DK1204679T3 - Peptider som indeholder N-substituerede D-aminosyrer til at forhindre associering af Beta-strenge - Google Patents

Peptider som indeholder N-substituerede D-aminosyrer til at forhindre associering af Beta-strenge

Info

Publication number
DK1204679T3
DK1204679T3 DK00949729T DK00949729T DK1204679T3 DK 1204679 T3 DK1204679 T3 DK 1204679T3 DK 00949729 T DK00949729 T DK 00949729T DK 00949729 T DK00949729 T DK 00949729T DK 1204679 T3 DK1204679 T3 DK 1204679T3
Authority
DK
Denmark
Prior art keywords
peptide
beta
strand
substituted
nalpha
Prior art date
Application number
DK00949729T
Other languages
Danish (da)
English (en)
Inventor
Kelvin Stott
Original Assignee
Senexis Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Senexis Ltd filed Critical Senexis Ltd
Application granted granted Critical
Publication of DK1204679T3 publication Critical patent/DK1204679T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Neurology (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Hospice & Palliative Care (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK00949729T 1999-07-28 2000-07-28 Peptider som indeholder N-substituerede D-aminosyrer til at forhindre associering af Beta-strenge DK1204679T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9917725.5A GB9917725D0 (en) 1999-07-28 1999-07-28 Peptides
PCT/GB2000/002923 WO2001007474A1 (en) 1999-07-28 2000-07-28 Peptides containing n-substituted d-amino acids for preventing beta-strand association

Publications (1)

Publication Number Publication Date
DK1204679T3 true DK1204679T3 (da) 2007-04-02

Family

ID=10858097

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00949729T DK1204679T3 (da) 1999-07-28 2000-07-28 Peptider som indeholder N-substituerede D-aminosyrer til at forhindre associering af Beta-strenge

Country Status (13)

Country Link
US (1) US7060671B1 (de)
EP (1) EP1204679B1 (de)
JP (1) JP2003505470A (de)
AT (1) ATE355302T1 (de)
AU (1) AU767396B2 (de)
CA (1) CA2379241A1 (de)
DE (1) DE60033668T2 (de)
DK (1) DK1204679T3 (de)
ES (1) ES2282125T3 (de)
GB (1) GB9917725D0 (de)
NZ (1) NZ516442A (de)
PT (1) PT1204679E (de)
WO (1) WO2001007474A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1202973B1 (de) 1999-07-21 2009-12-30 The Trustees Of The University Of Pennsylvania Herstellung von verbindungen zur bestimmung der hypoxie
ES2180417B1 (es) * 2001-03-14 2004-05-16 Consejo Superior De Investigaciones Cientificas Nueva proteina sobreexpresada en cancer de prostata.
DE10117281A1 (de) * 2001-04-06 2002-10-24 Inst Molekulare Biotechnologie Peptid zur Diagnose und Therapie der Alzheimer-Demenz
DE10230141B4 (de) * 2002-07-04 2004-07-15 Priontype Gmbh Verfahren und Kit zur Anreicherung und zum Nachweis von veränderten Prion-Proteinen (PrPSc)
EP1380290A1 (de) 2002-07-09 2004-01-14 Universitair Medisch Centrum Utrecht Cross-Beta-Strukturweg und seine therapeutische Relevanz
CA2615028A1 (en) 2005-07-13 2007-01-18 Crossbeta Biosciences B.V. Cross-.beta. structure binding compounds
US8114832B2 (en) 2005-07-13 2012-02-14 Crossbeta Biosciences B.V. Method for detecting and/or removing a protein comprising a cross-beta structure from a pharmaceutical composition
GB2432586B (en) * 2005-11-25 2010-01-13 Univ Open Treatment of neurodegenerative disorders
JP2007217330A (ja) * 2006-02-16 2007-08-30 Dainippon Sumitomo Pharma Co Ltd 新規ペプチド
US8188046B2 (en) 2006-10-16 2012-05-29 University Of South Florida Amyloid beta peptides and methods of use
US7618944B2 (en) * 2007-03-01 2009-11-17 Intezyne Technologies, Inc. Encapsulated amyloid-beta peptides
GB0716885D0 (en) * 2007-08-30 2007-10-10 United Arab Emirates Universit Diagnostic agent

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0815134B1 (de) 1995-03-14 2002-06-05 Praecis Pharmaceuticals Incorporated VERBINDUNGEN MIT AGGREGATIONS-MODULIERENDEN WIRKUNG AUF DAS AMYLOiD PROTEIN
US6034211A (en) * 1996-06-03 2000-03-07 Kelly; Jeffery W. β-sheet nucleating peptidomimetics
DE19725619A1 (de) 1997-06-17 1998-12-24 Fraunhofer Ges Forschung Peptide als Agonisten und/oder Inhibitoren der Amyloidbildung und Zytotoxizität sowie der Verwendung bei Alzheimer'schen Krankheit, beim Typ II Diabetes mellitus und bei spongiformen Encephalopathien
EP1161449B1 (de) * 1999-03-04 2007-07-04 Praecis Pharmaceuticals Incorporated Beta-amyloid-peptidaggregation regulierende peptide mit d-aminosäuren

Also Published As

Publication number Publication date
CA2379241A1 (en) 2001-02-01
EP1204679A1 (de) 2002-05-15
PT1204679E (pt) 2007-05-31
EP1204679B1 (de) 2007-02-28
AU6300400A (en) 2001-02-13
DE60033668D1 (de) 2007-04-12
ATE355302T1 (de) 2006-03-15
GB9917725D0 (en) 1999-09-29
AU767396B2 (en) 2003-11-06
NZ516442A (en) 2003-10-31
ES2282125T3 (es) 2007-10-16
DE60033668T2 (de) 2007-06-21
JP2003505470A (ja) 2003-02-12
US7060671B1 (en) 2006-06-13
WO2001007474A1 (en) 2001-02-01

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