ATE507235T1 - Synthese von glucagon-ähnlichen peptiden - Google Patents

Synthese von glucagon-ähnlichen peptiden

Info

Publication number: ATE507235T1
Authority: AT; Austria
Prior art keywords: glucagone; peptides; synthesis; devised; peptide
Prior art date: 2006-02-08

Application number

AT07702683T

Other languages

English (en)

Inventor

Oleg Werbitzky

Stephane Varray

Matthieu Giraud

Carsten Meininghaus

Original Assignee

Lonza Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-02-08

Filing date

2007-01-11

Publication date

2011-05-15

2007-01-11 Application filed by Lonza Ag filed Critical Lonza Ag

2011-05-15 Application granted granted Critical

2011-05-15 Publication of ATE507235T1 publication Critical patent/ATE507235T1/de

Links

108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
230000015572 biosynthetic process Effects 0.000 title 1
102000004196 processed proteins & peptides Human genes 0.000 title 1
238000003786 synthesis reaction Methods 0.000 title 1
102100025101 GATA-type zinc finger protein 1 Human genes 0.000 abstract 1
101710198884 GATA-type zinc finger protein 1 Proteins 0.000 abstract 1
DTHNMHAUYICORS-KTKZVXAJSA-N Glucagon-like peptide 1 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC=1N=CNC=1)[C@@H](C)O)[C@@H](C)O)C(C)C)C1=CC=CC=C1 DTHNMHAUYICORS-KTKZVXAJSA-N 0.000 abstract 1
230000002194 synthesizing effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/10—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length using coupling agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Endocrinology (AREA)
Gastroenterology & Hepatology (AREA)
Zoology (AREA)
Toxicology (AREA)
Diabetes (AREA)
Emergency Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Hematology (AREA)
Obesity (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Analytical Chemistry (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

AT07702683T 2006-02-08 2007-01-11 Synthese von glucagon-ähnlichen peptiden ATE507235T1 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP06002537		2006-02-08
PCT/EP2007/000198 WO2007090496A1 (en)	2006-02-08	2007-01-11	Synthesis of glucagon-like peptide

Publications (1)

Publication Number	Publication Date
ATE507235T1 true ATE507235T1 (de)	2011-05-15

Family

ID=37697824

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT07702683T ATE507235T1 (de)	2006-02-08	2007-01-11	Synthese von glucagon-ähnlichen peptiden

Country Status (19)

Country	Link
US (2)	US8445433B2 (de)
EP (1)	EP1987052B1 (de)
JP (1)	JP5199126B2 (de)
KR (1)	KR101297942B1 (de)
CN (1)	CN101379075B (de)
AT (1)	ATE507235T1 (de)
AU (1)	AU2007214088B2 (de)
BR (1)	BRPI0707599A2 (de)
CA (1)	CA2641053A1 (de)
DE (1)	DE602007014184D1 (de)
DK (1)	DK1987052T3 (de)
ES (1)	ES2364982T3 (de)
IL (1)	IL193134A (de)
MX (1)	MX2008010136A (de)
NO (1)	NO20083378L (de)
PT (1)	PT1987052E (de)
TW (1)	TWI404724B (de)
WO (1)	WO2007090496A1 (de)
ZA (1)	ZA200806690B (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP5473925B2 (ja)	2007-10-27	2014-04-16	コーデンファーマコロラドインコーポレイテッド	固相および溶液相の組み合わせ技法を使用するインスリン分泌性ペプチドの合成
CA2707132A1 (en) *	2007-12-11	2009-06-18	F. Hoffmann-La Roche Ag	Insulinotropic peptide synthesis using solid and solution phase combination techniques
WO2010125079A2 (en) *	2009-05-01	2010-11-04	F. Hoffmann-La Roche Ag	Insulinotropic peptide synthesis using solid and solution phase combination techniques
CN102250235A (zh) *	2011-06-23	2011-11-23	成都圣诺科技发展有限公司	奈西立肽的制备方法
GB201310921D0 (en)	2013-06-19	2013-07-31	Chemical & Biopharmaceutical Lab Of Patras S A	Peptide-resin conjugate and use thereof
CA2933405A1 (en) *	2013-12-13	2015-06-18	Medimmune Limited	Protease-resistant peptides
CN104017064B (zh) *	2014-06-13	2016-08-24	杭州阿诺生物医药科技股份有限公司	一种制备特立帕肽的方法
GR20140100479A (el)	2014-09-23	2016-05-05	Novetide, Ltd.,	Συνθεση λιραγλουτιδης
CN104356221B (zh) *	2014-10-24	2018-06-26	杭州阿诺生物医药科技股份有限公司	一种制备培西加南的方法
JP6991196B2 (ja) *	2016-03-23	2022-02-03	バッヘン・ホールディング・アクチエンゲゼルシャフト	グルカゴン様ペプチドを製造するための方法
US20200317721A1 (en)	2017-10-04	2020-10-08	Chemical & Biopharmaceutical Laboratories Of Patras S.A.	A process for preparing a glucagon-like peptide
EP3897570A1 (de)	2018-12-19	2021-10-27	KRKA, d.d., Novo mesto	Pharmazeutische zusammensetzung mit glp-1-analog
WO2020190757A1 (en)	2019-03-15	2020-09-24	Novetide Ltd.	Improved processes for the preparation of semaglutide
WO2021123228A1 (en)	2019-12-18	2021-06-24	Krka, D.D., Novo Mesto	Pharmaceutical composition comprising glp-1 analogue
WO2021136223A1 (en)	2019-12-31	2021-07-08	Beijing Ql Biopharmaceutical Co., Ltd.	Fusion proteins of glp-1 and gdf15 and conjugates thereof
AR122579A1 (es) *	2020-06-12	2022-09-21	Lilly Co Eli	Proceso para preparar un agonista dual glp-1 / glucagón
CA3193453A1 (en)	2020-09-30	2022-04-07	Beijing Ql Biopharmaceutical Co., Ltd.	Polypeptide conjugates and methods of uses
MX2023007965A (es) *	2021-01-04	2023-08-14	Biocon Ltd	Sintesis de teduglutida.
CN114249808B (zh) *	2021-12-27	2024-11-12	江苏诺泰澳赛诺生物制药股份有限公司	一种Cagrilintide的合成方法
EP4323413A4 (de)	2022-03-30	2025-10-15	Beijing Ql Biopharmaceutical Co Ltd	Flüssige pharmazeutische zusammensetzungen aus polypeptidkonjugaten und verfahren zur verwendung davon

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3421303A1 (de)	1984-06-08	1985-12-12	Hoechst Ag, 6230 Frankfurt	Salze aus 3-hydroxy-4-oxo-3,4-dihydro-1,2,3-benzotriazin und amino-verbindungen
US5574008A (en)	1994-08-30	1996-11-12	Eli Lilly And Company	Biologically active fragments of glucagon-like insulinotropic peptide
US6268343B1 (en) *	1996-08-30	2001-07-31	Novo Nordisk A/S	Derivatives of GLP-1 analogs
PT1180121E (pt)	1999-05-17	2004-03-31	Conjuchem Inc	Peptidos insulinotropicos de longa duracao
ATE264870T1 (de)	2000-01-27	2004-05-15	Lilly Co Eli	Verfahren zur lösung von glucagon-ähnlichen peptid-1 (glp-1) verbindungen
US6969702B2 (en) *	2002-11-20	2005-11-29	Neuronova Ab	Compounds and methods for increasing neurogenesis
EP1670515A2 (de) *	2003-09-19	2006-06-21	Novo Nordisk A/S	Albumin bindende derivate von therapeutischen peptiden
ES2484796T3 (es) *	2005-03-18	2014-08-12	Novo Nordisk A/S	Compuestos de GLP-1 extendidos

2007
- 2007-01-11 AT AT07702683T patent/ATE507235T1/de not_active IP Right Cessation
- 2007-01-11 CN CN2007800046554A patent/CN101379075B/zh not_active Expired - Fee Related
- 2007-01-11 WO PCT/EP2007/000198 patent/WO2007090496A1/en not_active Ceased
- 2007-01-11 IL IL193134A patent/IL193134A/en active IP Right Review Request
- 2007-01-11 BR BRPI0707599-5A patent/BRPI0707599A2/pt not_active Application Discontinuation
- 2007-01-11 DE DE602007014184T patent/DE602007014184D1/de active Active
- 2007-01-11 KR KR1020087021965A patent/KR101297942B1/ko not_active Expired - Fee Related
- 2007-01-11 PT PT07702683T patent/PT1987052E/pt unknown
- 2007-01-11 US US12/162,562 patent/US8445433B2/en not_active Expired - Fee Related
- 2007-01-11 DK DK07702683.9T patent/DK1987052T3/da active
- 2007-01-11 CA CA002641053A patent/CA2641053A1/en not_active Abandoned
- 2007-01-11 MX MX2008010136A patent/MX2008010136A/es not_active Application Discontinuation
- 2007-01-11 AU AU2007214088A patent/AU2007214088B2/en not_active Ceased
- 2007-01-11 JP JP2008553641A patent/JP5199126B2/ja not_active Expired - Fee Related
- 2007-01-11 ES ES07702683T patent/ES2364982T3/es active Active
- 2007-01-11 EP EP07702683A patent/EP1987052B1/de active Active
- 2007-02-05 TW TW096104026A patent/TWI404724B/zh not_active IP Right Cessation
2008
- 2008-07-31 ZA ZA200806690A patent/ZA200806690B/xx unknown
- 2008-08-04 NO NO20083378A patent/NO20083378L/no not_active Application Discontinuation
2013
- 2013-04-29 US US13/872,952 patent/US9040480B2/en active Active

Also Published As

Publication number	Publication date
TW200745157A (en)	2007-12-16
AU2007214088B2 (en)	2012-03-22
US20090292106A1 (en)	2009-11-26
US9040480B2 (en)	2015-05-26
EP1987052A1 (de)	2008-11-05
US20130324699A1 (en)	2013-12-05
MX2008010136A (es)	2008-12-19
CA2641053A1 (en)	2007-08-16
WO2007090496A1 (en)	2007-08-16
KR20080100448A (ko)	2008-11-18
IL193134A0 (en)	2009-02-11
TWI404724B (zh)	2013-08-11
JP2009525997A (ja)	2009-07-16
KR101297942B1 (ko)	2013-08-19
IL193134A (en)	2014-06-30
ZA200806690B (en)	2009-07-29
BRPI0707599A2 (pt)	2011-05-10
CN101379075B (zh)	2013-05-15
EP1987052B1 (de)	2011-04-27
AU2007214088A1 (en)	2007-08-16
JP5199126B2 (ja)	2013-05-15
CN101379075A (zh)	2009-03-04
DK1987052T3 (da)	2011-08-15
US8445433B2 (en)	2013-05-21
NO20083378L (no)	2008-10-31
PT1987052E (pt)	2011-07-25
ES2364982T3 (es)	2011-09-20
DE602007014184D1 (de)	2011-06-09

Legal Events

Date	Code	Title	Description
2011-10-15	RER	Ceased as to paragraph 5 lit. 3 law introducing patent treaties

Publication	Publication Date	Title
DE602007014184D1 (de)	2011-06-09	Synthese von glucagon-ähnlichen peptiden
EA200601795A1 (ru)	2007-04-27	Синтез эфиров бороновой кислоты и кислотных соединений
IL186774A0 (en)	2008-02-09	Method of peptide synthesis
DK1737889T3 (da)	2011-01-03	Fremgangsmåde til fastfase-peptidsyntese
FR2915490B1 (fr)	2011-10-28	Formation de proteoliposomes contenant des proteines membranaires a l'aide d'un systeme de synthese proteique acellulaire
EA200602129A1 (ru)	2007-04-27	Новое применение пептидных соединений для лечения дискинезии
MX2009008271A (es)	2009-08-12	Procesos e intermediarios para la preparacion de un inhibidor de proteasa macrocilico del vhc.
ATE500249T1 (de)	2011-03-15	Synthese von himbacinanaloga
DK1480998T3 (da)	2007-03-26	Mellemprodukter og fremgangsmåder til fremstilling af heptapeptidoxytocinanaloger
IL184080A (en)	2010-12-30	Synthesis of peptide t-20 using peptide intermediate fragments
IL184081A (en)	2010-12-30	Method of preparing a peptide intermediate fragment for the synthesis of a peptide
DK1771463T3 (da)	2008-04-21	Fremgangsmåde til peptidsyntese
DK1542968T3 (da)	2009-04-20	Fremgangsmåde til fremstilling af mellemforbindelser
IL199752A0 (en)	2010-04-15	Purification of taci-fc
TW200720288A (en)	2007-06-01	Method of peptide synthesis
ATE439371T1 (de)	2009-08-15	Synthese von peptid t-1249 mit peptidzwischenproduktfragmenten
DK1805203T3 (da)	2010-05-17	Peptid-cyklisering på harpiks
IL182884A0 (en)	2008-04-13	Cyclization of a peptide
TW200716668A (en)	2007-05-01	Method of peptide synthesis
ATE453623T1 (de)	2010-01-15	Synthese von dipeptidanaloga