DK1246807T3 - Hydantoin-, thiohydantoin-, purimidindion- og thioxopyrimidinonderivater, fremgangsmåder til deres fremstilling og deres anvendelse som lægemidler - Google Patents

Hydantoin-, thiohydantoin-, purimidindion- og thioxopyrimidinonderivater, fremgangsmåder til deres fremstilling og deres anvendelse som lægemidler

Info

Publication number: DK1246807T3
Authority: DK; Denmark
Prior art keywords: thioxopyrimidinone; purimidinedione; thiohydantoin; hydantoin; pharmaceuticals
Prior art date: 1999-07-30

Application number

DK00958634T

Other languages

Danish (da)

English (en)

Inventor

Christophe Thurieau

Valerie Brault

Lydie Poitout

Original Assignee

Sod Conseils Rech Applic

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-07-30

Filing date

2000-07-28

Publication date

2006-03-20

2000-07-28 Application filed by Sod Conseils Rech Applic filed Critical Sod Conseils Rech Applic

2006-03-20 Application granted granted Critical

2006-03-20 Publication of DK1246807T3 publication Critical patent/DK1246807T3/da

Links

UGWULZWUXSCWPX-UHFFFAOYSA-N 2-sulfanylideneimidazolidin-4-one Chemical compound O=C1CNC(=S)N1 UGWULZWUXSCWPX-UHFFFAOYSA-N 0.000 title 1
239000003814 drug Substances 0.000 title 1
WJRBRSLFGCUECM-UHFFFAOYSA-N hydantoin Chemical compound O=C1CNC(=O)N1 WJRBRSLFGCUECM-UHFFFAOYSA-N 0.000 title 1
229940091173 hydantoin Drugs 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/86—Oxygen and sulfur atoms, e.g. thiohydantoin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
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- A61P1/12—Antidiarrhoeals
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- A—HUMAN NECESSITIES
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- A61P11/02—Nasal agents, e.g. decongestants
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- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A61P35/00—Antineoplastic agents
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
- A—HUMAN NECESSITIES
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Diabetes (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Immunology (AREA)
Endocrinology (AREA)
Hematology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Urology & Nephrology (AREA)
Orthopedic Medicine & Surgery (AREA)
Obesity (AREA)
Oncology (AREA)
Dermatology (AREA)
Pulmonology (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Communicable Diseases (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Gastroenterology & Hepatology (AREA)
Transplantation (AREA)
Vascular Medicine (AREA)
Child & Adolescent Psychology (AREA)

DK00958634T 1999-07-30 2000-07-28 Hydantoin-, thiohydantoin-, purimidindion- og thioxopyrimidinonderivater, fremgangsmåder til deres fremstilling og deres anvendelse som lægemidler DK1246807T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9909886A FR2796945B1 (fr)	1999-07-30	1999-07-30	Nouveaux derives d'hydantoines, de thiohydantoines, de pyrimidinediones et de thioxopyrimidinones, leurs procedes de preparation et leur application a titre de medicaments

Publications (1)

Publication Number	Publication Date
DK1246807T3 true DK1246807T3 (da)	2006-03-20

Family

ID=9548689

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK00958634T DK1246807T3 (da)	1999-07-30	2000-07-28	Hydantoin-, thiohydantoin-, purimidindion- og thioxopyrimidinonderivater, fremgangsmåder til deres fremstilling og deres anvendelse som lægemidler

Country Status (24)

Country	Link
US (3)	US6759415B1 (de)
EP (1)	EP1246807B1 (de)
JP (1)	JP2003518011A (de)
KR (1)	KR100712587B1 (de)
CN (1)	CN1177828C (de)
AR (1)	AR024939A1 (de)
AT (1)	ATE308525T1 (de)
AU (1)	AU779357B2 (de)
BR (1)	BR0012852A (de)
CA (1)	CA2380070C (de)
CZ (1)	CZ2002301A3 (de)
DE (1)	DE60023747T2 (de)
DK (1)	DK1246807T3 (de)
ES (1)	ES2252051T3 (de)
FR (1)	FR2796945B1 (de)
HK (1)	HK1052510B (de)
HU (1)	HUP0202989A3 (de)
IL (1)	IL147744A0 (de)
MX (1)	MXPA02001016A (de)
NO (1)	NO323605B1 (de)
NZ (1)	NZ516718A (de)
PL (1)	PL364726A1 (de)
RU (1)	RU2277093C2 (de)
WO (1)	WO2001009090A2 (de)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0011071D0 (en)	2000-05-08	2000-06-28	Novartis Ag	Organic compounds
JP4711523B2 (ja) *	2001-02-13	2011-06-29	日本臓器製薬株式会社	低アルブミン血症改善剤
PL374174A1 (en) *	2001-06-25	2005-10-03	Societe De Conseils De Recherches Et D'applications Scientifiques, S.A.S.	Pharmaceutical compositions which inhibit proliferation of pituitary adenomas and method of use thereof
FR2832710B1 (fr) *	2001-11-28	2004-09-03	Sod Conseils Rech Applic	Derives de 5-sulfanyl-4h-1,2,4-triazoles et leur utilisation en tant que medicaments
RU2367655C2 (ru) *	2001-11-28	2009-09-20	Сосьете Де Консей Де Решерш Э Д`Аппликасьон Сьентифик (С.К.Р.А.С.)	5-сульфанил-4н-1,2,4-триазольные производные и их применение в качестве лекарственного препарата
WO2003057214A1 (en)	2001-12-28	2003-07-17	Somatocor Pharmaceuticals, Inc.	Imidazolidin-2,4-dione derivatives as non-peptide somatostatin receptor ligands
HRP20050053A2 (en) *	2002-09-19	2005-04-30	Solvay Pharmaceuticals B.V.	1 h-1,2,4-triazole-3-carboxamide derivatives as cannabinoid-cb1 receptor ligands
US7354933B2 (en) *	2003-01-31	2008-04-08	Aventis Pharma Sa	Cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors
FR2850652B1 (fr) *	2003-01-31	2008-05-30	Aventis Pharma Sa	Nouveaux derives d'uree cyclique, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de kinases
DE10325813B4 (de) *	2003-06-06	2007-12-20	Universitätsklinikum Freiburg	Prophylaxe und/oder Therapie bei der portalen Hypertonie
EP1621535A1 (de) *	2004-07-27	2006-02-01	Aventis Pharma S.A.	Cyclische Substituirte Harnstoffderivate, Verfahren zu ihrer Herstellung, und ihre pharmazeutische Verwendung als Kinase Inhibitoren
EP1621536A1 (de) *	2004-07-27	2006-02-01	Aventis Pharma S.A.	Amino zyklische Urea-Derivaten, ihre Herstellung und deren pharmazeutische Verwendungen als Kinase Inhibitoren
EP1621539A1 (de) *	2004-07-27	2006-02-01	Aventis Pharma S.A.	Heterocyclische-substituirte cyclische Harnstoffderivate, Verfaren zu ihrer Herstellung, und ihre pharmaceutische Verwendung als Kinase Inhibitoren
EP3106162A1 (de) *	2005-05-13	2016-12-21	The Regents of the University of California	Diarylhydantoinverbindungen als androgene rezeptorantagonisten zur behandlung von krebs
FR2896503B1 (fr) *	2006-01-23	2012-07-13	Aventis Pharma Sa	Nouveaux derives soufres d'uree cyclique, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de kinases
FR2896504B1 (fr) *	2006-01-23	2012-07-13	Aventis Pharma Sa	Nouveaux derives d'uree cyclique, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de kinases
AU2007283113A1 (en) *	2006-08-08	2008-02-14	Sanofi-Aventis	Arylaminoaryl-alkyl-substituted imidazolidine-2,4-diones, processes for preparing them, medicaments comprising these compounds, and their use
US8889709B2 (en)	2006-09-21	2014-11-18	Probiodrug Ag	Use of isoQC inhibitors in the treatment and prevention of inflammatory diseases or conditions
US9277737B2 (en)	2006-09-21	2016-03-08	Probiodrug Ag	Mouse models carrying a knock-out mutation of the QPCTL-gene
NZ575727A (en)	2006-09-21	2011-12-22	Probiodrug Ag	Novel genes related to glutaminyl cyclase
EP2416657A4 (de) *	2009-04-09	2012-09-05	Medivation Prostate Therapeutics Inc	Substituierte di-arylhydantoin- und di-arylthiohydantoinverbindungen sowie verfahren für ihre verwendung
SG11201401531RA (en) *	2011-11-11	2014-07-30	Pfizer	2-thiopyrimidinones
US20170281641A1 (en) *	2014-09-03	2017-10-05	Genzyme Corporation	CYCLIC UREA COMPOUNDS AS TROPOMYOSIN-RELATED KINASE (TRK) iNHIBITORS
CN117120436A (zh) *	2021-03-30	2023-11-24	苏州开拓药业股份有限公司	一种一步法合成乙内酰硫脲衍生物的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2693461B1 (fr) *	1992-07-08	1994-09-02	Roussel Uclaf	Nouvelles phénylimidazolidines substituées, leur procédé de préparation, leur application comme médicaments et les compositions pharmaceutiques les renfermant.
AU2764797A (en) *	1996-05-14	1997-12-05	Novo Nordisk A/S	Somatostatin agonists and antagonists
JP3088758B2 (ja) *	1996-09-24	2000-09-18	大鵬薬品工業株式会社	ウラシル誘導体を含有する癌転移抑制剤
US6025372A (en) *	1997-04-04	2000-02-15	Merck & Co., Inc.	Somatostatin agonists
ES2174447T3 (es) *	1997-06-24	2002-11-01	Novo Nordisk As	Uso de agonistas y antagonistas de somatostatina para el tratamiento de enfermedades oculares.
HUP0302962A2 (hu)	1998-06-12	2003-12-29	Societe De Conseils De Recherches Et D'applications Scientifiques S.A.S.	Béta-karbolinszármazékok, ezeket a vegyületeket tartalmazó gyógyászati készítmények és a vegyületek alkalmazása
DK1086086T3 (da) *	1998-06-12	2005-01-24	Sod Conseils Rech Applic	Imidazolylderivater og anvendelse deraf som somatostatinreceptorligander
CA2335184A1 (en)	1998-06-16	1999-12-23	Thomas D. Gordon	Cyclic somatostatin analogs

1999
- 1999-07-30 FR FR9909886A patent/FR2796945B1/fr not_active Expired - Fee Related
2000
- 2000-07-25 AR ARP000103851A patent/AR024939A1/es active IP Right Grant
- 2000-07-28 IL IL14774400A patent/IL147744A0/xx not_active IP Right Cessation
- 2000-07-28 PL PL00364726A patent/PL364726A1/xx not_active Application Discontinuation
- 2000-07-28 RU RU2002105024/04A patent/RU2277093C2/ru not_active IP Right Cessation
- 2000-07-28 CN CNB008110654A patent/CN1177828C/zh not_active Expired - Fee Related
- 2000-07-28 BR BR0012852-0A patent/BR0012852A/pt not_active Application Discontinuation
- 2000-07-28 DE DE60023747T patent/DE60023747T2/de not_active Expired - Lifetime
- 2000-07-28 JP JP2001514294A patent/JP2003518011A/ja active Pending
- 2000-07-28 NZ NZ516718A patent/NZ516718A/xx not_active IP Right Cessation
- 2000-07-28 HU HU0202989A patent/HUP0202989A3/hu unknown
- 2000-07-28 DK DK00958634T patent/DK1246807T3/da active
- 2000-07-28 AU AU70091/00A patent/AU779357B2/en not_active Ceased
- 2000-07-28 CA CA2380070A patent/CA2380070C/fr not_active Expired - Fee Related
- 2000-07-28 WO PCT/FR2000/002164 patent/WO2001009090A2/fr not_active Ceased
- 2000-07-28 AT AT00958634T patent/ATE308525T1/de not_active IP Right Cessation
- 2000-07-28 MX MXPA02001016A patent/MXPA02001016A/es active IP Right Grant
- 2000-07-28 CZ CZ2002301A patent/CZ2002301A3/cs unknown
- 2000-07-28 HK HK03104848.3A patent/HK1052510B/zh not_active IP Right Cessation
- 2000-07-28 KR KR1020027001224A patent/KR100712587B1/ko not_active Expired - Fee Related
- 2000-07-28 ES ES00958634T patent/ES2252051T3/es not_active Expired - Lifetime
- 2000-07-28 US US10/048,144 patent/US6759415B1/en not_active Expired - Fee Related
- 2000-07-28 EP EP00958634A patent/EP1246807B1/de not_active Expired - Lifetime
2002
- 2002-01-29 NO NO20020463A patent/NO323605B1/no not_active IP Right Cessation
2004
- 2004-03-30 US US10/813,139 patent/US7199145B2/en not_active Expired - Fee Related
2006
- 2006-06-01 US US11/444,769 patent/US7332517B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
ATE308525T1 (de)	2005-11-15
NO323605B1 (no)	2007-06-18
HK1052510A1 (en)	2003-09-19
PL364726A1 (en)	2004-12-13
HK1052510B (zh)	2005-04-29
KR20020025203A (ko)	2002-04-03
FR2796945A1 (fr)	2001-02-02
CN1399631A (zh)	2003-02-26
NO20020463D0 (no)	2002-01-29
MXPA02001016A (es)	2002-08-12
US7199145B2 (en)	2007-04-03
CZ2002301A3 (cs)	2002-08-14
DE60023747T2 (de)	2006-08-03
AU7009100A (en)	2001-02-19
WO2001009090A3 (fr)	2002-08-08
CN1177828C (zh)	2004-12-01
ES2252051T3 (es)	2006-05-16
NZ516718A (en)	2003-04-29
US20040209908A1 (en)	2004-10-21
NO20020463L (no)	2002-02-13
HUP0202989A2 (hu)	2002-12-28
WO2001009090A2 (fr)	2001-02-08
JP2003518011A (ja)	2003-06-03
FR2796945B1 (fr)	2002-06-28
US7332517B2 (en)	2008-02-19
US20070021420A1 (en)	2007-01-25
KR100712587B1 (ko)	2007-05-02
AR024939A1 (es)	2002-10-30
CA2380070C (fr)	2010-11-09
DE60023747D1 (de)	2005-12-08
HUP0202989A3 (en)	2003-02-28
EP1246807B1 (de)	2005-11-02
CA2380070A1 (fr)	2001-02-08
EP1246807A2 (de)	2002-10-09
US6759415B1 (en)	2004-07-06
IL147744A0 (en)	2002-08-14
AU779357B2 (en)	2005-01-20
RU2277093C2 (ru)	2006-05-27
BR0012852A (pt)	2002-04-30

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