DK1265698T3 - Lipidnanokapsler, fremgangsmåde til fremstilling heraf samt anvendelse som medikament - Google Patents

Lipidnanokapsler, fremgangsmåde til fremstilling heraf samt anvendelse som medikament

Info

Publication number
DK1265698T3
DK1265698T3 DK01911828T DK01911828T DK1265698T3 DK 1265698 T3 DK1265698 T3 DK 1265698T3 DK 01911828 T DK01911828 T DK 01911828T DK 01911828 T DK01911828 T DK 01911828T DK 1265698 T3 DK1265698 T3 DK 1265698T3
Authority
DK
Denmark
Prior art keywords
nanocapsules
lipid
medicament
preparation
producing
Prior art date
Application number
DK01911828T
Other languages
English (en)
Inventor
Joel Richard
Jean-Pierre Benoit
Beatrice Heurtault
Patrick Saulnier
Jacques-Emile Proust
Brigitte Pech
Original Assignee
Mainelab
Univ Angers
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mainelab, Univ Angers filed Critical Mainelab
Application granted granted Critical
Publication of DK1265698T3 publication Critical patent/DK1265698T3/da

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02Making microcapsules or microballoons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5107Excipients; Inactive ingredients
    • A61K9/5123Organic compounds, e.g. fats, sugars
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51Nanocapsules; Nanoparticles
    • A61K9/5107Excipients; Inactive ingredients
    • A61K9/513Organic macromolecular compounds; Dendrimers
    • A61K9/5146Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/0004Preparation of sols
    • B01J13/0026Preparation of sols containing a liquid organic phase
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02Making microcapsules or microballoons
    • B01J13/06Making microcapsules or microballoons by phase separation
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09KMATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K23/00Use of substances as emulsifying, wetting, dispersing, or foam-producing agents
    • C09K23/017Mixtures of compounds
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09KMATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K23/00Use of substances as emulsifying, wetting, dispersing, or foam-producing agents
    • C09K23/14Derivatives of phosphoric acid
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09KMATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K23/00Use of substances as emulsifying, wetting, dispersing, or foam-producing agents
    • C09K23/34Higher-molecular-weight carboxylic acid esters
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B82NANOTECHNOLOGY
    • B82YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Materials Engineering (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Nanotechnology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK01911828T 2000-03-02 2001-03-02 Lipidnanokapsler, fremgangsmåde til fremstilling heraf samt anvendelse som medikament DK1265698T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0002688A FR2805761B1 (fr) 2000-03-02 2000-03-02 Nanocapsules lipidiques, procede de preparation et utilisation comme medicament
PCT/FR2001/000621 WO2001064328A1 (fr) 2000-03-02 2001-03-02 Nanocapsules lipidiques, procede de preparation et utilisation comme medicament

Publications (1)

Publication Number Publication Date
DK1265698T3 true DK1265698T3 (da) 2004-10-25

Family

ID=8847644

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01911828T DK1265698T3 (da) 2000-03-02 2001-03-02 Lipidnanokapsler, fremgangsmåde til fremstilling heraf samt anvendelse som medikament

Country Status (22)

Country Link
US (2) US8057823B2 (da)
EP (1) EP1265698B1 (da)
JP (1) JP4790187B2 (da)
KR (1) KR100638527B1 (da)
CN (1) CN1257011C (da)
AT (1) ATE269154T1 (da)
AU (2) AU2001240753B2 (da)
BR (1) BRPI0108921B8 (da)
CA (1) CA2401766C (da)
DE (1) DE60103863T2 (da)
DK (1) DK1265698T3 (da)
ES (1) ES2221640T3 (da)
FR (1) FR2805761B1 (da)
HU (1) HU226483B1 (da)
IL (1) IL151560A0 (da)
MX (1) MXPA02008638A (da)
NO (1) NO334188B1 (da)
PT (1) PT1265698E (da)
SI (1) SI1265698T1 (da)
TR (1) TR200401812T4 (da)
WO (1) WO2001064328A1 (da)
ZA (1) ZA200206985B (da)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0104698D0 (en) 2001-02-26 2001-04-11 Syngenta Ltd Process for producing microcapsules
FR2835430A1 (fr) * 2002-05-31 2003-08-08 Oreal Composition comprenant des nanocapsules enrobees de lecithine et un polymere d'acrylamide
FR2840532B1 (fr) * 2002-06-11 2005-05-06 Ethypharm Sa Nanocapsules lipidiques furtives, procede de preparation et utilisation comme vecteur de principes(s) actif(s)
BR0314767A (pt) * 2002-06-11 2005-07-26 Ethypharm Sa Nanocápsulas lipidìcas furtivas, processos para a preparação das mesmas e uso das mesmas como um veìculo para princìpio(s) ativo(s)
JP4886297B2 (ja) * 2002-11-01 2012-02-29 バイオデリバリー サイエンシーズ インターナショナル インコーポレイティッド ジオデート送達媒体
FR2849379B1 (fr) * 2002-12-26 2005-02-11 Cosnessens Encapsulation d'actifs liposolubles
US20060073196A1 (en) * 2003-02-12 2006-04-06 Institut National De La Sante Et De La Recherche Medicale (Inserm) Use of p-glycoprotein inhibitor surfactants at the surface of a colloidal carrier
FR2864900B1 (fr) 2004-01-09 2007-10-12 Oreal Dispersion aqueuse de nanocapsules a coeur huileux
US20110135734A1 (en) * 2004-04-20 2011-06-09 Yissum Research Development Company Of The Hebrew University Of Jerusalem Method For the Preparation of Nanoparticles From Nanoemulsions
DE102005037844A1 (de) * 2005-08-04 2007-04-05 Intendis Gmbh Wasserfreies Mehr-Phasen-Gel-System
US9486408B2 (en) 2005-12-01 2016-11-08 University Of Massachusetts Lowell Botulinum nanoemulsions
FR2907012B1 (fr) * 2006-10-12 2012-09-21 Galderma Sa Composition dermatologique comprenant des nanocapsules d'avermectine, son procede de preparation et son utilisation
GB0623838D0 (en) 2006-11-29 2007-01-10 Malvern Cosmeceutics Ltd Novel compositions
EP1955695A1 (en) * 2007-02-06 2008-08-13 Institut National De La Sante Et De La Recherche Medicale (Inserm) Nanocapsules of lipophilic complexes of nucleic acids
FR2916974B1 (fr) * 2007-06-11 2010-11-26 Univ Angers Procede de preparation de nanoparticules lipidiques
FR2916973B1 (fr) 2007-06-11 2010-02-26 Univ Angers Nanocapsules a coeur lipidique chargees en actif(s) hydrosoluble(s) ou hydrodispersible(s)
FR2917976B1 (fr) * 2007-06-29 2010-05-28 Galderma Sa Composition dermatologique comprenant des vehicules lipidiques de calcitriol, son procede de preparation et son utilisation
EP2036577A1 (de) * 2007-09-14 2009-03-18 mivenion GmbH Diagnostische Stoffe für die optische bildgebende Untersuchung auf der Basis von nanopartikulären Formulierungen
EP2039352A1 (en) * 2007-09-18 2009-03-25 Institut National De La Sante Et De La Recherche Medicale (Inserm) Aqueous-core lipid nanocapsules for encapsulating hydrophilic and/or lipophilic molecules
FR2934953B1 (fr) 2008-08-14 2011-01-21 Commissariat Energie Atomique Nanoemulsions de nanocristaux
FR2934954B1 (fr) 2008-08-14 2011-07-22 Commissariat Energie Atomique Emulsion fluorescente de vert d'indocyanine
FR2934955B1 (fr) * 2008-08-14 2011-07-08 Commissariat Energie Atomique Encapsulation d'agents therapeutiques lipophiles ou amphiphiles dans des nanoemulsions
FR2939699B1 (fr) * 2008-12-12 2011-05-06 Univ Angers Procede de preparation de nanoparticules lipidiques
FR2943544B1 (fr) * 2009-03-31 2012-04-20 Univ Angers Procede de preparation de capsules lipidiques fonctionnalisees.
FR2949063B1 (fr) 2009-08-11 2011-09-30 Pf Medicament Composition pharmaceutique comprenant un ester de dha destinee a etre administree par voie parenterale
FR2950253B1 (fr) 2009-09-24 2011-09-23 Ethypharm Sa Nanocapsules lipidiques, procede de preparation et utilisation comme medicament
IT1396951B1 (it) * 2009-12-18 2012-12-20 Neuroscienze Pharmaness S C A R L Composti farmaceutici
JP5943258B2 (ja) * 2011-01-24 2016-07-05 アンテリオス, インコーポレイテッド ナノ粒子組成物、その製剤およびその使用
CA2827239A1 (en) 2011-02-25 2012-08-30 Universite D'angers Nanocapsulation of essential oils for preventing or curing infectious diseases alone or with an antibiotic
FR2988609B1 (fr) * 2012-03-30 2015-09-04 Commissariat Energie Atomique Formulation pour l'hormonotherapie
US10511150B2 (en) 2012-04-06 2019-12-17 Furukawa Electric Co., Ltd. Wavelength-variable laser
WO2013178749A1 (fr) 2012-06-01 2013-12-05 Galderma Research & Development Nanocapsules lipidiques comprenant un rétinoide, nanodispersion et composition les contenant, leur procédé de préparation et leur utilisation en dermatologie
CN105007947B (zh) * 2013-01-14 2019-02-15 因佛斯特医疗有限公司 固溶体组合物及其在心血管疾病中的用途
EP2789619A1 (en) 2013-04-12 2014-10-15 Kemotech S.r.l. Pharmaceutical compounds wiht angiogenesis inbhibitory activity
FR3008900B1 (fr) 2013-07-25 2018-03-30 Centre Nat Rech Scient Nanoparticules lipidiques multicompartimentees
AU2014351831B2 (en) * 2013-11-22 2018-02-01 Dsm Ip Assets B.V. Process for making an anti-reflective coating composition and a porous coating made therefrom
MX2016006896A (es) 2013-12-04 2016-08-17 Galderma Res & Dev Microcapsulas de lipidos que comprenden preferiblemente una substancia activa lipofilica y composicion que las contiene, su metodo de preparacion y su uso en dermatolgia y cosmetica.
FR3017294B1 (fr) 2014-02-07 2021-10-01 Atlangram Nanoparticules lipidiques comprenant un antibiotique et leurs utilisations en therapie
US20170189344A1 (en) * 2014-05-30 2017-07-06 AbbVie Deutschland GmbH & Co. KG Highly drug-loaded poly(alkyl 2-cyanoacrylate) nanocapsules
JP2016163851A (ja) * 2015-03-06 2016-09-08 国立大学法人福井大学 コンポジット型可溶化ナノリポソーム及びその製造方法
US11197831B2 (en) 2015-05-29 2021-12-14 Galderma Research And Development Compositions comprising at least one dispersed active principle and lipid microcapsules
EP3541358A1 (en) 2016-11-21 2019-09-25 Eirion Therapeutics, Inc. Transdermal delivery of large agents
JPWO2018180966A1 (ja) * 2017-03-28 2019-06-27 富士フイルム株式会社 マイクロカプセル及びその製造方法
KR20200024940A (ko) * 2017-07-27 2020-03-09 로커스 아이피 컴퍼니 엘엘씨 의약품, 보충제 및 섭취된 물질의 생체 이용률을 향상시키기 위한 조성물
EP3453386A1 (en) 2017-09-08 2019-03-13 Universite D'angers Nanocapsules comprising modified nucleobases and/or nucleosides, hydrogels and oleogels comprising them and uses thereof
GB201721832D0 (en) * 2017-12-22 2018-02-07 Waterford Institute Of Tech Ocular drug delivery
WO2020021052A2 (en) 2018-07-27 2020-01-30 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of acyclic terpene alcohols for enhancing the antimicrobial activity of colistin
EP3679928A1 (fr) 2019-01-08 2020-07-15 Atlangram Composition pharmaceutique de type gel pour traiter/prevenir une infection
IT201900009258A1 (it) 2019-06-17 2020-12-17 R Bio Transfer S R L Metodo per la preparazione di nanoparticelle lipidiche
FR3099069A1 (fr) * 2019-07-24 2021-01-29 Université D`Angers Procede continu de nano-emulsification par inversion de phase en concentration
CN112773776B (zh) * 2019-11-11 2023-06-20 上海胜联医药科技有限公司 一种载药纳米粒体系
CN115006369B (zh) * 2021-03-03 2023-08-29 浙江大学 一种脑靶向类脂纳米囊载药系统及其制备方法和应用
IT202100023570A1 (it) 2021-09-13 2023-03-13 Bioema S R L S Biotecnologia Energia Mat Ambiente Metodo per la preparazione di nanoparticelle lipidiche

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235871A (en) * 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US5174930A (en) * 1986-12-31 1992-12-29 Centre National De La Recherche Scientifique (Cnrs) Process for the preparation of dispersible colloidal systems of amphiphilic lipids in the form of oligolamellar liposomes of submicron dimensions
FR2608942B1 (fr) * 1986-12-31 1991-01-11 Centre Nat Rech Scient Procede de preparation de systemes colloidaux dispersibles d'une substance, sous forme de nanocapsules
CA2068216C (en) * 1989-11-13 1999-04-13 Abraham J. Domb Lipospheres for controlled delivery of substances
FR2659554B1 (fr) * 1990-03-16 1994-09-30 Oreal Composition pour le traitement cosmetique et/ou pharmaceutique des couches superieures de l'epiderme par application topique sur la peau et procede de preparation correspondant.
ES2034891B1 (es) * 1991-08-08 1993-12-16 Cusi Lab Procedimiento de elaboracion en continuo de sistemas coloidales dispersos, en forma de nanocapsulas o nanoparticulas.
FR2681248B1 (fr) * 1991-09-13 1995-04-28 Oreal Composition pour un traitement cosmetique et/ou pharmaceutique de longue duree des couches superieures de l'epiderme par une application topique sur la peau.
IL101387A (en) * 1992-03-26 1999-11-30 Pharmos Ltd Emulsion with enhanced topical and/or transdermal systemic effect utilizing submicron oil droplets
FR2692167B1 (fr) 1992-06-16 1994-09-16 Centre Nat Rech Scient Préparation et application de nouveaux systèmes colloïdaux nanovésiculaires dispersibles à base de cyclodextrine, sous forme de nanocapsules.
ES2070076B1 (es) * 1993-04-20 1996-04-16 Cusi Lab Metodo para aumentar la estabilidad de las nanocapsulas durante su almacenamiento.
US5576016A (en) * 1993-05-18 1996-11-19 Pharmos Corporation Solid fat nanoemulsions as drug delivery vehicles
US5514670A (en) * 1993-08-13 1996-05-07 Pharmos Corporation Submicron emulsions for delivery of peptides
US5961970A (en) * 1993-10-29 1999-10-05 Pharmos Corporation Submicron emulsions as vaccine adjuvants
DE4337030A1 (de) * 1993-10-29 1995-05-04 Henkel Kgaa Verfahren zur Herstellung von Wachsdispersionen
ES2078190B1 (es) * 1994-05-20 1996-08-01 Cusi Lab Procedimiento para el recubrimiento de goticulas o particulas de tamaño nanometrico.
US5578298A (en) * 1994-05-27 1996-11-26 General Electric Company Microemulsions for high viscosity amino silicone fluids and gums and their preparation
FR2725369B1 (fr) * 1994-10-07 1997-01-03 Oreal Composition cosmetique ou dermatologique constituee d'une emulsion huile dans eau a base de globules huileux pourvus d'un enrobage cristal liquide lamellaire
US6245349B1 (en) * 1996-02-23 2001-06-12 éLAN CORPORATION PLC Drug delivery compositions suitable for intravenous injection
US5972389A (en) * 1996-09-19 1999-10-26 Depomed, Inc. Gastric-retentive, oral drug dosage forms for the controlled-release of sparingly soluble drugs and insoluble matter
FR2755856B1 (fr) * 1996-11-21 1999-01-29 Merck Clevenot Laboratoires Microcapsules de chitine ou de derives de chitine contenant une substance hydrophobe, notamment un filtre solaire et procede de preparation de telles microcapsules
CA2294032A1 (en) * 1997-07-29 1999-02-11 Pharmacia & Upjohn Company Self-emulsifying formulation for lipophilic compounds
TWI241915B (en) * 1998-05-11 2005-10-21 Ciba Sc Holding Ag A method of preparing a pharmaceutical end formulation using a nanodispersion
US6248363B1 (en) * 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions

Also Published As

Publication number Publication date
HUP0300209A2 (hu) 2003-06-28
JP4790187B2 (ja) 2011-10-12
CN1257011C (zh) 2006-05-24
BR0108921A (pt) 2003-01-21
DE60103863D1 (de) 2004-07-22
KR100638527B1 (ko) 2006-10-25
JP2003525257A (ja) 2003-08-26
CN1419472A (zh) 2003-05-21
PT1265698E (pt) 2004-11-30
FR2805761A1 (fr) 2001-09-07
EP1265698B1 (fr) 2004-06-16
SI1265698T1 (en) 2004-10-31
NO20024181D0 (no) 2002-09-02
MXPA02008638A (es) 2004-09-06
AU4075301A (en) 2001-09-12
CA2401766C (fr) 2009-05-19
CA2401766A1 (fr) 2001-09-07
TR200401812T4 (tr) 2004-09-21
US20030152635A1 (en) 2003-08-14
FR2805761B1 (fr) 2002-08-30
BR0108921B1 (pt) 2014-09-30
DE60103863T2 (de) 2005-06-30
ES2221640T3 (es) 2005-01-01
BRPI0108921B8 (pt) 2021-05-25
ATE269154T1 (de) 2004-07-15
ZA200206985B (en) 2003-10-07
US8057823B2 (en) 2011-11-15
WO2001064328A1 (fr) 2001-09-07
IL151560A0 (en) 2003-04-10
NO20024181L (no) 2002-10-22
KR20030003692A (ko) 2003-01-10
AU2001240753B2 (en) 2005-04-14
HU226483B1 (en) 2009-03-02
US20090238865A1 (en) 2009-09-24
HUP0300209A3 (en) 2005-04-28
EP1265698A1 (fr) 2002-12-18
NO334188B1 (no) 2014-01-13

Similar Documents

Publication Publication Date Title
NO20024181D0 (no) Lipidnanokapsler, fremgangsmåte for fremstilling derav, samt anvendelse av medikamentet
RU2159761C2 (ru) Замещенные 4-биарилмасляные или 5-биарилпентановые кислоты или их производные, способы их получения, фармацевтическая композиция и способ лечения
ATE253912T1 (de) Verwendung von nikotinergen acetylcholinrezeptor- agonisten zur herstellung eines medikaments zur behandlung von keratoconjuctivitis sicca
BR9916421A (pt) Modelo e método para uso de um agente racionalinterativo, servidor de múltiplos agentes esistema implementando os mesmos
BR0207760A (pt) Composição farmacêutica, uso da mesma, métodos para o tratamento de dor e de inflamação, e, processo para a preparação de uma composição
NO964639L (no) Substituerte sulfonimidamider, fremgangsmåte for fremstilling derav, deres anvendelse som medikament eller diagnostikum samt medikament inneholdende forbindelsen
SE0100200D0 (sv) New film coating
ATE429903T1 (de) Pharmazeutische zubereitung mit verzögerter wirkstoff-freisetzung enthaltend milchsäure- glycolsäure copolymer, und verfahren zu deren herstellung
BR0107899A (pt) Processo para produzir uma preparação de ingrediente ativo compreendendo ibuprofeno, preparação de ingrediente ativo, uso da mesma, preparação farmacêutica, uso da mesma, processo para produzir formas de dosagem sólidas, e, forma de dosagem sólida
DE60215641D1 (de) Filmbildende kosmetische zusammensetzung
WO2020173431A3 (zh) 包含抗cd47抗体的制剂及其制备方法和用途
NO960364D0 (no) Basisk-substituerte benzolguanidiner, fremgangsmåte for fremstilling derav, deres anvendelse som medikament eller diagnostikum samt medikament inneholdende forbindelsen
DE59407043D1 (de) Wässrige Wachs- und Silicondispersionen, deren Herstellung und Verwendung
BR0314777A (pt) Formas de dosagem de liberação modificada
ITMO20020221A1 (it) Cannula per l'erogazione di prodotti fluidi, particolarmente pomate, creme e paste medicinali o simili.
PT1408035E (pt) Metodo de preparacao de derivativos de 1.5-diaril-3-trifluorometilo-delta2-pirazolinas que sejam racemicos e enanciomericamente puros
ATA20322000A (de) Verfahren zur herstellung von zumindest einseitig beschichteten warm- oder kaltprodukten in form eines bandes
ITRM20000433A0 (it) Uso di fibrati per la preparazione di un medicamento utile nel trattamento dell'insufficenza cardiaca congestizia.
DE60143350D1 (de) Verfahren zur herstellung von 1,3-dialkyl-2-imidazolidinon-derivaten
IT1317733B1 (it) Metodo per la preparazione di essenze e rimedi florealiparticolarmente idonei per la floriterapia.
ITTO950133A0 (it) Sacca per elementi pompanti quali, ad esempio, elementi pompanti di dispositivi per assistenza cardiaca, e relativo gruppo di pompaggio.
ITMO20030036A0 (it) Sistema infusionale per la somministrazione di liquido medicale,diagnostico o simile.
BRPI0501241A (pt) composição cosmética, composição farmacêutica e processo para preparação das referidas composições
ITRM20010121A1 (it) Procedimento per l'accantonamento di quote giocate o scommesse, finalizzate al risparmio e mezzi di attuazione.
IT1308160B1 (it) Procedimento per il rivestimento della bordatura di lentiparticolarmente per occhiali o simili, e prodotto cosi' ottenuto.