TR200102441T2 - Paroksetin üretme süreci - Google Patents

Paroksetin üretme süreci

Info

Publication number
TR200102441T2
TR200102441T2 TR2001/02441T TR200102441T TR200102441T2 TR 200102441 T2 TR200102441 T2 TR 200102441T2 TR 2001/02441 T TR2001/02441 T TR 2001/02441T TR 200102441 T TR200102441 T TR 200102441T TR 200102441 T2 TR200102441 T2 TR 200102441T2
Authority
TR
Turkey
Prior art keywords
paroxetine
substitution
isomeric components
dealylation
cyral
Prior art date
Application number
TR2001/02441T
Other languages
English (en)
Inventor
Rossi Renzo
Turchetta Stefano
Donnarumma Maria
Original Assignee
Recordati Chemical And Pharmaceutical Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Recordati Chemical And Pharmaceutical Company filed Critical Recordati Chemical And Pharmaceutical Company
Publication of TR200102441T2 publication Critical patent/TR200102441T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Paroksetin üretimi için olan bir süreç tarif edilmektedir; öyle ki bu süreçte 4-(p-florofenil)-3-hidroksimetil-1,2,3,6-tetrahidropiridin N-ikameli türevleri, asagidaki tepkime dizisine uygun olarak isleme tabi tutulur: (a) Siral difosfinik baglarin bulundugu metal komplekslerin aktarimiyla hidrojenasyon katalize edilmesi; (b) -OH türevinin çikarilmasi ve nükleofilik ikame etme, ikame edici sesamoldür, (c) N-dealkilasyon. Süreç yüksek düzeyde stereospesifiktir ve istenen izomerik bilesenlerle zenginlestirilmis olan ara maddelerin olusumunu ortaya çikarir; söz konusu izomerik bilesenler daha sonra niceliksel açiga çikma oranlarinda paroksetine dönüstürülür.
TR2001/02441T 1999-02-23 2000-02-22 Paroksetin üretme süreci TR200102441T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT1999MI000364A IT1308629B1 (it) 1999-02-23 1999-02-23 Processo per la produzione di paroxetina.

Publications (1)

Publication Number Publication Date
TR200102441T2 true TR200102441T2 (tr) 2002-01-21

Family

ID=11382007

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/02441T TR200102441T2 (tr) 1999-02-23 2000-02-22 Paroksetin üretme süreci

Country Status (28)

Country Link
US (1) US6583287B1 (tr)
EP (1) EP1153023B1 (tr)
JP (1) JP2002537394A (tr)
KR (1) KR20010102366A (tr)
CN (1) CN1161353C (tr)
AT (1) ATE238295T1 (tr)
AU (1) AU759441B2 (tr)
BR (1) BR0008220A (tr)
CA (1) CA2361758A1 (tr)
CZ (1) CZ20012997A3 (tr)
DE (1) DE60002303T2 (tr)
DK (1) DK1153023T3 (tr)
ES (1) ES2195876T3 (tr)
HK (1) HK1040516B (tr)
HR (1) HRP20010608A2 (tr)
HU (1) HUP0105482A3 (tr)
IL (1) IL144883A (tr)
IT (1) IT1308629B1 (tr)
MX (1) MXPA01008502A (tr)
NO (1) NO319724B1 (tr)
PL (1) PL349358A1 (tr)
PT (1) PT1153023E (tr)
RU (1) RU2242473C2 (tr)
SK (1) SK12042001A3 (tr)
TR (1) TR200102441T2 (tr)
TW (1) TWI221473B (tr)
WO (1) WO2000050422A1 (tr)
YU (1) YU60801A (tr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1571152B1 (en) * 2004-03-03 2007-08-08 CHEMI S.p.A. Amorphous 3-Pyridil-1-Hydroxyethyliden-1,1-Biphosphonic acid monosodium salt and process for the preparation thereof .
US9138430B2 (en) * 2007-12-27 2015-09-22 Mylan Specialty L.P. Formulation and method for the release of paroxetine in the large intestine
WO2013115163A1 (ja) * 2012-01-31 2013-08-08 エーザイ・アール・アンド・ディー・マネジメント株式会社 パロキセチン誘導体
CN106831736A (zh) * 2017-02-15 2017-06-13 浙江华海药业股份有限公司 一种制备帕罗西汀杂质的方法
CN112521377A (zh) * 2020-11-26 2021-03-19 北京福元医药股份有限公司 一种盐酸帕罗西汀的连续化制备方法
CN115260153B (zh) * 2022-07-21 2023-10-27 威尚（上海）生物医药有限公司 一种6取代手性纯二氟哌啶喹唑啉衍生物及其制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0757758B2 (ja) 1988-10-24 1995-06-21 高砂香料工業株式会社 ルテニウム―ホスフィン錯体
DK715988D0 (da) * 1988-12-22 1988-12-22 Ferrosan As Etherifikation og dealkylering af piperidin-derivater samt intermediater
US5233084A (en) * 1989-06-22 1993-08-03 Monsanto Company Method for preparing α-arylpropionic acids
FR2651152B1 (fr) * 1989-08-23 1991-11-29 Elf Aquitaine Perfectionnement a la preparation de catalyseurs chiraux a base de complexes du ruthenium et du phosphore.
GB9209687D0 (en) * 1992-05-06 1992-06-17 Smithkline Beecham Plc Novel process
DE4422672A1 (de) * 1994-06-30 1996-01-04 Hoechst Ag Halogenierte Biphenyl-2,2'-diyl-bis-diphenylphosphine, ihre Herstellung und ihre Verwendung
AR001982A1 (es) * 1995-02-06 1998-01-07 Smithkline Beecham Plc Clorhidrato de paroxetina anhidratado, y procedimiento para su preparacion
CN1068597C (zh) 1995-05-17 2001-07-18 诺沃挪第克公司 制备4－芳基－哌啶衍生物的方法
HU221921B1 (hu) * 1996-07-08 2003-02-28 Richter Gedeon Vegyészeti Gyár Rt. N-benzil-piperidin- és tetrahidropiridinszármazékok és eljárás azok előállítására
WO1998050359A1 (en) * 1997-05-06 1998-11-12 Novo Nordisk A/S Novel heterocyclic compounds
ES2212287T3 (es) * 1997-05-20 2004-07-16 Firmenich Sa Catalizadores de rutenio y su uso en la hidrogenacion asimetrica de sustratos debilmente coordinantes.

Also Published As

Publication number Publication date
ATE238295T1 (de) 2003-05-15
CZ20012997A3 (cs) 2001-11-14
DK1153023T3 (da) 2003-08-11
HK1040516B (en) 2003-10-31
DE60002303T2 (de) 2004-04-01
HUP0105482A3 (en) 2002-11-28
SK12042001A3 (sk) 2001-12-03
MXPA01008502A (es) 2003-06-06
HK1040516A1 (en) 2002-06-14
EP1153023B1 (en) 2003-04-23
ITMI990364A1 (it) 2000-08-23
WO2000050422A1 (en) 2000-08-31
YU60801A (sh) 2005-07-19
NO20014078D0 (no) 2001-08-22
CN1341113A (zh) 2002-03-20
HRP20010608A2 (en) 2002-08-31
KR20010102366A (ko) 2001-11-15
BR0008220A (pt) 2001-11-06
AU3158300A (en) 2000-09-14
CA2361758A1 (en) 2000-08-31
NO319724B1 (no) 2005-09-05
HUP0105482A2 (en) 2002-08-28
TWI221473B (en) 2004-10-01
ES2195876T3 (es) 2003-12-16
IL144883A (en) 2004-12-15
DE60002303D1 (de) 2003-05-28
US6583287B1 (en) 2003-06-24
JP2002537394A (ja) 2002-11-05
RU2242473C2 (ru) 2004-12-20
PL349358A1 (en) 2002-07-15
IT1308629B1 (it) 2002-01-09
IL144883A0 (en) 2002-06-30
AU759441B2 (en) 2003-04-17
PT1153023E (pt) 2003-09-30
CN1161353C (zh) 2004-08-11
EP1153023A1 (en) 2001-11-14
NO20014078L (no) 2001-10-18

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