DK1178986T3 - Furanonderivater som inhibitorer af cathepsin S - Google Patents
Furanonderivater som inhibitorer af cathepsin SInfo
- Publication number
- DK1178986T3 DK1178986T3 DK00929721T DK00929721T DK1178986T3 DK 1178986 T3 DK1178986 T3 DK 1178986T3 DK 00929721 T DK00929721 T DK 00929721T DK 00929721 T DK00929721 T DK 00929721T DK 1178986 T3 DK1178986 T3 DK 1178986T3
- Authority
- DK
- Denmark
- Prior art keywords
- cathepsin
- inhibitors
- furanone derivatives
- furanone
- derivatives
- Prior art date
Links
- 108090000613 Cathepsin S Proteins 0.000 title 1
- 102100035654 Cathepsin S Human genes 0.000 title 1
- 150000002241 furanones Chemical class 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/22—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D307/85—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/14—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Furan Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9911417.5A GB9911417D0 (en) | 1999-05-18 | 1999-05-18 | Furanone derivatives as inhibitors of cathepsin s |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1178986T3 true DK1178986T3 (da) | 2004-07-05 |
Family
ID=10853598
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK00929721T DK1178986T3 (da) | 1999-05-18 | 2000-05-18 | Furanonderivater som inhibitorer af cathepsin S |
Country Status (16)
| Country | Link |
|---|---|
| EP (2) | EP1178986B1 (da) |
| JP (1) | JP2002544274A (da) |
| AR (1) | AR024040A1 (da) |
| AT (1) | ATE260274T1 (da) |
| AU (1) | AU763694B2 (da) |
| BR (1) | BR0010553A (da) |
| CA (1) | CA2374297A1 (da) |
| DE (1) | DE60008524T2 (da) |
| DK (1) | DK1178986T3 (da) |
| ES (1) | ES2215048T3 (da) |
| GB (1) | GB9911417D0 (da) |
| IL (2) | IL146409A0 (da) |
| MX (1) | MXPA01011872A (da) |
| MY (1) | MY130768A (da) |
| PT (1) | PT1178986E (da) |
| WO (1) | WO2000069855A2 (da) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2004512261A (ja) * | 2000-05-17 | 2004-04-22 | メディヴァー ユーケイ リミテッド | 分枝鎖アミノ酸 |
| DE60118793T2 (de) * | 2000-11-17 | 2007-04-26 | Medivir Ab | Cystein protease inhibitoren |
| US7030116B2 (en) | 2000-12-22 | 2006-04-18 | Aventis Pharmaceuticals Inc. | Compounds and compositions as cathepsin inhibitors |
| JP2004523506A (ja) | 2000-12-22 | 2004-08-05 | アクシス・ファーマシューティカルズ・インコーポレイテッド | カテプシン阻害剤としての新規な化合物と組成物 |
| WO2002057249A1 (en) * | 2001-01-17 | 2002-07-25 | Amura Therapeutics Limited | Cyclic 2-carbonylaminoketones as inhibitors of cruzipain and other cysteine proteases |
| US7132449B2 (en) * | 2001-01-17 | 2006-11-07 | Amura Therapeutics Limited | Inhibitors of cruzipain and other cysteine proteases |
| ATE356130T1 (de) | 2001-01-17 | 2007-03-15 | Amura Therapeutics Ltd | Inhibitoren von cruzipain und anderen cysteinproteasen |
| IL156776A0 (en) | 2001-01-17 | 2004-02-08 | Amura Therapeutics Ltd | Inhibitors of cruzipain and other cysteine proteases |
| RS19504A (sr) | 2001-09-14 | 2007-02-05 | Aventis Pharmaceuticals Inc., | Nova jedinjenja i kompozicije kao inhibitori katepsina |
| JP2005508979A (ja) * | 2001-10-29 | 2005-04-07 | ベーリンガー インゲルハイム ファーマシューティカルズ インコーポレイテッド | システインプロテアーゼの可逆性インヒビターとして有用な化合物 |
| HUP0401906A3 (en) | 2001-11-14 | 2008-07-28 | Aventis Pharma Inc | Novel cathepsin s inhibitors, process for their preparation and pharmaceutical compositions containing them |
| WO2003075853A2 (en) | 2002-03-08 | 2003-09-18 | Bristol-Myers Squibb Company | Cyclic derivatives as modulators of chemokine receptor activity |
| US20060100431A1 (en) * | 2002-07-16 | 2006-05-11 | Amura Therapeutics Limited | Biologically active compounds |
| MXPA05003254A (es) | 2002-09-24 | 2005-06-08 | Novartis Ag | Agonistas del receptor de esfingosina-1-fosfato en el tratamiento de trastornos de desmielinacion. |
| US7297714B2 (en) * | 2003-10-21 | 2007-11-20 | Irm Llc | Inhibitors of cathepsin S |
| WO2005082876A1 (en) * | 2004-03-01 | 2005-09-09 | Medivir Uk Ltd | C-5 substituted furanone dipeptide cathepsin s inhibitors |
| WO2006064286A1 (en) * | 2004-12-13 | 2006-06-22 | Medivir Uk Ltd | Cathepsin s inhibitors |
| GB0614042D0 (en) | 2006-07-14 | 2006-08-23 | Amura Therapeutics Ltd | Compounds |
| EP1916248A1 (en) * | 2006-10-24 | 2008-04-30 | Medivir Ab | Furanone derivatives as cysteine protease inhibitors |
| MY162041A (en) | 2007-02-28 | 2017-05-31 | Sanofi Aventis | Imaging probes |
| WO2009087379A2 (en) | 2008-01-09 | 2009-07-16 | Amura Therapeutics Limited | Tetrahydrofuro (3, 2 -b) pyrrol- 3 -one derivatives as inhibitors of cysteine proteinases |
| KR20180017232A (ko) | 2008-06-20 | 2018-02-20 | 노파르티스 아게 | 다발성 경화증을 치료하기 위한 소아용 조성물 |
| AU2020250933A1 (en) | 2019-04-05 | 2021-10-28 | Centre Hospitalier Régional Et Universitaire De Brest | Protease-activated receptor-2 inhibitors for the treatment of sensory neuropathy induced by a marine neurotoxic poisoning |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2111930A1 (en) * | 1992-12-25 | 1994-06-26 | Ryoichi Ando | Aminoketone derivatives |
| DK0912601T4 (da) * | 1996-04-22 | 2009-03-09 | Massachusetts Inst Technology | Suppression af immunrespons ved inhibering af cathepsin S |
| AR013079A1 (es) * | 1997-05-06 | 2000-12-13 | Smithkline Beecham Corp | Derivados sustituidos de tetrahidrofurano-3-onas, de tetrahidropirano-3- onas y tetrahidrotiofen-3-onas, un procedimiento para su preparacion unacomposicion farmaceutica de un medicamento util como inhibidores de proteasas e intermediarios |
-
1999
- 1999-05-18 GB GBGB9911417.5A patent/GB9911417D0/en not_active Ceased
-
2000
- 2000-05-17 MY MYPI20002178A patent/MY130768A/en unknown
- 2000-05-18 BR BR0010553-8A patent/BR0010553A/pt not_active IP Right Cessation
- 2000-05-18 AT AT00929721T patent/ATE260274T1/de not_active IP Right Cessation
- 2000-05-18 JP JP2000618272A patent/JP2002544274A/ja active Pending
- 2000-05-18 CA CA002374297A patent/CA2374297A1/en not_active Abandoned
- 2000-05-18 MX MXPA01011872A patent/MXPA01011872A/es active IP Right Grant
- 2000-05-18 IL IL14640988A patent/IL146409A0/xx unknown
- 2000-05-18 WO PCT/GB2000/001894 patent/WO2000069855A2/en not_active Ceased
- 2000-05-18 ES ES00929721T patent/ES2215048T3/es not_active Expired - Lifetime
- 2000-05-18 IL IL14640900A patent/IL146409A/xx not_active IP Right Cessation
- 2000-05-18 PT PT00929721T patent/PT1178986E/pt unknown
- 2000-05-18 DK DK00929721T patent/DK1178986T3/da active
- 2000-05-18 EP EP00929721A patent/EP1178986B1/en not_active Expired - Lifetime
- 2000-05-18 AU AU47722/00A patent/AU763694B2/en not_active Ceased
- 2000-05-18 DE DE60008524T patent/DE60008524T2/de not_active Expired - Fee Related
- 2000-05-18 EP EP20040002432 patent/EP1413580A1/en not_active Withdrawn
- 2000-05-19 AR ARP000102445A patent/AR024040A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| IL146409A (en) | 2005-11-20 |
| DE60008524T2 (de) | 2004-12-23 |
| AU763694B2 (en) | 2003-07-31 |
| GB9911417D0 (en) | 1999-07-14 |
| WO2000069855A2 (en) | 2000-11-23 |
| ATE260274T1 (de) | 2004-03-15 |
| EP1178986A2 (en) | 2002-02-13 |
| MY130768A (en) | 2007-07-31 |
| IL146409A0 (en) | 2002-07-25 |
| EP1178986B1 (en) | 2004-02-25 |
| WO2000069855A3 (en) | 2001-02-08 |
| AU4772200A (en) | 2000-12-05 |
| CA2374297A1 (en) | 2000-11-23 |
| JP2002544274A (ja) | 2002-12-24 |
| MXPA01011872A (es) | 2003-09-04 |
| PT1178986E (pt) | 2004-07-30 |
| EP1413580A1 (en) | 2004-04-28 |
| AR024040A1 (es) | 2002-09-04 |
| DE60008524D1 (de) | 2004-04-01 |
| BR0010553A (pt) | 2002-07-02 |
| ES2215048T3 (es) | 2004-10-01 |
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