DK120483A - Phenylpiperazinderivater og fremgangsmaade til deres fremstilling - Google Patents

Phenylpiperazinderivater og fremgangsmaade til deres fremstilling Download PDF

Info

Publication number: DK120483A
Authority: DK; Denmark
Prior art keywords: group; procedures; preparation; piperazine derivatives; derivatives
Prior art date: 1982-03-17

Application number

DK120483A

Other languages

English (en)

Other versions

DK156064C (da

DK120483D0 (da

DK156064B (da

Inventor

Hiroyuki Nagano

Mitiro Takagi

Noboru Kubodera

Isao Matsunaga

Hiroyuki Nabata

Yasuhiro Ohba

Kazushige Sakai

Shun-Ishi Hata

Yasumi Ushida

Original Assignee

Chugai Pharmaceutical Co Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-03-17

Filing date

1983-03-15

Publication date

1983-09-18

1983-03-15 Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd

1983-03-15 Publication of DK120483D0 publication Critical patent/DK120483D0/da

1983-09-18 Publication of DK120483A publication Critical patent/DK120483A/da

1989-06-19 Publication of DK156064B publication Critical patent/DK156064B/da

1989-11-06 Application granted granted Critical

1989-11-06 Publication of DK156064C publication Critical patent/DK156064C/da

Links

238000000034 method Methods 0.000 title abstract 2
YZTJYBJCZXZGCT-UHFFFAOYSA-N phenylpiperazine Chemical class C1CNCCN1C1=CC=CC=C1 YZTJYBJCZXZGCT-UHFFFAOYSA-N 0.000 title abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 abstract 2
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 abstract 1
230000003042 antagnostic effect Effects 0.000 abstract 1
230000000903 blocking effect Effects 0.000 abstract 1
125000004432 carbon atom Chemical group C* 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
229940079593 drug Drugs 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
125000004043 oxo group Chemical group O=* 0.000 abstract 1
229920006395 saturated elastomer Polymers 0.000 abstract 1
229940076279 serotonin Drugs 0.000 abstract 1
125000004417 unsaturated alkyl group Chemical group 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
- C07D239/96—Two oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Cardiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Heart & Thoracic Surgery (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Paper (AREA)
Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Inks, Pencil-Leads, Or Crayons (AREA)

DK120483A 1982-03-17 1983-03-15 Analogifremgangsmaade til fremstilling af 2,4-(1h,3h)-quinazolindionderivater eller farmaceutisk acceptable syreadditionssalte deraf DK156064C (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP57040904A JPS58159480A (ja)	1982-03-17	1982-03-17	新規なフエニルピペラジン誘導体
JP4090482		1982-03-17

Publications (4)

Publication Number	Publication Date
DK120483D0 DK120483D0 (da)	1983-03-15
DK120483A true DK120483A (da)	1983-09-18
DK156064B DK156064B (da)	1989-06-19
DK156064C DK156064C (da)	1989-11-06

Family

ID=12593492

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK120483A DK156064C (da)	1982-03-17	1983-03-15	Analogifremgangsmaade til fremstilling af 2,4-(1h,3h)-quinazolindionderivater eller farmaceutisk acceptable syreadditionssalte deraf

Country Status (12)

Country	Link
US (1)	US4578465A (da)
EP (1)	EP0089065B1 (da)
JP (1)	JPS58159480A (da)
KR (1)	KR900004125B1 (da)
AT (1)	ATE27817T1 (da)
CA (1)	CA1248102A (da)
DE (2)	DE89065T1 (da)
DK (1)	DK156064C (da)
ES (3)	ES520693A0 (da)
FI (1)	FI77456C (da)
MX (1)	MX7157E (da)
ZA (1)	ZA831674B (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS608274A (ja) *	1983-06-27	1985-01-17	Fujisawa Pharmaceut Co Ltd	新規キナゾリノン誘導体およびその製造法・並びに抗アレルギ−剤
JPS60169467A (ja) *	1984-02-10	1985-09-02	Chugai Pharmaceut Co Ltd	新規なフエニルピペラジン誘導体
US4711883A (en) *	1985-09-30	1987-12-08	Ortho Pharmaceutical Corporation	Substituted 3-(4-phenyl-1-piperazinyl)alkylquinazolin-2,4-(1H,3H) diones, methods of preparation, compositions and method of use
GB8524663D0 (en) *	1985-10-07	1985-11-13	Fujisawa Pharmaceutical Co	Quinazoline derivatives
JPS62135464A (ja) *	1985-12-10	1987-06-18	Nippon Kayaku Co Ltd	フエニルピペラジン誘導体
US4670560A (en) *	1986-04-28	1987-06-02	Ortho Pharmaceutical Corporation	Thienopyrimidine-2,4-dione derivatives and intermediates thereof
IL90879A0 (en) *	1988-09-02	1990-02-09	Janssen Pharmaceutica Nv	3-piperidinyl-indazole derivatives,their preparation and antihypertensive compositions containing them
US5160727A (en) *	1990-02-13	1992-11-03	Warner-Lambert Company	Tumor cell sensitization method using quinazolinedione derivatives
PT2400968T (pt) *	2009-02-26	2016-12-09	Reviva Pharmaceuticals Inc	Composições, sintese e métodos de utilização dos derivados de arilpiperazína
BRPI1003506B1 (pt) *	2010-09-24	2019-12-03	Ache Int Bvi Ltd	composto alquil-piperazino-fenil-4(3h)quinazolinonas e uso do composto alquil-piperazino-fenil-4(3h)quinazolinonas associado aos receptores serotoninérgicos 5-ht1a e 5-ht2a
KR102132078B1 (ko) *	2018-09-20	2020-07-08	원광대학교산학협력단	방향족 화합물, 아민 및 친핵체를 이용한 3가지 성분 반응으로 1-에틸-4-페닐피페라진 유도체를 제조하는 방법

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3274194A (en) *	1963-03-29	1966-09-20	Miles Lab	Quinazolinedione derivatives
US3322766A (en) *	1964-11-13	1967-05-30	Shulton Inc	3-beta-(4-pyridyl) ethyl-2, 3-dihydro-4(1h)-quinazolinones
AT269143B (de) *	1966-06-30	1969-03-10	Miles Lab	Verfahren zur Herstellung von neuen Chinazolindionderivaten und ihrer Säureadditionssalze bzw. ihrer entsprechenden Piperaziniumverbindungen
CA933160A (en) *	1968-02-29	1973-09-04	Wallace And Tiernan Inc.	Process for preparing diuretic 2,4-quinazolinediones and the products obtained thereby
DE1934037A1 (de) *	1969-07-04	1971-01-07	Cassella Farbwerke Mainkur Ag	Basisch substituierte Derivate des 2,4-(1H,3H)-Chinazolindions
US3726979A (en) *	1971-04-09	1973-04-10	E Hong	Method of producing serotonin antagonism
US3819630A (en) *	1972-08-21	1974-06-25	R Parcell	3-(1-piperazinylalkyl)-2,4-quinazolinedione compounds and methods for their production
US3879393A (en) *	1973-06-18	1975-04-22	Miles Lab	Derivatives of 1,3-disubstituted 2,4(1h,3h)-quinazolinediones
EP0040793B1 (en) *	1980-05-22	1985-08-28	Masayuki Ishikawa	Novel quinazoline-dione compounds, process for production thereof and pharmaceutical use thereof

1982
- 1982-03-17 JP JP57040904A patent/JPS58159480A/ja active Granted
1983
- 1983-03-09 CA CA000423221A patent/CA1248102A/en not_active Expired
- 1983-03-11 ZA ZA831674A patent/ZA831674B/xx unknown
- 1983-03-15 DK DK120483A patent/DK156064C/da not_active IP Right Cessation
- 1983-03-16 DE DE198383102601T patent/DE89065T1/de active Pending
- 1983-03-16 KR KR1019830001046A patent/KR900004125B1/ko not_active Expired
- 1983-03-16 DE DE8383102601T patent/DE3372095D1/de not_active Expired
- 1983-03-16 ES ES520693A patent/ES520693A0/es active Granted
- 1983-03-16 AT AT83102601T patent/ATE27817T1/de not_active IP Right Cessation
- 1983-03-16 EP EP83102601A patent/EP0089065B1/en not_active Expired
- 1983-03-17 FI FI830893A patent/FI77456C/fi not_active IP Right Cessation
- 1983-03-17 MX MX8310535U patent/MX7157E/es unknown
- 1983-11-16 ES ES527318A patent/ES527318A0/es active Granted
- 1983-11-16 ES ES527319A patent/ES8504778A1/es not_active Expired
1984
- 1984-04-30 US US06/604,415 patent/US4578465A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
ATE27817T1 (de)	1987-07-15
ES8504777A1 (es)	1985-05-01
FI77456B (fi)	1988-11-30
KR900004125B1 (ko)	1990-06-16
DK156064C (da)	1989-11-06
CA1248102A (en)	1989-01-03
MX7157E (es)	1987-11-27
ES527319A0 (es)	1985-05-01
JPH033669B2 (da)	1991-01-21
ES8504778A1 (es)	1985-05-01
EP0089065B1 (en)	1987-06-16
ZA831674B (en)	1984-04-25
KR840004104A (ko)	1984-10-06
DE3372095D1 (en)	1987-07-23
DE89065T1 (de)	1985-04-11
US4578465A (en)	1986-03-25
JPS58159480A (ja)	1983-09-21
FI77456C (fi)	1989-03-10
EP0089065A2 (en)	1983-09-21
DK120483D0 (da)	1983-03-15
FI830893L (fi)	1983-09-18
FI830893A0 (fi)	1983-03-17
EP0089065A3 (en)	1984-05-23
DK156064B (da)	1989-06-19
ES527318A0 (es)	1985-05-01
ES8404347A1 (es)	1984-05-01
ES520693A0 (es)	1984-05-01

Legal Events

Date	Code	Title	Description
2000-10-23	PBP	Patent lapsed

Publication	Publication Date	Title
DK584886A (da)	1987-06-07	Vanduoploeselige, mono- og disubstituerede derivater af rapamycin og farmaceutisk acceptable salte deraf
ES431058A1 (es)	1976-10-16	Procedimiento para la preparacion de nuevos n-(metoximetil - furilmetil)-6, 7-benzomorfanos y -morfinanos.
RO93855A (ro)	1988-02-29	Procedeu pentru prepararea de arilciclobutilalchilamina
DK120483A (da)	1983-09-18	Phenylpiperazinderivater og fremgangsmaade til deres fremstilling
ES394369A1 (es)	1974-11-01	Procedimiento para la preparacion de derivados de la isoin-dolina.
ES413639A1 (es)	1976-01-16	Un procedimiento para la preparacion de un compuesto deri- vado de dopamina.
ES460040A1 (es)	1978-05-01	Un procedimiento para preparar derivados de 4-hidroxifeni- lalcanolaminas.
SE7501365L (da)	1975-08-11
SE7605361L (sv)	1976-11-17	Sett att framstella nya n-substituerade fenylpiperazinderivat
SE7704616L (sv)	1977-10-31	Sett att framstella nya 11-desoxi-prostaglandin-fÿ2-derivat
ES442648A1 (es)	1977-04-16	Procedimiento para la preparacion de derivados de aminopro- panol.
ES472276A1 (es)	1979-10-01	Un procedimiento para la preparacion de un grupo de cis-4a- aril-octahidro-1h-2-pirindinas 2-sustituidas
DK287980A (da)	1981-01-05	Fremgangsmaade til fremstilling af anthracyclinglycosider
ES440030A1 (es)	1977-02-16	Un procedimiento para preparar nuevos derivados de 2-ami- noindano.
ES8801637A1 (es)	1988-02-16	Un procedimiento para la preparacion de benzimidazoles.
ES422837A1 (es)	1976-09-16	Procedimiento para la preparacion de derivados ergolinicos.
SE7606497L (sv)	1976-12-11	Substituerade 4-fenylimidazoliner, deras syraadditinossalter och forfarande for framstellning derav
SE8703494D0 (sv)	1987-09-09	Mellanprodukter anvendbara vid framstellning av 2-tiofen-ettiksyraderivat
ES465366A2 (es)	1978-09-16	Un procedimiento de preparacion de derivados de metoxi-2- benzamidas.
SE7706693L (sv)	1977-12-12	Sett att framstella hydrazinopyridazinderivat
ES393340A1 (es)	1973-08-16	Procedimiento para la preparacion de derivados de bornanami-na.
ES417269A1 (es)	1976-03-16	Procedimiento para preparar derivados de imidazolidinona.
SE7507176L (sv)	1975-12-29	1h-(pyridino(3,2-e)-2,1,3-tiadiazin-4-on-2,2-dioxid)
ES438056A3 (es)	1977-02-01	Procedimiento para la preparacion de nuevos derivados de a- cidos carboxilicos ciclicos.
ES433593A1 (es)	1977-02-16	Un procedimiento para preparar derivados del 1, 4-dioxido dequinoxalin-2-carboxamida.