DK1173440T3 - Tetracycliske azepinoindolforbindelser som 5-HT receptorligander - Google Patents

Tetracycliske azepinoindolforbindelser som 5-HT receptorligander

Info

Publication number: DK1173440T3
Authority: DK; Denmark
Prior art keywords: azepinoindole; tetracyclic; compounds; receptor ligands; ligands
Prior art date: 1999-04-23

Application number

DK00923532T

Other languages

Danish (da)

English (en)

Inventor

Jackson B Hester Jr

Bruce N Rogers

Brad A Acker

Kristine E Frank

Michael Dalton Ennis

Velde Susan L Vander

E Jon Jacobsen

Original Assignee

Upjohn Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-04-23

Filing date

2000-04-20

Publication date

2004-12-20

2000-04-20 Application filed by Upjohn Co filed Critical Upjohn Co

2004-12-20 Application granted granted Critical

2004-12-20 Publication of DK1173440T3 publication Critical patent/DK1173440T3/da

Links

108091032151 5-hydroxytryptamine receptor family Proteins 0.000 title 1
102000014630 G protein-coupled serotonin receptor activity proteins Human genes 0.000 title 1
239000003446 ligand Substances 0.000 title 1
ISZIQZCZKOFSBT-UHFFFAOYSA-N pyrrolo[2,3-g][1]benzazepine Chemical class N1=CC=CC=C2C3=NC=CC3=CC=C21 ISZIQZCZKOFSBT-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/16—Peri-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/16—Peri-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D513/16—Peri-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Reproductive Health (AREA)
Immunology (AREA)
Endocrinology (AREA)
Pain & Pain Management (AREA)
Diabetes (AREA)
Hospice & Palliative Care (AREA)
Psychology (AREA)
Obesity (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Urology & Nephrology (AREA)
Addiction (AREA)
Otolaryngology (AREA)
Hematology (AREA)
Child & Adolescent Psychology (AREA)
Gynecology & Obstetrics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

DK00923532T 1999-04-23 2000-04-20 Tetracycliske azepinoindolforbindelser som 5-HT receptorligander DK1173440T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US13081199P	1999-04-23	1999-04-23
PCT/US2000/010600 WO2000064899A1 (en)	1999-04-23	2000-04-20	Tetracyclic azepinoindole compounds as 5-ht receptor ligands
EP00923532A EP1173440B1 (de)	1999-04-23	2000-04-20	Tetracyclische azepinoindol verbindungen als 5-ht rezeptor liganden

Publications (1)

Publication Number	Publication Date
DK1173440T3 true DK1173440T3 (da)	2004-12-20

Family

ID=22446459

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK00923532T DK1173440T3 (da)	1999-04-23	2000-04-20	Tetracycliske azepinoindolforbindelser som 5-HT receptorligander

Country Status (20)

Country	Link
EP (1)	EP1173440B1 (de)
JP (1)	JP2002543080A (de)
KR (1)	KR20020005708A (de)
CN (1)	CN1183132C (de)
AR (1)	AR023574A1 (de)
AT (1)	ATE276255T1 (de)
AU (1)	AU760943C (de)
BR (1)	BR0009983A (de)
CA (1)	CA2367682A1 (de)
DE (1)	DE60013803T2 (de)
DK (1)	DK1173440T3 (de)
EC (1)	ECSP003426A (de)
ES (1)	ES2226822T3 (de)
HK (1)	HK1045512B (de)
NZ (1)	NZ514553A (de)
PE (1)	PE20010052A1 (de)
PT (1)	PT1173440E (de)
SI (1)	SI1173440T1 (de)
WO (1)	WO2000064899A1 (de)
ZA (1)	ZA200108636B (de)

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Family Cites Families (3)

* Cited by examiner, † Cited by third party
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US3839357A (en) *	1966-05-10	1974-10-01	Upjohn Co	1,2,3,4,5,6-hexahydroazepino(4,5-b)indoles
US3676558A (en) *	1970-08-28	1972-07-11	Upjohn Co	Anorexigenic compositions comprising 6-alkyl-1,2,3,4,5,6-hexahydroazepino 4,5-indoles as active ingredient and process of treatment
EP0377238A1 (de) *	1988-12-22	1990-07-11	Duphar International Research B.V	Annelierte Indolo(3,2-c)-lactame

2000
- 2000-04-19 AR ARP000101881A patent/AR023574A1/es unknown
- 2000-04-19 PE PE2000000368A patent/PE20010052A1/es not_active Application Discontinuation
- 2000-04-20 KR KR1020017013458A patent/KR20020005708A/ko not_active Ceased
- 2000-04-20 BR BR0009983-0A patent/BR0009983A/pt not_active IP Right Cessation
- 2000-04-20 DK DK00923532T patent/DK1173440T3/da active
- 2000-04-20 WO PCT/US2000/010600 patent/WO2000064899A1/en not_active Ceased
- 2000-04-20 AU AU43637/00A patent/AU760943C/en not_active Ceased
- 2000-04-20 AT AT00923532T patent/ATE276255T1/de not_active IP Right Cessation
- 2000-04-20 PT PT00923532T patent/PT1173440E/pt unknown
- 2000-04-20 DE DE60013803T patent/DE60013803T2/de not_active Expired - Fee Related
- 2000-04-20 EP EP00923532A patent/EP1173440B1/de not_active Expired - Lifetime
- 2000-04-20 JP JP2000614251A patent/JP2002543080A/ja active Pending
- 2000-04-20 CN CNB008066639A patent/CN1183132C/zh not_active Expired - Fee Related
- 2000-04-20 NZ NZ514553A patent/NZ514553A/en unknown
- 2000-04-20 SI SI200030516T patent/SI1173440T1/xx unknown
- 2000-04-20 HK HK02107016.3A patent/HK1045512B/zh not_active IP Right Cessation
- 2000-04-20 ES ES00923532T patent/ES2226822T3/es not_active Expired - Lifetime
- 2000-04-20 CA CA002367682A patent/CA2367682A1/en not_active Abandoned
- 2000-04-27 EC EC2000003426A patent/ECSP003426A/es unknown
2001
- 2001-10-19 ZA ZA200108636A patent/ZA200108636B/en unknown

Also Published As

Publication number	Publication date
DE60013803T2 (de)	2005-11-17
AR023574A1 (es)	2002-09-04
CA2367682A1 (en)	2000-11-02
EP1173440A1 (de)	2002-01-23
SI1173440T1 (en)	2005-02-28
ECSP003426A (es)	2000-10-24
CN1183132C (zh)	2005-01-05
WO2000064899A1 (en)	2000-11-02
KR20020005708A (ko)	2002-01-17
ATE276255T1 (de)	2004-10-15
PT1173440E (pt)	2004-12-31
HK1045512B (zh)	2005-09-02
DE60013803D1 (de)	2004-10-21
EP1173440B1 (de)	2004-09-15
ZA200108636B (en)	2003-02-19
JP2002543080A (ja)	2002-12-17
BR0009983A (pt)	2002-04-16
HK1045512A1 (en)	2004-10-15
CN1348454A (zh)	2002-05-08
ES2226822T3 (es)	2005-04-01
AU760943B2 (en)	2003-05-22
PE20010052A1 (es)	2001-01-27
NZ514553A (en)	2003-10-31
AU4363700A (en)	2000-11-10
AU760943C (en)	2003-12-04

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