ATE351914T1 - Verfahren zur erzeugung von schnell mutierender hefe - Google Patents

Verfahren zur erzeugung von schnell mutierender hefe

Info

Publication number
ATE351914T1
ATE351914T1 AT01911013T AT01911013T ATE351914T1 AT E351914 T1 ATE351914 T1 AT E351914T1 AT 01911013 T AT01911013 T AT 01911013T AT 01911013 T AT01911013 T AT 01911013T AT E351914 T1 ATE351914 T1 AT E351914T1
Authority
AT
Austria
Prior art keywords
repair system
mismatch repair
yeast
producing rapidly
rapidly mutating
Prior art date
Application number
AT01911013T
Other languages
English (en)
Inventor
Nicholas C Nicolaides
Philip M Sass
Luigi Grasso
Bert Vogelstein
Kenneth W Kinzler
Original Assignee
Univ Johns Hopkins
Morphotek Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Johns Hopkins, Morphotek Inc filed Critical Univ Johns Hopkins
Application granted granted Critical
Publication of ATE351914T1 publication Critical patent/ATE351914T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
AT01911013T 2000-02-23 2001-02-21 Verfahren zur erzeugung von schnell mutierender hefe ATE351914T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US18433600P 2000-02-23 2000-02-23

Publications (1)

Publication Number Publication Date
ATE351914T1 true ATE351914T1 (de) 2007-02-15

Family

ID=22676473

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01911013T ATE351914T1 (de) 2000-02-23 2001-02-21 Verfahren zur erzeugung von schnell mutierender hefe

Country Status (8)

Country Link
US (4) US6656736B2 (de)
EP (1) EP1259628B1 (de)
AT (1) ATE351914T1 (de)
AU (1) AU2001238558A1 (de)
CA (1) CA2399191C (de)
DE (1) DE60126065T2 (de)
DK (1) DK1259628T5 (de)
WO (1) WO2001062945A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1268765B1 (de) * 2000-02-11 2008-08-13 The Johns Hopkins University Methode zur herstellung hypermutierender bakterien
CA2399191C (en) * 2000-02-23 2010-12-14 The Johns Hopkins University Methods for generating hypermutable yeast
CA2408826C (en) * 2000-05-12 2012-08-14 The Johns Hopkins University A method for generating hypermutable organisms
EP1364008A2 (de) * 2000-07-27 2003-11-26 University Of Delaware Verfahren zur verbesserung gezielter genmanipulationen mit hilfe von oligonukleotiden
AU2003205173C1 (en) * 2002-01-18 2009-01-29 Eisai, Inc. A method for generating engineered cells for locus specific gene regulation and analysis
JP2005531291A (ja) * 2002-02-21 2005-10-20 モーフオテク・インコーポレーテツド Ｐｍｓｒ相同体を使用する超変異性細胞の作成方法
EP1476577B1 (de) * 2002-02-21 2009-04-15 Morphotek Inc. Regulierte vektoren zur steuerung der dna-hypermutabilität in eukaryontischen zellen
CA2488668C (en) * 2002-06-06 2013-02-26 Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of Agriculture And Agri-Food Modifying the dna recombination potential in eukaryotes
WO2008089355A1 (en) * 2007-01-17 2008-07-24 Life Technologies Corporation Methods and compositions for improving the health of cells in culture
AU2008218925A1 (en) * 2007-02-20 2008-08-28 Anaptysbio, Inc. Somatic hypermutation systems
WO2013120037A1 (en) * 2012-02-10 2013-08-15 Regents Of The University Of Minnesota Dna assimilation

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6191268B1 (en) 1993-12-17 2001-02-20 Dana-Farber Cancer Institute Compositions and methods relating to DNA mismatch repair genes
US5587290A (en) * 1995-06-26 1996-12-24 The Regents Of The University Of California Stress tolerant yeast mutants
US5843757A (en) 1995-08-24 1998-12-01 The Johns Hopkins University Human JTV1 gene overlaps PMS2 gene
US5907079A (en) 1996-01-18 1999-05-25 Amgen Canada Inc. MSH2 disrupted mice develop lymphomas
US6326204B1 (en) 1997-01-17 2001-12-04 Maxygen, Inc. Evolution of whole cells and organisms by recursive sequence recombination
AUPO974597A0 (en) 1997-10-10 1997-11-06 Rhone-Poulenc Agro Methods for obtaining plant varieties
US6146894A (en) * 1998-04-14 2000-11-14 The Johns Hopkins University Method for generating hypermutable organisms
CA2399191C (en) * 2000-02-23 2010-12-14 The Johns Hopkins University Methods for generating hypermutable yeast

Also Published As

Publication number Publication date
DE60126065D1 (de) 2007-03-08
EP1259628A1 (de) 2002-11-27
US6921666B2 (en) 2005-07-26
DK1259628T3 (da) 2007-05-21
US20080176329A1 (en) 2008-07-24
WO2001062945A1 (en) 2001-08-30
US20040092021A1 (en) 2004-05-13
DK1259628T5 (da) 2018-06-14
CA2399191C (en) 2010-12-14
EP1259628B1 (de) 2007-01-17
US20050272140A1 (en) 2005-12-08
US20020123149A1 (en) 2002-09-05
US7514216B2 (en) 2009-04-07
US7759121B2 (en) 2010-07-20
AU2001238558A1 (en) 2001-09-03
US6656736B2 (en) 2003-12-02
DE60126065T2 (de) 2007-08-30
CA2399191A1 (en) 2001-08-30

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