DK1189886T3 - Ethansulfonyl-piperidinderivater - Google Patents

Ethansulfonyl-piperidinderivater

Info

Publication number: DK1189886T3
Authority: DK; Denmark
Prior art keywords: ethanesulfonyl; piperidine derivatives; piperidine; derivatives
Prior art date: 1999-06-08

Application number

DK00936835T

Other languages

English (en)

Inventor

Neidhart Marie-Paule Heitz

Georg Jaeschke

Emmanuel Pinard

Rene Wyler

Serge Burner

Bernd Buettelmann

Alexander Alanine

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-06-08

Filing date

2000-05-31

Publication date

2006-05-15

2000-05-31 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2006-05-15 Application granted granted Critical

2006-05-15 Publication of DK1189886T3 publication Critical patent/DK1189886T3/da

Links

GZJHPGLSIOWQJE-UHFFFAOYSA-N 1-ethylsulfonylpiperidine Chemical class CCS(=O)(=O)N1CCCCC1 GZJHPGLSIOWQJE-UHFFFAOYSA-N 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/54—Sulfur atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
- C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/42—Oxygen atoms attached in position 3 or 5

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Psychiatry (AREA)
Psychology (AREA)
Pain & Pain Management (AREA)
Hospice & Palliative Care (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Hydrogenated Pyridines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK00936835T 1999-06-08 2000-05-31 Ethansulfonyl-piperidinderivater DK1189886T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP99111126		1999-06-08

Publications (1)

Publication Number	Publication Date
DK1189886T3 true DK1189886T3 (da)	2006-05-15

Family

ID=8238316

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK00936835T DK1189886T3 (da)	1999-06-08	2000-05-31	Ethansulfonyl-piperidinderivater

Country Status (38)

Country	Link
US (1)	US6310213B1 (da)
EP (1)	EP1189886B1 (da)
JP (1)	JP3645856B2 (da)
KR (1)	KR100571162B1 (da)
CN (1)	CN1142141C (da)
AR (1)	AR024282A1 (da)
AT (1)	ATE315025T1 (da)
AU (1)	AU770787B2 (da)
BR (1)	BR0011419A (da)
CA (1)	CA2376091C (da)
CO (1)	CO5160328A1 (da)
CZ (1)	CZ299483B6 (da)
DE (1)	DE60025348T2 (da)
DK (1)	DK1189886T3 (da)
EG (1)	EG26101A (da)
ES (1)	ES2254183T3 (da)
GC (1)	GC0000256A (da)
GT (1)	GT200000089A (da)
HK (1)	HK1046412B (da)
HR (1)	HRP20010885B1 (da)
HU (1)	HU228591B1 (da)
IL (2)	IL146750A0 (da)
JO (1)	JO2260B1 (da)
MA (1)	MA26797A1 (da)
MX (1)	MXPA01012585A (da)
MY (1)	MY128818A (da)
NO (1)	NO320613B1 (da)
PA (1)	PA8496601A1 (da)
PE (1)	PE20010218A1 (da)
PL (1)	PL196053B1 (da)
RS (1)	RS50033B (da)
RU (1)	RU2242464C2 (da)
SI (1)	SI1189886T1 (da)
TN (1)	TNSN00125A1 (da)
TR (1)	TR200103532T2 (da)
TW (1)	TWI254043B (da)
WO (1)	WO2000075109A1 (da)
ZA (1)	ZA200109706B (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE60104923T2 (de)	2000-03-22	2005-08-25	F. Hoffmann-La Roche Ag	Piperidin- und Pirazinverbindungen zur Verwendung in der Behandlung von Alzheimer
ES2225553T3 (es) *	2000-04-20	2005-03-16	F. Hoffmann-La Roche Ag	Derivados de pirrolidina y piperidina y su empleo para el tratamiento de trastornos neurodegenerativos.
PE20020291A1 (es) *	2000-08-21	2002-04-17	Hoffmann La Roche	Profarmacos para ligandos del receptor nmda
EP1332363A4 (en) *	2000-10-09	2007-08-29	Kay Double	PROOF OF NEURODEGENERATIVE DISEASES
US6951875B2 (en) *	2001-10-29	2005-10-04	Hoffmann-La Roche Inc.	Conjugated aromatic compounds with a pyridine substituent
US7005432B2 (en) *	2002-05-16	2006-02-28	Hoffman-La Roche Inc.	Substituted imidazol-pyridazine derivatives
RU2268715C1 (ru) *	2004-06-22	2006-01-27	ГУ "Научно-исследовательский институт экспериментальной медицины" РАМН (ГУ НИИЭМ РАМН)	Нейропротекторное средство
WO2009118187A1 (en) *	2008-03-27	2009-10-01	Evotec Neurosciences Gmbh	Methods for treating disorders using nmda nr2b-subtype selective antagonist
CA2842183A1 (en) *	2011-07-18	2013-01-24	Adolor Corporation	Processes for the preparation of peripheral opioid antagonist compounds and intermediates thereto
CN119233970B (zh) *	2023-04-20	2025-08-29	纽欧申医药(上海)有限公司	含氮杂环类化合物及其制备方法和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2571904B2 (ja) *	1991-07-17	1997-01-16	フアイザー・インコーポレイテツド	抗虚血剤としての２−（４−ヒドロキシピペリジノ）−１−アルカノール誘導体
DE4410822A1 (de) *	1994-03-24	1995-09-28	Schering Ag	Neue Piperidin-Derivate
ZA9610745B (en) *	1995-12-22	1997-06-24	Warner Lambert Co	4-Subsituted piperidine analogs and their use as subtype selective nmda receptor antagonists
TW498067B (en) *	1996-07-19	2002-08-11	Hoffmann La Roche	4-hydroxy-piperidine derivatives

2000
- 2000-05-24 TW TW089109992A patent/TWI254043B/zh not_active IP Right Cessation
- 2000-05-31 ES ES00936835T patent/ES2254183T3/es not_active Expired - Lifetime
- 2000-05-31 KR KR1020017015765A patent/KR100571162B1/ko not_active Expired - Fee Related
- 2000-05-31 HU HU0201916A patent/HU228591B1/hu not_active IP Right Cessation
- 2000-05-31 RU RU2001135806/04A patent/RU2242464C2/ru not_active IP Right Cessation
- 2000-05-31 CA CA002376091A patent/CA2376091C/en not_active Expired - Fee Related
- 2000-05-31 CN CNB008086028A patent/CN1142141C/zh not_active Expired - Fee Related
- 2000-05-31 EP EP00936835A patent/EP1189886B1/en not_active Expired - Lifetime
- 2000-05-31 WO PCT/EP2000/004953 patent/WO2000075109A1/en not_active Ceased
- 2000-05-31 HK HK02108022.3A patent/HK1046412B/zh not_active IP Right Cessation
- 2000-05-31 CZ CZ20014349A patent/CZ299483B6/cs not_active IP Right Cessation
- 2000-05-31 MX MXPA01012585A patent/MXPA01012585A/es active IP Right Grant
- 2000-05-31 RS YUP-865/01A patent/RS50033B/sr unknown
- 2000-05-31 AT AT00936835T patent/ATE315025T1/de active
- 2000-05-31 DE DE60025348T patent/DE60025348T2/de not_active Expired - Lifetime
- 2000-05-31 DK DK00936835T patent/DK1189886T3/da active
- 2000-05-31 BR BR0011419-7A patent/BR0011419A/pt not_active Application Discontinuation
- 2000-05-31 HR HR20010885A patent/HRP20010885B1/xx not_active IP Right Cessation
- 2000-05-31 PL PL00352723A patent/PL196053B1/pl unknown
- 2000-05-31 SI SI200030793T patent/SI1189886T1/sl unknown
- 2000-05-31 IL IL14675000A patent/IL146750A0/xx active IP Right Grant
- 2000-05-31 JP JP2001501590A patent/JP3645856B2/ja not_active Expired - Fee Related
- 2000-05-31 TR TR2001/03532T patent/TR200103532T2/xx unknown
- 2000-05-31 AU AU52181/00A patent/AU770787B2/en not_active Ceased
- 2000-06-02 PE PE2000000547A patent/PE20010218A1/es not_active Application Discontinuation
- 2000-06-02 US US09/585,755 patent/US6310213B1/en not_active Expired - Lifetime
- 2000-06-03 TN TNTNSN00125A patent/TNSN00125A1/fr unknown
- 2000-06-05 AR ARP000102775A patent/AR024282A1/es active IP Right Grant
- 2000-06-05 PA PA20008496601A patent/PA8496601A1/es unknown
- 2000-06-05 EG EG2000060739A patent/EG26101A/en active
- 2000-06-06 MY MYPI20002522A patent/MY128818A/en unknown
- 2000-06-07 GT GT200000089A patent/GT200000089A/es unknown
- 2000-06-07 JO JO200087A patent/JO2260B1/en active
- 2000-06-07 GC GCP2000702 patent/GC0000256A/en active
- 2000-06-07 CO CO00042340A patent/CO5160328A1/es unknown
2001
- 2001-11-26 IL IL146750A patent/IL146750A/en not_active IP Right Cessation
- 2001-11-26 ZA ZA200109706A patent/ZA200109706B/en unknown
- 2001-12-04 NO NO20015920A patent/NO320613B1/no not_active IP Right Cessation
- 2001-12-07 MA MA26438A patent/MA26797A1/fr unknown

Also Published As

Publication number	Publication date
WO2000075109A1 (en)	2000-12-14
HRP20010885B1 (en)	2010-07-31
CO5160328A1 (es)	2002-05-30
CN1354745A (zh)	2002-06-19
MY128818A (en)	2007-02-28
NO20015920D0 (no)	2001-12-04
YU86501A (sh)	2004-09-03
KR100571162B1 (ko)	2006-04-17
RS50033B (sr)	2008-11-28
TNSN00125A1 (fr)	2005-11-10
EG26101A (en)	2013-02-17
KR20020008850A (ko)	2002-01-31
NO320613B1 (no)	2005-12-27
PL196053B1 (pl)	2007-11-30
DE60025348T2 (de)	2006-08-24
NO20015920L (no)	2001-12-04
JP2003501415A (ja)	2003-01-14
IL146750A (en)	2006-12-10
EP1189886B1 (en)	2006-01-04
DE60025348D1 (de)	2006-03-30
MA26797A1 (fr)	2004-12-20
CZ20014349A3 (cs)	2002-05-15
PE20010218A1 (es)	2001-02-28
CA2376091C (en)	2006-03-14
CA2376091A1 (en)	2000-12-14
BR0011419A (pt)	2002-02-26
ATE315025T1 (de)	2006-02-15
MXPA01012585A (es)	2002-04-10
AU770787B2 (en)	2004-03-04
PA8496601A1 (es)	2001-12-14
HUP0201916A2 (en)	2002-10-28
SI1189886T1 (sl)	2006-04-30
PL352723A1 (en)	2003-09-08
ES2254183T3 (es)	2006-06-16
IL146750A0 (en)	2002-07-25
JP3645856B2 (ja)	2005-05-11
HU228591B1 (hu)	2013-04-29
HK1046412B (zh)	2004-07-09
RU2242464C2 (ru)	2004-12-20
HK1046412A1 (en)	2003-01-10
AU5218100A (en)	2000-12-28
ZA200109706B (en)	2003-02-26
HUP0201916A3 (en)	2003-05-28
CN1142141C (zh)	2004-03-17
GC0000256A (en)	2006-11-01
US6310213B1 (en)	2001-10-30
HRP20010885A2 (en)	2004-02-29
TR200103532T2 (tr)	2002-05-21
CZ299483B6 (cs)	2008-08-13
GT200000089A (es)	2001-11-29
AR024282A1 (es)	2002-09-25
EP1189886A1 (en)	2002-03-27
JO2260B1 (en)	2004-10-07
TWI254043B (en)	2006-05-01

Publication	Publication Date	Title
IS5381A (is)	2000-08-25	4-fenyl-pyridin afleiður
NO20021077D0 (no)	2002-03-05	Amino-triazolopyridin-derivater
ATE293104T1 (de)	2005-04-15	Thiazolylamid-derivate
DE60009747D1 (de)	2004-05-13	Admantan-derivate
EE200100613A (et)	2003-02-17	13-metüülerütromütsiini derivaadid
DK1187814T3 (da)	2004-12-20	5-phenyl-pyrimidinderivater
DK1202953T3 (da)	2006-12-27	Substituerede 2-dialkylaminoalkylbiphenylderivater
NO20021803D0 (no)	2002-04-17	Isoksazolkarboksamid-derivater
PT1237857E (pt)	2004-10-29	Novos derivados fenalquiloxi-fenilo
ATE257148T1 (de)	2004-01-15	Propargyletherderivate
ATE374747T1 (de)	2007-10-15	Monofluoralkylderivate
DK1154988T3 (da)	2004-11-22	Mevinolinderivater
ATE293592T1 (de)	2005-05-15	Resorcinderivate
DE60006703D1 (de)	2003-12-24	4-hydroxybiphenylhydrazid-derivate
DK1187815T3 (da)	2006-06-19	4-phenyl-pyrimidinderivater
TR200002831A3 (tr)	2001-04-20	Kinolin-4-Il türevleri I
DK1189886T3 (da)	2006-05-15	Ethansulfonyl-piperidinderivater
NO20022867D0 (no)	2002-06-14	Syklopentenon-derivater
NO20020212D0 (no)	2002-01-15	3-amino-2-benzyl-1-fenyl-propanderivater
PT1194401E (pt)	2004-02-27	Derivados de diacil-hidrazina
DK1178984T3 (da)	2003-06-10	1-trifluormethyl-4-hydroxy-7-piperidinylaminomethylchroman-derivater
DE59909774D1 (de)	2004-07-22	1-cycloalkylpyrazolyl-benzoyl-derivate