DK1224192T3 - Halvsandwich-ruthenium (II)-forbindelser omfattende nitrogenholdige ligander til behandling af cancer - Google Patents

Halvsandwich-ruthenium (II)-forbindelser omfattende nitrogenholdige ligander til behandling af cancer

Info

Publication number: DK1224192T3
Authority: DK; Denmark
Prior art keywords: sup; sub; compounds; optionally substituted; cancer
Prior art date: 1999-10-27

Application number

DK00971599T

Other languages

English (en)

Inventor

Robert Edward Morris

Peter John Sadler

Haimei Chen

Duncan Jodrell

Original Assignee

Univ Court The University Of E

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-10-27

Filing date

2000-10-26

Publication date

2006-01-02

1999-10-27 Priority claimed from GBGB9925274.4A external-priority patent/GB9925274D0/en

2000-06-30 Priority claimed from GB0016054A external-priority patent/GB0016054D0/en

2000-10-26 Application filed by Univ Court The University Of E filed Critical Univ Court The University Of E

2006-01-02 Application granted granted Critical

2006-01-02 Publication of DK1224192T3 publication Critical patent/DK1224192T3/da

Links

YAYGSLOSTXKUBW-UHFFFAOYSA-N ruthenium(2+) Chemical class [Ru+2] YAYGSLOSTXKUBW-UHFFFAOYSA-N 0.000 title abstract 2
206010028980 Neoplasm Diseases 0.000 title 1
201000011510 cancer Diseases 0.000 title 1
239000003446 ligand Substances 0.000 title 1
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 5
125000002947 alkylene group Chemical group 0.000 abstract 5
125000003118 aryl group Chemical group 0.000 abstract 4
125000002877 alkyl aryl group Chemical group 0.000 abstract 3
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
-1 cylcoalkyl Chemical group 0.000 abstract 2
125000001475 halogen functional group Chemical group 0.000 abstract 2
125000000753 cycloalkyl group Chemical group 0.000 abstract 1
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0046—Ruthenium compounds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F17/00—Metallocenes
- C07F17/02—Metallocenes of metals of Groups 8, 9 or 10 of the Periodic Table

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Inorganic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

DK00971599T 1999-10-27 2000-10-26 Halvsandwich-ruthenium (II)-forbindelser omfattende nitrogenholdige ligander til behandling af cancer DK1224192T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9925274.4A GB9925274D0 (en)	1999-10-27	1999-10-27	Ruthenium (II) compounds
GB0016054A GB0016054D0 (en)	2000-06-30	2000-06-30	Ruthenium (II) compounds

Publications (1)

Publication Number	Publication Date
DK1224192T3 true DK1224192T3 (da)	2006-01-02

Family

ID=26244569

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK00971599T DK1224192T3 (da)	1999-10-27	2000-10-26	Halvsandwich-ruthenium (II)-forbindelser omfattende nitrogenholdige ligander til behandling af cancer

Country Status (8)

Country	Link
US (3)	US6750251B2 (da)
EP (1)	EP1224192B1 (da)
JP (1)	JP2003512471A (da)
AT (1)	ATE303393T1 (da)
DE (1)	DE60022372T2 (da)
DK (1)	DK1224192T3 (da)
ES (1)	ES2248136T3 (da)
WO (1)	WO2001030790A1 (da)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE60022372T2 (de) *	1999-10-27	2006-06-08	The University Court Of The University Of Edinburgh	Halbsandwich ruthenium(ii)-verbindungen mit einem stickstoff-haltigen liganden zur krebstherapie
GB0215526D0 (en) *	2002-07-05	2002-08-14	Univ Edinburgh	Anticancer compounds
BRPI0409768A (pt) *	2003-04-30	2006-05-09	Univ Edinburgh	composto, uso de composto, composição farmacêutica, método para tratar e/ou prevenir cáncer, e, processo para preparar o composto
GB0418643D0 (en) *	2004-08-20	2004-09-22	Univ Edinburgh	Ruthenium (II) compounds
GB0604602D0 (en) *	2006-03-07	2006-04-19	Univ Edinburgh	Ruthenium (II) compounds
WO2007128158A1 (en)	2006-05-09	2007-11-15	Ecole Polytechnique Federale De Lausanne (Epfl)	Transition metal complexes for inhibiting resistance in the treatment of cancer and metastasis
GB0610062D0 (en) *	2006-05-19	2006-06-28	Univ Edinburgh	Ruthenium (ll) compounds
WO2011044472A1 (en) *	2009-10-08	2011-04-14	Angus Chemical Company	Low-voc polyamines
US8383673B2 (en) *	2010-03-19	2013-02-26	City University Of Hong Kong	Nitridoosmium(VI) complexes for treatment of cancer
WO2013038395A1 (en)	2011-09-16	2013-03-21	Universidade De Lisboa	Transition metal complexes for pharmaceutical applications
WO2013136296A2 (en)	2012-03-14	2013-09-19	Universidade De Lisboa	Water-soluble organometallic ruthenium and iron compunds presenting heteroaromatic ligands
US9290528B1 (en)	2013-03-15	2016-03-22	University Of Kentucky Research Foundation	Light-activated compounds
US9751081B2 (en)	2014-12-01	2017-09-05	Clemson University	Self-regenerating antioxidant catalysts and methods of using the same
US10053480B1 (en)	2017-10-11	2018-08-21	King Saud University	Anti-quorum and DNA cleaving agent

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4980472A (en)	1983-06-23	1990-12-25	American Cyanamid Company	Method of making (3-amino-1H-pyrazol-4-yl) (aryl)methanones
EP0188585A1 (de)	1984-07-24	1986-07-30	Byk Gulden Lomberg Chemische Fabrik GmbH	Tumorhemmend wirkende rutheniumverbindungen
DE3572981D1 (en)	1984-07-24	1989-10-19	Asta Pharma Ag	Ruthenium compounds having a tumor inhibiting activity
US4980473A (en) *	1985-01-18	1990-12-25	The Trustees Of Columbia University In The City Of New York	Chemical probes for left-handed DNA and chiral metal complexes as Z-specific anti-tumor agents
US5225556A (en)	1985-01-18	1993-07-06	The Trustees Of Columbia University In The City Of New York	Chemical probes for left-handed DNA and for A-DNA; chiral metal complexes as Z-specific antitumor agents and as double strand cleavers
US4699978A (en)	1985-01-18	1987-10-13	The Trustees Of Columbia University In The City Of New York	Site-specific chiral ruthenium (II) and cobalt (III) antitumor agents
US5386044A (en)	1993-11-30	1995-01-31	E. I. Du Pont De Nemours And Company	Polyhaloaromatic ruthenium complexes and reactions thereof
AU4017695A (en)	1994-10-28	1996-05-23	Procept, Inc.	Ruthenium complexes and their use as immunosuppressive agents
US5708022A (en)	1994-10-28	1998-01-13	Procept, Inc.	Method for inhibiting immune response
JPH11209314A (ja) *	1997-09-30	1999-08-03	Takasago Internatl Corp	シクロオクタジエン類の製造方法
DE60022372T2 (de) *	1999-10-27	2006-06-08	The University Court Of The University Of Edinburgh	Halbsandwich ruthenium(ii)-verbindungen mit einem stickstoff-haltigen liganden zur krebstherapie
GB0016052D0 (en) *	2000-06-30	2000-08-23	Univ Edinburgh	Ruthenium (II) compounds
GB0028025D0 (en)	2000-11-17	2001-01-03	Univ York	Compounds
GB0215526D0 (en) *	2002-07-05	2002-08-14	Univ Edinburgh	Anticancer compounds

2000
- 2000-10-26 DE DE60022372T patent/DE60022372T2/de not_active Expired - Fee Related
- 2000-10-26 ES ES00971599T patent/ES2248136T3/es not_active Expired - Lifetime
- 2000-10-26 DK DK00971599T patent/DK1224192T3/da active
- 2000-10-26 AT AT00971599T patent/ATE303393T1/de not_active IP Right Cessation
- 2000-10-26 WO PCT/GB2000/004144 patent/WO2001030790A1/en not_active Ceased
- 2000-10-26 EP EP00971599A patent/EP1224192B1/en not_active Expired - Lifetime
- 2000-10-26 JP JP2001533142A patent/JP2003512471A/ja active Pending
2002
- 2002-04-26 US US10/134,404 patent/US6750251B2/en not_active Expired - Fee Related
2004
- 2004-05-18 US US10/848,416 patent/US6979681B2/en not_active Expired - Fee Related
2005
- 2005-06-23 US US11/165,372 patent/US20050239765A1/en not_active Abandoned

Also Published As

Publication number	Publication date
WO2001030790A1 (en)	2001-05-03
JP2003512471A (ja)	2003-04-02
DE60022372T2 (de)	2006-06-08
US20030023088A1 (en)	2003-01-30
US20050239765A1 (en)	2005-10-27
US6979681B2 (en)	2005-12-27
EP1224192A1 (en)	2002-07-24
US20040220166A1 (en)	2004-11-04
ATE303393T1 (de)	2005-09-15
EP1224192B1 (en)	2005-08-31
ES2248136T3 (es)	2006-03-16
DE60022372D1 (de)	2005-10-06
US6750251B2 (en)	2004-06-15

Publication	Publication Date	Title
BR0213140A (pt)	2004-10-19	Fungicidas de pirazol-pirimidina
DE60022372D1 (de)	2005-10-06	Halbsandwich ruthenium(ii)-verbindungen mit einem stickstoff-haltigen liganden zur krebstherapie
DE59711733D1 (de)	2004-07-29	3-thiocarbamoylpyrazol-derivate als pestiziden
CY1106858T1 (el)	2012-05-23	Νεα παραγωγα κυκλικου αμιδιου
AU2003254852A8 (en)	2004-02-25	Fused heterocyclic compounds as peptidase inhibitors
MX9800867A (es)	1998-04-30	Halogenobencimidazoles y su empleo como microbicidas.
RU93046499A (ru)	1996-10-10	Способ увеличения относительной плотности полиамидов
DE69821622D1 (de)	2004-03-18	Verfahren zur herstellung von phosphinverbindungen
ES8700856A1 (es)	1986-11-16	Un procedimiento para la preparacion de compuestos de 1, 4-dihidropiridina
EP0602254A4 (en)	1995-02-08	POLYMERIZABLE MONOMER AND ITS POLYMER; ASSOCIATED PRODUCTION PROCESS.
DK1447400T3 (da)	2008-12-08	Bicyklisk forbindelse
ATE260268T1 (de)	2004-03-15	Cumarin-derivate mit comt hemmender wirkung
ATE168369T1 (de)	1998-08-15	Alkoxymethylation von pyrrolen um pestizide herzustellen
ES2064729T3 (es)	1995-02-01	Complejos de rutenio (iii) como agentes antineoplasticos.
MY127738A (en)	2006-12-29	Tridentate ligands and relative complexes with transition metals
PE20000734A1 (es)	2000-08-18	Compuestos heterociclicos derivados de furopiridina y su uso terapeutico
NZ337749A (en)	2000-09-29	Benzimidazole derivative and their use in allergy-related disease
EA200300458A1 (ru)	2003-08-28	Новые соединения аминотриазолона, способ их получения и фармацевтические композиции, содержащие их
ECSP003761A (es)	2002-06-26	Compuestos heterociclicos sililados
ATE257831T1 (de)	2004-01-15	Synthese von wasserlöslischem 9-dihydroplacitaxel derivate aus 9-dihydro-13-acetylbacchatin iii
DE60023909D1 (de)	2005-12-15	Fungizide mit einer fluorovinyl-oder fluoropropenyloxyphenyloxim-einheit und ein verfahren zu ihrer herstellung.
DE60043228D1 (de)	2009-12-10	Herstellungsverfahren von 2-cyanopyridinen
EP0145095A3 (en)	1985-10-30	1,2,4-oxa (thia) diazolin-3-one derivatives
PT782574E (pt)	2002-08-30	Carboxamidas biciclicas como antagonistas 5-ht1a
ATE367377T1 (de)	2007-08-15	Bis(5-aryl-2-pyridyl)derivate