DK1183236T3 - Cinnamoylaminoalkylsubstituerede benzensulfonamidderivater - Google Patents

Cinnamoylaminoalkylsubstituerede benzensulfonamidderivater

Info

Publication number
DK1183236T3
DK1183236T3 DK00938626T DK00938626T DK1183236T3 DK 1183236 T3 DK1183236 T3 DK 1183236T3 DK 00938626 T DK00938626 T DK 00938626T DK 00938626 T DK00938626 T DK 00938626T DK 1183236 T3 DK1183236 T3 DK 1183236T3
Authority
DK
Denmark
Prior art keywords
cinnamoylaminoalkyl
benzenesulfonamide derivatives
substituted benzenesulfonamide
substituted
derivatives
Prior art date
Application number
DK00938626T
Other languages
Danish (da)
English (en)
Inventor
Holger Heitsch
Heinrich Christian Englert
Klaus Wirth
Heinz Goegelein
Original Assignee
Aventis Pharma Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Gmbh filed Critical Aventis Pharma Gmbh
Application granted granted Critical
Publication of DK1183236T3 publication Critical patent/DK1183236T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
    • C07C311/52—Y being a hetero atom
    • C07C311/53—X and Y not being nitrogen atoms, e.g. N-sulfonylcarbamic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
    • C07C311/52—Y being a hetero atom
    • C07C311/54—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea
    • C07C311/57—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/58—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings having nitrogen atoms of the sulfonylurea groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/40—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of thiourea or isothiourea groups further bound to other hetero atoms
    • C07C335/42—Sulfonylthioureas; Sulfonylisothioureas
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DK00938626T 1999-05-20 2000-05-06 Cinnamoylaminoalkylsubstituerede benzensulfonamidderivater DK1183236T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19923086A DE19923086A1 (de) 1999-05-20 1999-05-20 Cinnamoylaminoalkyl-substituierte Benzolsulfonamidderivate, Verfahren zu ihrer Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
PCT/EP2000/004091 WO2000071513A1 (en) 1999-05-20 2000-05-06 Cinnamoylaminoalkyl-substituted benzenesulfonamide derivatives

Publications (1)

Publication Number Publication Date
DK1183236T3 true DK1183236T3 (da) 2004-02-23

Family

ID=7908577

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00938626T DK1183236T3 (da) 1999-05-20 2000-05-06 Cinnamoylaminoalkylsubstituerede benzensulfonamidderivater

Country Status (30)

Country Link
US (1) US6350778B1 (pl)
EP (1) EP1183236B1 (pl)
JP (1) JP4559640B2 (pl)
KR (1) KR100968729B1 (pl)
CN (1) CN1243730C (pl)
AR (1) AR035625A1 (pl)
AT (1) ATE252554T1 (pl)
AU (1) AU771675B2 (pl)
BR (1) BR0010821B1 (pl)
CA (1) CA2374226C (pl)
CZ (1) CZ302943B6 (pl)
DE (2) DE19923086A1 (pl)
DK (1) DK1183236T3 (pl)
EE (1) EE04611B1 (pl)
ES (1) ES2208342T3 (pl)
HK (1) HK1047574B (pl)
HR (1) HRP20010845B1 (pl)
HU (1) HU229041B1 (pl)
IL (2) IL146372A0 (pl)
ME (1) MEP41508A (pl)
MX (1) MXPA01011725A (pl)
NO (1) NO321558B1 (pl)
PL (1) PL201560B1 (pl)
PT (1) PT1183236E (pl)
RS (1) RS50172B (pl)
RU (1) RU2242462C2 (pl)
SK (1) SK287237B6 (pl)
TR (1) TR200103312T2 (pl)
WO (1) WO2000071513A1 (pl)
ZA (1) ZA200109481B (pl)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10054481A1 (de) 2000-11-03 2002-05-08 Aventis Pharma Gmbh Acylaminoalkyl-substituierte Benzolsulfonamidderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
DE10054482A1 (de) * 2000-11-03 2002-05-08 Aventis Pharma Gmbh Heteroarylacryloylaminoalkyl-substituierte Benzolsulfonamidderivate, ihre Herstellung, ihre Verwendung und sie enthaltende pharmazeutische Präparate
CN1237185C (zh) * 2003-06-04 2006-01-18 中国科学院上海药物研究所 Sars冠状病毒3cl蛋白酶三维结构模型与抗sars药物

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1185180B (de) 1963-10-19 1965-01-14 Hoechst Ag Verfahren zur Herstellung von Benzolsulfonylharnstoffen
DE1518874C3 (de) * 1964-10-07 1975-03-13 Farbwerke Hoechst Ag, Vormals Meister Lucius & Bruening, 6000 Frankfurt Benzolsulfonylharnstoffe und Verfahren zu ihrer Herstellung
DE1518816C3 (de) 1965-03-24 1975-05-22 Farbwerke Hoechst Ag, Vormals Meister Lucius & Bruening, 6000 Frankfurt Benzolsulfonylharnstoffe, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Präparate
DE1545810A1 (de) * 1965-05-06 1969-12-11 Hoechst Ag Verfahren zur Herstellung von Benzolsulfonylsemicarbaziden
US4066639A (en) 1965-05-06 1978-01-03 Hoechst Aktiengesellschaft Benzene-sulfonyl semicarbazides and process for preparing them
DE2413514C3 (de) * 1974-03-21 1982-03-04 Hoechst Ag, 6000 Frankfurt N-Acylaminoathylbenzolsulfonyl-N'-methylharnstoffe, Verfahren zu ihrer Herstellung und deren Verwendung
DE59401361D1 (de) 1993-02-23 1997-02-06 Hoechst Ag Substituierte Benzolsulfonylharnstoffe und -thioharnstoffe- Verfahren zu ihrer Herstellung und ihre Verwendung als Pharmazeutika
DE4341655A1 (de) 1993-12-07 1995-06-08 Hoechst Ag Aminosubstituierte Benzolsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung und ihre Verwendung als Pharmazeutika
JPH0826995A (ja) * 1994-07-22 1996-01-30 Nisshin Flour Milling Co Ltd ベンズイミダゾール誘導体を含有する抗不整脈剤
DE19505397A1 (de) * 1995-02-17 1996-08-22 Hoechst Ag Substituierte Benzolsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19832009A1 (de) 1998-07-16 2000-01-20 Hoechst Marion Roussel De Gmbh 2,5-Substituierte Benzolsulfonylharnstoffe und -thioharnstoffe, Verfahren zu ihrer Herstellung, ihre Verwendung und sie enthaltende pharamazeutische Präparate
HK1040187B (zh) 1998-09-10 2005-09-02 萨诺费－阿文蒂斯德国有限公司 苯磺酰(硫)脲與β-受體阻滯劑聯合在製備用於心臟迷走神經機能障礙治療和預防的藥物中的用途
US6632836B1 (en) * 1998-10-30 2003-10-14 Merck & Co., Inc. Carbocyclic potassium channel inhibitors
US6194458B1 (en) * 1998-10-30 2001-02-27 Merck & Co., Inc. Benzamide potassium channel inhibitors
US6303637B1 (en) * 1998-10-30 2001-10-16 Merck & Co., Inc. Heterocyclic potassium channel inhibitors

Also Published As

Publication number Publication date
RS50172B (sr) 2009-05-06
HRP20010845A2 (en) 2003-04-30
CN1360571A (zh) 2002-07-24
IL146372A0 (en) 2002-07-25
CZ302943B6 (cs) 2012-01-25
RU2242462C2 (ru) 2004-12-20
WO2000071513A1 (en) 2000-11-30
NO20015636L (no) 2002-01-15
MEP41508A (en) 2011-02-10
EP1183236B1 (en) 2003-10-22
CZ20014149A3 (cs) 2002-03-13
ATE252554T1 (de) 2003-11-15
HUP0201906A3 (en) 2005-04-28
EE04611B1 (et) 2006-04-17
HK1047574A1 (en) 2003-02-28
YU81701A (sh) 2004-07-15
KR20020005046A (ko) 2002-01-16
HK1047574B (zh) 2006-08-04
HRP20010845B1 (hr) 2010-08-31
PL351751A1 (en) 2003-06-16
PL201560B1 (pl) 2009-04-30
AR035625A1 (es) 2004-06-23
SK287237B6 (sk) 2010-04-07
TR200103312T2 (tr) 2002-04-22
MXPA01011725A (es) 2002-04-24
NO321558B1 (no) 2006-05-29
AU5393300A (en) 2000-12-12
AU771675B2 (en) 2004-04-01
DE19923086A1 (de) 2000-11-23
CA2374226C (en) 2010-08-31
JP4559640B2 (ja) 2010-10-13
HU229041B1 (hu) 2013-07-29
US6350778B1 (en) 2002-02-26
HRP20010845A9 (hr) 2010-06-30
PT1183236E (pt) 2004-03-31
HUP0201906A2 (en) 2002-09-28
NO20015636D0 (no) 2001-11-19
BR0010821B1 (pt) 2011-07-12
EE200100609A (et) 2003-02-17
DE60006104T2 (de) 2004-08-05
ZA200109481B (en) 2002-06-25
JP2003500388A (ja) 2003-01-07
IL146372A (en) 2007-05-15
KR100968729B1 (ko) 2010-07-08
CA2374226A1 (en) 2000-11-30
EP1183236A1 (en) 2002-03-06
DE60006104D1 (de) 2003-11-27
BR0010821A (pt) 2002-03-05
SK16692001A3 (sk) 2002-04-04
ES2208342T3 (es) 2004-06-16
CN1243730C (zh) 2006-03-01

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