ATE352302T1 - Verwendung von 2- 5-(4-fluorphenyl)-3- pyridylmethylaminomethyl-chroman und seiner physiologisch annehmbaren salze - Google Patents

Verwendung von 2- 5-(4-fluorphenyl)-3- pyridylmethylaminomethyl-chroman und seiner physiologisch annehmbaren salze

Info

Publication number
ATE352302T1
ATE352302T1 AT02790172T AT02790172T ATE352302T1 AT E352302 T1 ATE352302 T1 AT E352302T1 AT 02790172 T AT02790172 T AT 02790172T AT 02790172 T AT02790172 T AT 02790172T AT E352302 T1 ATE352302 T1 AT E352302T1
Authority
AT
Austria
Prior art keywords
pyridylmethylaminomethyl
chromane
fluorophenyl
acceptable salts
physiologically acceptable
Prior art date
Application number
AT02790172T
Other languages
English (en)
Inventor
Gerd Bartoszyk
Hermann Russ
Christoph Seyfried
Frank Weber
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Application granted granted Critical
Publication of ATE352302T1 publication Critical patent/ATE352302T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT02790172T 2001-07-26 2002-07-10 Verwendung von 2- 5-(4-fluorphenyl)-3- pyridylmethylaminomethyl-chroman und seiner physiologisch annehmbaren salze ATE352302T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP01118097 2001-07-26

Publications (1)

Publication Number Publication Date
ATE352302T1 true ATE352302T1 (de) 2007-02-15

Family

ID=8178137

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02790172T ATE352302T1 (de) 2001-07-26 2002-07-10 Verwendung von 2- 5-(4-fluorphenyl)-3- pyridylmethylaminomethyl-chroman und seiner physiologisch annehmbaren salze

Country Status (23)

Country Link
US (1) US7872030B2 (de)
EP (1) EP1408964B1 (de)
JP (1) JP2004538289A (de)
KR (1) KR20040029325A (de)
CN (1) CN1292749C (de)
AR (1) AR037496A1 (de)
AT (1) ATE352302T1 (de)
AU (1) AU2002355170B2 (de)
BR (1) BR0211358A (de)
CA (1) CA2455621C (de)
CY (1) CY1107616T1 (de)
DE (1) DE60217870T2 (de)
DK (1) DK1408964T3 (de)
ES (1) ES2280602T3 (de)
HU (1) HUP0402092A3 (de)
MX (1) MXPA04000775A (de)
MY (1) MY134059A (de)
PE (1) PE20030277A1 (de)
PL (1) PL208258B1 (de)
PT (1) PT1408964E (de)
RU (1) RU2297833C2 (de)
SI (1) SI1408964T1 (de)
WO (1) WO2003009835A2 (de)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007013830A1 (en) 2005-07-26 2007-02-01 Portela & Ca. S.A. Nitrocatechol derivatives as comt inhibitors
EP2422819B1 (de) 2006-01-26 2017-03-01 Ionis Pharmaceuticals, Inc. Zusammensetzung und deren Verwendungen in Bezug auf Huntingtin
EP1845097A1 (de) * 2006-04-10 2007-10-17 Portela & Ca., S.A. Oxadiazolderivate als COMT Inihibitoren
DK2481410T3 (en) 2007-01-31 2016-10-24 Bial - Portela & Ca S A Nitrocatecholderivater as COMT inhibitors administered in a specific dosage regimen
BRPI0908731A2 (pt) 2008-03-17 2017-05-16 Bial - Portela & C A S A formas cristalinas de 5-[3-(2,5-dicloro-4,6-dimetil-1-óxi-piridina-3-il)[1,2,4]oxadiazol-5-il]-3-nitrobenzeno-1,2-diol
CN102448444B (zh) 2009-04-01 2016-05-25 巴尔-波特拉及康邦亚股份有限公司 包括硝基儿茶酚衍生物的药物制剂及其制备方法
EP3626823A1 (de) 2009-09-11 2020-03-25 Ionis Pharmaceuticals, Inc. Modulation der huntingtin-expression
US20140045900A1 (en) 2011-02-11 2014-02-13 Bial-Portela & Ca, S.A. Administration regime for nitrocatechols
US9126988B2 (en) 2011-12-13 2015-09-08 Bial—Portela & Ca, S.A. Intermediate for preparing a catechol-O-methyltransferase inhibitor
WO2016083863A1 (en) 2014-11-28 2016-06-02 Bial - Portela & Ca, S.A. Medicaments for slowing parkinson's disease

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CA1337429C (en) 1983-12-05 1995-10-24 Guy Rosalia Eugene Van Lommen Derivatives of 2,2'-iminobisethanol
SE460947B (sv) * 1986-08-26 1989-12-11 Lejus Medical Ab En multiple-unit-dos komposition av l-dopa
DE3901814A1 (de) * 1988-07-28 1990-02-01 Bayer Ag Substituierte aminomethylzetraline sowie ihre heterocyclischen analoga
ATE145208T1 (de) * 1990-07-06 1996-11-15 Yoshitomi Pharmaceutical Kondensierte thiophenverbindungen und deren verwendung
DE4135474A1 (de) 1991-10-28 1993-04-29 Bayer Ag 2-aminomethyl-chromane
US5314888A (en) * 1992-02-21 1994-05-24 Trustees Of Tufts College Veterinary method for treating inappropriate elimination of urine in household pets
SI9300097B (en) 1992-02-27 2001-12-31 Janssen Pharmaceutica Nv (benzodioxan, benzofuran or benzopyran) alkylamino) alkyl substituted guanidines
AU3929493A (en) 1992-03-11 1993-10-05 Interneuron Pharmaceuticals, Inc. Reducing post-prandial fluctuations in plasma concentrations of large neutral amino acids (lnaa)
DE4226527A1 (de) 1992-08-11 1994-02-17 Merck Patent Gmbh 1,4-Benzodioxanderivate
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BR9408506A (pt) * 1994-01-31 1997-08-05 Pfizer Compostos neuroprotetores
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ES2169102T3 (es) * 1994-10-14 2002-07-01 Merck Patent Gmbh (r)-(-)-2-(5-(4-fluorfenil)-3-piridilmetilaminometil)-cromano como agente activo sobre el sistema nervioso central.
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DE69819266T2 (de) * 1997-09-02 2004-07-29 Duphar International Research B.V. Piperidin- und Piperazin Derivate als 5-HT1-Rezeptor-Agonisten
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Also Published As

Publication number Publication date
PL367291A1 (en) 2005-02-21
RU2004105844A (ru) 2005-05-10
MXPA04000775A (es) 2004-04-20
KR20040029325A (ko) 2004-04-06
AU2002355170B2 (en) 2007-06-07
CA2455621C (en) 2010-11-16
SI1408964T1 (sl) 2007-06-30
DE60217870T2 (de) 2007-11-15
HUP0402092A2 (hu) 2005-02-28
MY134059A (en) 2007-11-30
DK1408964T3 (da) 2007-05-21
US20040171645A1 (en) 2004-09-02
CN1292749C (zh) 2007-01-03
DE60217870D1 (de) 2007-03-15
EP1408964A2 (de) 2004-04-21
BR0211358A (pt) 2004-09-21
WO2003009835A2 (en) 2003-02-06
HUP0402092A3 (en) 2010-06-28
PE20030277A1 (es) 2003-03-25
HK1068793A1 (en) 2005-07-29
PL208258B1 (pl) 2011-04-29
CA2455621A1 (en) 2003-02-06
PT1408964E (pt) 2007-05-31
CY1107616T1 (el) 2013-03-13
ES2280602T3 (es) 2007-09-16
WO2003009835A3 (en) 2003-08-07
EP1408964B1 (de) 2007-01-24
US7872030B2 (en) 2011-01-18
AR037496A1 (es) 2004-11-17
JP2004538289A (ja) 2004-12-24
RU2297833C2 (ru) 2007-04-27
CN1535150A (zh) 2004-10-06

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