DK1254362T3 - Analyse af fluorescensintensitet og levetidsfordeling - Google Patents

Analyse af fluorescensintensitet og levetidsfordeling

Info

Publication number
DK1254362T3
DK1254362T3 DK01913810T DK01913810T DK1254362T3 DK 1254362 T3 DK1254362 T3 DK 1254362T3 DK 01913810 T DK01913810 T DK 01913810T DK 01913810 T DK01913810 T DK 01913810T DK 1254362 T3 DK1254362 T3 DK 1254362T3
Authority
DK
Denmark
Prior art keywords
particles
function
determining
argument
photon counts
Prior art date
Application number
DK01913810T
Other languages
English (en)
Inventor
Peet Kask
Karsten Gall
Kaupo Palo
Leif Brand
Original Assignee
Olympus Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Olympus Corp filed Critical Olympus Corp
Application granted granted Critical
Publication of DK1254362T3 publication Critical patent/DK1254362T3/da

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458—Fluorescence microscopy
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J3/00—Spectrometry; Spectrophotometry; Monochromators; Measuring colours
    • G01J3/28—Investigating the spectrum
    • G01J3/44—Raman spectrometry; Scattering spectrometry ; Fluorescence spectrometry
    • G01J3/4406—Fluorescence spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6408—Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/02—Investigating particle size or size distribution
    • G01N15/0205—Investigating particle size or size distribution by optical means
    • G01N15/0211—Investigating a scatter or diffraction pattern
    • G01N2015/0216—Investigating a scatter or diffraction pattern from fluctuations of diffraction pattern
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6445—Measuring fluorescence polarisation

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
DK01913810T 2000-02-10 2001-02-10 Analyse af fluorescensintensitet og levetidsfordeling DK1254362T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18154800P 2000-02-10 2000-02-10
PCT/EP2001/001470 WO2001059436A2 (en) 2000-02-10 2001-02-10 Fluorescence intensity and lifetime distribution analysis

Publications (1)

Publication Number Publication Date
DK1254362T3 true DK1254362T3 (da) 2008-05-05

Family

ID=22664753

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01913810T DK1254362T3 (da) 2000-02-10 2001-02-10 Analyse af fluorescensintensitet og levetidsfordeling

Country Status (9)

Country Link
US (1) US6690463B2 (da)
EP (1) EP1254362B1 (da)
JP (1) JP4776854B2 (da)
AT (1) ATE381013T1 (da)
AU (1) AU2001239258A1 (da)
DE (1) DE60131837T2 (da)
DK (1) DK1254362T3 (da)
ES (1) ES2298221T3 (da)
WO (1) WO2001059436A2 (da)

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WO2004081548A1 (en) * 2003-03-10 2004-09-23 Tiax Llc System and method for bioaerosol discrimination by time-resolved fluorescence
US7060992B1 (en) 2003-03-10 2006-06-13 Tiax Llc System and method for bioaerosol discrimination by time-resolved fluorescence
US20060237665A1 (en) * 2003-03-10 2006-10-26 Barney William S Bioaerosol discrimination
JP2007508810A (ja) 2003-09-30 2007-04-12 エヴォテック ニューロサイエンシス ゲゼルシャフト ミット ベシュレンクテル ハフツング スルホトランスフェラーゼの神経変性疾患に関する診断的および治療的使用
JP3793531B2 (ja) * 2003-10-07 2006-07-05 オリンパス株式会社 蛍光寿命測定装置
WO2005043137A1 (de) * 2003-10-18 2005-05-12 Bayer Healthcare Ag Direkte beobachtung molekularer veränderungen in biologischen testsystemen mittels messungen der fluoreszenz-lebensdauer
EP1528379A1 (en) * 2003-10-27 2005-05-04 Evotec Technologies GmbH A method for resolving species of fluorescent molecules in a sample
JP4323369B2 (ja) * 2004-04-09 2009-09-02 オリンパス株式会社 走査型蛍光顕微鏡装置
US20050231717A1 (en) * 2004-04-16 2005-10-20 Industrial Technology Research Institute Fluorescence inspection spectrometer
US7332700B2 (en) * 2004-04-26 2008-02-19 Bruce Masato Ishimoto Photomultiplier tube with dynode modulation for photon-counting
JP2008508893A (ja) 2004-08-11 2008-03-27 エボテツク・ニユーロサイエンシーズ・ゲー・エム・ベー・ハー 形質膜ａｔｐアーゼの診断及び治療への使用
JP2006133164A (ja) * 2004-11-09 2006-05-25 Fyuuensu:Kk カルモデュリンの構造変化を検出する方法、カルモデュリンの構造変化に影響を与える活性を有する物質を探索する方法
WO2006125830A2 (en) 2005-05-27 2006-11-30 Evotec Neurosciences Gmbh Kcnn3 as diagnostic and therapeutic target for neurodegenerative diseases
ATE534751T1 (de) 2005-05-30 2011-12-15 Takeda Pharmaceutical Verwendung von prkx zur diagnose und therapie von alzheimer krankheit
US20090133135A1 (en) 2005-06-01 2009-05-21 Evotec Neurosciences Gmbh Diagnostic and Therapeutic Target SLC39A11 Proteins for Neurodegenerative Diseases
WO2006134128A2 (en) 2005-06-16 2006-12-21 Evotec Neurosciences Gmbh Diagnostic and therapeutic target adarb2 proteins for neurodegenerative diseases
GB2434483A (en) 2006-01-20 2007-07-25 Fianium Ltd High-Power Short Optical Pulse Source
FR2896877A1 (fr) * 2006-01-31 2007-08-03 Commissariat Energie Atomique Appareil et procede de caracterisation d'un systeme de comptage de particules elementaires
EP1930716A1 (de) 2006-12-08 2008-06-11 Micronas GmbH Verfahren und Vorrichtung zur Detektion eines Liganden in einem Fluid
JP5354938B2 (ja) * 2007-05-02 2013-11-27 オリンパス株式会社 蛍光顕微鏡装置
GB2451442B (en) * 2007-07-30 2013-03-06 Lein Applied Diagnostics Ltd Optical measurement apparatus and method therefor
GB0800936D0 (en) 2008-01-19 2008-02-27 Fianium Ltd A source of optical supercontinuum generation having a selectable pulse repetition frequency
DE102008045886A1 (de) * 2008-09-03 2010-03-04 Friedrich-Schiller-Universität Jena Verfahren zur exakten Bestimmung der Fluoreszenz in einem Schichtsystem, beispielsweise dem Auge
EP2340429B1 (en) * 2008-10-14 2022-08-24 Tissuevision, Inc. Devices and methods for direct sampling analog time-resolved detection
EP2186827A1 (en) 2008-11-14 2010-05-19 HS LifeSciences Ltd. Surrogate marker directed cDNA cloning of selectively induced mRNAs
US8611535B2 (en) * 2010-09-15 2013-12-17 At&T Intellectual Property I, L.P. Characterization of an entangled photon system
DE102011055330B4 (de) * 2011-11-14 2024-10-31 Leica Microsystems Cms Gmbh Verfahren zum Messen der Lebensdauer eines angeregten Zustandes in einer Probe
US8981318B1 (en) * 2011-12-30 2015-03-17 Gene Capture, Inc. Multi-dimensional scanner for nano-second time scale signal detection
US8743356B1 (en) 2012-11-22 2014-06-03 Her Majesty The Queen In Right Of Canada As Represented By The Minister Of National Defence Man-portable device for detecting hazardous material
DE102014017006B4 (de) * 2014-11-17 2019-07-11 Technische Universität Ilmenau Verfahren zur Bestimmung und Auswertung zeitaufgelöster Fluoreszenz- oder Reflexionsbilder an ausgedehnten dreidimensionalen Oberflächen
KR101859172B1 (ko) * 2016-12-22 2018-05-16 (주) 인텍플러스 아날로그 평균지연 방법에서 수집한 신호로부터 가상의 형광분포 모델을 통해 최소자승오차를 계산하여 2개 이상의 형광수명 성분을 구하는 형광수명 측정장치 및 그 측정방법
EP4170436A4 (en) 2020-08-06 2024-07-10 Hamamatsu Photonics K.K. TIME MEASUREMENT DEVICE, FLUORESCENCE LIFE MEASUREMENT DEVICE, AND TIME MEASUREMENT METHOD
WO2022030062A1 (ja) 2020-08-06 2022-02-10 浜松ホトニクス株式会社 時間計測装置、蛍光寿命計測装置、及び時間計測方法
DE102022121505A1 (de) * 2022-08-25 2024-03-07 Carl Zeiss Meditec Ag Verfahren, Computerprogramm und Datenverarbeitungseinheit zur Vorbereitung der Beobachtung einer Fluoreszenzintensität, Verfahren zum Beobachten einer Fluoreszenzintensität und optisches Beobachtungssystem

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EP0836090A1 (en) 1996-10-12 1998-04-15 Evotec BioSystems GmbH Method of analysis of samples by determination of the distribution of specific brightnesses of particles
ATE252729T1 (de) * 1996-11-27 2003-11-15 Max Planck Gesellschaft Verfahren und anordnung zum bestimmen vorgegebener eigenschaften von zielpartikeln eines probenmediums
EP0884583A1 (en) * 1997-06-10 1998-12-16 Evotec BioSystems GmbH A method for characterizing samples in at least two dimensional space of specific physical properties
EP0945718A1 (en) 1998-03-21 1999-09-29 Evotec BioSystems AG A method for characterizing samples by determination of a function of at least one specific property of units of said sample
US6556296B1 (en) * 1997-09-29 2003-04-29 Evotec Biosystems Ag Method for characterizing samples by determination of a function of at least one specific property of particles in a sample
EP1064579A4 (en) * 1998-03-16 2007-11-07 Praelux Inc CONFOCAL IMAGING SYSTEM FOR MICROSCOPY
US6376843B1 (en) * 1999-06-23 2002-04-23 Evotec Oai Ag Method of characterizing fluorescent molecules or other particles using generating functions
WO2000066985A1 (en) * 1999-04-29 2000-11-09 Evotec Biosystems Ag A method of characterizing fluorescent molecules or other particles using generating functions

Also Published As

Publication number Publication date
ES2298221T3 (es) 2008-05-16
US20020063863A1 (en) 2002-05-30
WO2001059436A2 (en) 2001-08-16
US6690463B2 (en) 2004-02-10
DE60131837D1 (de) 2008-01-24
EP1254362A2 (en) 2002-11-06
ATE381013T1 (de) 2007-12-15
EP1254362B1 (en) 2007-12-12
AU2001239258A1 (en) 2001-08-20
DE60131837T2 (de) 2008-11-27
JP4776854B2 (ja) 2011-09-21
JP2003522946A (ja) 2003-07-29
WO2001059436A3 (en) 2002-03-14

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