DK1154986T3 - Fremgangsmåde til fremstilling af iopamidol - Google Patents

Fremgangsmåde til fremstilling af iopamidol

Info

Publication number: DK1154986T3
Authority: DK; Denmark
Prior art keywords: preparation; iopamidol; contrast agents; ionic contrast; purifying
Prior art date: 1999-02-26

Application number

DK00911908T

Other languages

English (en)

Inventor

Richard A Lorenzini

Ashok V Bhatia

Steven A Chamberlin

Keith A Drengler

John J Hufnagel

Xiu C Wang

Original Assignee

Bracco Imaging Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-02-26

Filing date

2000-02-23

Publication date

2004-10-18

2000-02-23 Application filed by Bracco Imaging Spa filed Critical Bracco Imaging Spa

2004-10-18 Application granted granted Critical

2004-10-18 Publication of DK1154986T3 publication Critical patent/DK1154986T3/da

Links

238000000034 method Methods 0.000 title abstract 3
XQZXYNRDCRIARQ-LURJTMIESA-N iopamidol Chemical compound C[C@H](O)C(=O)NC1=C(I)C(C(=O)NC(CO)CO)=C(I)C(C(=O)NC(CO)CO)=C1I XQZXYNRDCRIARQ-LURJTMIESA-N 0.000 title 1
229960004647 iopamidol Drugs 0.000 title 1
239000002872 contrast media Substances 0.000 abstract 2

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/46—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having carbon atoms of carboxamide groups, amino groups and at least three atoms of bromine or iodine, bound to carbon atoms of the same non-condensed six-membered aromatic ring

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Detergent Compositions (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK00911908T 1999-02-26 2000-02-23 Fremgangsmåde til fremstilling af iopamidol DK1154986T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US09/257,690 US6803485B2 (en)	1999-02-26	1999-02-26	Process for the preparation of iopamidol
PCT/US2000/004511 WO2000050385A1 (en)	1999-02-26	2000-02-23	Process for the preparation of iopamidol
EP20000911908 EP1154986B1 (en)	1999-02-26	2000-02-23	Process for the preparation of iopamidol

Publications (1)

Publication Number	Publication Date
DK1154986T3 true DK1154986T3 (da)	2004-10-18

Family

ID=22977346

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK00911908T DK1154986T3 (da)	1999-02-26	2000-02-23	Fremgangsmåde til fremstilling af iopamidol

Country Status (10)

Country	Link
US (4)	US6803485B2 (da)
EP (1)	EP1154986B1 (da)
JP (1)	JP4540233B2 (da)
AT (1)	ATE268749T1 (da)
CA (1)	CA2364819C (da)
DE (1)	DE60011396T2 (da)
DK (1)	DK1154986T3 (da)
ES (1)	ES2220429T3 (da)
PT (1)	PT1154986E (da)
WO (1)	WO2000050385A1 (da)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6803485B2 (en) *	1999-02-26	2004-10-12	Bracco Imaging S.P.A.	Process for the preparation of iopamidol
IT1319671B1 (it)	2000-12-01	2003-10-23	Bracco Spa	Processo per la preparazione di (s)-n,n'-bis(2-idrossi-1-(idrossimetil)etil)-5-((2-idrossi-1-ossopropil)ammino)
GB0123013D0 (en) *	2001-09-25	2001-11-14	Upperton Ltd	Improvements relating to imaging contrast agents
US20040054162A1 (en) *	2001-10-30	2004-03-18	Hanna Michelle M.	Molecular detection systems utilizing reiterative oligonucleotide synthesis
NO20055643D0 (no) *	2005-11-29	2005-11-29	Amersham Health As	Preparation of lodixanol
US8907193B2 (en) *	2007-02-20	2014-12-09	Ubisoft Entertainment	Instrument game system and method
ES2391002T3 (es) *	2008-01-14	2012-11-20	Mallinckrodt Llc	Proceso para la preparación de iosimenol
US20110021824A1 (en) *	2009-07-21	2011-01-27	Ge Healthcare As	Adsorptive purification method for iodixanol
WO2012136813A2 (en)	2011-04-07	2012-10-11	Universitetet I Oslo	Agents for medical radar diagnosis
PT105770B (pt) *	2011-06-24	2013-07-08	Hovione Farmaciencia S A	Novo intermediário e seu uso na preparação de agente de contrate triiodado
CN103382160B (zh) *	2012-05-02	2017-10-27	上海海神化学生物科技有限公司	碘帕醇的合成及其合成中间体的制备
PL3066071T3 (pl)	2013-11-05	2018-09-28	Bracco Imaging S.P.A	Sposób otrzymywania jopamidolu
CN105017062B (zh) *	2014-04-18	2018-11-20	沈阳中海生物技术开发有限公司	制备碘普罗胺的新方法
CN104098484A (zh) *	2014-07-21	2014-10-15	杭州杜易科技有限公司	一种碘帕醇的制备方法
CN106831480B (zh) *	2015-12-07	2019-01-15	北京大学	基于碘帕醇脂质衍生物的造影剂及其制备方法与用途
JP7101694B2 (ja)	2016-11-16	2022-07-15	ペルシカファーマシューティカルズリミテッド	腰痛のための抗生物質製剤
WO2019097242A1 (en)	2017-11-16	2019-05-23	Persica Pharmaceuticals Ltd.	Linezolid formulations
KR102764630B1 (ko)	2021-04-08	2025-02-11	한양대학교 에리카산학협력단	이오파미돌의 제조방법
CN115010617B (zh) *	2022-07-11	2024-06-11	安徽普利药业有限公司	一种碘帕醇的制备方法
CN116063195A (zh) *	2023-01-07	2023-05-05	安庆朗坤药业有限公司	一种碘帕醇中间体碘化物的制备方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CH608189A5 (da)	1974-12-13	1978-12-29	Savac Ag
IT1193211B (it)	1979-08-09	1988-06-15	Bracco Ind Chimica Spa	Derivati dell'acido 2,4,6-triiodo-isoftalico,metodo per la loro preparazione e mezzi di contrasto che li contengono
US4396598A (en) *	1982-01-11	1983-08-02	Mallinckrodt, Inc.	Triiodoisophthalamide X-ray contrast agent
FR2541676A1 (fr)	1983-02-25	1984-08-31	Guerbet Sa	Composes non-ioniques a structures benzenique iodee ou bromee et produits opacifiants en contenant
US4997983A (en) *	1990-01-31	1991-03-05	Mallinckrodt, Inc.	Process for production of ioversol
US5204005A (en)	1990-02-26	1993-04-20	Mallinckrodt, Inc.	Reversed phase chromatographic process
US5527926A (en)	1990-11-26	1996-06-18	Bracco International B.V.	Methods and compositions for using non-ionic contrast agents to reduce the risk of clot formation in diagnostic procedures
IT1248741B (it)	1991-02-26	1995-01-26	Bracco Spa	Processo di concentrazione e di purificazione di composti organici
US5256393A (en)	1991-04-16	1993-10-26	Mallinckrodt Medical, Inc.	Use of azeotropic distillation in process to dry 5-amino-N,N'bis (2,3-dihydroxypropyl)-2,4,6-triiodoisphthalamide
CA2068089C (en)	1991-05-31	2003-09-16	Ramachandran S. Ranganathan	Method and compositions for using non-ionic contrast agents to reduce the risk of clot formulation in diagnostic procedures
US5177261A (en) *	1991-07-22	1993-01-05	Mallinckrodt Medical, Inc.	Synthesis of ioversol using chloroacetyl chloride
IT1256162B (it)	1992-10-27	1995-11-29	Zambon Spa	Processo per la preparazione di un intermedio della sintesi organica
IT1256163B (it)	1992-10-27	1995-11-29	Zambon Spa	Processo per la preparazione di un intermedio della sintesi organica
US5396003A (en) *	1993-05-27	1995-03-07	Mallinckrodt Medical Pmc	Recovery and purification of 1,1,2-trichloroethane for reuse in the production of ioversol
IL110391A (en)	1993-07-30	1998-12-06	Zambon Spa	Process for the crystallization of iopamidol
IT1274027B (it)	1994-03-03	1997-07-14	Zambon Spa	Processo per la preparazione e purificazione di mezzi di contrasto iodurati
US5371278A (en)	1994-03-25	1994-12-06	Mallinckrodt Medical Pmc	Synthesis of ioversol using a minimal excess of acetoxyacetylchloride
IT1286522B1 (it) *	1996-12-04	1998-07-15	Dibra Spa	Processo per la preparazione di derivati dell'acido 5-ammino-2,4,6- triiodo-1,3-benzenedicarbossilico
US6803485B2 (en) *	1999-02-26	2004-10-12	Bracco Imaging S.P.A.	Process for the preparation of iopamidol

1999
- 1999-02-26 US US09/257,690 patent/US6803485B2/en not_active Expired - Lifetime
2000
- 2000-02-23 CA CA002364819A patent/CA2364819C/en not_active Expired - Lifetime
- 2000-02-23 WO PCT/US2000/004511 patent/WO2000050385A1/en not_active Ceased
- 2000-02-23 ES ES00911908T patent/ES2220429T3/es not_active Expired - Lifetime
- 2000-02-23 EP EP20000911908 patent/EP1154986B1/en not_active Expired - Lifetime
- 2000-02-23 DE DE60011396T patent/DE60011396T2/de not_active Expired - Lifetime
- 2000-02-23 AT AT00911908T patent/ATE268749T1/de active
- 2000-02-23 JP JP2000600969A patent/JP4540233B2/ja not_active Expired - Lifetime
- 2000-02-23 DK DK00911908T patent/DK1154986T3/da active
- 2000-02-23 PT PT00911908T patent/PT1154986E/pt unknown
2004
- 2004-06-16 US US10/869,519 patent/US6875887B2/en not_active Expired - Lifetime
2005
- 2005-02-24 US US11/064,779 patent/US7115778B2/en not_active Expired - Lifetime
2006
- 2006-08-16 US US11/464,981 patent/US7282607B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US20070078281A1 (en)	2007-04-05
US7115778B2 (en)	2006-10-03
EP1154986A1 (en)	2001-11-21
JP2002537371A (ja)	2002-11-05
PT1154986E (pt)	2004-09-30
US20050192465A1 (en)	2005-09-01
JP4540233B2 (ja)	2010-09-08
US7282607B2 (en)	2007-10-16
WO2000050385A1 (en)	2000-08-31
CA2364819A1 (en)	2000-08-31
US6803485B2 (en)	2004-10-12
US20010056206A1 (en)	2001-12-27
CA2364819C (en)	2008-12-02
US6875887B2 (en)	2005-04-05
ATE268749T1 (de)	2004-06-15
EP1154986B1 (en)	2004-06-09
ES2220429T3 (es)	2004-12-16
DE60011396D1 (de)	2004-07-15
US20040236150A1 (en)	2004-11-25
DE60011396T2 (de)	2005-06-23

Publication	Publication Date	Title
PT1154986E (pt)	2004-09-30	Processo para a preparacao de iopamidol
UA34466C2 (uk)	2001-03-15	Засіб для несистемної боротьби з паразитуючими комахами
ATE289640T1 (de)	2005-03-15	Amidofunktionelle aminopolydiorganosiloxane
DK0789578T3 (da)	2003-09-22	Inhibitorer af multikatalytisk protease
DK1181272T3 (da)	2002-12-30	Fremgangsmåde til fremstilling af rent citalopram
DK1181713T3 (da)	2005-01-31	Fremgangsmåde til fremstilling af rent citalopram
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DK1140886T3 (da)	2003-07-28	Fremgangsmåde til fremstilling af 5-cyanophtalid
DK1309582T3 (da)	2005-03-14	Fremgangsmåde til fremstilling af citalopram
DK1380121T3 (da)	2007-12-27	Fremgangsmåde til fremstilling af oxazolidinoner
IT1317716B1 (it)	2003-07-15	Processo per la preparazione di perfluoropoliossialchileni conterminali ossidrilici.
FI20010131L (fi)	2002-07-23	Ääniviestijärjestelmä
ATE202483T1 (de)	2001-07-15	Immuntolerante prothrombinkomplex-präparation
MY141607A (en)	2010-05-31	Lactam compound
DE60239842D1 (de)	2011-06-01	Verfahren zur Herstellung von 10,11-dihydro-10-oxo-5h-dibenzoÄb,fÜazepin-5-carboxamid
DE60215408D1 (de)	2006-11-30	Verfahren zur Herstellung von Trialkylmetallverbindungen der Gruppe Va Metalle
MXPA03003347A (es)	2003-06-19	Procedimiento para purificacion de pravastatina.
DK1296970T3 (da)	2008-07-14	Fremgangsmåde til fremstilling af citalopram
DK1206452T3 (da)	2005-03-14	Fremgangsmåde til fremstilling af benzoperhydro-isoindolforbindelser
ATE252589T1 (de)	2003-11-15	Aluminosiloxanverbindungen und verfahren zu ihrer herstellung
DK1373232T3 (da)	2006-03-27	Fremgangsmåde til fremstilling af N-substituerede 2,6-dialkylmorpholiner
DK1228056T3 (da)	2005-01-24	Fremgangsmåde til fremstilling af citalopram
ATE407694T1 (de)	2008-09-15	Methode zur beschleunigung der schleimauflöserate
DK1200387T3 (da)	2004-07-19	Fremgangsmåde til den cis-selektive katalytiske hydrogenering af cyclohexylidenaminer
DK1165483T3 (da)	2004-07-05	Fremgangsmåde til fremstilling af carbonylfluorid