DK1257577T3 - Fremgangsmåde til oplösning af glucagon som peptidforbindelse - Google Patents

Fremgangsmåde til oplösning af glucagon som peptidforbindelse

Info

Publication number: DK1257577T3
Authority: DK; Denmark
Prior art keywords: glp; compound; solution; peptide compound; aqueous
Prior art date: 2000-01-27

Application number

DK01904785T

Other languages

English (en)

Inventor

Joseph Vincent Junior Rinella

Walter Francis Junior Prouty

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-01-27

Filing date

2001-01-16

Publication date

2004-08-02

2001-01-16 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

2004-08-02 Application granted granted Critical

2004-08-02 Publication of DK1257577T3 publication Critical patent/DK1257577T3/da

Links

102000051325 Glucagon Human genes 0.000 title 1
108060003199 Glucagon Proteins 0.000 title 1
150000001875 compounds Chemical class 0.000 title 1
MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 title 1
229960004666 glucagon Drugs 0.000 title 1
108090000765 processed proteins & peptides Proteins 0.000 title 1
102100025101 GATA-type zinc finger protein 1 Human genes 0.000 abstract 6
101710198884 GATA-type zinc finger protein 1 Proteins 0.000 abstract 6
-1 GLP-1 compound Chemical class 0.000 abstract 4
DTHNMHAUYICORS-KTKZVXAJSA-N Glucagon-like peptide 1 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 DTHNMHAUYICORS-KTKZVXAJSA-N 0.000 abstract 3
239000000243 solution Substances 0.000 abstract 3
239000007864 aqueous solution Substances 0.000 abstract 2
239000011260 aqueous acid Substances 0.000 abstract 1
230000006340 racemization Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
General Health & Medical Sciences (AREA)
Endocrinology (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Toxicology (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Analytical Chemistry (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK01904785T 2000-01-27 2001-01-16 Fremgangsmåde til oplösning af glucagon som peptidforbindelse DK1257577T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US17843800P	2000-01-27	2000-01-27
US22405800P	2000-08-09	2000-08-09

Publications (1)

Publication Number	Publication Date
DK1257577T3 true DK1257577T3 (da)	2004-08-02

Family

ID=26874307

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK01904785T DK1257577T3 (da)	2000-01-27	2001-01-16	Fremgangsmåde til oplösning af glucagon som peptidforbindelse

Country Status (17)

Country	Link
US (4)	US7598222B2 (da)
EP (1)	EP1257577B1 (da)
JP (1)	JP2003523366A (da)
KR (1)	KR20020073184A (da)
AT (1)	ATE264870T1 (da)
AU (1)	AU2001232735A1 (da)
BR (1)	BR0107837A (da)
CA (1)	CA2396920A1 (da)
DE (1)	DE60102899T2 (da)
DK (1)	DK1257577T3 (da)
ES (1)	ES2218381T3 (da)
HU (1)	HUP0204281A3 (da)
IL (2)	IL150913A0 (da)
MX (1)	MXPA02007231A (da)
PT (1)	PT1257577E (da)
TR (1)	TR200401142T4 (da)
WO (1)	WO2001055213A2 (da)

Families Citing this family (80)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2686899B1 (fr)	1992-01-31	1995-09-01	Rhone Poulenc Rorer Sa	Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
US9006175B2 (en)	1999-06-29	2015-04-14	Mannkind Corporation	Potentiation of glucose elimination
EP2206720A1 (en)	2000-04-12	2010-07-14	Human Genome Sciences, Inc.	Albumin fusion proteins
AU2002316811A1 (en)	2001-06-28	2003-03-03	Novo Nordisk A/S	Stable formulation of modified glp-1
EP2261250B1 (en)	2001-12-21	2015-07-01	Human Genome Sciences, Inc.	GCSF-Albumin fusion proteins
US6923175B2 (en)	2002-03-20	2005-08-02	Mannkind Corporation	Inhalation apparatus
CA2513213C (en)	2003-01-22	2013-07-30	Human Genome Sciences, Inc.	Albumin fusion proteins
US7550590B2 (en) *	2003-03-25	2009-06-23	Takeda Pharmaceutical Company Limited	Dipeptidyl peptidase inhibitors
CN102134577A (zh) *	2003-03-28	2011-07-27	独立行政法人农业生物资源研究所	高产重组蛋白的植物贮藏器官的生产方法以及新型重组蛋白
WO2004103993A1 (en)	2003-05-14	2004-12-02	Syrrx, Inc.	Dipeptidyl peptidase inhibitors
EP2292253A3 (en) *	2003-06-03	2011-12-14	Novo Nordisk A/S	Stabilized pharmaceutical peptide compositions
ATE541582T1 (de)	2003-06-03	2012-02-15	Novo Nordisk As	Stabilisierte pharmazeutische glp-1 peptid zusammensetzungen
EP1633391B1 (en) *	2003-06-03	2011-10-19	Novo Nordisk A/S	Stabilized pharmaceutical peptide compositions
US8921311B2 (en)	2003-08-01	2014-12-30	Mannkind Corporation	Method for treating hyperglycemia
KR20060041309A (ko) *	2003-08-13	2006-05-11	다케다 야쿠힌 고교 가부시키가이샤	４-피리미돈 유도체 및 펩티딜 펩티다제 저해제로서의 그의용도
US7790734B2 (en) *	2003-09-08	2010-09-07	Takeda Pharmaceutical Company Limited	Dipeptidyl peptidase inhibitors
WO2005030751A2 (en) *	2003-09-08	2005-04-07	Takeda Pharmaceutical Company Limited	Dipeptidyl peptidase inhibitors
TR201906789T4 (tr)	2003-11-20	2019-05-21	Novo Nordisk As	Üretim ve enjeksiyon cihazlarında kullanım için en uygun olan propilen glikol ihtiva eden peptit formülasyonları.
CN102127057A (zh) *	2004-03-15	2011-07-20	武田药品工业株式会社	二肽基肽酶抑制剂
ATE486064T1 (de)	2004-08-20	2010-11-15	Mannkind Corp	Katalyse der diketopiperazinsynthese
KR20130066695A (ko)	2004-08-23	2013-06-20	맨카인드 코포레이션	약물 전달용 디케토피페라진염, 디케토모르포린염 또는 디케토디옥산염
US8710181B2 (en)	2004-08-31	2014-04-29	Novo Nordisk A/S	Use of tris(hydroxymethyl) aminomethane for the stabilization of peptides, polypeptides and proteins
RU2413530C9 (ru)	2004-11-12	2021-05-18	Ново Нордиск А/С	Стабильные препараты инсулинотропных пептидов
DE602005023058D1 (de)	2004-11-19	2010-09-30	Mitsui Chemicals Inc	Feine partikel aus ethylenpolymer, feine partikel aus mit funktionellen gruppen modifiziertem ethylenpolymer und katalysatorträger für ihre herstellung
WO2006068978A2 (en)	2004-12-21	2006-06-29	Takeda Pharmaceutial Company Limited	Dipeptidyl peptidase inhibitors
WO2006069779A1 (en) *	2004-12-30	2006-07-06	F. Hoffmann-La Roche Ag	Preparing of peptides with excellent solubility
TW200643033A (en) *	2005-03-08	2006-12-16	Chugai Pharmaceutical Co Ltd	Conjugate of water-soluble modified hyaluronic acid and glp-1 analogue
EP1875961B1 (en)	2005-04-07	2018-08-29	Mitsui Chemicals, Inc.	Capsular fine particle comprising olefinic polymer
GEP20135838B (en)	2005-09-14	2013-06-10	Takeda Pharmaceutical	Dipeptidyl peptidase inhibitors usage at diabetes treatment
PE20070622A1 (es) *	2005-09-14	2007-08-22	Takeda Pharmaceutical	Administracion de inhibidores de dipeptidil peptidasa
MX373000B (es)	2005-09-14	2020-05-21	Mannkind Corp	Metodo para formulacion de farmaco basado en el aumento de la afinidad de agentes activos hacia las superficies de microparticulas cristalinas.
EP2073810B1 (en) *	2006-09-13	2011-08-31	Takeda Pharmaceutical Company Limited	Use of 2-6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2h-pyrimidin-1-ylmethyl-4-fluoro-benzonitrile for treating diabetes, cancer, autoimmune disorders and hiv infection
PL1931350T5 (pl) *	2005-09-14	2021-11-15	Takeda Pharmaceutical Company Limited	Podanie inhibitorów dipeptydylo-peptydazy
CN101360723A (zh) *	2005-09-16	2009-02-04	武田药品工业株式会社	制备嘧啶二酮衍生物的方法
TW200745079A (en) *	2005-09-16	2007-12-16	Takeda Pharmaceuticals Co	Polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile and methods of use therefor
TW200745080A (en) *	2005-09-16	2007-12-16	Takeda Pharmaceuticals Co	Polymorphs of tartrate salt of 2-[2-(3-(R)-amino-piperidin-1-yl)-5-fluoro-6-oxo-6H-pyrimidin-1-ylmethyl]-benzonitrile and methods of use therefor
CN101379075B (zh)	2006-02-08	2013-05-15	隆萨股份公司	类胰高血糖素肽的合成
EP1986679B1 (en)	2006-02-22	2017-10-25	MannKind Corporation	A method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent
WO2007112347A1 (en)	2006-03-28	2007-10-04	Takeda Pharmaceutical Company Limited	Dipeptidyl peptidase inhibitors
EP1999108A1 (en) *	2006-03-28	2008-12-10	Takeda Pharmaceutical Company Limited	Preparation of (r)-3-aminopiperidine dihydrochloride
US8324383B2 (en)	2006-09-13	2012-12-04	Takeda Pharmaceutical Company Limited	Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile
TW200838536A (en) *	2006-11-29	2008-10-01	Takeda Pharmaceutical	Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor
US8093236B2 (en)	2007-03-13	2012-01-10	Takeda Pharmaceuticals Company Limited	Weekly administration of dipeptidyl peptidase inhibitors
US8485180B2 (en)	2008-06-13	2013-07-16	Mannkind Corporation	Dry powder drug delivery system
CN101827626B (zh)	2008-06-13	2015-03-18	曼金德公司	干粉吸入器和用于药物输送的系统
ES2421385T3 (es)	2008-06-20	2013-09-02	Mannkind Corp	Aparato interactivo y procedimiento para establecer el perfil, en tiempo real, de esfuerzos de inhalación
TWI532497B (zh)	2008-08-11	2016-05-11	曼凱公司	超快起作用胰島素之用途
US8314106B2 (en)	2008-12-29	2012-11-20	Mannkind Corporation	Substituted diketopiperazine analogs for use as drug delivery agents
DK2379100T3 (da)	2009-01-08	2014-12-01	Mannkind Corp	Behandling af hyperglykæmi med glp-1
DK2405963T3 (da)	2009-03-11	2013-12-16	Mannkind Corp	Apparat, system og fremgangsmåde til at måle modstand i en inhalator
KR102584844B1 (ko)	2009-06-12	2023-10-04	맨카인드 코포레이션	한정된 비표면적을 갖는 디케토피페라진 마이크로입자
EP2482840A4 (en) *	2009-08-07	2013-06-26	Mannkind Corp	VAL (8) GLP-1 COMPOSITION AND METHOD FOR THE TREATMENT OF REAGENTS AND / OR IRRITATION SYNDROME
CA2778698A1 (en)	2009-11-03	2011-05-12	Mannkind Corporation	An apparatus and method for simulating inhalation efforts
CN102985125A (zh)	2010-06-21	2013-03-20	曼金德公司	干粉药物输送系统和方法
CN102718858B (zh) *	2011-03-29	2014-07-02	天津药物研究院	胰高血糖素样肽-1类似物单体、二聚体及其制备方法与应用
SG194034A1 (en)	2011-04-01	2013-11-29	Mannkind Corp	Blister package for pharmaceutical cartridges
WO2012174472A1 (en)	2011-06-17	2012-12-20	Mannkind Corporation	High capacity diketopiperazine microparticles
MX2014004983A (es)	2011-10-24	2014-09-22	Mannkid Corp	Metodos y composiciones para tratar dolor.
KR102264177B1 (ko)	2012-07-12	2021-06-11	맨카인드 코포레이션	건조 분말 약물 전달 시스템 및 방법
WO2014066856A1 (en)	2012-10-26	2014-05-01	Mannkind Corporation	Inhalable influenza vaccine compositions and methods
EP3587404B1 (en)	2013-03-15	2022-07-13	MannKind Corporation	Microcrystalline diketopiperazine compositions, methods for preparation and use thereof
WO2014147129A1 (en)	2013-03-21	2014-09-25	Sanofi-Aventis Deutschland Gmbh	Synthesis of cyclic imide containing peptide products
CN105189465B (zh)	2013-03-21	2019-02-26	赛诺菲-安万特德国有限公司	合成含有乙内酰脲的肽产物
MX375448B (es)	2013-07-18	2025-03-06	Mannkind Corp	Composiciones farmacéuticas en polvo seco estables al calor y métodos.
EP3030294B1 (en)	2013-08-05	2020-10-07	MannKind Corporation	Insufflation apparatus
US10307464B2 (en)	2014-03-28	2019-06-04	Mannkind Corporation	Use of ultrarapid acting insulin
US10561806B2 (en)	2014-10-02	2020-02-18	Mannkind Corporation	Mouthpiece cover for an inhaler
US9969769B2 (en)	2014-12-19	2018-05-15	Cem Corporation	Coupling method for peptide synthesis at elevated temperatures
US10308677B2 (en)	2014-12-19	2019-06-04	Cem Corporation	Coupling method for peptide synthesis at elevated temperatures
KR102844773B1 (ko)	2015-12-23	2025-08-13	암젠 인크	위 억제 펩티드 수용체 (gipr)에 대한 결합 단백질을 glp-1 효능제와 조합하여 사용하여 대사 장애를 치료하거나 개선시키는 방법
BR112019014588A2 (pt)	2017-01-17	2020-02-18	Amgen Inc.	Método de tratamento ou amenização de distúrbios metabólicos usando agonistas do receptor de glp-1 conjugados a antagonistas para receptor do peptídeo inibidor gástrico (gipr)
CN110831969B (zh)	2017-06-20	2024-06-21	安进公司	使用抑胃肽受体（gipr）结合蛋白与glp-1激动剂的组合治疗或改善代谢障碍的方法
MX2019015544A (es)	2017-06-21	2020-07-28	Amgen Inc	Metodo para tratar o mejorar trastornos metabolicos con proteinas de fusion de agonistas del receptor de glp-1/proteinas de union antagonistas para el receptor peptidico inhibidor gastrico (gipr).
HRP20240485T1 (hr)	2017-08-24	2024-07-05	Novo Nordisk A/S	Pripravci glp-1 i njihova upotreba
EP3728303A1 (en)	2017-12-19	2020-10-28	Novo Nordisk A/S	Solubility of glp-1 peptide
WO2019200594A1 (zh) *	2018-04-19	2019-10-24	杭州先为达生物科技有限公司	酰化的glp-1衍生物
PE20230819A1 (es)	2020-02-18	2023-05-19	Novo Nordisk As	Composiciones y usos de glp-1
EP4281039A2 (en)	2021-01-25	2023-11-29	Mylan Ireland Limited	Pharmaceutical glp peptide compositions and methods of preparation thereof
WO2022266927A1 (zh) *	2021-06-24	2022-12-29	深圳翰宇药业股份有限公司	一种利拉鲁肽变构体及其制备方法、应用
CN120615079A (zh)	2023-02-09	2025-09-09	三井化学株式会社	镁化合物粒子的制造方法、烯烃聚合物粒子形状的控制方法、烯烃聚合物粒子

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3419824A1 (de) *	1984-05-26	1985-11-28	Bayer Ag, 5090 Leverkusen	Verfahren und formwerkzeug zum herstellen von formteilen mit grill-, gitter- oder rostartigen bereichen, wie kfz-soft-faces, spoiler, bumper, aus einer fliessfaehigen masse
NZ250844A (en)	1993-04-07	1996-03-26	Pfizer	Treatment of non-insulin dependant diabetes with peptides; composition
US6384016B1 (en) *	1998-03-13	2002-05-07	Novo Nordisk A/S	Stabilized aqueous peptide solutions
US6380357B2 (en)	1997-12-16	2002-04-30	Eli Lilly And Company	Glucagon-like peptide-1 crystals
US6844321B2 (en) *	2000-01-31	2005-01-18	Novo Nordisk A/S	Crystallization of a GLP-1 analogue

2001
- 2001-01-16 TR TR2004/01142T patent/TR200401142T4/xx unknown
- 2001-01-16 US US10/169,657 patent/US7598222B2/en not_active Expired - Fee Related
- 2001-01-16 AT AT01904785T patent/ATE264870T1/de not_active IP Right Cessation
- 2001-01-16 AU AU2001232735A patent/AU2001232735A1/en not_active Abandoned
- 2001-01-16 JP JP2001561060A patent/JP2003523366A/ja not_active Withdrawn
- 2001-01-16 DE DE60102899T patent/DE60102899T2/de not_active Expired - Lifetime
- 2001-01-16 MX MXPA02007231A patent/MXPA02007231A/es active IP Right Grant
- 2001-01-16 BR BR0107837-2A patent/BR0107837A/pt not_active IP Right Cessation
- 2001-01-16 WO PCT/US2001/000010 patent/WO2001055213A2/en not_active Ceased
- 2001-01-16 DK DK01904785T patent/DK1257577T3/da active
- 2001-01-16 EP EP01904785A patent/EP1257577B1/en not_active Expired - Lifetime
- 2001-01-16 ES ES01904785T patent/ES2218381T3/es not_active Expired - Lifetime
- 2001-01-16 IL IL15091301A patent/IL150913A0/xx unknown
- 2001-01-16 PT PT01904785T patent/PT1257577E/pt unknown
- 2001-01-16 CA CA002396920A patent/CA2396920A1/en not_active Abandoned
- 2001-01-16 KR KR1020027009546A patent/KR20020073184A/ko not_active Ceased
- 2001-01-16 HU HU0204281A patent/HUP0204281A3/hu not_active Application Discontinuation
2008
- 2008-02-07 IL IL189371A patent/IL189371A0/en unknown
2009
- 2009-09-01 US US12/551,841 patent/US8222205B2/en not_active Expired - Fee Related
2012
- 2012-04-27 US US13/458,057 patent/US8268780B2/en not_active Expired - Fee Related
- 2012-08-10 US US13/571,443 patent/US8455433B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
MXPA02007231A (es)	2002-12-09
JP2003523366A (ja)	2003-08-05
US8455433B2 (en)	2013-06-04
EP1257577A2 (en)	2002-11-20
US20030060412A1 (en)	2003-03-27
IL189371A0 (en)	2008-06-05
HUP0204281A2 (hu)	2003-04-28
KR20020073184A (ko)	2002-09-19
DE60102899T2 (de)	2005-03-31
US20120208980A1 (en)	2012-08-16
US20110053838A1 (en)	2011-03-03
ES2218381T3 (es)	2004-11-16
HUP0204281A3 (en)	2007-03-28
PT1257577E (pt)	2004-08-31
WO2001055213A2 (en)	2001-08-02
US8268780B2 (en)	2012-09-18
US8222205B2 (en)	2012-07-17
WO2001055213A3 (en)	2002-02-28
CA2396920A1 (en)	2001-08-02
IL150913A0 (en)	2003-02-12
US20120101034A9 (en)	2012-04-26
US7598222B2 (en)	2009-10-06
AU2001232735A1 (en)	2001-08-07
US20130072658A1 (en)	2013-03-21
DE60102899D1 (de)	2004-05-27
TR200401142T4 (tr)	2004-07-21
EP1257577B1 (en)	2004-04-21
BR0107837A (pt)	2003-01-14
ATE264870T1 (de)	2004-05-15

Publication	Publication Date	Title
DK1257577T3 (da)	2004-08-02	Fremgangsmåde til oplösning af glucagon som peptidforbindelse
DK1347747T3 (da)	2006-04-10	Fremgangsmåde til behandling af submikropartikelsuspensioner af farmaceutiske midler
YU2003A (sh)	2006-08-17	Stabilne soli o-acetilsalicilne kiseline sa baznim amino-kiselinama
ATE52282T1 (de)	1990-05-15	Saure, pseudoplastische zusammensetzungen.
PL362667A1 (en)	2004-11-02	Novel amlodipine camsylate and method for preparing thereof
EA200400455A1 (ru)	2004-10-28	Способ приготовления быстрорастворимой дозировочной формы
DK1150999T3 (da)	2006-10-30	Cyclosporinderivater og fremgangsmåde til fremstilling deraf
ES8706837A1 (es)	1987-07-01	Procedimiento para recemizar una n-benciliden-amida de aminoacido opticamente activa.
DE50115655D1 (de)	2010-11-18	Verfahren zur herstellung von unsymmetrischen 4,6-bis(aryloxy)pyrimidin-derivaten
DE60123125D1 (de)	2006-10-26	Verfahren zur herstellung von 1-(aminomethyl) cyclohexanessigsäure
ATE322891T1 (de)	2006-04-15	Arzneistoffabgabesystem für wasser schwerlösliche arzneimittel
DK1180094T3 (da)	2004-11-01	Kondenserede polycykliske aminosyrer som farmaceutiske midler
ATE277887T1 (de)	2004-10-15	Verfahren zur herstellung von 1,4-bis((2- (dimethylamino)ethyl amino)-5,8- dihydroxyanthracene-9,10-dion
MXPA03005676A (es)	2004-04-21	Formas de dosis solidas de sodio de divalproex.
NO20030618D0 (no)	2003-02-07	Fremgangsmåte til fremstilling av peptidsalter, deres anvendelse, og farmasöytiske preparater som inneholder disse peptidsaltene
ATE516014T1 (de)	2011-07-15	Neue verwendung, pharmazeutische präparate und verfahren zu ihrer herstellung
DK1109782T3 (da)	2005-10-17	Fremgangsmåde til fremstilling af N-beskyttede azetidin-2-carboxylsyrer (AzeOH'er)
DE602005011797D1 (de)	2009-01-29	Aufreinigung von n-(phosphonomethyl)glycin
DK1017666T3 (da)	2004-02-23	Fremgangsmåde til at forøge den optiske renhed af 2R-[1-hydroxy-1-trifluormethyl-3-cyclopropylpropyn-2-yl]-4-chloranilin
EP1065199A3 (en)	2003-11-05	"Process for the recovery of strong acids from aqueous solution"
DE50304869D1 (de)	2006-10-12	Verfahren zur herstellung einer spezifischen kristallmodifikation von 2-(2-chlor-4-mesyl-benzoyl)-cyclohexan-1,3-dion
DK1120117T3 (da)	2008-01-14	Fremgangsmåde til at öge produktionen af æg og forstærke æggeskal hos fjerkræ
DE60105216D1 (de)	2004-10-07	Verfahren zur Herstellung von aromatischen Acylthiocarbonsäurederivaten
DK1513838T3 (da)	2006-11-13	Teknisk fremgangsmåde til fremstilling af tropenol
RU2002111626A (ru)	2003-11-20	Способ экстракции кобальта из водных растворов