DK1224161T3 - Nitroxyderivater af (R)- og (S)-carnitin - Google Patents

Nitroxyderivater af (R)- og (S)-carnitin

Info

Publication number
DK1224161T3
DK1224161T3 DK00951861T DK00951861T DK1224161T3 DK 1224161 T3 DK1224161 T3 DK 1224161T3 DK 00951861 T DK00951861 T DK 00951861T DK 00951861 T DK00951861 T DK 00951861T DK 1224161 T3 DK1224161 T3 DK 1224161T3
Authority
DK
Denmark
Prior art keywords
carnitine
derivatives
formula
nitroxy derivatives
nitroxy
Prior art date
Application number
DK00951861T
Other languages
Danish (da)
English (en)
Inventor
Oreste Piccolo
Roberto Castagnani
Witt Paolo De
Original Assignee
Sigma Tau Ind Farmaceuti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Ind Farmaceuti filed Critical Sigma Tau Ind Farmaceuti
Application granted granted Critical
Publication of DK1224161T3 publication Critical patent/DK1224161T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/30—Preparation of optical isomers
    • C07C227/32—Preparation of optical isomers by stereospecific synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Cardiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK00951861T 1999-08-05 2000-07-31 Nitroxyderivater af (R)- og (S)-carnitin DK1224161T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT1999RM000508A IT1306184B1 (it) 1999-08-05 1999-08-05 Nitrilossi derivati della (r) e (s)-carnitina.
PCT/IT2000/000325 WO2001010819A1 (en) 1999-08-05 2000-07-31 Nitroxy derivatives of (r) and (s)-carnitine

Publications (1)

Publication Number Publication Date
DK1224161T3 true DK1224161T3 (da) 2005-01-24

Family

ID=11406927

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00951861T DK1224161T3 (da) 1999-08-05 2000-07-31 Nitroxyderivater af (R)- og (S)-carnitin

Country Status (16)

Country Link
US (2) US6395923B2 (cs)
EP (1) EP1224161B1 (cs)
JP (1) JP2003506429A (cs)
KR (1) KR100772205B1 (cs)
AT (1) ATE276231T1 (cs)
AU (1) AU6470400A (cs)
CA (1) CA2379047A1 (cs)
CZ (1) CZ20025A3 (cs)
DE (1) DE60013876T2 (cs)
DK (1) DK1224161T3 (cs)
ES (1) ES2226896T3 (cs)
HU (1) HUP0203034A3 (cs)
IT (1) IT1306184B1 (cs)
PT (1) PT1224161E (cs)
SK (1) SK287134B6 (cs)
WO (1) WO2001010819A1 (cs)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITRM20010456A1 (it) 2001-07-26 2003-01-27 Sigma Tau Ind Farmaceuti Procedimento per la preparazione di (r)- o (s)- amminocarnitina sale interno, dei suoi sali e dei suoi derivati.
US8466187B2 (en) 2007-09-18 2013-06-18 Thermolife International, Llc Amino acid compositions
US12612370B2 (en) 2011-03-02 2026-04-28 Thermolife International, Llc Amino acid compositions
US11497599B2 (en) 2017-03-17 2022-11-15 Amo Groningen B.V. Diffractive intraocular lenses for extended range of vision
CA3096256A1 (en) 2018-04-06 2019-10-10 Amo Development, Llc Methods and systems for changing a refractive property of an implantable intraocular lens
US20200129464A1 (en) * 2018-10-29 2020-04-30 Lonza Inc. Method and Composition for Increasing the Bioavailability of Carnitine
US10703707B2 (en) 2018-11-07 2020-07-07 Industrial Technology Research Institute Method for preparing nitrate ester
AU2021377897A1 (en) 2020-11-12 2024-09-12 Thermolife International, Llc Methods of increasing blood oxygen saturation
KR20230145103A (ko) 2021-02-11 2023-10-17 써모라이프 인터내셔널, 엘엘씨 산화질소 기체의 투여 방법

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3830931A (en) * 1972-11-06 1974-08-20 Felice S De Carnitine and its use in the treatment of arrhythmia and impaired cardiac function
US5214166A (en) * 1986-11-29 1993-05-25 The United States Of America As Represented By The Secretary Of The Navy Method of synthesizing nitrato alkyl oxetanes
CH679856A5 (cs) * 1990-07-04 1992-04-30 Lonza Ag
IT1256705B (it) * 1992-12-21 1995-12-12 Sigma Tau Ind Farmaceuti Procedimento per la preparazione di l-(-)-carnitina a partire da un prodotto di scarto avente opposta configurazione.
IT1261231B (it) * 1993-04-08 1996-05-09 Sigma Tau Ind Farmaceuti Procedimento migliorato per la preparazione di l-(-)-carnitina a partire da un prodotto di scarto avente opposta configurazione.
IT1261489B (it) * 1993-07-29 1996-05-23 Sigma Tau Ind Farmaceuti Procedimento per la produzione di r amminocarnitina e s amminocarnitina.
HUP0002925A3 (en) * 1997-06-11 2002-11-28 Isis Pharma Gmbh Novel pentaerythrite derivatives, the production and use thereof and intermediate products for the synthesis of the same

Also Published As

Publication number Publication date
US20010011074A1 (en) 2001-08-02
EP1224161A1 (en) 2002-07-24
ATE276231T1 (de) 2004-10-15
CA2379047A1 (en) 2001-02-15
US20020119965A1 (en) 2002-08-29
SK287134B6 (sk) 2010-01-07
IT1306184B1 (it) 2001-05-30
SK1752002A3 (en) 2002-06-04
DE60013876D1 (de) 2004-10-21
HUP0203034A2 (hu) 2003-02-28
AU6470400A (en) 2001-03-05
ITRM990508A1 (it) 2001-02-05
ITRM990508A0 (it) 1999-08-05
WO2001010819A1 (en) 2001-02-15
CZ20025A3 (cs) 2002-07-17
DE60013876T2 (de) 2005-09-29
JP2003506429A (ja) 2003-02-18
KR20020025213A (ko) 2002-04-03
PT1224161E (pt) 2005-01-31
HUP0203034A3 (en) 2003-11-28
ES2226896T3 (es) 2005-04-01
US6395923B2 (en) 2002-05-28
PL358333A1 (en) 2004-08-09
EP1224161B1 (en) 2004-09-15
US6548693B2 (en) 2003-04-15
KR100772205B1 (ko) 2007-11-01

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