ATE264870T1 - Verfahren zur lösung von glucagon-ähnlichen peptid-1 (glp-1) verbindungen - Google Patents

Verfahren zur lösung von glucagon-ähnlichen peptid-1 (glp-1) verbindungen

Info

Publication number: ATE264870T1
Authority: AT; Austria
Prior art keywords: glp; solution; compound; compounds; glucagon
Prior art date: 2000-01-27

Application number

AT01904785T

Other languages

English (en)

Inventor

Walter Francis Junior Prouty

Joseph Vincent Junior Rinella

Original Assignee

Lilly Co Eli

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-01-27

Filing date

2001-01-16

Publication date

2004-05-15

2001-01-16 Application filed by Lilly Co Eli filed Critical Lilly Co Eli

2004-05-15 Application granted granted Critical

2004-05-15 Publication of ATE264870T1 publication Critical patent/ATE264870T1/de

Links

GCYXWQUSHADNBF-AAEALURTSA-N preproglucagon 78-108 Chemical class C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 GCYXWQUSHADNBF-AAEALURTSA-N 0.000 title 1
102100025101 GATA-type zinc finger protein 1 Human genes 0.000 abstract 6
101710198884 GATA-type zinc finger protein 1 Proteins 0.000 abstract 6
-1 GLP-1 compound Chemical class 0.000 abstract 4
DTHNMHAUYICORS-KTKZVXAJSA-N Glucagon-like peptide 1 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 DTHNMHAUYICORS-KTKZVXAJSA-N 0.000 abstract 3
239000000243 solution Substances 0.000 abstract 3
239000007864 aqueous solution Substances 0.000 abstract 2
239000011260 aqueous acid Substances 0.000 abstract 1
230000006340 racemization Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Medicinal Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
General Health & Medical Sciences (AREA)
Endocrinology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Toxicology (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Immunology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Analytical Chemistry (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

AT01904785T 2000-01-27 2001-01-16 Verfahren zur lösung von glucagon-ähnlichen peptid-1 (glp-1) verbindungen ATE264870T1 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US17843800P	2000-01-27	2000-01-27
US22405800P	2000-08-09	2000-08-09
PCT/US2001/000010 WO2001055213A2 (en)	2000-01-27	2001-01-16	Process for solubilizing glucagon-like peptide 1 (glp-1) compounds

Publications (1)

Publication Number	Publication Date
ATE264870T1 true ATE264870T1 (de)	2004-05-15

Family

ID=26874307

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT01904785T ATE264870T1 (de)	2000-01-27	2001-01-16	Verfahren zur lösung von glucagon-ähnlichen peptid-1 (glp-1) verbindungen

Country Status (17)

Country	Link
US (4)	US7598222B2 (de)
EP (1)	EP1257577B1 (de)
JP (1)	JP2003523366A (de)
KR (1)	KR20020073184A (de)
AT (1)	ATE264870T1 (de)
AU (1)	AU2001232735A1 (de)
BR (1)	BR0107837A (de)
CA (1)	CA2396920A1 (de)
DE (1)	DE60102899T2 (de)
DK (1)	DK1257577T3 (de)
ES (1)	ES2218381T3 (de)
HU (1)	HUP0204281A3 (de)
IL (2)	IL150913A0 (de)
MX (1)	MXPA02007231A (de)
PT (1)	PT1257577E (de)
TR (1)	TR200401142T4 (de)
WO (1)	WO2001055213A2 (de)

Families Citing this family (80)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2686899B1 (fr)	1992-01-31	1995-09-01	Rhone Poulenc Rorer Sa	Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant.
US9006175B2 (en)	1999-06-29	2015-04-14	Mannkind Corporation	Potentiation of glucose elimination
JP2003530838A (ja)	2000-04-12	2003-10-21	ヒューマンゲノムサイエンシズインコーポレイテッド	アルブミン融合タンパク質
EP1412384B1 (de)	2001-06-28	2007-12-26	Novo Nordisk A/S	Stabile formulierung von modifiziertem glp-1
ES2425738T3 (es)	2001-12-21	2013-10-17	Human Genome Sciences, Inc.	Proteínas de fusión de la albúmina
WO2003080149A2 (en)	2002-03-20	2003-10-02	Mannkind Corporation	Inhalation apparatus
EP1594530A4 (de)	2003-01-22	2006-10-11	Human Genome Sciences Inc	Albuminfusionsproteine
US20040242568A1 (en) *	2003-03-25	2004-12-02	Syrrx, Inc.	Dipeptidyl peptidase inhibitors
CA2741545A1 (en)	2003-03-28	2004-10-14	National Institute Of Agrobiological Sciences	Process for producing plant storage organ with high production of recombinant glp-1 and novel recombinant glp-1
WO2004103993A1 (en)	2003-05-14	2004-12-02	Syrrx, Inc.	Dipeptidyl peptidase inhibitors
BRPI0410972C1 (pt) *	2003-06-03	2021-05-25	Novo Nordisk As	método para aumentar a vida de armazenagem de uma composição farmacêutica, composição farmacêutica, e, método para tratamento de hiperglicemia
CN1812808B (zh)	2003-06-03	2012-07-04	诺沃挪第克公司	稳定化的药物肽组合物
EP1633391B1 (de) *	2003-06-03	2011-10-19	Novo Nordisk A/S	Stabilisierte pharmazeutische peptid zusammensetzungen
US8921311B2 (en)	2003-08-01	2014-12-30	Mannkind Corporation	Method for treating hyperglycemia
EP1506967B1 (de) *	2003-08-13	2007-11-21	Takeda Pharmaceutical Company Limited	Dipeptidyl Peptidase Inhibitoren.
JP2007513058A (ja) *	2003-09-08	2007-05-24	武田薬品工業株式会社	ジペプチジルぺプチダーゼ阻害剤
EP1699777B1 (de) *	2003-09-08	2012-12-12	Takeda Pharmaceutical Company Limited	Dipeptidylpeptidase-hemmer
DK3300721T4 (da)	2003-11-20	2025-03-03	Novo Nordisk As	Propylenglycol-holdige peptidformuleringer hvilke er optimale til fremstilling og til anvendelse i injektionsindretninger
MXPA06010571A (es) *	2004-03-15	2007-02-16	Takeda Pharmaceutical	Inhibidores de dipeptidil peptidasa.
ATE486064T1 (de)	2004-08-20	2010-11-15	Mannkind Corp	Katalyse der diketopiperazinsynthese
HUE025151T2 (en)	2004-08-23	2016-01-28	Mannkind Corp	Diceto-piperazine salts for drug delivery
PL1789434T3 (pl) *	2004-08-31	2014-07-31	Novo Nordisk As	Zastosowanie tris(hydroksymetylo)aminometanu do stabilizacji peptydów, polipeptydów i białek
CN106137952B (zh)	2004-11-12	2020-11-17	诺和诺德公司	促胰岛素肽的稳定制剂
ATE478099T1 (de)	2004-11-19	2010-09-15	Mitsui Chemicals Inc	Feine partikel aus ethylenpolymer, feine partikel aus mit funktionellen gruppen modifiziertem ethylenpolymer und katalysatorträger für ihre herstellung
EP1828192B1 (de)	2004-12-21	2014-12-03	Takeda Pharmaceutical Company Limited	Dipeptidylpeptidasehemmer
WO2006069779A1 (en) *	2004-12-30	2006-07-06	F. Hoffmann-La Roche Ag	Preparing of peptides with excellent solubility
TW200643033A (en) *	2005-03-08	2006-12-16	Chugai Pharmaceutical Co Ltd	Conjugate of water-soluble modified hyaluronic acid and glp-1 analogue
EP1875961B1 (de)	2005-04-07	2018-08-29	Mitsui Chemicals, Inc.	Kapselförmiges feines teilchen, umfassend olefinisches polymer
WO2007033265A1 (en) *	2005-09-14	2007-03-22	Takeda Pharmaceutical Company Limited	Dipeptidyl peptidase inhibitors for treating diabetis
CA2622608C (en) *	2005-09-14	2014-08-19	Takeda Pharmaceutical Company Limited	Dipeptidyl peptidase inhibitors for treating diabetes
KR101486397B1 (ko)	2005-09-14	2015-01-28	맨카인드 코포레이션	활성제에 대한 결정질 미립자 표면의 친화력의 증가를 기반으로 하는 약물 제제화의 방법
ME02005B (me)	2005-09-14	2012-08-31	Takeda Pharmaceuticals Co	Inhibitori dipeptidil peptidaze za lečenje dijabetesa
CN101360723A (zh) *	2005-09-16	2009-02-04	武田药品工业株式会社	制备嘧啶二酮衍生物的方法
TW200745080A (en) *	2005-09-16	2007-12-16	Takeda Pharmaceuticals Co	Polymorphs of tartrate salt of 2-[2-(3-(R)-amino-piperidin-1-yl)-5-fluoro-6-oxo-6H-pyrimidin-1-ylmethyl]-benzonitrile and methods of use therefor
TW200745079A (en) *	2005-09-16	2007-12-16	Takeda Pharmaceuticals Co	Polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile and methods of use therefor
CA2641053A1 (en) *	2006-02-08	2007-08-16	Lonza Ag	Synthesis of glucagon-like peptide
KR20080096809A (ko)	2006-02-22	2008-11-03	맨카인드 코포레이션	디케토피페라진 및 활성제를 포함하는 마이크로입자의 약학특성의 개선 방법
US20100029941A1 (en) *	2006-03-28	2010-02-04	Takeda Pharmaceutical Company Limited	Preparation of (r)-3-aminopiperidine dihydrochloride
WO2007112347A1 (en)	2006-03-28	2007-10-04	Takeda Pharmaceutical Company Limited	Dipeptidyl peptidase inhibitors
MY145447A (en) *	2006-09-13	2012-02-15	Takeda Pharmaceutical	Use of 2-6(3-amino-piperidin-1-yl)-3-methyl-2, 4-dioxo-3, 4-dihydrp-2h-pyrimidin-1-ylmethyl-4-fluoro-benzonitrile
US8324383B2 (en)	2006-09-13	2012-12-04	Takeda Pharmaceutical Company Limited	Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile
TW200838536A (en) *	2006-11-29	2008-10-01	Takeda Pharmaceutical	Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor
US8093236B2 (en)	2007-03-13	2012-01-10	Takeda Pharmaceuticals Company Limited	Weekly administration of dipeptidyl peptidase inhibitors
ES2929343T3 (es)	2008-06-13	2022-11-28	Mannkind Corp	Inhalador de polvo seco accionado por aspiración para la administración de fármacos
US8485180B2 (en)	2008-06-13	2013-07-16	Mannkind Corporation	Dry powder drug delivery system
MX2010014240A (es)	2008-06-20	2011-03-25	Mankind Corp	Un metodo y aparato interactivo para perfilar en tiempo real esfuerzos de inhalacion.
TWI494123B (zh)	2008-08-11	2015-08-01	Mannkind Corp	超快起作用胰島素之用途
US8314106B2 (en)	2008-12-29	2012-11-20	Mannkind Corporation	Substituted diketopiperazine analogs for use as drug delivery agents
MX2011007371A (es)	2009-01-08	2011-09-06	Mannkind Corp	Metodo para tratar la hiperglucemia con la molecula.
WO2010105094A1 (en)	2009-03-11	2010-09-16	Mannkind Corporation	Apparatus, system and method for measuring resistance of an inhaler
MY157166A (en)	2009-06-12	2016-05-13	Mankind Corp	Diketopiperazine microparticles with defined specific surface areas
US8642548B2 (en) *	2009-08-07	2014-02-04	Mannkind Corporation	Val (8) GLP-1 composition and method for treating functional dyspepsia and/or irritable bowel syndrome
WO2011056889A1 (en)	2009-11-03	2011-05-12	Mannkind Corporation	An apparatus and method for simulating inhalation efforts
BR112012033060A2 (pt)	2010-06-21	2018-02-27	Mannkind Corp	métodos de sistema de liberação de fármaco em pó seco
CN102718858B (zh) *	2011-03-29	2014-07-02	天津药物研究院	胰高血糖素样肽-1类似物单体、二聚体及其制备方法与应用
AU2012236150B2 (en)	2011-04-01	2016-03-31	Mannkind Corporation	Blister package for pharmaceutical cartridges
WO2012174472A1 (en)	2011-06-17	2012-12-20	Mannkind Corporation	High capacity diketopiperazine microparticles
BR112014009686A2 (pt)	2011-10-24	2018-08-07	Mannkind Corp	composição analgésica inalável, pó seco e método para tratar dor
AU2013289957B2 (en)	2012-07-12	2017-02-23	Mannkind Corporation	Dry powder drug delivery systems and methods
WO2014066856A1 (en)	2012-10-26	2014-05-01	Mannkind Corporation	Inhalable influenza vaccine compositions and methods
KR102246914B1 (ko)	2013-03-15	2021-04-30	맨카인드 코포레이션	미세결정성 디케토피페라진 조성물 및 방법
ES2624961T3 (es)	2013-03-21	2017-07-18	Sanofi-Aventis Deutschland Gmbh	Síntesis de productos de péptido que contienen imida cíclica
ES2623979T3 (es)	2013-03-21	2017-07-12	Sanofi-Aventis Deutschland Gmbh	Síntesis de productos peptídicos que contienen hidantoína
CN114848614A (zh)	2013-07-18	2022-08-05	曼金德公司	热稳定性干粉药物组合物和方法
EP3030294B1 (de)	2013-08-05	2020-10-07	MannKind Corporation	Insufflationsvorrichtung
US10307464B2 (en)	2014-03-28	2019-06-04	Mannkind Corporation	Use of ultrarapid acting insulin
US10561806B2 (en)	2014-10-02	2020-02-18	Mannkind Corporation	Mouthpiece cover for an inhaler
US9969769B2 (en)	2014-12-19	2018-05-15	Cem Corporation	Coupling method for peptide synthesis at elevated temperatures
US10308677B2 (en)	2014-12-19	2019-06-04	Cem Corporation	Coupling method for peptide synthesis at elevated temperatures
SG11201805255TA (en)	2015-12-23	2018-07-30	Amgen Inc	Method of treating or ameliorating metabolic disorders using binding proteins for gastric inhibitory peptide receptor (gipr) in combination with glp-1 agonists
JOP20190177A1 (ar)	2017-01-17	2019-07-16	Amgen Inc	طريقة لعلاج أو تحسين اضطرابات أيضية باستخدام مساعدات مستقبل glp-1 مقترنة بمناهضات لمستقبل ببتيد مثبط معوي (gipr)
AU2018288854B2 (en)	2017-06-20	2025-06-26	Amgen Inc.	Method of treating or ameliorating metabolic disorders using binding proteins for gastric inhibitory peptide receptor (GIPR) in combination with GLP-1 agonists
CA3263567A1 (en)	2017-06-21	2025-10-30	Amgen Inc.	Method of treating or ameliorating metabolic disorders using antagonistic binding proteins for gastric inhibitory peptide receptor (gipr)/glp-1 receptor agonist fusion proteins
TWI847306B (zh)	2017-08-24	2024-07-01	丹麥商諾佛儂迪克股份有限公司	Ｇｌｐ-１組成物及其用途
WO2019120480A1 (en)	2017-12-19	2019-06-27	Novo Nordisk A/S	Solubility of glp-1 peptide
WO2019200594A1 (zh) *	2018-04-19	2019-10-24	杭州先为达生物科技有限公司	酰化的glp-1衍生物
BR112022013795A2 (pt)	2020-02-18	2022-09-13	Novo Nordisk As	Composição farmacêutica líquida, e, kit
WO2022157747A2 (en)	2021-01-25	2022-07-28	Mylan Ireland Limited	Pharmaceutical peptide compositions and methods of preparation thereof
WO2022266927A1 (zh) *	2021-06-24	2022-12-29	深圳翰宇药业股份有限公司	一种利拉鲁肽变构体及其制备方法、应用
WO2024166998A1 (ja)	2023-02-09	2024-08-15	三井化学株式会社	マグネシウム化合物粒子の製造方法、オレフィン重合体粒子形状の制御方法、オレフィン重合体粒子

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3419824A1 (de) *	1984-05-26	1985-11-28	Bayer Ag, 5090 Leverkusen	Verfahren und formwerkzeug zum herstellen von formteilen mit grill-, gitter- oder rostartigen bereichen, wie kfz-soft-faces, spoiler, bumper, aus einer fliessfaehigen masse
NZ250844A (en) *	1993-04-07	1996-03-26	Pfizer	Treatment of non-insulin dependant diabetes with peptides; composition
US6380357B2 (en)	1997-12-16	2002-04-30	Eli Lilly And Company	Glucagon-like peptide-1 crystals
ATE269103T1 (de) *	1998-03-13	2004-07-15	Novo Nordisk As	Stabilisierte wässerige glukagonlösungen enthaltend detergenzien
US6844321B2 (en) *	2000-01-31	2005-01-18	Novo Nordisk A/S	Crystallization of a GLP-1 analogue

2001
- 2001-01-16 BR BR0107837-2A patent/BR0107837A/pt not_active IP Right Cessation
- 2001-01-16 CA CA002396920A patent/CA2396920A1/en not_active Abandoned
- 2001-01-16 EP EP01904785A patent/EP1257577B1/de not_active Expired - Lifetime
- 2001-01-16 AU AU2001232735A patent/AU2001232735A1/en not_active Abandoned
- 2001-01-16 AT AT01904785T patent/ATE264870T1/de not_active IP Right Cessation
- 2001-01-16 KR KR1020027009546A patent/KR20020073184A/ko not_active Ceased
- 2001-01-16 DE DE60102899T patent/DE60102899T2/de not_active Expired - Lifetime
- 2001-01-16 IL IL15091301A patent/IL150913A0/xx unknown
- 2001-01-16 US US10/169,657 patent/US7598222B2/en not_active Expired - Fee Related
- 2001-01-16 PT PT01904785T patent/PT1257577E/pt unknown
- 2001-01-16 HU HU0204281A patent/HUP0204281A3/hu not_active Application Discontinuation
- 2001-01-16 MX MXPA02007231A patent/MXPA02007231A/es active IP Right Grant
- 2001-01-16 ES ES01904785T patent/ES2218381T3/es not_active Expired - Lifetime
- 2001-01-16 DK DK01904785T patent/DK1257577T3/da active
- 2001-01-16 TR TR2004/01142T patent/TR200401142T4/xx unknown
- 2001-01-16 JP JP2001561060A patent/JP2003523366A/ja not_active Withdrawn
- 2001-01-16 WO PCT/US2001/000010 patent/WO2001055213A2/en not_active Ceased
2008
- 2008-02-07 IL IL189371A patent/IL189371A0/en unknown
2009
- 2009-09-01 US US12/551,841 patent/US8222205B2/en not_active Expired - Fee Related
2012
- 2012-04-27 US US13/458,057 patent/US8268780B2/en not_active Expired - Fee Related
- 2012-08-10 US US13/571,443 patent/US8455433B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
EP1257577B1 (de)	2004-04-21
AU2001232735A1 (en)	2001-08-07
US8268780B2 (en)	2012-09-18
DE60102899T2 (de)	2005-03-31
US20030060412A1 (en)	2003-03-27
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