DK1259628T3 - Fremgangsmåde til dannelse af hypermutabel gær - Google Patents

Fremgangsmåde til dannelse af hypermutabel gær

Info

Publication number
DK1259628T3
DK1259628T3 DK01911013T DK01911013T DK1259628T3 DK 1259628 T3 DK1259628 T3 DK 1259628T3 DK 01911013 T DK01911013 T DK 01911013T DK 01911013 T DK01911013 T DK 01911013T DK 1259628 T3 DK1259628 T3 DK 1259628T3
Authority
DK
Denmark
Prior art keywords
repair system
mismatch repair
formation
hypermutable
yeast
Prior art date
Application number
DK01911013T
Other languages
English (en)
Other versions
DK1259628T5 (da
Inventor
Bert Vogelstein
Kenneth W Kinzler
Nicholas C Nicolaides
Philip M Sass
Luigi Grasso
Original Assignee
Univ Johns Hopkins
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Johns Hopkins filed Critical Univ Johns Hopkins
Application granted granted Critical
Publication of DK1259628T3 publication Critical patent/DK1259628T3/da
Publication of DK1259628T5 publication Critical patent/DK1259628T5/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DK01911013.9T 2000-02-23 2001-02-21 Fremgangsmåde til dannelse af hypermutabel gær DK1259628T5 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18433600P 2000-02-23 2000-02-23
PCT/US2001/005447 WO2001062945A1 (en) 2000-02-23 2001-02-21 Methods for generating hypermutable yeast

Publications (2)

Publication Number Publication Date
DK1259628T3 true DK1259628T3 (da) 2007-05-21
DK1259628T5 DK1259628T5 (da) 2018-06-14

Family

ID=22676473

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01911013.9T DK1259628T5 (da) 2000-02-23 2001-02-21 Fremgangsmåde til dannelse af hypermutabel gær

Country Status (8)

Country Link
US (4) US6656736B2 (da)
EP (1) EP1259628B1 (da)
AT (1) ATE351914T1 (da)
AU (1) AU2001238558A1 (da)
CA (1) CA2399191C (da)
DE (1) DE60126065T2 (da)
DK (1) DK1259628T5 (da)
WO (1) WO2001062945A1 (da)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE404665T1 (de) * 2000-02-11 2008-08-15 Univ Johns Hopkins Methode zur herstellung hypermutierender bakterien
CA2399191C (en) * 2000-02-23 2010-12-14 The Johns Hopkins University Methods for generating hypermutable yeast
WO2001088192A2 (en) 2000-05-12 2001-11-22 The Johns Hopkins University A method for generating hypermutable organisms
NZ524366A (en) * 2000-07-27 2005-12-23 Univ Delaware Methods for enhancing targeted gene alteration using oligonucleotides
CA2473741C (en) * 2002-01-18 2015-12-22 Morphotek, Inc. A method for generating engineered cells for locus specific gene regulation and analysis
DE60335502D1 (de) * 2002-02-21 2011-02-03 Morphotek Inc Regulierte Vektoren zur Steuerung der DNA-Hypermutabilität in eukaryotischen Zellen
EP1572935A4 (en) * 2002-02-21 2006-09-13 Morphotek Inc PROCESS FOR THE PREPARATION OF HYPERMUTABLE CELLS USING PMSR HOMOLOGATES
WO2003104451A2 (en) * 2002-06-06 2003-12-18 Her Majesty The Queen In Right Of Canada As Represented By The Minister Of Agriculture And Agri-Food Modifying dna recombination and repair
EP2115127A4 (en) * 2007-01-17 2010-04-07 Life Technologies Corp METHOD AND COMPOSITIONS FOR IMPROVING CELL HEALTH IN CULTURES
US20090075378A1 (en) * 2007-02-20 2009-03-19 Anaptysbio, Inc. Somatic hypermutation systems
EP2814969A4 (en) * 2012-02-10 2016-02-17 Univ Minnesota Dna assimilation

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6191268B1 (en) 1993-12-17 2001-02-20 Dana-Farber Cancer Institute Compositions and methods relating to DNA mismatch repair genes
US5587290A (en) * 1995-06-26 1996-12-24 The Regents Of The University Of California Stress tolerant yeast mutants
US5843757A (en) 1995-08-24 1998-12-01 The Johns Hopkins University Human JTV1 gene overlaps PMS2 gene
US5907079A (en) 1996-01-18 1999-05-25 Amgen Canada Inc. MSH2 disrupted mice develop lymphomas
US6326204B1 (en) 1997-01-17 2001-12-04 Maxygen, Inc. Evolution of whole cells and organisms by recursive sequence recombination
AUPO974597A0 (en) 1997-10-10 1997-11-06 Rhone-Poulenc Agro Methods for obtaining plant varieties
US6146894A (en) * 1998-04-14 2000-11-14 The Johns Hopkins University Method for generating hypermutable organisms
CA2399191C (en) * 2000-02-23 2010-12-14 The Johns Hopkins University Methods for generating hypermutable yeast

Also Published As

Publication number Publication date
US7759121B2 (en) 2010-07-20
ATE351914T1 (de) 2007-02-15
DE60126065D1 (de) 2007-03-08
US20050272140A1 (en) 2005-12-08
AU2001238558A1 (en) 2001-09-03
EP1259628B1 (en) 2007-01-17
DK1259628T5 (da) 2018-06-14
EP1259628A1 (en) 2002-11-27
WO2001062945A1 (en) 2001-08-30
US20040092021A1 (en) 2004-05-13
CA2399191C (en) 2010-12-14
US20020123149A1 (en) 2002-09-05
US20080176329A1 (en) 2008-07-24
DE60126065T2 (de) 2007-08-30
US6656736B2 (en) 2003-12-02
CA2399191A1 (en) 2001-08-30
US7514216B2 (en) 2009-04-07
US6921666B2 (en) 2005-07-26

Similar Documents

Publication Publication Date Title
DK1259628T3 (da) Fremgangsmåde til dannelse af hypermutabel gær
ATE432981T1 (de) Multi-stellen-mutagenese
WO1999014336A3 (en) Thermostable luciferases and methods of production
TW200631187A (en) Method of making solar cell contacts
WO2004026992A3 (en) Method of producing charcoal from biomass
WO2000067336A3 (en) Electrochemical uses of amorphous fluoropolymers
MY138541A (en) A method producing a complex structure by assembling stressed structures
AU2001272951A1 (en) Coping with standoffs
WO2008080124A3 (en) Butanol production by metabolically engineered yeast
DK460685D0 (da) Fremgangsmaade til fremstilling af bakteriestammer
NO20081598L (no) Modulelement for konstruksjoner, stotteelement og framgangsmate for fremstilling av samme
DK1851815T3 (da) Fremgangsmåde til fremstilling af en brændselscellekatode
EP0845538A3 (en) Method of producing erythritol
WO2019026056A3 (en) Support structure for wind-driven power generators
NO20051841L (no) Fremgangsmate for a oke produksjon av blodplater og hematopoietiske stamceller.
WO2001048854A3 (de) Membran-elektroden-einheit für eine brennstoffzelle und herstellungsverfahren dazu
WO2001060981A8 (en) Tooth progenitor cell and method for its production
DK0873411T3 (da) Forbedrede mutanter af (2,5-DKG)-reductase-A
WO2004047209A3 (en) Method for forming a separator plate for a fuel cell, and separator plate
PT93615A (pt) Estirpe de sccharomyces cerivisiae produtora de uma proteina heterologa e processo para a preparacao de hirudina recombinante por meio de por meio de fermentacao da referida estirpe
BR112018004066A2 (pt) cepas de levedura que coexpressam glucoamilases exógenas, processo para produzir as referidas cepas de levedura e o uso destas para produzir bioetanol
WO2019045416A3 (ko) 에탄올 비생산성 아세토젠 균주를 에탄올 생성균주로 전환하는 방법 및 상기 에탄올 생성균주로부터 일산화탄소를 이용한 에탄올의 제조방법
TW200732248A (en) Novel metal (III)-chromium-phosphate complex and use thereof
MX2024010214A (es) Variantes de glicosiltransferasa termoestables
KR960014333A (ko) 고생산 세포융합변이균주에 의한 사이클로스포린 a의 제조방법