DK1274685T3 - Et pyridin-N-oxid-derivat og fremgangsmåde til omdannelse deraf til farmaceutisk effektive forbindelser - Google Patents

Et pyridin-N-oxid-derivat og fremgangsmåde til omdannelse deraf til farmaceutisk effektive forbindelser

Info

Publication number: DK1274685T3
Authority: DK; Denmark
Prior art keywords: pyridine; conversion; pharmaceutically effective; oxide; oxide derivative
Prior art date: 2000-04-18

Application number

DK01928133T

Other languages

Danish (da)

English (en)

Inventor

Laszlo Ueroegdi

Csakai Zita Jegesne

Laszlo Oetvoes

J0Zsef Toth

Istvan Toemoeskoezi

Schmidt Aniko Szakacsne

Ferencne Reider

Barlay Maria Schneiderne

Lajos Gruber

Original Assignee

Biorex Kutato Fejlesztoe Kft

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-04-18

Filing date

2001-04-17

Publication date

2006-11-06

2001-04-17 Application filed by Biorex Kutato Fejlesztoe Kft filed Critical Biorex Kutato Fejlesztoe Kft

2006-11-06 Application granted granted Critical

2006-11-06 Publication of DK1274685T3 publication Critical patent/DK1274685T3/da

Links

150000001875 compounds Chemical class 0.000 title abstract 3
238000006243 chemical reaction Methods 0.000 title 1
238000000034 method Methods 0.000 title 1
ILVXOBCQQYKLDS-UHFFFAOYSA-N pyridine N-oxide Chemical class [O-][N+]1=CC=CC=C1 ILVXOBCQQYKLDS-UHFFFAOYSA-N 0.000 title 1
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 2
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
239000004480 active ingredient Substances 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
QPANXJTVLHTKCV-UHFFFAOYSA-N n'-(2-hydroxy-3-piperidin-1-ylpropoxy)-1-oxidopyridin-1-ium-3-carboximidamide Chemical compound C=1C=C[N+]([O-])=CC=1C(N)=NOCC(O)CN1CCCCC1 QPANXJTVLHTKCV-UHFFFAOYSA-N 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Pyridine Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DK01928133T 2000-04-18 2001-04-17 Et pyridin-N-oxid-derivat og fremgangsmåde til omdannelse deraf til farmaceutisk effektive forbindelser DK1274685T3 (da)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
HU0001583A HUP0001583A2 (hu)	2000-04-18	2000-04-18	Egy piridin-1-oxid-származék és eljárás annak átalakítására gyógyászati hatású vegyületekké

Publications (1)

Publication Number	Publication Date
DK1274685T3 true DK1274685T3 (da)	2006-11-06

Family

ID=90001563

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK01928133T DK1274685T3 (da)	2000-04-18	2001-04-17	Et pyridin-N-oxid-derivat og fremgangsmåde til omdannelse deraf til farmaceutisk effektive forbindelser

Country Status (31)

Country	Link
US (1)	US7126002B2 (sr)
EP (1)	EP1274685B1 (sr)
JP (1)	JP5066638B2 (sr)
KR (1)	KR100742482B1 (sr)
CN (1)	CN1216868C (sr)
AT (1)	ATE332894T1 (sr)
AU (2)	AU5499701A (sr)
BG (1)	BG65889B1 (sr)
BR (1)	BRPI0110184B8 (sr)
CA (1)	CA2406266C (sr)
CY (1)	CY1107473T1 (sr)
CZ (1)	CZ301576B6 (sr)
DE (1)	DE60121431T2 (sr)
DK (1)	DK1274685T3 (sr)
EE (1)	EE05085B1 (sr)
ES (1)	ES2267758T3 (sr)
HR (1)	HRP20020825A2 (sr)
HU (1)	HUP0001583A2 (sr)
IL (2)	IL152337A0 (sr)
MX (1)	MXPA02010320A (sr)
NO (1)	NO323535B1 (sr)
NZ (1)	NZ522017A (sr)
PL (1)	PL359826A1 (sr)
PT (1)	PT1274685E (sr)
RS (1)	RS51003B (sr)
RU (1)	RU2281282C2 (sr)
SI (1)	SI1274685T1 (sr)
SK (1)	SK287606B6 (sr)
UA (1)	UA75353C2 (sr)
WO (1)	WO2001079174A1 (sr)
ZA (1)	ZA200208460B (sr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HUP9900475D0 (en) *	1999-02-26	1999-04-28	Biorex Kutato Fejlesztoe Kft	O-(3-piperidino-2-hydroxy-1-propyl)-hiyroximic acid-halogenid derivative, it's use for treating insulin resistance, and pharmaceutical compositions containing them as active component
HU0103939D0 (en) *	2001-09-27	2001-11-28	Biorex Kutato Fejlesztoe Kft	Pharmaceutical composition containing methformin and n-[2-hydroxy-3-(1-piperidinyl)-propoxy]-pyridine-1-oxide-3-carboximidoyl chloride
WO2003057664A1 (en) *	2002-01-11	2003-07-17	Biorex Kutató És Fejlesztö Rt.	Carboxamidine derivatives and their use in the treatment of vascular diseases
HUP0303584A3 (en)	2003-10-30	2009-12-28	Cytrx Corp	Use of a hydroximic acid halide derivative in the treatment of neurodegenerative diseases
TW200831479A (en) *	2006-09-26	2008-08-01	Cytrx Corp	Pharmaceutical compositions and methods for treating diseases
JP5616336B2 (ja)	2008-06-26	2014-10-29	オルファザイムエーピーエスＯｒｐｈａｚｙｍｅＡｐｓ	酵素活性の調節因子としてのＨｓｐ７０の使用
US9662375B2 (en)	2010-11-30	2017-05-30	Orphazyme Aps	Methods for increasing intracellular activity of Hsp70
HUP1100534A2 (en)	2011-09-26	2013-04-29	Balazs Dr Hazay	Pharmaceutical composition for the treatment of muscle atrophy
HUP1100535A2 (en)	2011-09-26	2013-04-29	Bracelia Invest Ltd	Pharmaceutical composition for enhancement of stem cell treatment
US10709700B2 (en)	2014-09-15	2020-07-14	Orphazyme A/S	Arimoclomol formulation
WO2017178029A1 (en)	2016-04-13	2017-10-19	Orphazyme Aps	Heat shock proteins and cholesterol homeostasis
ES2831764T3 (es)	2016-04-29	2021-06-09	Orphazyme As	Arimoclomol para el tratamiento de trastornos asociados a glucocerebrosidasa
US20210145815A1 (en)	2017-09-22	2021-05-20	The University Of Adelaide	Methods and products for improving sperm quality
HUP1800298A1 (hu)	2018-08-30	2020-05-28	N Gene Res Laboratories Inc	Gyógyszerkombináció béta-receptor blokkolók hatásának módosítására és a mellékhatások csökkentésére
KR20230035586A (ko)	2020-06-24	2023-03-14	켐팜 덴마크 에이/에스	고셔병을 치료하기 위한 아리모클로몰
CN116783164A (zh) *	2020-11-19	2023-09-19	泽维拉丹麦股份有限公司	制备柠檬酸阿瑞洛莫及其中间体的方法
EP4247792A1 (en) *	2020-11-19	2023-09-27	Zevra Denmark A/S	Processes for preparing arimoclomol citrate and intermediates thereof
WO2022136640A1 (en)	2020-12-24	2022-06-30	Orphazyme A/S	Arimoclomol for the treatment of niemann pick disease, type c, in patients with er type missense mutations
EP4743072A1 (en)	2023-07-10	2026-05-20	N-Gene Research Laboratories Inc.	TELOMERE LENGTHENING AND/OR SUPPRESSION OF TELOMERE SHORTENING

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HU207988B (en) *	1988-10-20	1993-07-28	Biorex Kutato Fejlesztoe Kft	Process for producing halogenides of o-/3-amino-2-hydroxy-propyl/hydroximic acid and pharmaceutical compositions containing them as active components
HU9502843D0 (en)	1995-09-29	1995-11-28	Livigene Ltd	Pharmaceutical composition
HU222994B1 (hu) *	1995-11-02	2004-01-28	BIOREX Kutató és Fejlesztő Rt.	Hidroxilaminszármazékok és azok alkalmazása sejtek molekuláris chaperon-termelésének fokozására alkalmas gyógyszerkészítmények előállítására
HUP9900475D0 (en) *	1999-02-26	1999-04-28	Biorex Kutato Fejlesztoe Kft	O-(3-piperidino-2-hydroxy-1-propyl)-hiyroximic acid-halogenid derivative, it's use for treating insulin resistance, and pharmaceutical compositions containing them as active component

2000
- 2000-04-18 HU HU0001583A patent/HUP0001583A2/hu unknown
2001
- 2001-04-17 AT AT01928133T patent/ATE332894T1/de not_active IP Right Cessation
- 2001-04-17 AU AU5499701A patent/AU5499701A/xx active Pending
- 2001-04-17 JP JP2001576775A patent/JP5066638B2/ja not_active Expired - Lifetime
- 2001-04-17 PL PL35982601A patent/PL359826A1/xx not_active IP Right Cessation
- 2001-04-17 MX MXPA02010320A patent/MXPA02010320A/es active IP Right Grant
- 2001-04-17 ES ES01928133T patent/ES2267758T3/es not_active Expired - Lifetime
- 2001-04-17 DE DE60121431T patent/DE60121431T2/de not_active Expired - Lifetime
- 2001-04-17 CZ CZ20023445A patent/CZ301576B6/cs not_active IP Right Cessation
- 2001-04-17 CA CA2406266A patent/CA2406266C/en not_active Expired - Lifetime
- 2001-04-17 EP EP01928133A patent/EP1274685B1/en not_active Expired - Lifetime
- 2001-04-17 HR HRP20020825 patent/HRP20020825A2/hr not_active Application Discontinuation
- 2001-04-17 UA UA2002108255A patent/UA75353C2/uk unknown
- 2001-04-17 NZ NZ522017A patent/NZ522017A/en unknown
- 2001-04-17 RS YUP-783/02A patent/RS51003B/sr unknown
- 2001-04-17 WO PCT/HU2001/000046 patent/WO2001079174A1/en not_active Ceased
- 2001-04-17 CN CN018108318A patent/CN1216868C/zh not_active Expired - Lifetime
- 2001-04-17 PT PT01928133T patent/PT1274685E/pt unknown
- 2001-04-17 DK DK01928133T patent/DK1274685T3/da active
- 2001-04-17 BR BRPI0110184A patent/BRPI0110184B8/pt not_active IP Right Cessation
- 2001-04-17 IL IL15233701A patent/IL152337A0/xx active IP Right Grant
- 2001-04-17 SK SK1508-2002A patent/SK287606B6/sk not_active IP Right Cessation
- 2001-04-17 SI SI200130607T patent/SI1274685T1/sl unknown
- 2001-04-17 EE EEP200200591A patent/EE05085B1/xx not_active IP Right Cessation
- 2001-04-17 US US10/257,755 patent/US7126002B2/en not_active Expired - Lifetime
- 2001-04-17 RU RU2002130710/04A patent/RU2281282C2/ru not_active IP Right Cessation
- 2001-04-17 AU AU2001254997A patent/AU2001254997B2/en not_active Expired
- 2001-04-17 KR KR1020027014047A patent/KR100742482B1/ko not_active Expired - Fee Related
2002
- 2002-10-16 BG BG107199A patent/BG65889B1/bg unknown
- 2002-10-17 IL IL152337A patent/IL152337A/en unknown
- 2002-10-18 ZA ZA200208460A patent/ZA200208460B/en unknown
- 2002-10-18 NO NO20025015A patent/NO323535B1/no not_active IP Right Cessation
2006
- 2006-07-21 CY CY20061101020T patent/CY1107473T1/el unknown

Also Published As

Publication number	Publication date
EP1274685B1 (en)	2006-07-12
US20040006232A1 (en)	2004-01-08
CZ20023445A3 (cs)	2003-03-12
CA2406266C (en)	2010-07-20
IL152337A0 (en)	2003-05-29
HK1055741A1 (en)	2004-01-21
DE60121431T2 (de)	2007-01-18
EE05085B1 (et)	2008-10-15
RU2002130710A (ru)	2004-03-20
HUP0001583A2 (hu)	2002-11-28
CZ301576B6 (cs)	2010-04-21
HUP0001583D0 (en)	2000-06-28
JP5066638B2 (ja)	2012-11-07
NO323535B1 (no)	2007-06-04
NZ522017A (en)	2004-06-25
RS51003B (sr)	2010-10-31
ZA200208460B (en)	2003-10-20
MXPA02010320A (es)	2004-09-06
IL152337A (en)	2007-10-31
US7126002B2 (en)	2006-10-24
BG65889B1 (bg)	2010-04-30
AU2001254997B2 (en)	2006-11-23
JP2004501080A (ja)	2004-01-15
CA2406266A1 (en)	2001-10-25
BG107199A (bg)	2003-07-31
CY1107473T1 (el)	2012-12-19
NO20025015D0 (no)	2002-10-18
YU78302A (sh)	2005-09-19
PL359826A1 (en)	2004-09-06
NO20025015L (no)	2002-12-16
SI1274685T1 (sl)	2006-10-31
UA75353C2 (en)	2006-04-17
AU5499701A (en)	2001-10-30
SK15082002A3 (sk)	2003-05-02
RU2281282C2 (ru)	2006-08-10
EP1274685A1 (en)	2003-01-15
WO2001079174A8 (en)	2002-12-27
KR100742482B1 (ko)	2007-07-25
HRP20020825A2 (en)	2004-12-31
PT1274685E (pt)	2006-09-29
KR20030011309A (ko)	2003-02-07
BRPI0110184B8 (pt)	2021-05-25
SK287606B6 (sk)	2011-03-04
BR0110184A (pt)	2003-06-17
EE200200591A (et)	2004-04-15
DE60121431D1 (de)	2006-08-24
BRPI0110184B1 (pt)	2015-12-29
ES2267758T3 (es)	2007-03-16
WO2001079174A1 (en)	2001-10-25
CN1216868C (zh)	2005-08-31
ATE332894T1 (de)	2006-08-15
CN1434800A (zh)	2003-08-06

Publication	Publication Date	Title
NO20025015D0 (no)	2002-10-18	Et pyridin-1-oksidderivat, og fremgangsmåte for dets overföring til farmasöytisk effektive forbindelser
EA200100971A1 (ru)	2002-02-28	Новые соединения и композиции в качестве ингибиторов протеазы
MY144659A (en)	2011-10-31	2-hydroxy-3-heteroarylindole derivatives as gsk3 inhibitors
TW200510375A (en)	2005-03-16	New compounds
EA199800290A1 (ru)	1998-10-29	(метилсульфонил) фенил-2-(5н)-фураноны в качестве ингибиторов циклооксигеназы-2
EA200600892A1 (ru)	2006-12-29	Новые хинолиновые производные
NO20033732L (no)	2003-10-22	N-substituerte ikke-aryl-heterosykliske NMDA/NR2B-antagonister, og farmasoytiske preparater som omfatter slike forbindelser.
DK0923554T3 (da)	2002-04-29	N-Benzylpiperidin- og tetrahydropyridinderivater
SE0100569D0 (sv)	2001-02-20	New compounds
ES2161417T3 (es)	2001-12-01	Compuestos de 2-aril-3-aminoariloxinaftilo, intermediarios, composiciones y procedimientos.
ATE253359T1 (de)	2003-11-15	Antithrombotische mittel
EA200000322A1 (ru)	2000-10-30	Способ синтеза производных хинолина
DE69828522D1 (de)	2005-02-10	Antithrombotische mittel
EA200300771A1 (ru)	2004-02-26	Новая соль бензоилгуанидина
MXPA03009723A (es)	2004-03-16	Procedimientos e intermediarios para preparar epoxidos substituidos de bencilo.
SE9901340D0 (sv)	1999-04-15	Novel process
BG104964A (bg)	2001-07-31	Подобрен метод за получаване на фармацевтично ценни норбензоморфанови производни
SE9901338D0 (sv)	1999-04-15	Novel process
BG105178A (bg)	2001-12-29	Нови 2,3,3а,4,9,9а-хексахидро-8-хидрокси-1н-бенз/f/индоли, метод за получаването им и приложението им като лекарствени средства
DE69824410D1 (en)	2004-07-15	Antithrombosemittel
EA200100156A3 (ru)	2001-10-22	Новые производные 6-сульфамоил-3-хинолилфосфоновой кислоты, способ их получения и содержащие их фармацевтические композиции