DK1226137T3 - Phenyl- og pyridyltetrahydro-pyridiner med en hæmmende virkning på TNF - Google Patents

Phenyl- og pyridyltetrahydro-pyridiner med en hæmmende virkning på TNF

Info

Publication number: DK1226137T3
Authority: DK; Denmark
Prior art keywords: tetrahydropyridines; tnf; pyridyl; phenyl; inhibitory effect
Prior art date: 1999-10-22

Application number

DK00969646T

Other languages

English (en)

Inventor

Rosanna Cardamone

Bernard Bourrie

Marco Baroni

Pierre Casellas

Umberto Guzzi

Original Assignee

Sanofi Aventis

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-10-22

Filing date

2000-10-19

Publication date

2004-11-22

1999-10-22 Priority claimed from FR9913206A external-priority patent/FR2800071B1/fr

2000-06-28 Priority claimed from FR0008328A external-priority patent/FR2810984B1/fr

2000-10-19 Application filed by Sanofi Aventis filed Critical Sanofi Aventis

2004-11-22 Application granted granted Critical

2004-11-22 Publication of DK1226137T3 publication Critical patent/DK1226137T3/da

Links

230000002401 inhibitory effect Effects 0.000 title 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 title 1
-1 pyridyl tetrahydropyridines Chemical class 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A43—FOOTWEAR
- A43B—CHARACTERISTIC FEATURES OF FOOTWEAR; PARTS OF FOOTWEAR
- A43B7/00—Footwear with health or hygienic arrangements
- A43B7/12—Special watertight footwear
- A43B7/125—Special watertight footwear provided with a vapour permeable member, e.g. a membrane
- A—HUMAN NECESSITIES
- A43—FOOTWEAR
- A43B—CHARACTERISTIC FEATURES OF FOOTWEAR; PARTS OF FOOTWEAR
- A43B9/00—Footwear characterised by the assembling of the individual parts
- A43B9/02—Footwear stitched or nailed through
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
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- B29D35/062—Producing footwear having soles or heels formed and joined on to preformed uppers using a moulding technique, e.g. by injection moulding, pressing and vulcanising by injection moulding using means to bond the moulding material to the preformed uppers
- B—PERFORMING OPERATIONS; TRANSPORTING
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- B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B29D35/14—Multilayered parts
- B29D35/142—Soles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D215/14—Radicals substituted by oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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- B29C45/00—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor
- B29C45/14—Injection moulding, i.e. forcing the required volume of moulding material through a nozzle into a closed mould; Apparatus therefor incorporating preformed parts or layers, e.g. injection moulding around inserts or for coating articles
- B29C45/14836—Preventing damage of inserts during injection, e.g. collapse of hollow inserts, breakage
- B29C2045/14844—Layers protecting the insert from injected material

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Virology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Physical Education & Sports Medicine (AREA)
Mechanical Engineering (AREA)
Neurology (AREA)
Immunology (AREA)
Rheumatology (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Orthopedic Medicine & Surgery (AREA)
Cardiology (AREA)
Diabetes (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Hematology (AREA)
Dermatology (AREA)
Biotechnology (AREA)
Pulmonology (AREA)
Epidemiology (AREA)
Urology & Nephrology (AREA)
AIDS & HIV (AREA)
Endocrinology (AREA)

DK00969646T 1999-10-22 2000-10-19 Phenyl- og pyridyltetrahydro-pyridiner med en hæmmende virkning på TNF DK1226137T3 (da)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
FR9913206A FR2800071B1 (fr)	1999-10-22	1999-10-22	Tetrahydropyridines, procede pour leur preparation et compositions pharmaceutiques les contenant
FR0008328A FR2810984B1 (fr)	2000-06-28	2000-06-28	Pyridyl-tetrahydropyridines, procede pour leur preparation et compositions pharmaceutiques les contenant
PCT/FR2000/002910 WO2001029026A1 (fr)	1999-10-22	2000-10-19	Phenyl- et pyridyl-tetrahydro-pyridines possedant une activite inhibitrice de fnt
EP00969646A EP1226137B8 (fr)	1999-10-22	2000-10-19	Phenyl- et pyridyl-tetrahydro-pyridines possedant une activite inhibitrice de fnt

Publications (1)

Publication Number	Publication Date
DK1226137T3 true DK1226137T3 (da)	2004-11-22

Family

ID=26212500

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK00969646T DK1226137T3 (da)	1999-10-22	2000-10-19	Phenyl- og pyridyltetrahydro-pyridiner med en hæmmende virkning på TNF

Country Status (35)

Country	Link
US (1)	US6509351B1 (da)
EP (1)	EP1226137B8 (da)
JP (1)	JP4831908B2 (da)
KR (1)	KR100755115B1 (da)
CN (1)	CN1158276C (da)
AR (1)	AR026188A1 (da)
AT (1)	ATE271554T1 (da)
AU (1)	AU778306B2 (da)
BG (1)	BG65564B1 (da)
BR (1)	BR0014871A (da)
CA (1)	CA2386417C (da)
CZ (1)	CZ301566B6 (da)
DE (1)	DE60012355T2 (da)
DK (1)	DK1226137T3 (da)
EA (1)	EA004508B1 (da)
EE (1)	EE05055B1 (da)
ES (1)	ES2223594T3 (da)
HK (1)	HK1046532B (da)
HR (1)	HRP20020347B1 (da)
HU (1)	HUP0204444A3 (da)
IL (2)	IL149250A0 (da)
IS (1)	IS2308B (da)
ME (1)	MEP25108A (da)
MX (1)	MXPA02003979A (da)
NO (1)	NO322596B1 (da)
NZ (1)	NZ518112A (da)
PL (1)	PL198421B1 (da)
PT (1)	PT1226137E (da)
RS (1)	RS50399B (da)
SI (1)	SI1226137T1 (da)
SK (1)	SK287098B6 (da)
TR (1)	TR200201075T2 (da)
TW (1)	TWI224097B (da)
UA (1)	UA72934C2 (da)
WO (1)	WO2001029026A1 (da)

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* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2823748B1 (fr) *	2001-04-20	2004-02-20	Sanofi Synthelabo	Tetrahydropyridyl-alkyl-benzodiazines, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2831166B1 (fr) *	2001-10-18	2004-02-27	Sanofi Synthelabo	Aralkyl-tetrahydro-pyridines, leur preparation et compositions pharmaceutiques les contenant
FR2832405B1 (fr) *	2001-11-19	2004-12-10	Sanofi Synthelabo	Tetrahydropyridyl-alkyl-heterocycles azotes, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2840896B1 (fr) *	2002-06-18	2005-04-08	Sanofi Synthelabo	Phenyl-et pyridyl-piperazines, procede pour leur preparation et compositions pharmaceutiques les contenant
US7632950B2 (en)	2003-08-18	2009-12-15	Fujifilm Finechemicals Co., Ltd	Pyridyltetrahydropyridines and pyridylpiperidines and method of manufacturing them
FR2883285B1 (fr) *	2005-03-17	2007-05-18	Sanofi Aventis Sa	Sel besylate de la 7-(2-(4-(3-trifluoromethyl-phenyl) -1,2,3,6-tetrahudro-pyrid-1-yl)ethyl) isoquinoleine, sa preparation et son utilisation en therapeutique

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US3991061A (en)	1975-07-16	1976-11-09	G. D. Searle & Co.	Azanaphthaleneacetic acid derivatives
US4704390A (en) *	1986-02-13	1987-11-03	Warner-Lambert Company	Phenyl and heterocyclic tetrahydropyridyl alkoxy-benzheterocyclic compounds as antipsychotic agents
US5118691A (en)	1990-09-20	1992-06-02	Warner-Lambert Co.	Substituted tetrahydropyridines as central nervous system agents
US5045550A (en) *	1990-09-20	1991-09-03	Warner-Lambert Co.	Substituted tetrahydropyridines as central nervous system agents
US5273977A (en) *	1990-11-05	1993-12-28	Warner-Lambert Company	Substituted tetrahydropyridines and hydroxypiperidines as central nervous system agents
JP2001511764A (ja) *	1996-04-12	2001-08-14	住友製薬株式会社	ピペリジニルピリミジン誘導体
US5776939A (en)	1997-06-12	1998-07-07	Eli Lilly And Company	Drug resistance and multidrug resistance modulators
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FR2803593B1 (fr) *	2000-01-06	2002-02-15	Sanofi Synthelabo	Nouvelles tetrahydropyridines, procede pour leur preparation et compositions pharmaceutiques les contenant

2000
- 2000-10-19 IL IL14925000A patent/IL149250A0/xx active IP Right Grant
- 2000-10-19 CA CA2386417A patent/CA2386417C/en not_active Expired - Fee Related
- 2000-10-19 DK DK00969646T patent/DK1226137T3/da active
- 2000-10-19 BR BR0014871-7A patent/BR0014871A/pt active Search and Examination
- 2000-10-19 WO PCT/FR2000/002910 patent/WO2001029026A1/fr not_active Ceased
- 2000-10-19 JP JP2001531826A patent/JP4831908B2/ja not_active Expired - Fee Related
- 2000-10-19 DE DE60012355T patent/DE60012355T2/de not_active Expired - Lifetime
- 2000-10-19 US US10/111,045 patent/US6509351B1/en not_active Expired - Lifetime
- 2000-10-19 MX MXPA02003979A patent/MXPA02003979A/es active IP Right Grant
- 2000-10-19 SK SK528-2002A patent/SK287098B6/sk not_active IP Right Cessation
- 2000-10-19 HR HR20020347A patent/HRP20020347B1/xx not_active IP Right Cessation
- 2000-10-19 RS YUP-289/02A patent/RS50399B/sr unknown
- 2000-10-19 NZ NZ518112A patent/NZ518112A/en not_active IP Right Cessation
- 2000-10-19 EP EP00969646A patent/EP1226137B8/fr not_active Expired - Lifetime
- 2000-10-19 AU AU79313/00A patent/AU778306B2/en not_active Ceased
- 2000-10-19 EE EEP200200210A patent/EE05055B1/xx not_active IP Right Cessation
- 2000-10-19 CZ CZ20021382A patent/CZ301566B6/cs not_active IP Right Cessation
- 2000-10-19 AT AT00969646T patent/ATE271554T1/de active
- 2000-10-19 TR TR2002/01075T patent/TR200201075T2/xx unknown
- 2000-10-19 UA UA2002043167A patent/UA72934C2/uk unknown
- 2000-10-19 EA EA200200352A patent/EA004508B1/ru not_active IP Right Cessation
- 2000-10-19 KR KR1020027005110A patent/KR100755115B1/ko not_active Expired - Fee Related
- 2000-10-19 CN CNB008160759A patent/CN1158276C/zh not_active Expired - Fee Related
- 2000-10-19 ME MEP-251/08A patent/MEP25108A/xx unknown
- 2000-10-19 SI SI200030499T patent/SI1226137T1/xx unknown
- 2000-10-19 ES ES00969646T patent/ES2223594T3/es not_active Expired - Lifetime
- 2000-10-19 HU HU0204444A patent/HUP0204444A3/hu unknown
- 2000-10-19 PL PL354922A patent/PL198421B1/pl unknown
- 2000-10-19 PT PT00969646T patent/PT1226137E/pt unknown
- 2000-10-19 HK HK02108188.3A patent/HK1046532B/zh not_active IP Right Cessation
- 2000-10-20 AR ARP000105527A patent/AR026188A1/es not_active Application Discontinuation
- 2000-10-23 TW TW089122181A patent/TWI224097B/zh not_active IP Right Cessation
2002
- 2002-04-09 IS IS6336A patent/IS2308B/is unknown
- 2002-04-15 BG BG106613A patent/BG65564B1/bg unknown
- 2002-04-19 NO NO20021872A patent/NO322596B1/no not_active IP Right Cessation
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Also Published As

Publication number	Publication date
IS6336A (is)	2002-04-09
EP1226137B1 (fr)	2004-07-21
HK1046532A1 (en)	2003-01-17
HRP20020347A2 (en)	2003-08-31
WO2001029026A1 (fr)	2001-04-26
NO20021872L (no)	2002-06-21
DE60012355D1 (de)	2004-08-26
NO20021872D0 (no)	2002-04-19
BG65564B1 (bg)	2008-12-30
TR200201075T2 (tr)	2002-11-21
HRP20020347B1 (en)	2010-10-31
EA200200352A1 (ru)	2002-10-31
HUP0204444A2 (en)	2003-05-28
KR20020040904A (ko)	2002-05-30
UA72934C2 (uk)	2005-05-16
CN1391570A (zh)	2003-01-15
CZ301566B6 (cs)	2010-04-21
EP1226137A1 (fr)	2002-07-31
CZ20021382A3 (cs)	2002-07-17
EE200200210A (et)	2003-06-16
YU28902A (sh)	2004-11-25
ATE271554T1 (de)	2004-08-15
SK287098B6 (sk)	2009-12-07
BR0014871A (pt)	2002-06-11
DE60012355T2 (de)	2005-12-22
SK5282002A3 (en)	2002-08-06
SI1226137T1 (en)	2005-02-28
PL354922A1 (en)	2004-03-22
NZ518112A (en)	2003-11-28
CN1158276C (zh)	2004-07-21
NO322596B1 (no)	2006-10-30
KR100755115B1 (ko)	2007-09-04
CA2386417A1 (en)	2001-04-26
JP4831908B2 (ja)	2011-12-07
CA2386417C (en)	2010-09-28
RS50399B (sr)	2009-12-31
AU778306B2 (en)	2004-11-25
IL149250A (en)	2007-08-19
TWI224097B (en)	2004-11-21
PL198421B1 (pl)	2008-06-30
AR026188A1 (es)	2003-01-29
MEP25108A (en)	2011-12-20
AU7931300A (en)	2001-04-30
HK1046532B (zh)	2005-03-18
US6509351B1 (en)	2003-01-21
EE05055B1 (et)	2008-08-15
IL149250A0 (en)	2002-11-10
EA004508B1 (ru)	2004-04-29
HUP0204444A3 (en)	2004-07-28
BG106613A (en)	2003-02-28
IS2308B (is)	2007-10-15
PT1226137E (pt)	2004-11-30
ES2223594T3 (es)	2005-03-01
EP1226137B8 (fr)	2004-12-15
JP2003512370A (ja)	2003-04-02
MXPA02003979A (es)	2003-01-28
ME01727B (me)	2010-05-07

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