DK1210325T3 - Aminobenzofenoner som inhibitorer for IL-1beta og TNF-alfa - Google Patents

Aminobenzofenoner som inhibitorer for IL-1beta og TNF-alfa

Info

Publication number: DK1210325T3
Authority: DK; Denmark
Prior art keywords: substituent; alkyl; group; carbamoyl; alkoxycarbonyl
Prior art date: 1999-07-16

Application number

DK00943701T

Other languages

Danish (da)

English (en)

Inventor

Erik Rytter Ottosen

Original Assignee

Leo Pharma As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-07-16

Filing date

2000-07-11

Publication date

2005-01-31

2000-07-11 Application filed by Leo Pharma As filed Critical Leo Pharma As

2005-01-31 Application granted granted Critical

2005-01-31 Publication of DK1210325T3 publication Critical patent/DK1210325T3/da

Links

MAOBFOXLCJIFLV-UHFFFAOYSA-N (2-aminophenyl)-phenylmethanone Chemical class NC1=CC=CC=C1C(=O)C1=CC=CC=C1 MAOBFOXLCJIFLV-UHFFFAOYSA-N 0.000 title 1
MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 title 1
108060008682 Tumor Necrosis Factor Proteins 0.000 title 1
102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1
-1 hydroxy, mercapto Chemical group 0.000 abstract 6
125000001424 substituent group Chemical group 0.000 abstract 6
125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 4
125000004455 (C1-C3) alkylthio group Chemical group 0.000 abstract 3
125000006274 (C1-C3)alkoxy group Chemical group 0.000 abstract 3
125000004890 (C1-C6) alkylamino group Chemical group 0.000 abstract 3
125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 3
229910052736 halogen Inorganic materials 0.000 abstract 3
150000002367 halogens Chemical group 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 3
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 3
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 3
150000001875 compounds Chemical class 0.000 abstract 2
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 abstract 1
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
- C07C311/52—Y being a hetero atom
- C07C311/54—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea
- C07C311/57—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings
- C07C311/60—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings having nitrogen atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/40—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Rheumatology (AREA)
Immunology (AREA)
Dermatology (AREA)
Pulmonology (AREA)
Physical Education & Sports Medicine (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Virology (AREA)
Pain & Pain Management (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
Cardiology (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
Vascular Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Diabetes (AREA)
Orthopedic Medicine & Surgery (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

DK00943701T 1999-07-16 2000-07-11 Aminobenzofenoner som inhibitorer for IL-1beta og TNF-alfa DK1210325T3 (da)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US14406299P	1999-07-16	1999-07-16
PCT/DK2000/000387 WO2001005751A1 (en)	1999-07-16	2000-07-11	AMINOBENZOPHENONES AS INHIBITORS OF IL-1β AND TNF-$g(a)
EP00943701A EP1210325B1 (en)	1999-07-16	2000-07-11	Aminobenzophenones as inhibitors of il-1beta and tnf-alpha

Publications (1)

Publication Number	Publication Date
DK1210325T3 true DK1210325T3 (da)	2005-01-31

Family

ID=22506888

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK00943701T DK1210325T3 (da)	1999-07-16	2000-07-11	Aminobenzofenoner som inhibitorer for IL-1beta og TNF-alfa

Country Status (18)

Country	Link
US (1)	US6750253B1 (pl)
EP (1)	EP1210325B1 (pl)
JP (1)	JP2003505363A (pl)
KR (1)	KR20020033733A (pl)
CN (1)	CN1249025C (pl)
AT (1)	ATE278663T1 (pl)
AU (1)	AU768878B2 (pl)
CA (1)	CA2379293A1 (pl)
CZ (1)	CZ2002157A3 (pl)
DE (1)	DE60014681T2 (pl)
DK (1)	DK1210325T3 (pl)
ES (1)	ES2228556T3 (pl)
HK (1)	HK1048464B (pl)
HU (1)	HUP0201913A3 (pl)
PL (1)	PL353644A1 (pl)
PT (1)	PT1210325E (pl)
RU (1)	RU2247719C2 (pl)
WO (1)	WO2001005751A1 (pl)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU6008101A (en)	2000-05-22	2001-12-03	Leo Pharm Prod Ltd	Benzophenones as inhibitors of il-1beta and tnf-alpha
CA2458611C (en) *	2001-08-28	2012-05-29	Leo Pharma A/S	Aminobenzophenones as interleukin 1-beta and tumour necrosis factor-alpha inhibitors
US20030225089A1 (en) *	2002-04-10	2003-12-04	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Pharmaceutical compositions based on anticholinergics and p38 kinase inhibitors
WO2004004725A2 (en)	2002-07-09	2004-01-15	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Pharmaceutical compositions of anticholinergics and p38 kinase inhibitors in the treatment of respiratory diseases
US7977387B2 (en)	2003-07-24	2011-07-12	Leo Pharma A/S	Aminobenzophenone compounds
US20060035893A1 (en)	2004-08-07	2006-02-16	Boehringer Ingelheim International Gmbh	Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders
CN101115728B (zh)	2004-12-13	2012-12-19	利奥制药有限公司	三唑取代的氨基二苯甲酮化合物
PE20060777A1 (es)	2004-12-24	2006-10-06	Boehringer Ingelheim Int	Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas
NZ570257A (en) *	2006-02-16	2011-11-25	Anacor Pharmaceuticals Inc	Boron-containing small molecules as anti-inflammatory agents
CA2646240A1 (en) *	2006-03-16	2007-09-20	Xuemin Shi	Combination therapy for treatment of patients with neurological disorders and cerebral infarction
EP1992344A1 (en)	2007-05-18	2008-11-19	Institut Curie	P38 alpha as a therapeutic target in pathologies linked to FGFR3 mutation
EP2206534A1 (de)	2008-10-09	2010-07-14	c-a-i-r biosciences GmbH	Dibenzocycloheptanonderivate und pharmazeutische Mittel, welche diese Verbindungen enthalten
KR100984851B1 (ko) *	2009-02-05	2010-10-04	주식회사 엠에스엠텍	램프이탈방지형 엘이디 조명
US8912184B1 (en)	2010-03-01	2014-12-16	Alzheimer's Institute Of America, Inc.	Therapeutic and diagnostic methods
US10684274B2 (en)	2016-01-12	2020-06-16	The George Washington University, A Congressionlly Chartered Not-For-Profit Corporation	Compounds inhibiting Nef-calnexin interaction

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9701453D0 (en) *	1997-01-24	1997-03-12	Leo Pharm Prod Ltd	Aminobenzophenones

2000
- 2000-07-11 AU AU58070/00A patent/AU768878B2/en not_active Ceased
- 2000-07-11 DK DK00943701T patent/DK1210325T3/da active
- 2000-07-11 WO PCT/DK2000/000387 patent/WO2001005751A1/en not_active Ceased
- 2000-07-11 CN CNB008115044A patent/CN1249025C/zh not_active Expired - Fee Related
- 2000-07-11 US US10/030,970 patent/US6750253B1/en not_active Expired - Fee Related
- 2000-07-11 CZ CZ2002157A patent/CZ2002157A3/cs unknown
- 2000-07-11 AT AT00943701T patent/ATE278663T1/de not_active IP Right Cessation
- 2000-07-11 JP JP2001511412A patent/JP2003505363A/ja active Pending
- 2000-07-11 DE DE60014681T patent/DE60014681T2/de not_active Expired - Fee Related
- 2000-07-11 PL PL00353644A patent/PL353644A1/pl not_active Application Discontinuation
- 2000-07-11 CA CA002379293A patent/CA2379293A1/en not_active Abandoned
- 2000-07-11 HU HU0201913A patent/HUP0201913A3/hu unknown
- 2000-07-11 PT PT00943701T patent/PT1210325E/pt unknown
- 2000-07-11 RU RU2002103865/04A patent/RU2247719C2/ru not_active IP Right Cessation
- 2000-07-11 HK HK03100584.9A patent/HK1048464B/zh not_active IP Right Cessation
- 2000-07-11 ES ES00943701T patent/ES2228556T3/es not_active Expired - Lifetime
- 2000-07-11 KR KR1020027000600A patent/KR20020033733A/ko not_active Ceased
- 2000-07-11 EP EP00943701A patent/EP1210325B1/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
EP1210325B1 (en)	2004-10-06
CN1249025C (zh)	2006-04-05
PL353644A1 (pl)	2003-12-01
AU5807000A (en)	2001-02-05
DE60014681D1 (de)	2004-11-11
HK1048464A1 (en)	2003-04-04
KR20020033733A (ko)	2002-05-07
EP1210325A1 (en)	2002-06-05
PT1210325E (pt)	2005-01-31
RU2247719C2 (ru)	2005-03-10
CA2379293A1 (en)	2001-01-25
ATE278663T1 (de)	2004-10-15
US6750253B1 (en)	2004-06-15
WO2001005751A1 (en)	2001-01-25
DE60014681T2 (de)	2006-02-02
HUP0201913A2 (en)	2002-10-28
HK1048464B (zh)	2006-09-01
CN1368957A (zh)	2002-09-11
AU768878B2 (en)	2004-01-08
CZ2002157A3 (cs)	2002-08-14
JP2003505363A (ja)	2003-02-12
HUP0201913A3 (en)	2002-11-28
ES2228556T3 (es)	2005-04-16

Publication	Publication Date	Title
DK1202957T3 (da)	2005-01-31	Aminobenzofenoner som inhibitorer for IL-1beta og TNF-alfa
ATE362912T1 (de)	2007-06-15	Aminobenzophenone als inhibitoren von il-1beta und tnf-alpha
PL353644A1 (pl)	2003-12-01	Aminobenzofenony jako inhibitory IL-1beta i TNF-alAminobenzofenony jako inhibitory IL-1beta i TNF-alfafa
PE20060525A1 (es)	2006-07-13	Compuestos heterociclicos como inhibidores de cetp
MY151455A (en)	2014-05-30	Carbonylamino pyrrolopyrazoles, potent kinase inhibitors
NO20050525L (no)	2005-05-06	Benzimidazol-1-yl-tiofenforbindelser for behandling av cancer
TR200201505T2 (tr)	2003-01-21	Terapötik maddeler olarak pirazolopirimidinler
DK1625126T3 (da)	2008-03-31	Imidazo- og thiazolopyridiner som JAK3-kinaseinhibitorer
ECSP066886A (es)	2006-11-24	Compuestos y métodos para el tratamiento de dislipidemia
DK1663242T3 (da)	2011-08-01	2,4-Pyrimidindiamin-forbindelser og anvendelse som antiproliferative midler
MX2007004781A (es)	2007-05-11	Derivados de 3-arilamino piridina.
NO20044995L (no)	2005-01-18	Heterosykliske forbindelser
DK1268471T3 (da)	2004-02-09	N-heterocykliske derivater som NOS-inhibitorer
DK1641803T3 (da)	2009-06-29	Thienopyrimidinderivater som kaliumkanalinhibitorer
TW200700422A (en)	2007-01-01	Compounds for inhibiting ksp kinesin activity
DK1210320T3 (da)	2005-01-31	Aminobenzofenoner som inhibitorer for IL-1beta og TNF-alfa
ATE277897T1 (de)	2004-10-15	Aminobenzophenone als inhibitoren von il-1beta und tnf-alpha
DE60204701D1 (de)	2005-07-21	Tricyclische imidazopyridine
DK1373220T3 (da)	2007-10-08	Benzimidazoler, som er nyttige ved behandling af seksuel dysfunktion
NO20050666L (no)	2005-03-11	2,7-substituerte indoler og deres anvendelse som 5-HT6 modulatorer
TW200700066A (en)	2007-01-01	Compounds for inhibiting ksp kinesin activity
ATE251117T1 (de)	2003-10-15	Neue aminobenzophenone
TW200607808A (en)	2006-03-01	Pyrido-pyrimidine derivatives, preparation thereof and application thereof
PT984936E (pt)	2004-02-27	Cianoguanidinas como inibidores da proliferacao celular
ATE274515T1 (de)	2004-09-15	Pyrazolopyridinderivate