DK11892D0 - Oxiranderivater og fremgangsmaade til fremstilling deraf - Google Patents

Oxiranderivater og fremgangsmaade til fremstilling deraf

Info

Publication number
DK11892D0
DK11892D0 DK92118A DK11892A DK11892D0 DK 11892 D0 DK11892 D0 DK 11892D0 DK 92118 A DK92118 A DK 92118A DK 11892 A DK11892 A DK 11892A DK 11892 D0 DK11892 D0 DK 11892D0
Authority
DK
Denmark
Prior art keywords
oxirand
procedures
derivatives
preparing
oxirand derivatives
Prior art date
Application number
DK92118A
Other languages
English (en)
Other versions
DK165321B (da
DK165321C (da
DK11892A (da
Inventor
Guy Rosalia Eugene Van Lommen
Marcel Frans Leopold De Bruyn
Marc Francis Josephin Schroven
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of DK11892A publication Critical patent/DK11892A/da
Publication of DK11892D0 publication Critical patent/DK11892D0/da
Publication of DK165321B publication Critical patent/DK165321B/da
Application granted granted Critical
Publication of DK165321C publication Critical patent/DK165321C/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D407/00Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D407/00Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/04Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/81Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/66Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D311/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78Ring systems having three or more relevant rings
    • C07D311/92Naphthopyrans; Hydrogenated naphthopyrans

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK011892A 1983-12-05 1992-01-31 Oxiranderivater og fremgangsmaade til fremstilling deraf DK165321C (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US55808183A 1983-12-05 1983-12-05
US55808183 1983-12-05

Publications (4)

Publication Number Publication Date
DK11892A DK11892A (da) 1992-01-31
DK11892D0 true DK11892D0 (da) 1992-01-31
DK165321B DK165321B (da) 1992-11-09
DK165321C DK165321C (da) 1993-03-29

Family

ID=24228139

Family Applications (2)

Application Number Title Priority Date Filing Date
DK577084A DK165112C (da) 1983-12-05 1984-12-04 2,2'-iminobisethanolderivater, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat indeholdende disse
DK011892A DK165321C (da) 1983-12-05 1992-01-31 Oxiranderivater og fremgangsmaade til fremstilling deraf

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK577084A DK165112C (da) 1983-12-05 1984-12-04 2,2'-iminobisethanolderivater, fremgangsmaade til fremstilling deraf og farmaceutisk praeparat indeholdende disse

Country Status (32)

Country Link
EP (1) EP0145067B1 (da)
JP (1) JPS60132977A (da)
KR (1) KR870000923B1 (da)
AR (1) AR241414A1 (da)
AT (1) ATE40361T1 (da)
AU (1) AU573658B2 (da)
BG (1) BG43866A3 (da)
CA (1) CA1337429C (da)
CS (1) CS250242B2 (da)
CY (1) CY1609A (da)
DD (1) DD235453A5 (da)
DE (1) DE3476388D1 (da)
DK (2) DK165112C (da)
DZ (1) DZ712A1 (da)
ES (1) ES8603870A1 (da)
FI (1) FI82460C (da)
GR (1) GR81098B (da)
HK (1) HK52791A (da)
HU (1) HU202219B (da)
IE (1) IE57831B1 (da)
IL (1) IL73706A (da)
MA (1) MA20292A1 (da)
NO (2) NO169839C (da)
NZ (1) NZ210388A (da)
PH (1) PH22432A (da)
PL (1) PL146342B1 (da)
PT (1) PT79609B (da)
RO (1) RO91184B (da)
SG (1) SG47091G (da)
SU (1) SU1428199A3 (da)
ZA (1) ZA849445B (da)
ZW (1) ZW19784A1 (da)

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ES2212797T3 (es) * 1993-08-19 2004-08-01 Janssen Pharmaceutica N.V. Derivados de dihidrobenzopirano vasoconstrictores.
TW355683B (en) * 1994-02-17 1999-04-11 Janssen Pharmaceutica Nv Composition containing micronized nebivolol
ATE210657T1 (de) * 1994-10-14 2001-12-15 Merck Patent Gmbh Zns wirksames (r)-(-)-2-(5-(4-fluorophenyl)-3- pyridylmethylaminomethyl)chroman
JP3454832B2 (ja) * 1996-06-07 2003-10-06 バンダービルト ユニバーシティ 抗炎症剤として有用なジヒドロベンゾピランおよび関連化合物
JP2001526282A (ja) * 1997-12-19 2001-12-18 バイエル・コーポレーシヨン β−3アドレナリン受容体作用薬として有用なカルボキシル置換クロマン誘導体
US6541669B1 (en) 1998-06-08 2003-04-01 Theravance, Inc. β2-adrenergic receptor agonists
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UA73981C2 (en) 2000-03-10 2005-10-17 Merck Patent Gmbh (r)-(-)-2-[5-(4-fluorophenyl)-3-pyridylmethylaminomethyl]-chromane for treatment of extrapyramidal movement disorders (variants), pharmaceutical composition and kit
WO2002087508A2 (en) 2001-05-02 2002-11-07 Nitromed, Inc. Nitrosated and nitrosylated nebivolol and its metabolites, compositions and methods of use
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EP1741712B1 (en) 2004-07-30 2011-06-15 Torrent Pharmaceuticals Ltd amorphous form of nebivolol hydrochloride and its preparation
PL1776354T3 (pl) * 2004-08-11 2010-09-30 Hetero Drugs Ltd Nowy sposób wytwarzania związków pośrednich nebiwololu
CN100341866C (zh) * 2004-08-30 2007-10-10 中国科学院理化技术研究所 α,α’-[亚氨基二(亚甲基)]-双-(6-氟-3,4-二氢-2H-1-苯并吡喃-2-甲醇)甲烷磺酸盐的合成方法
JP2008528626A (ja) * 2005-01-31 2008-07-31 マイラン ラボラトリーズ インク. ヒドロキシル化されたネビボロールを含む薬学的組成物
KR101390563B1 (ko) * 2005-01-31 2014-04-30 밀란 인크. 글루쿠로니드화된 네비볼롤
WO2006084684A1 (de) * 2005-02-11 2006-08-17 Stada Arzneimittel Ag Pharmazeutische zusammensetzungen nebivolo und ein hydrophiles polymer
AT502220A1 (de) * 2005-07-19 2007-02-15 Pharmacon Forschung & Beratung Verfahren zur herstellung von nebivolol
RU2392277C2 (ru) * 2005-12-28 2010-06-20 Асино Фарма Аг Способ получения рацемического небиволола
EP1803716B1 (en) * 2005-12-28 2012-07-25 Acino Pharma AG A process for preparation of racemic nebivolol
US7560575B2 (en) 2005-12-28 2009-07-14 Acino Pharma Ag Process for preparation of racemic Nebivolol
WO2007083318A1 (en) 2006-01-18 2007-07-26 Hetero Drugs Limited Process for isolation of desired isomers of nebivolol intermediates
ITMI20061889A1 (it) * 2006-10-03 2008-04-04 Zambon Spa Processo di preparazione di nebivololo
ES2346371T3 (es) 2006-11-27 2010-10-14 Zach System S.P.A. Proceso para la preparacion de nebivolol.
WO2008089549A1 (en) 2007-01-22 2008-07-31 Genpharm Ulc Pharmaceutical compositions comprising nebivolol or a nebivolol analogue
CN101463024B (zh) 2007-12-21 2011-06-08 上海现代制药股份有限公司 一种制备rrrs和sssr型的奈必洛尔中间体混合物的方法
ITMI20080547A1 (it) * 2008-03-31 2009-10-01 Zach System Spa Processo di preparazione di nebivololo
IT1392067B1 (it) * 2008-10-31 2012-02-09 Zach System Spa Processo di preparazione di nebivololo
IT1395354B1 (it) * 2009-07-23 2012-09-14 Zach System Spa Processo di preparazione di nebivololo
DE102010005953A1 (de) 2010-01-27 2011-07-28 Corden PharmaChem GmbH, 68305 Verfahren zur Herstellung von Nebivolol
IT1397962B1 (it) 2010-02-11 2013-02-04 Menarini Int Operations Lu Sa Processo per la preparazione del nebivololo.
IT1402974B1 (it) 2010-11-30 2013-09-27 Menarini Int Operations Lu Sa Processo per la preparazione del nebivololo.
ITRM20110418A1 (it) 2011-08-02 2013-02-03 Menarini Int Operations Lu Sa Processo per la preparazione di epossidi quali intermedi per la sintesi del nebivololo.
ES2700973T3 (es) 2014-02-14 2019-02-20 Corden Pharma Int Gmbh Proceso sin base para la preparación de compuestos intermedios de cetona que se pueden usar para fabricar nebivolol
EP2907810A1 (en) 2014-02-14 2015-08-19 Corden Pharma International GmbH A new method for producing nebivolol hydrochloride of high purity
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EP3299364B1 (en) 2015-05-19 2021-10-20 Zhejiang Ausun Pharmaceutical Co., Ltd. Nebivolol synthesis method and intermediate compound thereof
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Also Published As

Publication number Publication date
HU202219B (en) 1991-02-28
FI844777A0 (fi) 1984-12-04
ZA849445B (en) 1986-07-30
NO169839B (no) 1992-05-04
EP0145067A2 (en) 1985-06-19
RO91184A (ro) 1987-07-30
HK52791A (en) 1991-07-19
JPS60132977A (ja) 1985-07-16
PH22432A (en) 1988-09-12
DK165112B (da) 1992-10-12
EP0145067B1 (en) 1989-01-25
ES538256A0 (es) 1986-01-01
DK165321B (da) 1992-11-09
KR870000923B1 (ko) 1987-05-07
DK165112C (da) 1993-03-01
CY1609A (en) 1992-04-03
GR81098B (en) 1984-12-17
KR850004485A (ko) 1985-07-15
DK165321C (da) 1993-03-29
MA20292A1 (fr) 1985-07-01
CS250242B2 (en) 1987-04-16
RO91184B (ro) 1987-07-31
HUT37418A (en) 1985-12-28
SG47091G (en) 1991-07-26
IL73706A0 (en) 1985-03-31
SU1428199A3 (ru) 1988-09-30
DD235453A5 (de) 1986-05-07
NO169839C (no) 1992-08-12
JPH0250114B2 (da) 1990-11-01
IE843103L (en) 1985-06-05
ES8603870A1 (es) 1986-01-01
FI844777L (fi) 1985-06-06
FI82460B (fi) 1990-11-30
IL73706A (en) 1988-07-31
FI82460C (fi) 1991-03-11
AU573658B2 (en) 1988-06-16
PT79609A (en) 1985-01-01
DK577084A (da) 1985-06-06
CA1337429C (en) 1995-10-24
DK11892A (da) 1992-01-31
EP0145067A3 (en) 1986-03-26
DE3476388D1 (en) 1989-03-02
NZ210388A (en) 1987-07-31
PT79609B (en) 1986-12-12
PL250524A1 (en) 1986-02-25
PL146342B1 (en) 1989-01-31
DK577084D0 (da) 1984-12-04
BG43866A3 (en) 1988-08-15
IE57831B1 (en) 1993-04-21
ATE40361T1 (de) 1989-02-15
AU3632684A (en) 1985-06-13
AR241414A1 (es) 1992-07-31
NO844845L (no) 1985-06-06
DZ712A1 (fr) 2004-09-13
NO2004007I2 (no) 2005-05-09
NO2004007I1 (no) 2004-12-20
ZW19784A1 (en) 1986-07-02

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