DK1200437T3 - Fremgangsmåde til fremstilling af optisk rene tetrahydropteriner og derivater deraf, især optisk rene tetrahydrofolsyre og optisk rene derivater deraf ved stereospecifik hydrogenering - Google Patents
Fremgangsmåde til fremstilling af optisk rene tetrahydropteriner og derivater deraf, især optisk rene tetrahydrofolsyre og optisk rene derivater deraf ved stereospecifik hydrogeneringInfo
- Publication number
- DK1200437T3 DK1200437T3 DK00956176T DK00956176T DK1200437T3 DK 1200437 T3 DK1200437 T3 DK 1200437T3 DK 00956176 T DK00956176 T DK 00956176T DK 00956176 T DK00956176 T DK 00956176T DK 1200437 T3 DK1200437 T3 DK 1200437T3
- Authority
- DK
- Denmark
- Prior art keywords
- optically pure
- derivatives
- folic acid
- hydrogenation
- reaction medium
- Prior art date
Links
- 238000005984 hydrogenation reaction Methods 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 4
- BOEUHAUGJSOEDZ-UHFFFAOYSA-N 2-amino-5,6,7,8-tetrahydro-1h-pteridin-4-one Chemical class N1CCNC2=C1C(=O)N=C(N)N2 BOEUHAUGJSOEDZ-UHFFFAOYSA-N 0.000 title abstract 3
- MSTNYGQPCMXVAQ-KIYNQFGBSA-N 5,6,7,8-tetrahydrofolic acid Chemical compound N1C=2C(=O)NC(N)=NC=2NCC1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 MSTNYGQPCMXVAQ-KIYNQFGBSA-N 0.000 title 1
- 230000000707 stereoselective effect Effects 0.000 title 1
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 abstract 6
- HNXQXTQTPAJEJL-UHFFFAOYSA-N 2-aminopteridin-4-ol Chemical compound C1=CN=C2NC(N)=NC(=O)C2=N1 HNXQXTQTPAJEJL-UHFFFAOYSA-N 0.000 abstract 4
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 abstract 4
- 229960000304 folic acid Drugs 0.000 abstract 4
- 235000019152 folic acid Nutrition 0.000 abstract 4
- 239000011724 folic acid Substances 0.000 abstract 4
- 239000012429 reaction media Substances 0.000 abstract 4
- 150000002224 folic acids Chemical class 0.000 abstract 3
- 239000003054 catalyst Substances 0.000 abstract 2
- -1 folic acid ester salts Chemical class 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 238000009876 asymmetric hydrogenation reaction Methods 0.000 abstract 1
- 150000001734 carboxylic acid salts Chemical class 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
- C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
- C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH01301/99A CH694251A5 (de) | 1999-07-14 | 1999-07-14 | Herstellung von Tetrahydropterin und Derivaten. |
| PCT/EP2000/006646 WO2001004120A1 (de) | 1999-07-14 | 2000-07-12 | Verfahren zur herstellung von optisch reinen tetrahydropterinen und derivaten, im speziellen optisch reiner tetrahydrofolsäure und ihren derivaten, durch stereospezifische hydrierung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1200437T3 true DK1200437T3 (da) | 2004-07-12 |
Family
ID=4207242
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK00956176T DK1200437T3 (da) | 1999-07-14 | 2000-07-12 | Fremgangsmåde til fremstilling af optisk rene tetrahydropteriner og derivater deraf, især optisk rene tetrahydrofolsyre og optisk rene derivater deraf ved stereospecifik hydrogenering |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US7816525B1 (da) |
| EP (1) | EP1200437B1 (da) |
| JP (1) | JP5121105B2 (da) |
| CN (2) | CN1264842C (da) |
| AT (1) | ATE261446T1 (da) |
| AU (1) | AU6822900A (da) |
| CA (1) | CA2378852C (da) |
| CH (1) | CH694251A5 (da) |
| DE (1) | DE50005609D1 (da) |
| DK (1) | DK1200437T3 (da) |
| ES (1) | ES2218203T3 (da) |
| PT (1) | PT1200437E (da) |
| WO (1) | WO2001004120A1 (da) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH694251A5 (de) * | 1999-07-14 | 2004-10-15 | Eprova Ag | Herstellung von Tetrahydropterin und Derivaten. |
| JP4562736B2 (ja) * | 2004-11-17 | 2010-10-13 | 日本曹達株式会社 | 光学活性アルコールの製造方法 |
| CN1962658B (zh) * | 2005-11-10 | 2010-05-12 | 北京大学 | 一种四氢吡啶并[3,2-d]嘧啶类化合物及制备抗肿瘤药物的用途 |
| KR101057576B1 (ko) * | 2007-08-16 | 2011-08-17 | 에스케이종합화학 주식회사 | 선택적 에틸렌 올리머고화 촉매계 |
| US20100047314A1 (en) * | 2008-08-22 | 2010-02-25 | Osteogenex Inc. | Folinic acid derivatives for promoting bone growth |
| AR110922A1 (es) | 2017-02-06 | 2019-05-15 | Gilead Sciences Inc | Compuestos inhibidores del vih |
| ES2966938T3 (es) | 2018-07-06 | 2024-04-25 | Merck Patent Gmbh | Sal cristalina de ácido 5-metil-(6S)-tetrahidrofólico y éster etílico de L-isoleucina |
| TWI829205B (zh) | 2018-07-30 | 2024-01-11 | 美商基利科學股份有限公司 | 抗hiv化合物 |
| CN115078292B (zh) * | 2021-03-10 | 2025-02-11 | 北京大学 | 一种水性超分子粘附材料及其制备方法 |
| CN113603691B (zh) * | 2021-08-12 | 2022-08-26 | 连云港冠昕医药科技有限公司 | L-5-甲基四氢叶酸钙的制备工艺 |
| CN115656372B (zh) * | 2022-10-27 | 2024-10-11 | 北京斯利安药业有限公司 | 一种s-四氢叶酸异构体手性分析方法 |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS53131298A (en) * | 1977-03-18 | 1978-11-15 | Ube Ind Ltd | Production of phosgene |
| JPS5959697A (ja) * | 1982-08-27 | 1984-04-05 | エフ・ホフマン―ラ ロシユ アーゲー | リン化合物 |
| JPS60178887A (ja) * | 1984-02-23 | 1985-09-12 | Kanegafuchi Chem Ind Co Ltd | ５，６，７，８−テトラヒドロ−ｌ−ビオプテリンの製造法 |
| JPS61100583A (ja) * | 1984-10-23 | 1986-05-19 | Mitsui Toatsu Chem Inc | ５，６，７，８−テトラヒドロ葉酸の製造方法 |
| GB8501919D0 (en) * | 1985-01-25 | 1985-02-27 | Shell Int Research | Carbonylation of allenically unsaturated compounds |
| EP0256982B1 (de) * | 1986-08-04 | 1991-08-28 | Ciba-Geigy Ag | Verfahren zur Herstellung von optisch aktiven sekundären Arylaminen |
| KR880007418A (ko) * | 1986-12-10 | 1988-08-27 | 오노 알버어스 | 공역 디엔의 선택적 카르보닐화 방법 및 이를 위한 유기 질소-함유 열기를 갖지 않는 촉매 시스템 |
| ATE139799T1 (de) * | 1989-12-11 | 1996-07-15 | American Cyanamid Co | Verfahren zur herstellung von optisch reinen diastereoisomeren von tetrahydrofolatverbindungen |
| CH681303A5 (da) * | 1991-01-16 | 1993-02-26 | Eprova Ag | |
| CH683261A5 (it) | 1991-10-10 | 1994-02-15 | Applied Pharma Res | Procedimento per la preparazione dell'acido metiltetraidrofolico nella forma (6(R,S)(-))N-5 e separazione del diastereoisomero attivo (6(S)(-))N-5) sotto forma di sali. |
| CH683690A5 (de) | 1991-12-21 | 1994-04-29 | Sapec Fine Chemicals | Verfahren zur Herstellung von diastereoisomerenreinen Tetrahydrofolaten. |
| DE4200933A1 (de) * | 1992-01-16 | 1993-07-22 | Basf Ag | Verfahren zur diastereoselektiven hydrierung von folsaeure zu tetrahydrosolsaeure |
| CH686672A5 (de) | 1992-12-01 | 1996-05-31 | Cerbios Pharma Sa | Verfahren zur Herstellung von (6S)-5,6,7,8-Tetrahydrofolsaeure. |
| CH686369A5 (de) | 1994-05-09 | 1996-03-15 | Eprova Ag | Stabile kristalline (6S)- und (6R)-Tetrahydrofolseure. |
| TW272949B (da) * | 1994-07-22 | 1996-03-21 | Taishal Kagaku Kogyo Kk | |
| CH689831A5 (de) | 1995-11-07 | 1999-12-15 | Eprova Ag | Stabile kristalline Tetrahydrofolsaeure-Salze. |
| JP2000514436A (ja) * | 1996-07-10 | 2000-10-31 | ノバルティス アクチエンゲゼルシャフト | 官能化されたフェロセニルジホスフィン類、その製造法、及びその用途 |
| US6162914A (en) * | 1998-04-24 | 2000-12-19 | Cerbios-Pharma S.A. | Process for the reduction of pterins |
| CH695217A5 (de) * | 1999-07-14 | 2006-01-31 | Merck Eprova Ag | Verfahren zur Trennung optischer Isomeren von Tetrahydrofolsäureestersalzen und Tetrahydrofolsäure. |
| CH694251A5 (de) * | 1999-07-14 | 2004-10-15 | Eprova Ag | Herstellung von Tetrahydropterin und Derivaten. |
| BR0112146A (pt) * | 2000-07-03 | 2003-05-06 | Speedel Pharma Ag | Preparação de ácidos (r)-2-alquil-3-fenilpropiÈnicos |
| US20020197589A1 (en) * | 2001-06-26 | 2002-12-26 | Leapfrog Enterprises, Inc. | Interactive educational apparatus with number array |
| GB0308801D0 (en) * | 2003-04-16 | 2003-05-21 | Celltech R&D Ltd | Chemical compounds |
| US20070213540A1 (en) * | 2006-03-09 | 2007-09-13 | Degussa Ag | Process for the hydrogenation of imines |
-
1999
- 1999-07-14 CH CH01301/99A patent/CH694251A5/de not_active IP Right Cessation
-
2000
- 2000-07-12 CN CNB008102473A patent/CN1264842C/zh not_active Expired - Lifetime
- 2000-07-12 EP EP00956176A patent/EP1200437B1/de not_active Expired - Lifetime
- 2000-07-12 DE DE50005609T patent/DE50005609D1/de not_active Expired - Lifetime
- 2000-07-12 DK DK00956176T patent/DK1200437T3/da active
- 2000-07-12 AT AT00956176T patent/ATE261446T1/de active
- 2000-07-12 US US10/030,692 patent/US7816525B1/en not_active Expired - Fee Related
- 2000-07-12 CN CNB2005101075792A patent/CN100381442C/zh not_active Expired - Lifetime
- 2000-07-12 PT PT00956176T patent/PT1200437E/pt unknown
- 2000-07-12 JP JP2001509729A patent/JP5121105B2/ja not_active Expired - Lifetime
- 2000-07-12 ES ES00956176T patent/ES2218203T3/es not_active Expired - Lifetime
- 2000-07-12 CA CA002378852A patent/CA2378852C/en not_active Expired - Lifetime
- 2000-07-12 WO PCT/EP2000/006646 patent/WO2001004120A1/de not_active Ceased
- 2000-07-12 AU AU68229/00A patent/AU6822900A/en not_active Abandoned
-
2008
- 2008-08-13 US US12/190,945 patent/US20080306263A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| PT1200437E (pt) | 2004-08-31 |
| WO2001004120A1 (de) | 2001-01-18 |
| EP1200437A1 (de) | 2002-05-02 |
| CN1781919A (zh) | 2006-06-07 |
| ES2218203T3 (es) | 2004-11-16 |
| JP5121105B2 (ja) | 2013-01-16 |
| JP2003504370A (ja) | 2003-02-04 |
| EP1200437B1 (de) | 2004-03-10 |
| DE50005609D1 (de) | 2004-04-15 |
| AU6822900A (en) | 2001-01-30 |
| CA2378852C (en) | 2007-05-22 |
| ATE261446T1 (de) | 2004-03-15 |
| CN1360587A (zh) | 2002-07-24 |
| CN100381442C (zh) | 2008-04-16 |
| CN1264842C (zh) | 2006-07-19 |
| CA2378852A1 (en) | 2001-01-18 |
| US20080306263A1 (en) | 2008-12-11 |
| CH694251A5 (de) | 2004-10-15 |
| US7816525B1 (en) | 2010-10-19 |
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