NO20014078L - Fremgangsmåte for fremstilling av paroksetin - Google Patents

Fremgangsmåte for fremstilling av paroksetin

Info

Publication number: NO20014078L
Authority: NO; Norway
Prior art keywords: paroxetine; preparation; sesamol; derivatisation; dealkylation
Prior art date: 1999-02-23

Application number

NO20014078A

Other languages

English (en)

Other versions

NO20014078D0 (no

NO319724B1 (no

Inventor

Renzo Rossi

Stefano Turchetta

Maria Donnarumma

Original Assignee

Recordati Chem Pharm

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-02-23

Filing date

2001-08-22

Publication date

2001-10-18

2001-08-22 Application filed by Recordati Chem Pharm filed Critical Recordati Chem Pharm

2001-08-22 Publication of NO20014078D0 publication Critical patent/NO20014078D0/no

2001-10-18 Publication of NO20014078L publication Critical patent/NO20014078L/no

2005-09-05 Publication of NO319724B1 publication Critical patent/NO319724B1/no

Links

AHOUBRCZNHFOSL-YOEHRIQHSA-N (+)-Casbol Chemical compound C1=CC(F)=CC=C1[C@H]1[C@H](COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-YOEHRIQHSA-N 0.000 title abstract 3
AHOUBRCZNHFOSL-UHFFFAOYSA-N Paroxetine hydrochloride Natural products C1=CC(F)=CC=C1C1C(COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-UHFFFAOYSA-N 0.000 title abstract 3
238000000034 method Methods 0.000 title abstract 3
229960002296 paroxetine Drugs 0.000 title abstract 3
UIOFUWFRIANQPC-JKIFEVAISA-N Floxacillin Chemical compound N([C@@H]1C(N2[C@H](C(C)(C)S[C@@H]21)C(O)=O)=O)C(=O)C1=C(C)ON=C1C1=C(F)C=CC=C1Cl UIOFUWFRIANQPC-JKIFEVAISA-N 0.000 abstract 1
LUSZGTFNYDARNI-UHFFFAOYSA-N Sesamol Natural products OC1=CC=C2OCOC2=C1 LUSZGTFNYDARNI-UHFFFAOYSA-N 0.000 abstract 1
ZSYVGBLSRONTAI-UHFFFAOYSA-N [4-(4-fluorophenyl)-1,2,3,6-tetrahydropyridin-3-yl]methanol Chemical class OCC1CNCC=C1C1=CC=C(F)C=C1 ZSYVGBLSRONTAI-UHFFFAOYSA-N 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
238000006900 dealkylation reaction Methods 0.000 abstract 1
238000001212 derivatisation Methods 0.000 abstract 1
238000005984 hydrogenation reaction Methods 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
239000003446 ligand Substances 0.000 abstract 1
238000004519 manufacturing process Methods 0.000 abstract 1
238000010534 nucleophilic substitution reaction Methods 0.000 abstract 1
230000000707 stereoselective effect Effects 0.000 abstract 1
229910052723 transition metal Inorganic materials 0.000 abstract 1
150000003624 transition metals Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Pain & Pain Management (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Psychiatry (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Plural Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

NO20014078A 1999-02-23 2001-08-22 Fremgangsmate for fremstilling av paroksetin NO319724B1 (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT1999MI000364A IT1308629B1 (it)	1999-02-23	1999-02-23	Processo per la produzione di paroxetina.
PCT/EP2000/001430 WO2000050422A1 (en)	1999-02-23	2000-02-22	Process for the production of paroxetine

Publications (3)

Publication Number	Publication Date
NO20014078D0 NO20014078D0 (no)	2001-08-22
NO20014078L true NO20014078L (no)	2001-10-18
NO319724B1 NO319724B1 (no)	2005-09-05

Family

ID=11382007

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20014078A NO319724B1 (no)	1999-02-23	2001-08-22	Fremgangsmate for fremstilling av paroksetin

Country Status (28)

Country	Link
US (1)	US6583287B1 (no)
EP (1)	EP1153023B1 (no)
JP (1)	JP2002537394A (no)
KR (1)	KR20010102366A (no)
CN (1)	CN1161353C (no)
AT (1)	ATE238295T1 (no)
AU (1)	AU759441B2 (no)
BR (1)	BR0008220A (no)
CA (1)	CA2361758A1 (no)
CZ (1)	CZ20012997A3 (no)
DE (1)	DE60002303T2 (no)
DK (1)	DK1153023T3 (no)
ES (1)	ES2195876T3 (no)
HK (1)	HK1040516B (no)
HR (1)	HRP20010608A2 (no)
HU (1)	HUP0105482A3 (no)
IL (1)	IL144883A (no)
IT (1)	IT1308629B1 (no)
MX (1)	MXPA01008502A (no)
NO (1)	NO319724B1 (no)
PL (1)	PL349358A1 (no)
PT (1)	PT1153023E (no)
RU (1)	RU2242473C2 (no)
SK (1)	SK12042001A3 (no)
TR (1)	TR200102441T2 (no)
TW (1)	TWI221473B (no)
WO (1)	WO2000050422A1 (no)
YU (1)	YU60801A (no)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP1571152B1 (en) *	2004-03-03	2007-08-08	CHEMI S.p.A.	Amorphous 3-Pyridil-1-Hydroxyethyliden-1,1-Biphosphonic acid monosodium salt and process for the preparation thereof .
US9138430B2 (en) *	2007-12-27	2015-09-22	Mylan Specialty L.P.	Formulation and method for the release of paroxetine in the large intestine
WO2013115163A1 (ja) *	2012-01-31	2013-08-08	エーザイ・アール・アンド・ディー・マネジメント株式会社	パロキセチン誘導体
CN106831736A (zh) *	2017-02-15	2017-06-13	浙江华海药业股份有限公司	一种制备帕罗西汀杂质的方法
CN112521377A (zh) *	2020-11-26	2021-03-19	北京福元医药股份有限公司	一种盐酸帕罗西汀的连续化制备方法
CN115260153B (zh) *	2022-07-21	2023-10-27	威尚（上海）生物医药有限公司	一种6取代手性纯二氟哌啶喹唑啉衍生物及其制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPH0757758B2 (ja)	1988-10-24	1995-06-21	高砂香料工業株式会社	ルテニウム―ホスフィン錯体
DK715988D0 (da) *	1988-12-22	1988-12-22	Ferrosan As	Etherifikation og dealkylering af piperidin-derivater samt intermediater
US5233084A (en) *	1989-06-22	1993-08-03	Monsanto Company	Method for preparing α-arylpropionic acids
FR2651152B1 (fr) *	1989-08-23	1991-11-29	Elf Aquitaine	Perfectionnement a la preparation de catalyseurs chiraux a base de complexes du ruthenium et du phosphore.
GB9209687D0 (en) *	1992-05-06	1992-06-17	Smithkline Beecham Plc	Novel process
DE4422672A1 (de) *	1994-06-30	1996-01-04	Hoechst Ag	Halogenierte Biphenyl-2,2'-diyl-bis-diphenylphosphine, ihre Herstellung und ihre Verwendung
AR001982A1 (es) *	1995-02-06	1998-01-07	Smithkline Beecham Plc	Clorhidrato de paroxetina anhidratado, y procedimiento para su preparacion
CN1068597C (zh)	1995-05-17	2001-07-18	诺沃挪第克公司	制备4－芳基－哌啶衍生物的方法
HU221921B1 (hu) *	1996-07-08	2003-02-28	Richter Gedeon Vegyészeti Gyár Rt.	N-benzil-piperidin- és tetrahidropiridinszármazékok és eljárás azok előállítására
WO1998050359A1 (en) *	1997-05-06	1998-11-12	Novo Nordisk A/S	Novel heterocyclic compounds
ES2212287T3 (es) *	1997-05-20	2004-07-16	Firmenich Sa	Catalizadores de rutenio y su uso en la hidrogenacion asimetrica de sustratos debilmente coordinantes.

1999
- 1999-02-23 IT IT1999MI000364A patent/IT1308629B1/it active
2000
- 2000-02-18 TW TW089102997A patent/TWI221473B/zh not_active IP Right Cessation
- 2000-02-22 US US09/890,414 patent/US6583287B1/en not_active Expired - Fee Related
- 2000-02-22 ES ES00909228T patent/ES2195876T3/es not_active Expired - Lifetime
- 2000-02-22 CN CNB008041873A patent/CN1161353C/zh not_active Expired - Fee Related
- 2000-02-22 HU HU0105482A patent/HUP0105482A3/hu unknown
- 2000-02-22 JP JP2000601002A patent/JP2002537394A/ja active Pending
- 2000-02-22 PT PT00909228T patent/PT1153023E/pt unknown
- 2000-02-22 SK SK1204-2001A patent/SK12042001A3/sk unknown
- 2000-02-22 BR BR0008220-1A patent/BR0008220A/pt not_active IP Right Cessation
- 2000-02-22 YU YU60801A patent/YU60801A/sh unknown
- 2000-02-22 HR HR20010608A patent/HRP20010608A2/hr not_active Application Discontinuation
- 2000-02-22 PL PL00349358A patent/PL349358A1/xx not_active IP Right Cessation
- 2000-02-22 HK HK02101971.9A patent/HK1040516B/en not_active IP Right Cessation
- 2000-02-22 IL IL14488300A patent/IL144883A/en not_active IP Right Cessation
- 2000-02-22 AU AU31583/00A patent/AU759441B2/en not_active Ceased
- 2000-02-22 CZ CZ20012997A patent/CZ20012997A3/cs unknown
- 2000-02-22 RU RU2001125933/04A patent/RU2242473C2/ru not_active IP Right Cessation
- 2000-02-22 DE DE60002303T patent/DE60002303T2/de not_active Expired - Fee Related
- 2000-02-22 WO PCT/EP2000/001430 patent/WO2000050422A1/en not_active Ceased
- 2000-02-22 EP EP00909228A patent/EP1153023B1/en not_active Expired - Lifetime
- 2000-02-22 AT AT00909228T patent/ATE238295T1/de not_active IP Right Cessation
- 2000-02-22 DK DK00909228T patent/DK1153023T3/da active
- 2000-02-22 CA CA002361758A patent/CA2361758A1/en not_active Abandoned
- 2000-02-22 MX MXPA01008502A patent/MXPA01008502A/es active IP Right Grant
- 2000-02-22 KR KR1020017010760A patent/KR20010102366A/ko not_active Ceased
- 2000-02-22 TR TR2001/02441T patent/TR200102441T2/xx unknown
2001
- 2001-08-22 NO NO20014078A patent/NO319724B1/no unknown

Also Published As

Publication number	Publication date
ATE238295T1 (de)	2003-05-15
CZ20012997A3 (cs)	2001-11-14
DK1153023T3 (da)	2003-08-11
HK1040516B (en)	2003-10-31
DE60002303T2 (de)	2004-04-01
HUP0105482A3 (en)	2002-11-28
SK12042001A3 (sk)	2001-12-03
MXPA01008502A (es)	2003-06-06
HK1040516A1 (en)	2002-06-14
EP1153023B1 (en)	2003-04-23
ITMI990364A1 (it)	2000-08-23
WO2000050422A1 (en)	2000-08-31
YU60801A (sh)	2005-07-19
NO20014078D0 (no)	2001-08-22
CN1341113A (zh)	2002-03-20
HRP20010608A2 (en)	2002-08-31
KR20010102366A (ko)	2001-11-15
BR0008220A (pt)	2001-11-06
AU3158300A (en)	2000-09-14
CA2361758A1 (en)	2000-08-31
NO319724B1 (no)	2005-09-05
HUP0105482A2 (en)	2002-08-28
TWI221473B (en)	2004-10-01
ES2195876T3 (es)	2003-12-16
IL144883A (en)	2004-12-15
DE60002303D1 (de)	2003-05-28
US6583287B1 (en)	2003-06-24
TR200102441T2 (tr)	2002-01-21
JP2002537394A (ja)	2002-11-05
RU2242473C2 (ru)	2004-12-20
PL349358A1 (en)	2002-07-15
IT1308629B1 (it)	2002-01-09
IL144883A0 (en)	2002-06-30
AU759441B2 (en)	2003-04-17
PT1153023E (pt)	2003-09-30
CN1161353C (zh)	2004-08-11
EP1153023A1 (en)	2001-11-14

Publication	Publication Date	Title
Makabe et al.	2003	Total synthesis of (−)-cassine
ATE440087T1 (de)	2009-09-15	2,4-diaminopyrimidinderivate, die sich als inhibitoren von pkc-theta eignen
AU4437896A (en)	1996-07-31	Piperidine derivatives having tachykinin antagonist activity
Huang	2006	Asymmetric synthesis of hydroxylated pyrrolidines, piperidines and related bioactive compounds: From N-acyliminium chemistry to N-α-carbanion chemistry
PL392726A1 (pl)	2010-12-06	Nowe związki pośrednie do syntezy związków triazolopirymidyny oraz sposób ich wytwarzania
GR1002466B (el)	1996-11-06	Νεες ενωσεις.
NO974608L (no)	1997-12-08	Nye mellomprodukter og fremgangsmåte for fremstilling av camptothecinderivater (CPT-11) og beslektede forbindelser
NO178187B (no)	1995-10-30	Analogifremgangsmåte for fremstilling av terapeutisk aktive 3-aminopiperidin-derivater og beslektede nitrogenholdige heterocykliske forbindelser
HU9601857D0 (en)	1996-08-28	New benzyl-piperidine- or -tetrahydro-pyridine derivatives and processes for producing them
BR0013885A (pt)	2002-05-07	Comprimidos aperfeiçoados
DE60019904D1 (de)	2005-06-09	Verwendung von sulfamat derivaten zur behandlung von impulsiven störungen
ATE305459T1 (de)	2005-10-15	Verfahren für die enantioselektive synthese von azetidinon-zwischenprodukten
SG158848A1 (en)	2010-02-26	Method for producing annelated piperazin-2-one derivatives and intermediates of said method
Xu et al.	2021	Construction of azacycles by intramolecular amination of organoboronates and organobis (boronates)
MXPA04006033A (es)	2004-09-27	Dicetopiperacinas sustituidas como antagonistas de oxitocina.
BR0108088A (pt)	2004-04-06	Pirrolidinas 1,3-dissubstituìdas e 1,3,3-trissubstituìdas como ligandos receptores de histamina-3 e suas aplicações terapêuticas
NO20014078L (no)	2001-10-18	Fremgangsmåte for fremstilling av paroksetin
ATE397599T1 (de)	2008-06-15	Als modulatoren der chemokinrezeptoraktivität geeignete piperidinderivate
Hanessian et al.	2002	The power of visual imagery in synthesis planning. Stereocontrolled approaches to CGP-60536B, a potent renin inhibitor
CA1076118A (en)	1980-04-22	Benzofuranyl derivatives of tetrahydropyridine and piperidine compounds
MXPA03010960A (es)	2004-02-27	Proceso para la produccion de fexofenadina derivado de piperidina.
Mehra et al.	2013	Diastereoselective synthesis of 2, 3-disubstituted 1-arylazetidines via NaBH4-promoted facile reduction of C-3 functionalized azetidin-2-ones
Alcaide et al.	2007	Stereocontrolled access to orthogonally protected anti, anti-4-aminopiperidine-3, 5-diols through chemoselective reduction of enantiopure β-lactam cyanohydrins
WO2005040129A3 (en)	2005-06-23	Ccr3 receptor antagonists
Wang et al.	2009	Stereospecific, Flexible and Redox‐Economic Asymmetric Synthesis of cis‐and trans‐3‐Hydroxypipecolic Acids and Analogs