DK116889A - Fremgangsmaade til fremstilling af 3-exomethylencephamderivater - Google Patents

Fremgangsmaade til fremstilling af 3-exomethylencephamderivater

Info

Publication number: DK116889A
Authority: DK; Denmark
Prior art keywords: derivatives; cephem; exomethylencepham; preparing; procedure
Prior art date: 1987-07-13

Application number

DK116889A

Other languages

English (en)

Other versions

DK116889D0 (da

Inventor

Jan Verweij

Jan Jacobus De Koning

Hendrik Adrianus Witkamp

Original Assignee

Gist Brocades Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-07-13

Filing date

1989-03-10

Publication date

1989-03-10

1989-03-10 Application filed by Gist Brocades Nv filed Critical Gist Brocades Nv

1989-03-10 Publication of DK116889D0 publication Critical patent/DK116889D0/da

1989-03-10 Publication of DK116889A publication Critical patent/DK116889A/da

Links

238000000034 method Methods 0.000 title abstract 2
150000001781 cephams Chemical class 0.000 abstract 3
JJYMUNWZKXXYFU-SSDOTTSWSA-N (6R)-3-(phosphanylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-en-8-one Chemical class S1CC(CP)=CN2C(=O)C[C@H]21 JJYMUNWZKXXYFU-SSDOTTSWSA-N 0.000 abstract 1
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 abstract 1
HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 abstract 1
229910052749 magnesium Inorganic materials 0.000 abstract 1
239000011777 magnesium Substances 0.000 abstract 1
229910052751 metal Inorganic materials 0.000 abstract 1
239000002184 metal Substances 0.000 abstract 1
-1 phosphonium cephem compounds Chemical class 0.000 abstract 1
229910052725 zinc Inorganic materials 0.000 abstract 1
239000011701 zinc Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/02—Preparation
- C07D501/04—Preparation from compounds already containing the ring or condensed ring systems, e.g. by dehydrogenation of the ring, by introduction, elimination or modification of substituents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Cephalosporin Compounds (AREA)
Steroid Compounds (AREA)
Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Investigating Or Analysing Biological Materials (AREA)
Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

DK116889A 1987-07-13 1989-03-10 Fremgangsmaade til fremstilling af 3-exomethylencephamderivater DK116889A (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP87201323		1987-07-13
PCT/NL1988/000035 WO1989000572A1 (en)	1987-07-13	1988-07-13	Process for the preparation of 3-exomethylene cepham derivatives

Publications (2)

Publication Number	Publication Date
DK116889D0 DK116889D0 (da)	1989-03-10
DK116889A true DK116889A (da)	1989-03-10

Family

ID=8197638

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK116889A DK116889A (da)	1987-07-13	1989-03-10	Fremgangsmaade til fremstilling af 3-exomethylencephamderivater

Country Status (19)

Country	Link
US (3)	US4985554A (da)
EP (1)	EP0299587B1 (da)
JP (1)	JPH0742291B2 (da)
KR (1)	KR0137221B1 (da)
CN (1)	CN1040441C (da)
AT (1)	ATE113952T1 (da)
AU (1)	AU619201B2 (da)
CA (1)	CA1338607C (da)
DE (1)	DE3852065T2 (da)
DK (1)	DK116889A (da)
ES (1)	ES2067465T3 (da)
FI (1)	FI891191L (da)
HU (1)	HU207865B (da)
IE (1)	IE66466B1 (da)
IL (1)	IL87110A (da)
NO (1)	NO891044D0 (da)
NZ (1)	NZ225388A (da)
PT (1)	PT87985B (da)
WO (1)	WO1989000572A1 (da)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0300546B1 (en) *	1987-07-10	1995-08-09	Gist-Brocades N.V.	Process for the preparation of cephem compounds and cephalosporin derivatives
US5159071A (en) *	1990-09-06	1992-10-27	Ranbaxy Laboratories Limited	Process for the manufacture of 7-amino-3-exomethylene-3-cepham-4-carboxylic acid ester
US6248881B1 (en)	1991-03-08	2001-06-19	Biochemie Gmbh	Intermediates and process for the production of 3-vinyl cephalosporins
US5604222A (en)	1993-12-27	1997-02-18	Lupin Laboratories, Ltd.	Method for the preparation of 2-chloro sulfinyl azetidinones
US5578721A (en)	1994-07-11	1996-11-26	Lupin Laboratories Limited	Process for preparation of 3-exomethylene cepham sulfoxide esters
ATE195125T1 (de) *	1995-11-06	2000-08-15	Dsm Nv	Verfahren zur de-esterifikation

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4731443A (en) *	1979-11-19	1988-03-15	Fujisawa Pharmaceutical Co., Ltd.	7-acylamino-3-vinylcephalosporanic acid derivatives
US4354022A (en) *	1981-06-05	1982-10-12	Fujisawa Pharmaceutical Co., Ltd.	Process for preparing 3-methylenecepham compounds or a salt thereof
US4558123A (en) *	1983-07-22	1985-12-10	Eli Lilly And Company	3-Exomethylene cephalosporins
US4705851A (en) *	1984-09-28	1987-11-10	Fujisawa Pharmaceutical Co., Ltd.	Process for the preparation of 3-phosphoniummethyl-3-cephem compounds

1988
- 1988-07-13 US US07/337,525 patent/US4985554A/en not_active Expired - Fee Related
- 1988-07-13 NZ NZ225388A patent/NZ225388A/en unknown
- 1988-07-13 IE IE213788A patent/IE66466B1/en not_active IP Right Cessation
- 1988-07-13 HU HU884578A patent/HU207865B/hu not_active IP Right Cessation
- 1988-07-13 WO PCT/NL1988/000035 patent/WO1989000572A1/en not_active Ceased
- 1988-07-13 CN CN88106371A patent/CN1040441C/zh not_active Expired - Fee Related
- 1988-07-13 EP EP88201495A patent/EP0299587B1/en not_active Expired - Lifetime
- 1988-07-13 ES ES88201495T patent/ES2067465T3/es not_active Expired - Lifetime
- 1988-07-13 FI FI891191A patent/FI891191L/fi not_active IP Right Cessation
- 1988-07-13 AT AT88201495T patent/ATE113952T1/de not_active IP Right Cessation
- 1988-07-13 JP JP63506023A patent/JPH0742291B2/ja not_active Expired - Lifetime
- 1988-07-13 DE DE3852065T patent/DE3852065T2/de not_active Expired - Fee Related
- 1988-07-13 PT PT87985A patent/PT87985B/pt not_active IP Right Cessation
- 1988-07-13 AU AU20783/88A patent/AU619201B2/en not_active Ceased
- 1988-07-13 CA CA000571920A patent/CA1338607C/en not_active Expired - Fee Related
- 1988-07-13 KR KR1019890700458A patent/KR0137221B1/ko not_active Expired - Fee Related
- 1988-07-14 IL IL87110A patent/IL87110A/xx unknown
1989
- 1989-03-10 DK DK116889A patent/DK116889A/da not_active Application Discontinuation
- 1989-03-10 NO NO891044A patent/NO891044D0/no unknown
- 1989-12-27 US US07/457,253 patent/US4994454A/en not_active Expired - Fee Related
1990
- 1990-09-10 US US07/581,518 patent/US5109132A/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
US5109132A (en)	1992-04-28
FI891191A0 (fi)	1989-03-13
ES2067465T3 (es)	1995-04-01
HU207865B (en)	1993-06-28
JPH02500843A (ja)	1990-03-22
KR0137221B1 (ko)	1998-04-25
FI891191A7 (fi)	1989-03-13
IL87110A (en)	1993-04-04
DE3852065T2 (de)	1995-04-06
ATE113952T1 (de)	1994-11-15
NZ225388A (en)	1991-07-26
CA1338607C (en)	1996-09-24
WO1989000572A1 (en)	1989-01-26
AU619201B2 (en)	1992-01-23
PT87985A (pt)	1989-06-30
PT87985B (pt)	1995-03-01
DK116889D0 (da)	1989-03-10
HUT52512A (da)	1990-07-28
IL87110A0 (en)	1988-12-30
EP0299587A1 (en)	1989-01-18
US4985554A (en)	1991-01-15
FI891191L (fi)	1989-03-13
JPH0742291B2 (ja)	1995-05-10
KR890701593A (ko)	1989-12-21
NO891044L (no)	1989-03-10
US4994454A (en)	1991-02-19
IE882137L (en)	1989-01-13
IE66466B1 (en)	1995-12-27
CN1031534A (zh)	1989-03-08
EP0299587B1 (en)	1994-11-09
CN1040441C (zh)	1998-10-28
NO891044D0 (no)	1989-03-10
AU2078388A (en)	1989-02-13
DE3852065D1 (de)	1994-12-15

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Legal Events

Date	Code	Title	Description
1995-04-03	AHB	Application shelved due to non-payment