ITRM990508A0 - Nitrilossi derivati della (r) e (s)-carnitina. - Google Patents
Nitrilossi derivati della (r) e (s)-carnitina.Info
- Publication number
- ITRM990508A0 ITRM990508A0 IT1999RM000508A ITRM990508A ITRM990508A0 IT RM990508 A0 ITRM990508 A0 IT RM990508A0 IT 1999RM000508 A IT1999RM000508 A IT 1999RM000508A IT RM990508 A ITRM990508 A IT RM990508A IT RM990508 A0 ITRM990508 A0 IT RM990508A0
- Authority
- IT
- Italy
- Prior art keywords
- nitriloxy
- carnitine
- derivatives
- nitriloxy derivatives
- Prior art date
Links
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical class C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 title 1
- PHIQHXFUZVPYII-LURJTMIESA-N (S)-carnitine Chemical compound C[N+](C)(C)C[C@@H](O)CC([O-])=O PHIQHXFUZVPYII-LURJTMIESA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/22—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/16—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions not involving the amino or carboxyl groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/30—Preparation of optical isomers
- C07C227/32—Preparation of optical isomers by stereospecific synthesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (19)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1999RM000508A IT1306184B1 (it) | 1999-08-05 | 1999-08-05 | Nitrilossi derivati della (r) e (s)-carnitina. |
| PCT/IT2000/000325 WO2001010819A1 (en) | 1999-08-05 | 2000-07-31 | Nitroxy derivatives of (r) and (s)-carnitine |
| CA002379047A CA2379047A1 (en) | 1999-08-05 | 2000-07-31 | Nitroxy derivatives of (r) and (s)-carnitine |
| EP00951861A EP1224161B1 (en) | 1999-08-05 | 2000-07-31 | Nitroxy derivatives of (r) and (s)-carnitine |
| DE60013876T DE60013876T2 (de) | 1999-08-05 | 2000-07-31 | Nitroxyderivate von (r) und (s)-carnitin |
| HU0203034A HUP0203034A3 (en) | 1999-08-05 | 2000-07-31 | Nitroxy derivatives of (r) and (s)-carnitine, process for their preparation and pharmaceutical compositions containing them |
| ES00951861T ES2226896T3 (es) | 1999-08-05 | 2000-07-31 | Derivados nitroxi de (r) y (s)-carnitina. |
| JP2001515286A JP2003506429A (ja) | 1999-08-05 | 2000-07-31 | （ｒ）および（ｓ）−カルニチンのニトリルオキシ誘導体 |
| CZ20025A CZ20025A3 (cs) | 1999-08-05 | 2000-07-31 | Nitriloxyderiváty(R) a (S)- karnitinu |
| PL358333A PL203519B1 (pl) | 1999-08-05 | 2000-07-31 | Sposób wytwarzania (R) i (S)-karnityny oraz zastosowanie zwi azku nitrooksylowego i pochodnej laktonu jako zwi azków po srednich |
| SI200030495T SI1224161T1 (en) | 1999-08-05 | 2000-07-31 | Nitroxy derivatives of (r) and (s)-carnitine |
| AT00951861T ATE276231T1 (de) | 1999-08-05 | 2000-07-31 | Nitroxyderivate von (r) und (s)-carnitin |
| DK00951861T DK1224161T3 (da) | 1999-08-05 | 2000-07-31 | Nitroxyderivater af (R)- og (S)-carnitin |
| KR1020027001592A KR100772205B1 (ko) | 1999-08-05 | 2000-07-31 | (ｒ) 및 (ｓ)-카르니틴의 니트록시 유도체 |
| PT00951861T PT1224161E (pt) | 1999-08-05 | 2000-07-31 | Derivados nitroxilo de (r)-carnitina e de (s)-carnitina |
| SK175-2002A SK287134B6 (sk) | 1999-08-05 | 2000-07-31 | Spôsob prípravy (R)- a (S)-karnitínu a medziprodukty na ich prípravu |
| AU64704/00A AU6470400A (en) | 1999-08-05 | 2000-07-31 | Nitroxy derivatives of (r) and (s)-carnitine |
| US09/804,270 US6395923B2 (en) | 1999-08-05 | 2001-03-13 | Nitriloxy derivatives of (R) and (S)-carnitine |
| US10/119,954 US6548693B2 (en) | 1999-08-05 | 2002-04-11 | Nitriloxy derivatives of (R) and (S)-carnitine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT1999RM000508A IT1306184B1 (it) | 1999-08-05 | 1999-08-05 | Nitrilossi derivati della (r) e (s)-carnitina. |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITRM990508A0 true ITRM990508A0 (it) | 1999-08-05 |
| ITRM990508A1 ITRM990508A1 (it) | 2001-02-05 |
| IT1306184B1 IT1306184B1 (it) | 2001-05-30 |
Family
ID=11406927
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT1999RM000508A IT1306184B1 (it) | 1999-08-05 | 1999-08-05 | Nitrilossi derivati della (r) e (s)-carnitina. |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US6395923B2 (it) |
| EP (1) | EP1224161B1 (it) |
| JP (1) | JP2003506429A (it) |
| KR (1) | KR100772205B1 (it) |
| AT (1) | ATE276231T1 (it) |
| AU (1) | AU6470400A (it) |
| CA (1) | CA2379047A1 (it) |
| CZ (1) | CZ20025A3 (it) |
| DE (1) | DE60013876T2 (it) |
| DK (1) | DK1224161T3 (it) |
| ES (1) | ES2226896T3 (it) |
| HU (1) | HUP0203034A3 (it) |
| IT (1) | IT1306184B1 (it) |
| PT (1) | PT1224161E (it) |
| SK (1) | SK287134B6 (it) |
| WO (1) | WO2001010819A1 (it) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITRM20010456A1 (it) | 2001-07-26 | 2003-01-27 | Sigma Tau Ind Farmaceuti | Procedimento per la preparazione di (r)- o (s)- amminocarnitina sale interno, dei suoi sali e dei suoi derivati. |
| US8466187B2 (en) | 2007-09-18 | 2013-06-18 | Thermolife International, Llc | Amino acid compositions |
| US12612370B2 (en) | 2011-03-02 | 2026-04-28 | Thermolife International, Llc | Amino acid compositions |
| US11497599B2 (en) | 2017-03-17 | 2022-11-15 | Amo Groningen B.V. | Diffractive intraocular lenses for extended range of vision |
| CA3096256A1 (en) | 2018-04-06 | 2019-10-10 | Amo Development, Llc | Methods and systems for changing a refractive property of an implantable intraocular lens |
| US20200129464A1 (en) * | 2018-10-29 | 2020-04-30 | Lonza Inc. | Method and Composition for Increasing the Bioavailability of Carnitine |
| US10703707B2 (en) | 2018-11-07 | 2020-07-07 | Industrial Technology Research Institute | Method for preparing nitrate ester |
| AU2021377897A1 (en) | 2020-11-12 | 2024-09-12 | Thermolife International, Llc | Methods of increasing blood oxygen saturation |
| KR20230145103A (ko) | 2021-02-11 | 2023-10-17 | 써모라이프 인터내셔널, 엘엘씨 | 산화질소 기체의 투여 방법 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3830931A (en) * | 1972-11-06 | 1974-08-20 | Felice S De | Carnitine and its use in the treatment of arrhythmia and impaired cardiac function |
| US5214166A (en) * | 1986-11-29 | 1993-05-25 | The United States Of America As Represented By The Secretary Of The Navy | Method of synthesizing nitrato alkyl oxetanes |
| CH679856A5 (it) * | 1990-07-04 | 1992-04-30 | Lonza Ag | |
| IT1256705B (it) * | 1992-12-21 | 1995-12-12 | Sigma Tau Ind Farmaceuti | Procedimento per la preparazione di l-(-)-carnitina a partire da un prodotto di scarto avente opposta configurazione. |
| IT1261231B (it) * | 1993-04-08 | 1996-05-09 | Sigma Tau Ind Farmaceuti | Procedimento migliorato per la preparazione di l-(-)-carnitina a partire da un prodotto di scarto avente opposta configurazione. |
| IT1261489B (it) * | 1993-07-29 | 1996-05-23 | Sigma Tau Ind Farmaceuti | Procedimento per la produzione di r amminocarnitina e s amminocarnitina. |
| HUP0002925A3 (en) * | 1997-06-11 | 2002-11-28 | Isis Pharma Gmbh | Novel pentaerythrite derivatives, the production and use thereof and intermediate products for the synthesis of the same |
-
1999
- 1999-08-05 IT IT1999RM000508A patent/IT1306184B1/it active
-
2000
- 2000-07-31 WO PCT/IT2000/000325 patent/WO2001010819A1/en not_active Ceased
- 2000-07-31 SK SK175-2002A patent/SK287134B6/sk not_active IP Right Cessation
- 2000-07-31 ES ES00951861T patent/ES2226896T3/es not_active Expired - Lifetime
- 2000-07-31 JP JP2001515286A patent/JP2003506429A/ja active Pending
- 2000-07-31 CA CA002379047A patent/CA2379047A1/en not_active Abandoned
- 2000-07-31 HU HU0203034A patent/HUP0203034A3/hu unknown
- 2000-07-31 KR KR1020027001592A patent/KR100772205B1/ko not_active Expired - Fee Related
- 2000-07-31 CZ CZ20025A patent/CZ20025A3/cs unknown
- 2000-07-31 PT PT00951861T patent/PT1224161E/pt unknown
- 2000-07-31 DK DK00951861T patent/DK1224161T3/da active
- 2000-07-31 EP EP00951861A patent/EP1224161B1/en not_active Expired - Lifetime
- 2000-07-31 DE DE60013876T patent/DE60013876T2/de not_active Expired - Lifetime
- 2000-07-31 AU AU64704/00A patent/AU6470400A/en not_active Abandoned
- 2000-07-31 AT AT00951861T patent/ATE276231T1/de not_active IP Right Cessation
-
2001
- 2001-03-13 US US09/804,270 patent/US6395923B2/en not_active Expired - Fee Related
-
2002
- 2002-04-11 US US10/119,954 patent/US6548693B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US20010011074A1 (en) | 2001-08-02 |
| DK1224161T3 (da) | 2005-01-24 |
| EP1224161A1 (en) | 2002-07-24 |
| ATE276231T1 (de) | 2004-10-15 |
| CA2379047A1 (en) | 2001-02-15 |
| US20020119965A1 (en) | 2002-08-29 |
| SK287134B6 (sk) | 2010-01-07 |
| IT1306184B1 (it) | 2001-05-30 |
| SK1752002A3 (en) | 2002-06-04 |
| DE60013876D1 (de) | 2004-10-21 |
| HUP0203034A2 (hu) | 2003-02-28 |
| AU6470400A (en) | 2001-03-05 |
| ITRM990508A1 (it) | 2001-02-05 |
| WO2001010819A1 (en) | 2001-02-15 |
| CZ20025A3 (cs) | 2002-07-17 |
| DE60013876T2 (de) | 2005-09-29 |
| JP2003506429A (ja) | 2003-02-18 |
| KR20020025213A (ko) | 2002-04-03 |
| PT1224161E (pt) | 2005-01-31 |
| HUP0203034A3 (en) | 2003-11-28 |
| ES2226896T3 (es) | 2005-04-01 |
| US6395923B2 (en) | 2002-05-28 |
| PL358333A1 (en) | 2004-08-09 |
| EP1224161B1 (en) | 2004-09-15 |
| US6548693B2 (en) | 2003-04-15 |
| KR100772205B1 (ko) | 2007-11-01 |
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