DK1228056T3 - Fremgangsmåde til fremstilling af citalopram - Google Patents

Fremgangsmåde til fremstilling af citalopram

Info

Publication number: DK1228056T3
Authority: DK; Denmark
Prior art keywords: citalopram; preparation
Prior art date: 1999-10-25

Application number

DK99950511T

Other languages

English (en)

Inventor

Hans Petersen

Peter Ellegaard

Michael Harold Rock

Original Assignee

Lundbeck & Co As H

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-10-25

Filing date

1999-10-25

Publication date

2005-01-24

1999-10-25 Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H

1999-10-25 Priority claimed from PCT/DK1999/000581 external-priority patent/WO2000012044A2/en

2005-01-24 Application granted granted Critical

2005-01-24 Publication of DK1228056T3 publication Critical patent/DK1228056T3/da

Links

WSEQXVZVJXJVFP-HXUWFJFHSA-N (R)-citalopram Chemical compound C1([C@@]2(C3=CC=C(C=C3CO2)C#N)CCCN(C)C)=CC=C(F)C=C1 WSEQXVZVJXJVFP-HXUWFJFHSA-N 0.000 title 1
229960001653 citalopram Drugs 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C255/56—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and doubly-bound oxygen atoms bound to the carbon skeleton

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Neurology (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Epidemiology (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Steroid Compounds (AREA)

DK99950511T 1999-10-25 1999-10-25 Fremgangsmåde til fremstilling af citalopram DK1228056T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
PCT/DK1999/000581 WO2000012044A2 (en)	1999-10-25	1999-10-25	Method for the preparation of citalopram

Publications (1)

Publication Number	Publication Date
DK1228056T3 true DK1228056T3 (da)	2005-01-24

Family

ID=8157164

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DK02028326T DK1298124T3 (da)	1999-10-25	1999-10-25	Fremgangsmåde til fremstilling af citalopram
DK99950511T DK1228056T3 (da)	1999-10-25	1999-10-25	Fremgangsmåde til fremstilling af citalopram

Family Applications Before (1)

Application Number	Title	Priority Date	Filing Date
DK02028326T DK1298124T3 (da)	1999-10-25	1999-10-25	Fremgangsmåde til fremstilling af citalopram

Country Status (25)

Country	Link
US (1)	US6566540B2 (da)
EP (1)	EP1298124B1 (da)
KR (1)	KR100505820B1 (da)
AR (1)	AR024518A1 (da)
AT (2)	ATE277032T1 (da)
CA (1)	CA2291133C (da)
CY (1)	CY1107635T1 (da)
CZ (1)	CZ292894B6 (da)
DE (3)	DE69920526T2 (da)
DK (2)	DK1298124T3 (da)
EA (1)	EA002801B1 (da)
ES (1)	ES2282365T3 (da)
HK (1)	HK1043129B (da)
HR (1)	HRP20020344B1 (da)
HU (1)	HUP0200169A3 (da)
IL (3)	IL143875A0 (da)
IS (1)	IS2260B (da)
NO (1)	NO20071311L (da)
NZ (1)	NZ512406A (da)
PL (1)	PL201056B1 (da)
PT (2)	PT1298124E (da)
SI (2)	SI1298124T1 (da)
SK (1)	SK287140B6 (da)
TR (1)	TR200401456T1 (da)
UA (1)	UA72238C2 (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AR034612A1 (es) *	2001-06-25	2004-03-03	Lundbeck & Co As H	Proceso para la preparacion del citalopram racemico y/o del s- o r-citalopram mediante la separacion de una mezcla de r- y s-citalopram
AR040970A1 (es) *	2002-08-12	2005-04-27	Lundbeck & Co As H	Metodo para la separacion de intermediarios que pueden ser utilizados para la preparacion de escitalopram
US20050137255A1 (en) *	2002-12-23	2005-06-23	H. Lundbeck A/S	Crystalline escitalopram hydrobromide and methods for preparing the same
NZ540281A (en) *	2002-12-23	2008-07-31	Lundbeck & Co As H	Escitalopram hydrobromide and a method for the preparation thereof
AU2003223105A1 (en) *	2003-03-24	2004-10-18	Hetero Drugs Limited	Novel crystalline forms of (s)-citalopram oxalate
US20050196453A1 (en) *	2004-03-05	2005-09-08	H. Lundbeck A/S	Crystalline composition containing escitalopram
KR20080080094A (ko) *	2005-10-14	2008-09-02	하. 룬트벡 아크티에 셀스카브	에스시탈로프람 및 부프로피온의 저용량 조합물을 이용한중추신경계 장애의 치료 방법
AU2006304889A1 (en) *	2005-10-14	2007-04-26	H. Lundbeck A/S	Stable pharmaceutical formulations containing escitalopram and bupropion
ES2653852T3 (es) *	2007-08-03	2018-02-09	Richter Gedeon Nyrt.	Composiciones farmacéuticas que contienen ligandos del receptor de dopamina y procedimientos de tratamiento usando ligandos del receptor de dopamina

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1143703A (da)	1965-03-18
GB1526331A (en)	1976-01-14	1978-09-27	Kefalas As	Phthalanes
GB8419963D0 (en) *	1984-08-06	1984-09-12	Lundbeck & Co As H	Intermediate compound and method
GB8814057D0 (en) *	1988-06-14	1988-07-20	Lundbeck & Co As H	New enantiomers & their isolation
DE3926765A1 (de)	1989-08-12	1991-02-14	Hoechst Ag	Verfahren zur verminderung von primaerem und sekundaerem amin in einem tertiaeren amin
US5296507A (en)	1990-09-06	1994-03-22	H.Lundbeck A/S	Treatment of cerbrovascular disorders
DE19626659A1 (de)	1996-07-03	1998-01-08	Basf Ag	Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de)	1996-07-10	1998-01-15	Basf Ag	Verfahren zur Herstellung von Phthaliden
JP3526581B2 (ja)	1997-07-08	2004-05-17	ハー・ルンドベック・アクティーゼルスカブ	シタロプラムの製造方法
UA62985C2 (en)	1997-11-10	2004-01-15	Lunnbeck As H	A method for the preparation of citalopram
CN1286687A (zh) *	1997-11-11	2001-03-07	H·隆德贝克有限公司	制备西酞普兰的方法
WO2000023431A1 (en)	1998-10-20	2000-04-27	H. Lundbeck A/S	Method for the preparation of citalopram
HK1043130B (zh)	1998-12-23	2005-03-04	H‧隆德贝克有限公司	制备5-氰基2-苯并[c]呋喃酮的方法
AR022329A1 (es)	1999-01-29	2002-09-04	Lundbeck & Co As H	Metodo para la preparacion de 5-cianoftalida
IL145615A0 (en)	1999-04-14	2002-06-30	Lundbeck & Co As H	Method for the preparation of citalopram
ITMI991579A1 (it)	1999-06-25	2001-01-15	Lundbeck & Co As H	Metodo per la preparazione di citalopram
ITMI991581A1 (it)	1999-06-25	2001-01-15	Lundbeck & Co As H	Metodo per la preparazione di citalopram
US6310222B1 (en)	1999-11-01	2001-10-30	Sumika Fine Chemicals Co., Ltd.	Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
NL1017415C1 (nl)	2000-02-24	2001-05-18	Lundbeck & Co As H	Werkwijze voor de bereiding van Citalopram.
IES20010143A2 (en)	2000-02-24	2001-07-25	Lundbeck & Co As H	Method for the preparation of citalopram
GB0005477D0 (en)	2000-03-07	2000-04-26	Resolution Chemicals Limited	Process for the preparation of citalopram
IL144816A (en)	2000-08-18	2005-09-25	Lundbeck & Co As H	Method for the preparation of citalopram
JP2003519121A (ja)	2000-12-28	2003-06-17	ハー・ルンドベック・アクチエゼルスカベット	純粋なシタロプラムの製造方法

1999
- 1999-10-25 HK HK02105036.3A patent/HK1043129B/zh not_active IP Right Cessation
- 1999-10-25 CA CA002291133A patent/CA2291133C/en not_active Expired - Fee Related
- 1999-10-25 KR KR10-2001-7008100A patent/KR100505820B1/ko not_active Expired - Fee Related
- 1999-10-25 SI SI9930960T patent/SI1298124T1/sl unknown
- 1999-10-25 PT PT02028326T patent/PT1298124E/pt unknown
- 1999-10-25 AT AT99950511T patent/ATE277032T1/de active
- 1999-10-25 DK DK02028326T patent/DK1298124T3/da active
- 1999-10-25 DE DE69920526T patent/DE69920526T2/de not_active Expired - Lifetime
- 1999-10-25 UA UA2001075224A patent/UA72238C2/uk unknown
- 1999-10-25 SI SI9930703T patent/SI1228056T1/xx unknown
- 1999-10-25 NZ NZ512406A patent/NZ512406A/xx not_active IP Right Cessation
- 1999-10-25 HU HU0200169A patent/HUP0200169A3/hu unknown
- 1999-10-25 SK SK50008-2009A patent/SK287140B6/sk not_active IP Right Cessation
- 1999-10-25 DE DE19983836A patent/DE19983836C1/de not_active Expired - Fee Related
- 1999-10-25 DE DE69935355T patent/DE69935355T2/de not_active Expired - Lifetime
- 1999-10-25 HR HR20020344A patent/HRP20020344B1/xx not_active IP Right Cessation
- 1999-10-25 EA EA200100593A patent/EA002801B1/ru not_active IP Right Cessation
- 1999-10-25 EP EP02028326A patent/EP1298124B1/en not_active Expired - Lifetime
- 1999-10-25 PT PT99950511T patent/PT1228056E/pt unknown
- 1999-10-25 DK DK99950511T patent/DK1228056T3/da active
- 1999-10-25 ES ES02028326T patent/ES2282365T3/es not_active Expired - Lifetime
- 1999-10-25 AT AT02028326T patent/ATE355268T1/de active
- 1999-10-25 PL PL349440A patent/PL201056B1/pl not_active IP Right Cessation
- 1999-10-25 IL IL14387599A patent/IL143875A0/xx active IP Right Grant
- 1999-10-25 TR TR2004/01456T patent/TR200401456T1/xx unknown
- 1999-11-10 AR ARP990105703A patent/AR024518A1/es active IP Right Grant
2001
- 2001-06-15 IS IS5970A patent/IS2260B/is unknown
- 2001-06-20 IL IL143875A patent/IL143875A/en not_active IP Right Cessation
2002
- 2002-05-03 US US10/138,811 patent/US6566540B2/en not_active Expired - Fee Related
- 2002-08-29 CZ CZ20022925A patent/CZ292894B6/cs not_active IP Right Cessation
2006
- 2006-07-18 IL IL176943A patent/IL176943A0/en unknown
2007
- 2007-03-09 NO NO20071311A patent/NO20071311L/no unknown
- 2007-05-21 CY CY20071100690T patent/CY1107635T1/el unknown

Also Published As

Publication number	Publication date
IL176943A0 (en)	2006-12-10
ES2282365T3 (es)	2007-10-16
PL349440A1 (en)	2002-07-29
PL201056B1 (pl)	2009-03-31
CA2291133C (en)	2003-06-17
PT1298124E (pt)	2007-05-31
HUP0200169A3 (en)	2002-11-28
HUP0200169A2 (en)	2002-06-29
SK287140B6 (sk)	2010-01-07
US20020177722A1 (en)	2002-11-28
PT1228056E (pt)	2005-02-28
TR200401456T1 (tr)	2005-04-21
IL143875A (en)	2008-03-20
US6566540B2 (en)	2003-05-20
IL143875A0 (en)	2002-04-21
AR024518A1 (es)	2002-10-16
SI1298124T1 (sl)	2007-08-31
EP1298124B1 (en)	2007-02-28
HRP20020344B1 (hr)	2010-10-31
HK1043129A1 (en)	2002-09-06
KR100505820B1 (ko)	2005-08-03
NZ512406A (en)	2004-01-30
IS2260B (is)	2007-06-15
CZ292894B6 (cs)	2003-12-17
DE19983836C1 (de)	2003-10-23
CY1107635T1 (el)	2013-04-18
SI1228056T1 (en)	2005-02-28
KR20010092799A (ko)	2001-10-27
CA2291133A1 (en)	2001-04-25
HK1043129B (zh)	2004-10-21
DE69920526T2 (de)	2006-02-23
EA200100593A1 (ru)	2001-10-22
DK1298124T3 (da)	2007-07-09
EA002801B1 (ru)	2002-10-31
DE69920526D1 (de)	2004-10-28
EP1298124A1 (en)	2003-04-02
ATE355268T1 (de)	2006-03-15
DE69935355D1 (de)	2007-04-12
UA72238C2 (en)	2005-02-15
HRP20020344A2 (en)	2004-02-29
NO20071311L (no)	2001-08-24
ATE277032T1 (de)	2004-10-15
IS5970A (is)	2001-06-15
DE69935355T2 (de)	2007-11-08

Publication	Publication Date	Title
DK1173431T4 (da)	2010-01-04	Fremgangsmåde til fremstilling af citalopram
DK1105382T3 (da)	2002-05-27	Fremgangsmåde til fremstilling af citalopram
DK1159274T3 (da)	2003-07-21	Fremgangsmåde til fremstilling af citalopram
DK1123284T3 (da)	2003-04-28	Fremgangsmåde til fremstilling af citalopram
DK1032566T3 (da)	2003-06-10	Fremgangsmåde til fremstilling af citalopram
DK1309582T3 (da)	2005-03-14	Fremgangsmåde til fremstilling af citalopram
DK1150966T3 (da)	2002-12-30	Fremgangsmåde til fremstilling af 5-cyanophthalid
DK1181272T3 (da)	2002-12-30	Fremgangsmåde til fremstilling af rent citalopram
DK1296935T3 (da)	2009-06-22	Fremgangsmåde til fremstilling af substituerede octanoylamider
DK1181713T3 (da)	2005-01-31	Fremgangsmåde til fremstilling af rent citalopram
DK1165576T3 (da)	2006-03-27	Fremgangsmåde til fremstilling af amin-platin-komplekser
DK1140886T3 (da)	2003-07-28	Fremgangsmåde til fremstilling af 5-cyanophtalid
DK1187833T3 (da)	2007-10-08	Fremgangsmåde til fremstilling af thiamethoxam
DK1296970T3 (da)	2008-07-14	Fremgangsmåde til fremstilling af citalopram
DK0973769T3 (da)	2004-12-13	Fremgangsmåde til fremstilling af eprosartan
DK1298124T3 (da)	2007-07-09	Fremgangsmåde til fremstilling af citalopram
NO20021118D0 (no)	2002-03-06	Fremgangsmåte for fremstilling av citalopram
DK0970073T3 (da)	2005-02-21	Fremgangsmåde til fremstilling af eprosartan
DK1203000T3 (da)	2003-06-02	Fremgangsmåde til fremstilling af phosphonomethylglycin
DK1240173T3 (da)	2003-09-15	Fremgangsmåde til fremstilling af N-phosphonomethylglycin
DK1012152T3 (da)	2003-02-10	Fremgangsmåde til fremstilling af oxazaphosphorin-2-aminer
DK1165483T3 (da)	2004-07-05	Fremgangsmåde til fremstilling af carbonylfluorid
DK1029867T3 (da)	2004-08-16	Fremgangsmåde til fremstilling af organiske azider
DK0949246T3 (da)	2003-04-07	Fremgangsmåde til fremstilling af phenoxyphenylsulfonylhalogenider
DK1226125T3 (da)	2005-01-24	Fremgangsmåde til fremstilling af mavesårsmidler