ATE507235T1 - Synthese von glucagon-ähnlichen peptiden - Google Patents

Synthese von glucagon-ähnlichen peptiden

Info

Publication number: ATE507235T1
Authority: AT; Austria
Prior art keywords: glucagone; peptides; synthesis; devised; peptide
Prior art date: 2006-02-08

Application number

AT07702683T

Other languages

English (en)

Inventor

Oleg Werbitzky

Stephane Varray

Matthieu Giraud

Carsten Meininghaus

Original Assignee

Lonza Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-02-08

Filing date

2007-01-11

Publication date

2011-05-15

2007-01-11 Application filed by Lonza Ag filed Critical Lonza Ag

2011-05-15 Application granted granted Critical

2011-05-15 Publication of ATE507235T1 publication Critical patent/ATE507235T1/de

Links

108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
230000015572 biosynthetic process Effects 0.000 title 1
102000004196 processed proteins & peptides Human genes 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1
102100025101 GATA-type zinc finger protein 1 Human genes 0.000 abstract 1
101710198884 GATA-type zinc finger protein 1 Proteins 0.000 abstract 1
DTHNMHAUYICORS-KTKZVXAJSA-N Glucagon-like peptide 1 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 DTHNMHAUYICORS-KTKZVXAJSA-N 0.000 abstract 1
230000002194 synthesizing effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/10—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using coupling agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Endocrinology (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Toxicology (AREA)
Diabetes (AREA)
Emergency Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Hematology (AREA)
Obesity (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Analytical Chemistry (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AT07702683T 2006-02-08 2007-01-11 Synthese von glucagon-ähnlichen peptiden ATE507235T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP06002537		2006-02-08
PCT/EP2007/000198 WO2007090496A1 (en)	2006-02-08	2007-01-11	Synthesis of glucagon-like peptide

Publications (1)

Publication Number	Publication Date
ATE507235T1 true ATE507235T1 (de)	2011-05-15

Family

ID=37697824

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT07702683T ATE507235T1 (de)	2006-02-08	2007-01-11	Synthese von glucagon-ähnlichen peptiden

Country Status (19)

Country	Link
US (2)	US8445433B2 (de)
EP (1)	EP1987052B1 (de)
JP (1)	JP5199126B2 (de)
KR (1)	KR101297942B1 (de)
CN (1)	CN101379075B (de)
AT (1)	ATE507235T1 (de)
AU (1)	AU2007214088B2 (de)
BR (1)	BRPI0707599A2 (de)
CA (1)	CA2641053A1 (de)
DE (1)	DE602007014184D1 (de)
DK (1)	DK1987052T3 (de)
ES (1)	ES2364982T3 (de)
IL (1)	IL193134A (de)
MX (1)	MX2008010136A (de)
NO (1)	NO20083378L (de)
PT (1)	PT1987052E (de)
TW (1)	TWI404724B (de)
WO (1)	WO2007090496A1 (de)
ZA (1)	ZA200806690B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP5473925B2 (ja) *	2007-10-27	2014-04-16	コーデンファーマコロラドインコーポレイテッド	固相および溶液相の組み合わせ技法を使用するインスリン分泌性ペプチドの合成
WO2009074483A2 (en) *	2007-12-11	2009-06-18	F. Hoffmann-La Roche Ag	Insulinotropic peptide synthesis using solid and solution phase combination techniques
EP2424888A2 (de) *	2009-05-01	2012-03-07	F. Hoffmann-La Roche AG	Synthese insulinotroper peptide unter anwendung von fest- und flüssigphasenkombinationsverfahren
CN102250235A (zh) *	2011-06-23	2011-11-23	成都圣诺科技发展有限公司	奈西立肽的制备方法
GB201310921D0 (en)	2013-06-19	2013-07-31	Chemical & Biopharmaceutical Lab Of Patras S A	Peptide-resin conjugate and use thereof
KR20160098406A (ko) *	2013-12-13	2016-08-18	메디뮨 리미티드	프로테아제 내성 펩티드
CN104017064B (zh) *	2014-06-13	2016-08-24	杭州阿诺生物医药科技股份有限公司	一种制备特立帕肽的方法
GR20140100479A (el)	2014-09-23	2016-05-05	Novetide, Ltd.,	Συνθεση λιραγλουτιδης
CN104356221B (zh) *	2014-10-24	2018-06-26	杭州阿诺生物医药科技股份有限公司	一种制备培西加南的方法
CA3018618A1 (en) *	2016-03-23	2017-09-28	Bachem Holding Ag	Method for preparing glucagon-like peptides
WO2019069274A1 (en)	2017-10-04	2019-04-11	Chemical & Biopharmaceutical Laboratories Of Patras S.A.	PROCESS FOR THE PREPARATION OF A GLUCAGON-LIKE PEPTIDE
WO2020127476A1 (en)	2018-12-19	2020-06-25	Krka, D.D., Novo Mesto	Pharmaceutical composition comprising glp-1 analogue
WO2020190757A1 (en)	2019-03-15	2020-09-24	Novetide Ltd.	Improved processes for the preparation of semaglutide
WO2021123228A1 (en)	2019-12-18	2021-06-24	Krka, D.D., Novo Mesto	Pharmaceutical composition comprising glp-1 analogue
CN116925237A (zh)	2019-12-31	2023-10-24	北京质肽生物医药科技有限公司	Glp-1和gdf15的融合蛋白以及其缀合物
AR122579A1 (es) *	2020-06-12	2022-09-21	Lilly Co Eli	Proceso para preparar un agonista dual glp-1 / glucagón
EP4222176A4 (de)	2020-09-30	2024-02-28	Beijing QL Biopharmaceutical Co., Ltd.	Polypeptidkonjugate und verfahren zur verwendung
US20240067694A1 (en) *	2021-01-04	2024-02-29	Biocon Limited	Synthesis of teduglutide
CN114249808B (zh) *	2021-12-27	2024-11-12	江苏诺泰澳赛诺生物制药股份有限公司	一种Cagrilintide的合成方法
KR20240163717A (ko)	2022-03-30	2024-11-19	베이징 큐엘 바이오파마슈티컬 컴퍼니 리미티드	폴리펩티드 접합체의 액체 약학 조성물 및 그의 사용 방법

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3421303A1 (de)	1984-06-08	1985-12-12	Hoechst Ag, 6230 Frankfurt	Salze aus 3-hydroxy-4-oxo-3,4-dihydro-1,2,3-benzotriazin und amino-verbindungen
US5574008A (en) *	1994-08-30	1996-11-12	Eli Lilly And Company	Biologically active fragments of glucagon-like insulinotropic peptide
US6268343B1 (en) *	1996-08-30	2001-07-31	Novo Nordisk A/S	Derivatives of GLP-1 analogs
SI1180121T1 (en) *	1999-05-17	2004-04-30	Conjuchem, Inc.	Long lasting insulinotropic peptides
HUP0204281A3 (en)	2000-01-27	2007-03-28	Lilly Co Eli	Process for sulubilizing glucagon-like peptide 1 (glp-1) compounds
US6969702B2 (en) *	2002-11-20	2005-11-29	Neuronova Ab	Compounds and methods for increasing neurogenesis
KR101241862B1 (ko) *	2003-09-19	2013-03-13	노보 노르디스크 에이/에스	신규 ｇｌｐ-1 유도체
JP5755398B2 (ja) *	2005-03-18	2015-07-29	ノヴォノルディスクアー／エス	伸長されたｇｌｐ−１化合物

2007
- 2007-01-11 DK DK07702683.9T patent/DK1987052T3/da active
- 2007-01-11 WO PCT/EP2007/000198 patent/WO2007090496A1/en not_active Ceased
- 2007-01-11 DE DE602007014184T patent/DE602007014184D1/de active Active
- 2007-01-11 US US12/162,562 patent/US8445433B2/en not_active Expired - Fee Related
- 2007-01-11 BR BRPI0707599-5A patent/BRPI0707599A2/pt not_active Application Discontinuation
- 2007-01-11 AU AU2007214088A patent/AU2007214088B2/en not_active Ceased
- 2007-01-11 CN CN2007800046554A patent/CN101379075B/zh not_active Expired - Fee Related
- 2007-01-11 EP EP07702683A patent/EP1987052B1/de active Active
- 2007-01-11 IL IL193134A patent/IL193134A/en active IP Right Review Request
- 2007-01-11 ES ES07702683T patent/ES2364982T3/es active Active
- 2007-01-11 CA CA002641053A patent/CA2641053A1/en not_active Abandoned
- 2007-01-11 JP JP2008553641A patent/JP5199126B2/ja not_active Expired - Fee Related
- 2007-01-11 MX MX2008010136A patent/MX2008010136A/es not_active Application Discontinuation
- 2007-01-11 PT PT07702683T patent/PT1987052E/pt unknown
- 2007-01-11 KR KR1020087021965A patent/KR101297942B1/ko not_active Expired - Fee Related
- 2007-01-11 AT AT07702683T patent/ATE507235T1/de not_active IP Right Cessation
- 2007-02-05 TW TW096104026A patent/TWI404724B/zh not_active IP Right Cessation
2008
- 2008-07-31 ZA ZA200806690A patent/ZA200806690B/xx unknown
- 2008-08-04 NO NO20083378A patent/NO20083378L/no not_active Application Discontinuation
2013
- 2013-04-29 US US13/872,952 patent/US9040480B2/en active Active

Also Published As

Publication number	Publication date
DK1987052T3 (da)	2011-08-15
ZA200806690B (en)	2009-07-29
IL193134A (en)	2014-06-30
EP1987052B1 (de)	2011-04-27
US20090292106A1 (en)	2009-11-26
KR20080100448A (ko)	2008-11-18
JP2009525997A (ja)	2009-07-16
CN101379075B (zh)	2013-05-15
JP5199126B2 (ja)	2013-05-15
CN101379075A (zh)	2009-03-04
AU2007214088B2 (en)	2012-03-22
CA2641053A1 (en)	2007-08-16
AU2007214088A1 (en)	2007-08-16
TWI404724B (zh)	2013-08-11
TW200745157A (en)	2007-12-16
US8445433B2 (en)	2013-05-21
US20130324699A1 (en)	2013-12-05
PT1987052E (pt)	2011-07-25
KR101297942B1 (ko)	2013-08-19
EP1987052A1 (de)	2008-11-05
IL193134A0 (en)	2009-02-11
NO20083378L (no)	2008-10-31
MX2008010136A (es)	2008-12-19
US9040480B2 (en)	2015-05-26
ES2364982T3 (es)	2011-09-20
BRPI0707599A2 (pt)	2011-05-10
DE602007014184D1 (de)	2011-06-09
WO2007090496A1 (en)	2007-08-16

Legal Events

Date	Code	Title	Description
2011-10-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE602007014184D1 (de)	2011-06-09	Synthese von glucagon-ähnlichen peptiden
EA200601795A1 (ru)	2007-04-27	Синтез эфиров бороновой кислоты и кислотных соединений
IL186774A0 (en)	2008-02-09	Method of peptide synthesis
DK1737889T3 (da)	2011-01-03	Fremgangsmåde til fastfase-peptidsyntese
FR2915490B1 (fr)	2011-10-28	Formation de proteoliposomes contenant des proteines membranaires a l'aide d'un systeme de synthese proteique acellulaire
EA200602129A1 (ru)	2007-04-27	Новое применение пептидных соединений для лечения дискинезии
MX2009008271A (es)	2009-08-12	Procesos e intermediarios para la preparacion de un inhibidor de proteasa macrocilico del vhc.
ATE500249T1 (de)	2011-03-15	Synthese von himbacinanaloga
DK1480998T3 (da)	2007-03-26	Mellemprodukter og fremgangsmåder til fremstilling af heptapeptidoxytocinanaloger
IL184080A (en)	2010-12-30	Synthesis of peptide t-20 using peptide intermediate fragments
IL184081A (en)	2010-12-30	Method of preparing a peptide intermediate fragment for the synthesis of a peptide
DK1771463T3 (da)	2008-04-21	Fremgangsmåde til peptidsyntese
DK1542968T3 (da)	2009-04-20	Fremgangsmåde til fremstilling af mellemforbindelser
IL199752A0 (en)	2010-04-15	Purification of taci-fc
TW200720288A (en)	2007-06-01	Method of peptide synthesis
ATE439371T1 (de)	2009-08-15	Synthese von peptid t-1249 mit peptidzwischenproduktfragmenten
DK1805203T3 (da)	2010-05-17	Peptid-cyklisering på harpiks
IL182884A0 (en)	2008-04-13	Cyclization of a peptide
TW200716668A (en)	2007-05-01	Method of peptide synthesis
ATE453623T1 (de)	2010-01-15	Synthese von dipeptidanaloga