DK1225175T3 - Mellemprodukt til syntese af D-chiro-3-inosose og (+)-D-chiro-inositol - Google Patents
Mellemprodukt til syntese af D-chiro-3-inosose og (+)-D-chiro-inositolInfo
- Publication number
- DK1225175T3 DK1225175T3 DK02007823T DK02007823T DK1225175T3 DK 1225175 T3 DK1225175 T3 DK 1225175T3 DK 02007823 T DK02007823 T DK 02007823T DK 02007823 T DK02007823 T DK 02007823T DK 1225175 T3 DK1225175 T3 DK 1225175T3
- Authority
- DK
- Denmark
- Prior art keywords
- chiro
- synthesis
- compounds
- synthon
- inosose
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title abstract 4
- 238000003786 synthesis reaction Methods 0.000 title abstract 4
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 4
- CDAISMWEOUEBRE-LKPKBOIGSA-N 1D-chiro-inositol Chemical compound O[C@H]1[C@@H](O)[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O CDAISMWEOUEBRE-LKPKBOIGSA-N 0.000 abstract 1
- QWOJMRHUQHTCJG-UHFFFAOYSA-N CC([CH2-])=O Chemical compound CC([CH2-])=O QWOJMRHUQHTCJG-UHFFFAOYSA-N 0.000 abstract 1
- 230000002210 biocatalytic effect Effects 0.000 abstract 1
- 238000001311 chemical methods and process Methods 0.000 abstract 1
- 150000002009 diols Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
- C07C29/136—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
- C07C29/143—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of ketones
- C07C29/145—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of ketones with hydrogen or hydrogen-containing gases
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C35/00—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
- C07C35/02—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring monocyclic
- C07C35/08—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring monocyclic containing a six-membered rings
- C07C35/14—Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring monocyclic containing a six-membered rings with more than one hydroxy group bound to the ring
- C07C35/16—Inositols
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
- C07D493/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95652292A | 1992-10-05 | 1992-10-05 | |
| US97405792A | 1992-11-10 | 1992-11-10 | |
| PCT/US1993/009103 WO1994007897A1 (en) | 1992-10-05 | 1993-09-23 | Syntheses of d-chiro-3-inosose and (+)-d-chiro-inositol |
| EP93922377A EP0663915B1 (en) | 1992-10-05 | 1993-09-23 | Syntheses of d-chiro-3-inosose and (+)-d-chiro-inositol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1225175T3 true DK1225175T3 (da) | 2005-06-20 |
Family
ID=27130376
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK02007823T DK1225175T3 (da) | 1992-10-05 | 1993-09-23 | Mellemprodukt til syntese af D-chiro-3-inosose og (+)-D-chiro-inositol |
Country Status (11)
| Country | Link |
|---|---|
| US (6) | US5563281A (da) |
| EP (2) | EP0663915B1 (da) |
| JP (1) | JP4242925B2 (da) |
| AT (1) | ATE292131T1 (da) |
| AU (1) | AU693075B2 (da) |
| CA (1) | CA2146353C (da) |
| DE (2) | DE69333788T2 (da) |
| DK (1) | DK1225175T3 (da) |
| MX (1) | MX9306095A (da) |
| NZ (3) | NZ314111A (da) |
| WO (1) | WO1994007897A1 (da) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5442079A (en) * | 1993-05-10 | 1995-08-15 | Virginia Polytechnic Institute And State University | Method for preparing erythruronolactone |
| JP2001163810A (ja) * | 1999-09-30 | 2001-06-19 | Microbial Chem Res Found | １ｄ−キロ−イノシトールの新規合成方法および中間体 |
| US7521481B2 (en) | 2003-02-27 | 2009-04-21 | Mclaurin Joanne | Methods of preventing, treating and diagnosing disorders of protein aggregation |
| EP1824496A4 (en) * | 2004-11-17 | 2008-07-16 | Joanne Mclaurin | COMPOSITIONS OF SCYLLO-INOSITOL DERIVATIVES AND METHOD FOR THE TREATMENT OF PROTEIN AGGREGATION DISORDERS |
| WO2007041855A1 (en) * | 2005-10-13 | 2007-04-19 | Waratah Pharmaceuticals, Inc. | Scyllo-inositol derivatives and their use in the treatment of diseases characterised by abnormal protein folding or aggregation or amyloid formation, deposition, accumulation or persistence |
| US20070197452A1 (en) * | 2006-02-17 | 2007-08-23 | Mclaurin Joanne | Treatment of amyloid-related diseases |
| CN103054837A (zh) * | 2006-03-09 | 2013-04-24 | 瓦拉塔药品公司 | 用于治疗蛋白积聚病症的环己烷多元醇制剂 |
| US20110028719A1 (en) * | 2006-05-19 | 2011-02-03 | Jacek Slon-Usakiewicz | Screening methods for amyloid beta modulators |
| US20100173960A1 (en) * | 2006-09-21 | 2010-07-08 | Antonio Cruz | The Combination of a Cyclohexanehexol and a NSAID for the Treatment of Neurodegenerative Diseases |
| US20090214474A1 (en) * | 2006-11-01 | 2009-08-27 | Barbara Brooke Jennings | Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development |
| US20110218176A1 (en) | 2006-11-01 | 2011-09-08 | Barbara Brooke Jennings-Spring | Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development |
| KR100748210B1 (ko) * | 2006-11-21 | 2007-08-09 | 주식회사 카이로켐 | 디-카이로-이노시톨의 제조방법 |
| WO2008061373A1 (en) * | 2006-11-24 | 2008-05-29 | Waratah Pharmaceuticals Inc. | Combination treatments for alzheimer's disease and similar diseases |
| CA2683546A1 (en) * | 2007-04-12 | 2008-10-23 | Joanne Mclaurin | Use of cyclohexanehexol derivatives in the treatment of .alpha.-synucleinopathies |
| CA2683580A1 (en) * | 2007-04-12 | 2008-10-23 | Joanne Mclaurin | Treatment of amyotrophic lateral sclerosis |
| JP2010523602A (ja) * | 2007-04-12 | 2010-07-15 | ワラタ ファーマシューティカルズ， インコーポレイテッド | 眼疾患の治療におけるシクロヘキサンヘキソール誘導体の使用 |
| WO2008124930A1 (en) * | 2007-04-12 | 2008-10-23 | Joanne Mclaurin | Use of cyclohexanehexol derivatives for the treatment of polyglutamine diseases |
| CA2740124A1 (en) * | 2008-10-09 | 2010-04-15 | Waratah Pharmaceuticals Inc. | Use of scyllo-inositols for the treatment of macular degeneration-related disorders |
| DE102014006563B4 (de) * | 2014-05-07 | 2017-05-11 | Nb Technologies Gmbh | Imprintstempel sowie Verfahren zur Herstellung und Anwendung eines Imprintstempels |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3065636B2 (ja) * | 1989-06-29 | 2000-07-17 | 塩野義製薬株式会社 | ［ジ―ｔｅｒｔ―ブチル（ヒドロキシ）フェニルチオ］置換ヒドロキサム酸誘導体 |
| US5200516A (en) * | 1990-02-16 | 1993-04-06 | Virginia Tech Intellectual Properties | Synthesis of sugars from substituted and unsubstituted arene diols |
| EP0477359B1 (en) * | 1990-04-16 | 1995-07-05 | Virginia Tech Intellectual Properties, Inc. | Synthesis of cyclitols from substituted arene diols |
| US5091596A (en) * | 1990-12-20 | 1992-02-25 | Univ. Of Va. Alumni Patents Foundation | Method for producing chiro-inositol |
-
1993
- 1993-09-23 NZ NZ314111A patent/NZ314111A/xx not_active IP Right Cessation
- 1993-09-23 AT AT02007823T patent/ATE292131T1/de not_active IP Right Cessation
- 1993-09-23 DE DE69333788T patent/DE69333788T2/de not_active Expired - Lifetime
- 1993-09-23 EP EP93922377A patent/EP0663915B1/en not_active Expired - Lifetime
- 1993-09-23 AU AU51393/93A patent/AU693075B2/en not_active Expired
- 1993-09-23 NZ NZ314112A patent/NZ314112A/xx not_active IP Right Cessation
- 1993-09-23 DK DK02007823T patent/DK1225175T3/da active
- 1993-09-23 WO PCT/US1993/009103 patent/WO1994007897A1/en not_active Ceased
- 1993-09-23 NZ NZ256610A patent/NZ256610A/en not_active IP Right Cessation
- 1993-09-23 JP JP50919294A patent/JP4242925B2/ja not_active Expired - Lifetime
- 1993-09-23 DE DE69332542T patent/DE69332542T2/de not_active Expired - Lifetime
- 1993-09-23 CA CA002146353A patent/CA2146353C/en not_active Expired - Lifetime
- 1993-09-23 EP EP02007823A patent/EP1225175B1/en not_active Expired - Lifetime
- 1993-09-30 MX MX9306095A patent/MX9306095A/es unknown
-
1995
- 1995-03-22 US US08/408,435 patent/US5563281A/en not_active Expired - Lifetime
- 1995-03-24 US US08/410,467 patent/US5578738A/en not_active Expired - Lifetime
- 1995-03-24 US US08/410,477 patent/US5600014A/en not_active Expired - Lifetime
- 1995-03-24 US US08/410,611 patent/US5602287A/en not_active Expired - Lifetime
- 1995-03-24 US US08/410,269 patent/US5633412A/en not_active Expired - Lifetime
- 1995-03-24 US US08/410,180 patent/US5602263A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US5600014A (en) | 1997-02-04 |
| US5578738A (en) | 1996-11-26 |
| EP0663915A1 (en) | 1995-07-26 |
| DE69332542T2 (de) | 2003-08-14 |
| DE69333788T2 (de) | 2006-02-16 |
| CA2146353C (en) | 2007-04-17 |
| US5602263A (en) | 1997-02-11 |
| CA2146353A1 (en) | 1994-04-14 |
| ATE292131T1 (de) | 2005-04-15 |
| NZ314111A (en) | 1997-08-22 |
| AU693075B2 (en) | 1998-06-25 |
| NZ314112A (en) | 1997-08-22 |
| NZ256610A (en) | 1997-03-24 |
| WO1994007897A1 (en) | 1994-04-14 |
| AU5139393A (en) | 1994-04-26 |
| MX9306095A (es) | 1994-06-30 |
| US5563281A (en) | 1996-10-08 |
| US5633412A (en) | 1997-05-27 |
| DE69332542D1 (de) | 2003-01-16 |
| EP1225175B1 (en) | 2005-03-30 |
| DE69333788D1 (de) | 2005-05-04 |
| EP1225175A1 (en) | 2002-07-24 |
| JP4242925B2 (ja) | 2009-03-25 |
| US5602287A (en) | 1997-02-11 |
| JPH08502255A (ja) | 1996-03-12 |
| EP0663915B1 (en) | 2002-12-04 |
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