EP EP00909228A patent/EP1153023B1/en not_active Expired - Lifetime
- 2000-02-22 BR BR0008220-1A patent/BR0008220A/pt not_active IP Right Cessation
- 2000-02-22 CZ CZ20012997A patent/CZ20012997A3/cs unknown
- 2000-02-22 CA CA002361758A patent/CA2361758A1/en not_active Abandoned
- 2000-02-22 PL PL00349358A patent/PL349358A1/xx not_active IP Right Cessation
- 2000-02-22 US US09/890,414 patent/US6583287B1/en not_active Expired - Fee Related
- 2000-02-22 TR TR2001/02441T patent/TR200102441T2/xx unknown
- 2000-02-22 HU HU0105482A patent/HUP0105482A3/hu unknown
- 2000-02-22 SK SK1204-2001A patent/SK12042001A3/sk unknown
- 2000-02-22 HK HK02101971.9A patent/HK1040516B/en not_active IP Right Cessation
2001
- 2001-08-22 NO NO20014078A patent/NO319724B1/no unknown

Also Published As

Publication number	Publication date
HUP0105482A3 (en)	2002-11-28
AU759441B2 (en)	2003-04-17
ES2195876T3 (es)	2003-12-16
NO319724B1 (no)	2005-09-05
IL144883A (en)	2004-12-15
ITMI990364A1 (it)	2000-08-23
DE60002303D1 (de)	2003-05-28
JP2002537394A (ja)	2002-11-05
CA2361758A1 (en)	2000-08-31
WO2000050422A1 (en)	2000-08-31
IT1308629B1 (it)	2002-01-09
PL349358A1 (en)	2002-07-15
DE60002303T2 (de)	2004-04-01
IL144883A0 (en)	2002-06-30
TR200102441T2 (tr)	2002-01-21
ATE238295T1 (de)	2003-05-15
AU3158300A (en)	2000-09-14
HK1040516B (en)	2003-10-31
KR20010102366A (ko)	2001-11-15
BR0008220A (pt)	2001-11-06
NO20014078D0 (no)	2001-08-22
HK1040516A1 (en)	2002-06-14
PT1153023E (pt)	2003-09-30
TWI221473B (en)	2004-10-01
SK12042001A3 (sk)	2001-12-03
HRP20010608A2 (en)	2002-08-31
MXPA01008502A (es)	2003-06-06
YU60801A (sh)	2005-07-19
NO20014078L (no)	2001-10-18
US6583287B1 (en)	2003-06-24
CN1341113A (zh)	2002-03-20
EP1153023B1 (en)	2003-04-23
EP1153023A1 (en)	2001-11-14
RU2242473C2 (ru)	2004-12-20
CN1161353C (zh)	2004-08-11
HUP0105482A2 (en)	2002-08-28
CZ20012997A3 (cs)	2001-11-14

Similar Documents

Publication	Publication Date	Title
Makabe et al.	2003	Total synthesis of (−)-cassine
Takahata et al.	2003	Asymmetric synthesis of the four possible fagomine isomers
ATE440087T1 (de)	2009-09-15	2,4-diaminopyrimidinderivate, die sich als inhibitoren von pkc-theta eignen
DE50307267D1 (de)	2007-06-21	Dihydropteridinone, verfahren zu deren herstellung und deren verwendung als arzneimittel
ATE381559T1 (de)	2008-01-15	Adamantan- und azabicyclooctan- und - nonanderivate, verfahren zu deren herstellung und deren verwendung als dpp-iv-inhibitoren
MXPA05012362A (es)	2006-02-02	Yodopirazolilcarboxanilidas.
MX2007006549A (es)	2007-06-18	Procedimiento para preparar derivados condensados de piperazin-2-ona, asi como productos intermedios del procedimiento.
Huang	2006	Asymmetric synthesis of hydroxylated pyrrolidines, piperidines and related bioactive compounds: From N-acyliminium chemistry to N-α-carbanion chemistry
ATE305459T1 (de)	2005-10-15	Verfahren für die enantioselektive synthese von azetidinon-zwischenprodukten
YU49003A (sh)	2006-05-25	Novi postupak za sintezu fenilamida 5-(4-fluorofenil) -1-(2-((2r,4r)-4-hidroksi-6-okso-tetrahidro-piran-2-il)- etil)-2-izopropil-4-fenil-1h-pirol-3-karboksilne kiseline
GR1002466B (el)	1996-11-06	Νεες ενωσεις.
ATE406353T1 (de)	2008-09-15	Piperidin-derivaten und deren verwendung bei der behandlung von durch chemokinen oder h1 vermittelten krankheiten
Zhao et al.	2001	Selective fowler reductions: asymmetric total syntheses of isofagomine and other 1-azasugars from methyl nicotinate
Kim et al.	2005	Asymmetric induction in the conjugate addition of thioacetic acid to methacrylamides with chiral auxiliaries
ATE397599T1 (de)	2008-06-15	Als modulatoren der chemokinrezeptoraktivität geeignete piperidinderivate
Hanessian et al.	2002	The power of visual imagery in synthesis planning. Stereocontrolled approaches to CGP-60536B, a potent renin inhibitor
NO20014078D0 (no)	2001-08-22	Fremgangsmate for fremstilling av paroksetin
DE60327375D1 (de)	2009-06-04	Arylindenopyridin- und arylindenopyrimidinverbindungen und ihre verwendung als adenosin-a2a-rezeptor antagonisten
MXPA03010960A (es)	2004-02-27	Proceso para la produccion de fexofenadina derivado de piperidina.
TNSN07115A1 (fr)	2008-06-02	Procede et intermediaires de preparation de derives de n-(1-benzhydryl-azetidin-3-yl)-n-phenyl-methylsulfonamide
Wang et al.	2009	Stereospecific, Flexible and Redox‐Economic Asymmetric Synthesis of cis‐and trans‐3‐Hydroxypipecolic Acids and Analogs
ATE383343T1 (de)	2008-01-15	Imidazolderivate verwendbar als histamin h3 rezeptorliganden
DE50102050D1 (de)	2004-05-27	Verfahren zur herstellung von heterocyclischen verbindungen
ATE419060T1 (de)	2009-01-15	Verfahren zur herstellung von pyrrolen
DK1387828T3 (da)	2006-02-27	Fremgangsmåde til fremstilling af biperiden IV