DK1246625T3 - Anvendelser og sammensætninger af nitratestere til tilvejebringelse af sedering - Google Patents

Anvendelser og sammensætninger af nitratestere til tilvejebringelse af sedering

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Publication number
DK1246625T3
DK1246625T3 DK00986925T DK00986925T DK1246625T3 DK 1246625 T3 DK1246625 T3 DK 1246625T3 DK 00986925 T DK00986925 T DK 00986925T DK 00986925 T DK00986925 T DK 00986925T DK 1246625 T3 DK1246625 T3 DK 1246625T3
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compositions
nitrate esters
provide sedation
sedation
nitrate
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DK00986925T
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English (en)
Inventor
Gregory R J Thatcher
Brian M Bennett
James N Reynolds
Khem Jhamandas
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Univ Kingston
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Publication of DK1246625T3 publication Critical patent/DK1246625T3/da

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    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/275—Nitriles; Isonitriles
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    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3808—Acyclic saturated acids which can have further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
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    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
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    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
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    • C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • C07J41/0061—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives one of the carbon atoms being part of an amide group

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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DK00986925T 1999-12-29 2000-12-27 Anvendelser og sammensætninger af nitratestere til tilvejebringelse af sedering DK1246625T3 (da)

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US09/473,713 US7115661B1 (en) 1999-12-29 1999-12-29 Methods and compositions for mitigating pain
PCT/CA2000/001523 WO2001049275A2 (en) 1999-12-29 2000-12-27 Methods and compositions for mitigating pain using nitrate esters

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US20040077702A1 (en) * 2001-09-14 2004-04-22 Wen-Mei Fu Treatment of nuerodegenerative diseases
WO2004004648A2 (en) 2002-07-03 2004-01-15 Nitromed, Inc. Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use
AU2003261281A1 (en) 2002-07-29 2004-02-16 Nicox S.A. Cyclooxygenase- 2 selective inhibitors, compositions and methods of use
JP2005089457A (ja) * 2003-09-03 2005-04-07 Yung Shin Pharmaceutical Industry Co Ltd 骨成長を促進するまたは骨吸収を阻害するための薬剤組成物
US8134010B2 (en) 2004-05-05 2012-03-13 Renopharm Ltd. Thiazole-based nitric oxide donors having aryl substituent(s) and uses thereof
US7968575B2 (en) 2004-05-05 2011-06-28 Renopharm Ltd. Nitric oxide donors and uses thereof
WO2005105065A2 (en) 2004-05-05 2005-11-10 Renopharm Ltd. Thiazole-based nitric oxide donors for treating inflammatory bowel diseases
US7189750B2 (en) * 2004-05-05 2007-03-13 Renopharm Ltd. Thiazole-based nitric oxide donors having at least two thiazole moieties and uses thereof
US7498445B2 (en) 2004-05-05 2009-03-03 Renopharm Ltd. Thiazole-based nitric oxide donors capable of releasing two or more nitric oxide molecules and uses thereof
TW200616604A (en) 2004-08-26 2006-06-01 Nicholas Piramal India Ltd Nitric oxide releasing prodrugs containing bio-cleavable linker
JP5198063B2 (ja) 2004-08-26 2013-05-15 アッパラオ・サティアム 新規バイオ開裂性リンカー
CA2580627A1 (en) * 2004-09-17 2006-03-23 Queen's University At Kingston Nitrate esters and their use for mitigating cellular damage
WO2009044902A1 (ja) * 2007-10-05 2009-04-09 Kyushu Institute Of Technology 誘電泳動装置および方法
WO2009152071A1 (en) * 2008-06-09 2009-12-17 Vanderbilt University Unnatural dispyrin analogues, preparation and uses thereof
WO2010011650A1 (en) * 2008-07-21 2010-01-28 Imi International Medical Innovations (D/B/A Procris Pharmaceuticals) Stable water-based topical pharmaceutical creams and methods of making and using same
US7807716B2 (en) * 2008-09-24 2010-10-05 Oral Delivery Technology Ltd. Nitric oxide amino acid ester compound, compositions for increasing nitric oxide levels and method of use
US8957086B2 (en) * 2010-05-05 2015-02-17 The Board Of Trustees Of The University Of Illinois Compounds and methods of treating brain disorders
WO2014013338A2 (en) * 2012-07-16 2014-01-23 Sgc Pharma, Inc. Compounds for the treatment of alzheimer's disease
US20160108016A1 (en) 2012-09-06 2016-04-21 Northeastern University Novel Cannabinergic Compounds and Uses Thereof
US11964956B2 (en) 2012-09-06 2024-04-23 Northeastern University Cannabinergic compounds and uses thereof
WO2014134127A1 (en) * 2013-02-26 2014-09-04 Northeastern University Cannabinergic nitrate esters and related analogs
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IL150487A0 (en) 2002-12-01
HK1050144A1 (en) 2003-06-13
EP1246625A2 (en) 2002-10-09
ATE283695T1 (de) 2004-12-15
US20070066575A1 (en) 2007-03-22
DE60016460D1 (de) 2005-01-05
WO2001049275A2 (en) 2001-07-12
JP2003519176A (ja) 2003-06-17
PT1246625E (pt) 2005-03-31
AU782489B2 (en) 2005-08-04
EP1246625B1 (en) 2004-12-01
CA2394184A1 (en) 2001-07-12
US7115661B1 (en) 2006-10-03
DE60016460T2 (de) 2005-12-22
ES2233489T3 (es) 2005-06-16
EP1518553A2 (en) 2005-03-30
AU782489C (en) 2006-04-27
WO2001049275A3 (en) 2001-12-13

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